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143 条记录 (耗时 0.057 秒)

    TYROSINE KINASE INHIBITORS
    2.
    发明申请
    TYROSINE KINASE INHIBITORS 有权

    公开(公告)号：US20210078990A1

    公开(公告)日：2021-03-18

    申请号：US17105334

    申请日：2020-11-25

    申请人： Rigel Pharmaceuticals, Inc.

    发明人： Ihab Darwish ,  Jiaxin Yu ,  Rao Kolluri ,  Sacha Holland

    IPC分类号： C07D413/14 ,  C07D417/14 ,  C07D453/00 ,  C07D491/107

    摘要： Disclosed are imidazole compounds, as well as pharmaceutical compositions and methods of use thereof. One embodiment is a compound having the structure and pharmaceutically acceptable salts, prodrugs and N-oxides thereof (and solvates and hydrates thereof), wherein R1, X, Y1, Y2, Y3 and Z are as described herein. In certain embodiments, a compound disclosed herein inhibits a cellular TAM receptor, and can be used to treat disease mediated by or involving the TAM receptor family.

    INDOLE AND BENZOFURAN FUSED ISOQUINUCLIDENE DERIVATIVES AND PROCESSES FOR PREPARING THEM
    9.
    发明申请
    INDOLE AND BENZOFURAN FUSED ISOQUINUCLIDENE DERIVATIVES AND PROCESSES FOR PREPARING THEM 审中-公开
    吲哚和苯并呋喃熔化的代谢物衍生物及其制备方法

    公开(公告)号：US20160024075A1

    公开(公告)日：2016-01-28

    申请号：US14873417

    申请日：2015-10-02

    申请人： DemeRx,Inc.

    发明人： Robert M. Moriarty

    IPC分类号： C07D453/00

    CPC分类号： C07D453/00 ,  C07D471/22 ,  C07D491/22

    摘要： Provided herein are indole and benzofuran fused isoquinuclidene derivatives. Also provided herein are processes, preferably enantioselective processes, for preparing such derivatives including processes for preparing (−) and (+) noribogaine or a salt thereof, in substantially enantiomerically pure forms.

    摘要翻译： 本文提供的是吲哚和苯并呋喃稠合的亚奎宁衍生物。 本文还提供用于制备此类衍生物的方法，优选对映选择性方法，包括以基本上对映体纯的形式制备（ - ）和（+）诺布恩或其盐的方法。