专利检索 ipc:"C07D413/08" 第 1 页

1.

发明公开
THERAPEUTIC COMPOUNDS AND METHODS 审中-公开

公开(公告)号：US20240287055A1

公开(公告)日：2024-08-29

申请号：US18630109

申请日：2024-04-09

申请人： Actio Biosciences, Inc.

发明人： Ashley KATANA , John Otto LINK

IPC分类号： C07D413/14 , C07D413/08

CPC分类号： C07D413/14 , C07D413/08

摘要： The disclosure provides a compound of formula I:

or a salt thereof, wherein R1, R2, R4, L1, L2, and A have any of the values described in the specification, as well as compositions comprising a compound of formula (I). The compounds are useful as TRPV4 antagonists.

2.

发明授权
Therapeutic compounds and methods 有权

公开(公告)号：US11987577B2

公开(公告)日：2024-05-21

申请号：US18363195

申请日：2023-08-01

申请人： Actio Biosciences, Inc.

发明人： Ashley Katana , John Otto Link

IPC分类号： C07D413/14 , C07D413/08

CPC分类号： C07D413/14 , C07D413/08

摘要： The disclosure provides a compound of formula I:

or a salt thereof, wherein R1, R2, R4, L1, L2, and A have any of the values described in the specification, as well as compositions comprising a compound of formula (I). The compounds are useful as TRPV4 antagonists.

3.

发明授权
Cardiac sarcomere inhibitors 有权

公开(公告)号：US11952381B2

公开(公告)日：2024-04-09

申请号：US17736895

申请日：2022-05-04

申请人： Cytokinetics, Inc.

发明人： Chihyuan Chuang , Bradley P. Morgan , Mark Vanderwal , Luke W. Ashcraft , Kevin Lau

IPC分类号： C07D487/10 , A61P9/04 , C07D241/08 , C07D241/38 , C07D401/04 , C07D401/06 , C07D401/08 , C07D403/08 , C07D405/04 , C07D405/12 , C07D405/14 , C07D409/14 , C07D413/08 , C07D413/14 , C07D417/08 , C07D491/107

CPC分类号： C07D487/10 , A61P9/04 , C07D241/08 , C07D241/38 , C07D401/04 , C07D401/06 , C07D401/08 , C07D403/08 , C07D405/04 , C07D405/12 , C07D405/14 , C07D409/14 , C07D413/08 , C07D413/14 , C07D417/08 , C07D491/107

摘要： Provided are compounds of Formula (I):

or a pharmaceutically acceptable salt thereof, wherein R1, R2A, R2B, R3, R4, and R5 are as defined herein. Also provided is a pharmaceutically acceptable composition comprising a compound of Formula (I), or a pharmaceutically acceptable salt thereof. Also provided are methods of using a compound of Formula (I), or a pharmaceutically acceptable salt thereof.

4.

发明授权
5-membered heteroaryl carboxamide compounds for treatment of HBV 有权

公开(公告)号：US11560370B1

公开(公告)日：2023-01-24

申请号：US17287681

申请日：2019-10-22

申请人： Assembly Biosciences, Inc.

发明人： Simon Nicolas Haydar , Leping Li , Mark G. Bures , Roopa Rai , Lynne Bannen , Michael Walker

IPC分类号： A61P31/20 , A61K31/40 , A61K31/4025 , A61K31/415 , A61K31/4155 , A61K31/42 , A61K31/422 , A61K31/425 , A61K31/427 , C07D231/38 , C07D261/14 , C07D401/08 , C07D403/04 , C07D403/08 , C07D403/10 , C07D403/12 , C07D405/04 , C07D407/04 , C07D409/04 , C07D409/08 , C07D413/04 , C07D413/08 , C07D417/08

摘要： The present disclosure provides, in part, 5-membered heteroaryl carboxamide compounds, and pharmaceutical compositions thereof, useful for disruption of HBV core protein assembly, and methods of treating Hepatitis B (HBV) infection.

5.

发明申请
3-ARYL-BICYCLIC [4,5,0] HYDROXAMIC ACIDS AS HDAC INHIBITORS 有权

公开(公告)号：US20210009540A1

公开(公告)日：2021-01-14

申请号：US17031815

申请日：2020-09-24

申请人： Valo Early Discovery, Inc.

发明人： Xiaozhang Zheng , Pui Yee Ng , Bingsong Han , Jennifer R. Thomason , Mary-Margaret Zablocki , Cuixian Liu , Aleksandra Rudnitskaya , David R. Lancia, JR. , David S. Millan , Matthew W. Martin

IPC分类号： C07D267/14 , C07D413/06 , C07D413/12 , C07D413/04 , C07D267/12 , C07D243/14 , C07D291/08 , C07D401/06 , C07D401/10 , C07D403/06 , C07D403/10 , C07D405/06 , C07D413/14 , C07D417/04 , C07D471/04 , C07D498/04 , C07D498/08 , C07D493/08 , C07D413/08 , C07D491/107 , C07D495/10

摘要： The present invention relates to inhibitors of zinc-dependent histone deacetylases (HDACs) useful in the treatment of diseases or disorders associated with HDAC6, having a Formula I: where R, L, X1, X2, X3, X4, Y1, Y2, Y3, and Y4 are described herein.

6.

发明申请
3-ALKYL BICYCLIC [4,5,0] HYDROXAMIC ACIDS AS HDAC INHIBITORS 有权

公开(公告)号：US20210009539A1

公开(公告)日：2021-01-14

申请号：US17031814

申请日：2020-09-24

申请人： Valo Early Discovery, Inc.

发明人： Xiaozhang Zheng , Pui Yee Ng , Bingsong Han , Jennifer R. Thomason , Mary-Margaret Zablocki , Cuixian Liu , Aleksandra Rudnitskaya , David R. Lancia, JR. , David S. Millan , Matthew W. Martin , Kenneth W. Bair

IPC分类号： C07D267/14 , C07D413/06 , C07D413/12 , C07D413/04 , C07D267/12 , C07D243/14 , C07D291/08 , C07D401/06 , C07D401/10 , C07D403/06 , C07D403/10 , C07D405/06 , C07D413/14 , C07D417/04 , C07D471/04 , C07D498/04 , C07D498/08 , C07D493/08 , C07D413/08 , C07D491/107 , C07D495/10

摘要： The present disclosure relates to inhibitors of zinc-dependent histone deacetylases (HDACs) useful in the treatment of diseases or disorders associated with an HDAC, e.g., HDAC6, having a Formula I: where R, L, X1, X2, X3, X4, Y1, Y2, Y3, and Y4 are described herein.

7.

发明申请
3-ARYL-4-AMIDO-BICYCLIC [4,5,0] HYDROXAMIC ACIDS AS HDAC INHIBITORS 有权

公开(公告)号：US20210009538A1

公开(公告)日：2021-01-14

申请号：US17031812

申请日：2020-09-24

申请人： Valo Early Discovery, Inc.

发明人： Xiaozhang Zheng , Pui Yee Ng , Bingsong Han , Jennifer R. Thomason , Mary-Margaret Zablocki , Cuixian Liu , Aleksandra Rudnitskaya , David R. Lancia, JR. , David S. Millan , Matthew W. Martin

IPC分类号： C07D267/14 , C07D413/06 , C07D413/12 , C07D413/04 , C07D267/12 , C07D243/14 , C07D291/08 , C07D401/06 , C07D401/10 , C07D403/06 , C07D403/10 , C07D405/06 , C07D413/14 , C07D417/04 , C07D471/04 , C07D498/04 , C07D498/08 , C07D493/08 , C07D413/08 , C07D491/107 , C07D495/10

摘要： The present disclosure relates to inhibitors of zinc-dependent histone deacetylases (HDACs) useful in the treatment of diseases or disorders associated with an HDAC, e.g., HDAC6, having a Formula I: where R, L, X1, X2, X3, X4, Y1, Y2, Y3, and Y4 are described herein.

8.

再颁专利
Nitrogen-containing heterocyclic compound and use of same 有权

公开(公告)号：USRE48334E1

公开(公告)日：2020-12-01

申请号：US15445251

申请日：2017-02-28

申请人： Takeda Pharmaceutical Company Limited

发明人： Junya Shirai , Hideyuki Sugiyama , Taku Kamei , Hironobu Maezaki

IPC分类号： C07D401/04 , C07D207/14 , C07D211/58 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/06 , C07D403/10 , C07D405/06 , C07D405/12 , C07D409/04 , C07D409/06 , C07D409/12 , C07D413/04 , C07D413/06 , C07D413/08 , C07D413/14 , C07D417/08

摘要： The present invention relates to a compound represented by the formula wherein ring A is a nitrogen-containing heterocycle; ring B is an aromatic ring optionally having substituent(s); ring D is an aromatic ring optionally having substituent(s); L is a group represented by the formula R2, R3, R4a and R4b are each independently a hydrogen atom, an optionally halogenated C1-6 alkyl group or an optionally halogenated C3-6 cycloalkyl group, or R2 and R3 are optionally bonded via an alkylene chain or an alkenylene chain, or R4a and R4b are optionally bonded via an alkylene chain or an alkenylene chain; R1 is a hydrogen atom or a substituent; m and n are each independently an integer of 0 to 5; m+n is an integer of 2 to 5; and is a single bond or double bond, or a salt thereof; and the like. The compound has a superior tachykinin receptor antagonistic action, and is useful as an agent for the prophylaxis or treatment of various diseases such as lower urinary tract diseases, digestive tract diseases, central neurological disease and the like.