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    MESEMBRINE DERIVATIVES
    9.
    发明公开
    MESEMBRINE DERIVATIVES 审中-公开

    公开(公告)号：US20240294510A1

    公开(公告)日：2024-09-05

    申请号：US18622877

    申请日：2024-03-30

    申请人： Justin Kirkland

    发明人： Justin Kirkland

    IPC分类号： C07D405/04 ,  A61K31/403 ,  A61K31/404

    CPC分类号： C07D405/04 ,  A61K31/403 ,  A61K31/404

    摘要： Disclosed herein are 3′,4′ “methylenedioxy” analogs of the natural alkaloids and analogs of mesembrine. For example, the present disclosure provides 3′,4′-methylenedioxy-mesembrine, 3′,4′-methylenedioxy-delta-7-mesembrenone, 3′,4′-methylenedioxy-mesembrano, 3′,4′-methylenedioxy-mesembrenonel, 3′,4′-methylenedioxy-mesembrane, 3′,4′-methylenedioxy-N-demethylmesembrenol, 3′,4′-methylenedioxy-N-demethylmesembranol, 3′,4′-methylenedioxy-joubertinanmine, 3′,4′-methylenedioxy-epijoubertinanmine (chirality signified by “epi”), 3′,4′-methylenedioxy-tortuosamine, 3′,4′methylenedioxy-N-demethyl-mesembrenone, 3′,4′methylenedioxy-N-demethyl-N-formyl-mesembrenone, 3′,4′methylenedioxy-O-acetylmesembranol, 3′,4′-methylenedioxy-N-formyltortuosamine, and 3′,4′-methylenedioxy-N-acetyltortuosamine.