公开(公告)号：US20240190842A1

公开(公告)日：2024-06-13

申请号：US18504246

申请日：2023-11-08

申请人： Accutar Biotechnology Inc.

发明人： Yimin Qian ,  Robert Z. Luo ,  Ji Liu ,  Ke Liu ,  Wei He ,  Jie Fan

IPC分类号： C07D401/14 ,  A61P35/00 ,  C07D471/04 ,  C07D471/08 ,  C07D487/18

CPC分类号： C07D401/14 ,  A61P35/00 ,  C07D471/04 ,  C07D471/08 ,  C07D487/18

摘要： The present disclosure relates to novel quinolinone-8-carbonitrile based compounds, pharmaceutical compositions containing such compounds, and their use in prevention and treatment of cancer and related diseases and conditions. The compounds disclosed herein exhibit androgen receptor degradation activity.

公开(公告)号：US20240114782A1

公开(公告)日：2024-04-04

申请号：US18266832

申请日：2021-12-15

申请人： Merck Patent GmbH

发明人： Philipp STOESSEL

IPC分类号： H10K85/60 ,  C07D471/08 ,  C07D471/16 ,  C07D487/06 ,  C07D487/16 ,  C07D487/18 ,  C07D487/22 ,  C07D491/16 ,  C07D491/20 ,  C07D491/22 ,  C07D495/16 ,  C07D495/22 ,  C07D498/22 ,  C07F7/08 ,  C09K11/02 ,  C09K11/06 ,  H10K85/40

CPC分类号： H10K85/6572 ,  C07D471/08 ,  C07D471/16 ,  C07D487/06 ,  C07D487/16 ,  C07D487/18 ,  C07D487/22 ,  C07D491/16 ,  C07D491/20 ,  C07D491/22 ,  C07D495/16 ,  C07D495/22 ,  C07D498/22 ,  C07F7/0814 ,  C09K11/02 ,  C09K11/06 ,  H10K85/40 ,  H10K85/615 ,  H10K85/624 ,  H10K85/654 ,  H10K85/657 ,  H10K50/11

摘要： The present invention relates to aromatic compounds suitable for use in electronic devices, and to electronic devices, especially organic electroluminescent devices, comprising these compounds.

公开(公告)号：US20230250105A1

公开(公告)日：2023-08-10

申请号：US18175030

申请日：2023-02-27

申请人： UCB Biopharma SRL ,  SANOFI

发明人： Daniel Christopher Brookings ,  Teresa De Haro Garcia ,  Yann Foricher ,  Helen Tracey Horsley ,  Martin Clive Hutchings ,  James Andrew Johnson ,  Malcolm Maccoss ,  Mengyang Xuan ,  Zhaoning Zhu

IPC分类号： C07D487/18

CPC分类号： C07D487/18 ,  C07B2200/05

摘要： A compound of formula (I) as defined herein, or a pharmaceutically acceptable salt thereof, being potent modulators of human TNFα activity, are accordingly of benefit in the treatment and/or prevention of various human ailments, including autoimmune and inflammatory disorders; neurological and neurodegenerative disorders; pain and nociceptive disorders; cardiovascular disorders; metabolic disorders; ocular disorders; and oncological disorders.

公开(公告)号：US20230203058A1

公开(公告)日：2023-06-29

申请号：US17917462

申请日：2021-04-07

申请人： ITEOS BELGIUM SA

发明人： Michael Deligny ,  Stefano Crosginani ,  Erica Joke Katelijne Houthuys

IPC分类号： C07D498/08 ,  A61P35/00 ,  C07D487/08 ,  C07D487/18 ,  C07D273/08 ,  A61K45/06 ,  A61K31/551 ,  A61K31/395

CPC分类号： C07D498/08 ,  A61K31/395 ,  A61K31/551 ,  A61K45/06 ,  A61P35/00 ,  C07D273/08 ,  C07D487/08 ,  C07D487/18

摘要： The present invention relates to macrocyclic diamine derivatives of formula II, including pharmaceutically acceptable salts and solvates thereof. Compounds of the invention are inhibitors of ENT family transporter, especially of ENT1, and are useful as therapeutic compounds for the treatment of cancers. The invention also relates to the combined use of the macrocyclic diamine derivatives with an adenosine receptor antagonist, for the treatment of cancers.

公开(公告)号：US20230192692A1

公开(公告)日：2023-06-22

申请号：US17754924

申请日：2020-10-10

申请人： TIANJIN NORMAL UNIVERSITY

发明人： Chunju LI ,  Kaidi XU ,  ZhiYuan ZHANG

IPC分类号： C07D471/08 ,  C07C43/205 ,  C07D513/18 ,  C07C49/755 ,  C07D487/18 ,  C07C50/34 ,  C07D487/22 ,  C07C49/255 ,  C07F5/02 ,  C07C59/68 ,  C07C51/41 ,  C07C37/50

CPC分类号： C07D471/08 ,  C07C43/2055 ,  C07D513/18 ,  C07C49/755 ,  C07D487/18 ,  C07C50/34 ,  C07D487/22 ,  C07C49/255 ,  C07F5/027 ,  C07C59/68 ,  C07C51/41 ,  C07C37/50

摘要： A series of new macrocycles and cage-like molecules are obtained in a high yield from a bis-(2,4-dialkoxyphenyl)arene (naphthalene, anthracene, pyrene, porphyrin, etc.) or a tris-(2,4-dialkoxyphenyl)arene (benzene, sym-tribenzobenzene) and paraformaldehyde under the catalysis of a Lewis acid. In addition, perhydroxybiphenylarenes (tetrabiphenyl trimer, naphthalene dimer, etc.) can be obtained by means of demethylation, and a variety of water-soluble derivatives can be obtained by further modification, with same exhibiting a good bond ability for guest molecules (purpurine, etc.). Moreover, the functional group introduced into the backbone enables the macrocycle to have excellent adsorption and separation capabilities and a photophysical property. The macrocyclic and cage-like molecules have commercially available raw materials, are simple to synthesize, have a high yield, and are convenient to modify, such that same have wide application prospects in gas adsorption and separation, facilitate performance improvement of luminescent materials, perform adsorption of water-soluble toxic substances, etc.

公开(公告)号：US11572374B2

公开(公告)日：2023-02-07

申请号：US17266466

申请日：2019-08-13

申请人： Amgen Inc. ,  Carmot Therapeutics, Inc.

发明人： John R. Butler ,  Daniel Erlanson ,  Russell Graceffa ,  Jeffrey Iwig ,  Joon Won Jeong ,  Ryan D. White ,  Yongwei Wu ,  Shuyan Yi ,  Xiao Mei Zheng ,  Jesse M. McFarland ,  Abhisek Banerjee

IPC分类号： C07D519/00 ,  C07D487/18

摘要： The present invention provides a compound of formula (I) or a pharmaceutically acceptable salt thereof, pharmaceutical compositions comprising a compound of the invention, a method for manufacturing compounds of the invention and therapeutic uses thereof.

公开(公告)号：US20220363694A1

公开(公告)日：2022-11-17

申请号：US17266466

申请日：2019-08-13

申请人： Amgen Inc. ,  Carmot Therapeutics, Inc.

发明人： John R. BUTLER ,  Daniel ERLANSON ,  Russell GRACEFFA ,  Jeffrey IWIG ,  Joon Won JEONG ,  Ryan D. WHITE ,  Yongwei WU ,  Shuyan YI ,  Xiao Mei ZHENG ,  Jesse M. MCFARLAND ,  Abhisek BANERJEE

IPC分类号： C07D519/00 ,  C07D487/18

摘要： The present invention provides a compound of formula (I) or a pharmaceutically acceptable salt thereof, pharmaceutical compositions comprising a compound of the invention, a method for manufacturing compounds of the invention and therapeutic uses thereof.

公开(公告)号：US11478451B1

公开(公告)日：2022-10-25

申请号：US16764565

申请日：2018-11-15

申请人： Bayer Aktiengesellschaft ,  Bayer Pharma Aktiengesellschaft ,  The Broad Institute, Inc.

发明人： Kai Thede ,  Anne Mengel ,  Clara Christ ,  Joachim Kuhnke ,  Sarah Anna Liesa Johannes ,  Philipp Buchgraber ,  Ulrich Klar ,  Ulrike Rauh ,  Stefan Kaulfuss ,  Amaury Ernesto Fernandez-Montalvan ,  Nicolas Werbeck ,  Ursula Moenning ,  Katrin Nowak-Reppel ,  Chris Lemke ,  Michael H. Serrano-Wu ,  David McKinney ,  Mark Fitzgerald ,  Christopher Nasveschuk ,  Kiel Lazarski ,  Steven J. Ferrara ,  Laura Furst ,  Guo Wei ,  Patrick R. McCarren ,  Rebecca Ann Harvey ,  Daniel Payne ,  Thomas Pesnot ,  Craig Wilson

IPC分类号： A61K31/4162 ,  A61K45/06 ,  A61P35/00 ,  A61K31/496 ,  C07D487/18 ,  A61K31/5377 ,  C07D498/18

摘要： The present invention relates to macrocyclic indole derivatives of general formula (I): in which R1, R2, R3, R4, R5, R6, A and L are as defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds, and the use of said compounds for manufacturing pharmaceutical compositions for the treatment or prophylaxis of diseases, in particular of hyperproliferative disorders, as a sole agent or in combination with other active ingredients.

公开(公告)号：US11351168B1

公开(公告)日：2022-06-07

申请号：US16825285

申请日：2020-03-20

申请人： Celgene CAR LLC

发明人： Juswinder Singh ,  Russell C. Petter ,  Richland Wayne Tester ,  Arthur F. Kluge ,  Hormoz Mazdiyasni ,  William Frederick Westlin, III ,  Deqiang Niu ,  Lixin Qiao

IPC分类号： C07D239/30 ,  A61K31/505 ,  C07D495/04 ,  C07D239/48 ,  C07D401/14 ,  C07D403/12 ,  C07D407/12 ,  C07D413/12 ,  C07D413/14 ,  C07D471/04 ,  C07D487/04 ,  C07D487/18 ,  A61K31/506 ,  A61K31/519 ,  A61K31/5377 ,  A61K31/538 ,  A61K31/541 ,  A61K45/06 ,  C07D401/12 ,  C07D405/12 ,  C07D405/14 ,  C07D487/08 ,  C07D239/47

摘要： The present invention provides 2,4-disubstituted pyrimidine compounds useful as kinase inhibitors, pharmaceutically acceptable compositions thereof, and methods of using the same.

公开(公告)号：US20210252012A1

公开(公告)日：2021-08-19

申请号：US17176018

申请日：2021-02-15

申请人： UCB Biopharma SRL ,  SANOFI

发明人： Daniel Christopher Brookings ,  Teresa De Haro Garcia ,  Yann Foricher ,  Helen Tracey Horsley ,  Martin Clive Hutchings ,  James Andrew Johnson ,  Malcolm Maccoss ,  Mengyang Xuan ,  Zhaoning Zhu

IPC分类号： A61K31/55 ,  C07D487/18

摘要： A compound of formula (I) as defined herein, or a pharmaceutically acceptable salt thereof, being potent modulators of human TNFα activity, are accordingly of benefit in the treatment and/or prevention of various human ailments, including autoimmune and inflammatory disorders; neurological and neurodegenerative disorders; pain and nociceptive disorders; cardiovascular disorders; metabolic disorders; ocular disorders; and oncological disorders.