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567 条记录 (耗时 0.027 秒)

    COMPOUNDS
    2.
    发明公开
    COMPOUNDS 审中-公开

    公开(公告)号：US20240228494A1

    公开(公告)日：2024-07-11

    申请号：US18556260

    申请日：2022-04-25

    申请人： PATHIOS THERAPEUTICS LIMITED

    发明人： David MILLER ,  Tom MCCARTHY ,  Alan NAYLOR ,  Gavin MILNE

    IPC分类号： C07D471/18 ,  A61K31/4353 ,  A61K31/519

    CPC分类号： C07D471/18 ,  A61K31/4353 ,  A61K31/519

    摘要： One aspect of the invention relates to a compound of formula (I), or a pharmaceutically acceptable salt or solvate thereof, (I) ring A is an is optionally substituted 5 or 6 membered aromatic or heteroaromatic ring; Y is selected from CH2, C═N—OH, and CR10R10′; Ra and Rb are each independently selected from H and alkyl; Z is selected from O, S, NR17 and CR18; X is selected from O and NH; p is 0, 1 or 2; q is 0 or 1; and r is 0 or 1; wherein at least one of p, q and r is other than zero, and with the proviso that: (i) when r is 0, p is 1 and q is 1, when X is NH, Z is other than O; (ii) when r and q are both 0, and p is 1, Z is not O; R1, R4, and R5 are each independently selected from H, alkyl, alkoxy, OH, F, Cl, Br, and I; R2 and R3 are each independently selected from H, F, Cl, Br, I, CN, methoxy, haloalkyl, haloalkoxy and CO2-alkyl; R10 and R10′ are each independently selected from H, F, alkyl, and haloalkyl; R15 and R16 are each independently selected from H, alkoxy, alkyl and OH; R17 is selected from H, CN, OH, alkoxy and alkyl; R18 is NO2 or CN; and wherein the compound is other than: (6S,9R)-10-benzyl-4-chloro-6,7,8,9-tetrahydro-5H-6,9-epiminocyclohepta[d]-pyrimidine; (6S,9R)-10-benzyl-1,5,6,7,8,9-hexahydro-4H-6,9-epiminocyclohepta[d]pyrimidin-4-one; (6R,9S)-10-benzyl-1,5,6,7,8,9-hexahydro-4H-6,9-epiminocyclohepta[d]pyrimidin-4-one; 10-benzyl-1,5,6,7,8,9-hexahydro-4H-6,9-epiminocyclohepta[d]pyrimidin-4-one; 10-(2,4,6-trimethoxybenzyl)-6,7,8,9-tetrahydro-5H-5,8-epiminocyclohepta[d]-pyrimidine; and 2-methoxy-5-((6,7,8,9-tetrahydro-5H-5,8-epiminocyclohepta[d]pyrimidin-10-yl)methyl)-benzonitrile. Further aspects of the invention relate to compounds of formula (I) for use in the field of immuno-oncology, immunology, and related applications.

    Ibogaine-related compounds and corresponding methods
    7.
    发明授权
    Ibogaine-related compounds and corresponding methods 有权

    公开(公告)号：US11680066B2

    公开(公告)日：2023-06-20

    申请号：US17300293

    申请日：2021-05-13

    申请人： Jeffrey Alan McKinney

    发明人： Jeffrey Alan McKinney

    IPC分类号： A61K31/55 ,  A61P25/22 ,  A61P25/30 ,  C07D471/18

    CPC分类号： C07D471/18 ,  C07B2200/05

    摘要： The present invention relates to Ibogaine derivatives and related methods. It more specifically relates to deutero- and fluoro-derivatives of Ibogaine and related methods. In one aspect, the present invention provides a compound. The structure of the compound is shown as compound 1 in FIG. 1. In another aspect, the present invention provides a method of treating an addiction disorder. The method comprises administration of compound 1. In another aspect, the present invention provides a method of treating an anxiety-related disorder or impulse control disorder. The method comprises administration of compound 1.