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公开(公告)号：US20230203053A1
公开(公告)日：2023-06-29
申请号：US17962187
申请日：2022-10-07
发明人： Raymond A. Chavez , Stephen Collins
IPC分类号： C07D489/00 , A61P25/02 , A61P25/04
CPC分类号： C07D489/00 , A61P25/02 , A61P25/04 , C07B2200/07
摘要： The present invention encompasses improved morphian compositions and methods of use of the improved compositions for modulating neuropathic pain, opioid-induced glial activation, or a combination thereof beyond what is currently known in the art. The methods involve administering the compound of Formula I to a subject.
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公开(公告)号：US11534436B2
公开(公告)日：2022-12-27
申请号：US16913404
申请日：2020-06-26
IPC分类号： A61K31/485 , C07D211/62 , C07D217/04 , C07D221/22 , C07D221/28 , C07D223/04 , C07D401/12 , C07D405/12 , C07D489/00 , C07D489/09
摘要： The present application relates methods for treating a depressive symptom comprising administering an effective amount of a μ opioid receptor agonist or a pharmaceutically acceptable salt thereof to a subject in need thereof. Non-limiting examples of such agonist include the compounds of Formulas I, II, III, and IV, as well as the compounds of Table A.
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公开(公告)号：US10975099B2
公开(公告)日：2021-04-13
申请号：US16674040
申请日：2019-11-05
发明人： Brian M. Aquila , Hoan Huynh , Lewis D. Pennington , Ingo Mugge , Baudouin Gerard , Markus Haeberlein , Roman A. Valiulin , Julius F. Remenar , Demetri Theodore Moustakas , Thomas Andrew Wynn , Todd Bosanac
IPC分类号： C07D519/00 , C07D489/00 , A61K31/485 , A61K9/00 , A61P25/30
摘要： The present invention provides compounds useful for the treatment of opioid dependence, alcohol dependence, alcohol use disorder, or the prevention of relapse to opioid dependence in a subject in need thereof. Related pharmaceutical compositions and methods are also provided herein.
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公开(公告)号：US10752592B2
公开(公告)日：2020-08-25
申请号：US16363465
申请日：2019-03-25
IPC分类号： C07D221/28 , C07D221/26 , C07D405/06 , A61K31/485 , C07D489/00
摘要： The present application relates to analogues of morphan and morphinan, compositions thereof, and methods for treating a disease or condition comprising administering an effective amount of the compounds or compositions to a subject in need thereof.
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公开(公告)号：US10167295B2
公开(公告)日：2019-01-01
申请号：US14851248
申请日：2015-09-11
IPC分类号： C07D401/06 , C07D403/12 , C07D405/12 , C07D405/14 , C07D491/107 , C07D489/02 , C07D207/09 , C07D211/06 , C07D207/06 , C07D207/263 , C07D211/12 , C07D489/00
摘要： Provided herein, inter alia, are methods and compositions for achieving an analgesic effect in subjects in need thereof.
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公开(公告)号：US20180353597A1
公开(公告)日：2018-12-13
申请号：US16105299
申请日：2018-08-20
发明人： Mariusz BANASZCZYK , Normand HÉBERT , Neil STOWE
IPC分类号： A61K39/385 , A61K39/39 , C08L25/06 , A61K39/00 , G01N33/94 , C07D489/02 , C07K16/06 , C07K16/44 , C07D489/04 , C07D489/00 , C07F9/6561
CPC分类号： A61K39/385 , A61K39/0013 , A61K39/39 , A61K2039/6081 , A61K2039/627 , C07D489/00 , C07D489/02 , C07D489/04 , C07F9/6561 , C07K16/06 , C07K16/44 , C07K2317/33 , C08L25/06 , G01N33/9486
摘要： The present invention relates to novel 6-acetylmorphine analogs, and methods for their synthesis and use. Such analogs are designed to provide a convenient linkage chemistry for coupling under mild conditions to a suitable group on a target protein, polypeptide, solid phase or detectable label.
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公开(公告)号：US10052379B2
公开(公告)日：2018-08-21
申请号：US15640781
申请日：2017-07-03
发明人： Mariusz Banaszczyk , Normand Hébert , Neil Stowe
IPC分类号： A61K39/385 , C07D489/02 , C07F9/6561 , C07D489/00 , C07D489/04 , C07K16/44 , C07K16/06 , A61K39/39 , G01N33/94 , A61K39/00 , C08L25/06
CPC分类号： A61K39/385 , A61K39/0013 , A61K39/39 , A61K2039/6081 , A61K2039/627 , C07D489/00 , C07D489/02 , C07D489/04 , C07F9/6561 , C07K16/06 , C07K16/44 , C07K2317/33 , C08L25/06 , G01N33/9486
摘要： The present invention relates to novel 6-acetylmorphine analogs, and methods for their synthesis and use. Such analogs are designed to provide a convenient linkage chemistry for coupling under mild conditions to a suitable group on a target protein, polypeptide, solid phase or detectable label.
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公开(公告)号：US20170327511A1
公开(公告)日：2017-11-16
申请号：US15523054
申请日：2015-11-02
IPC分类号： C07D489/04 , A61K31/485 , A61K31/00 , C07D489/00
CPC分类号： C07D489/04 , A61K31/00 , A61K31/485 , C07D489/00 , C07D489/02
摘要： There is provided a novel process for the preparation of a hydrocodone salt. In particular, there is provided a novel process for the preparation of a free-flowing slurry of a hydrocodone salt, for example, a free-flowing slurry of hydrocodone bitartrate hemipentahydrate.
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公开(公告)号：US09776971B2
公开(公告)日：2017-10-03
申请号：US13228527
申请日：2011-09-09
申请人： Edwin S. C. Wu , Mao-Hsiung Yen , Chin-Tsai Fan
发明人： Edwin S. C. Wu , Mao-Hsiung Yen , Chin-Tsai Fan
IPC分类号： A61K31/485 , C07D221/28 , C07D489/00 , C07D489/02 , C07D489/08 , A61K38/21 , A61K45/06 , C07D453/00
CPC分类号： C07D221/28 , A61K31/485 , A61K38/21 , A61K45/06 , C07D453/00 , C07D489/00 , C07D489/02 , C07D489/08 , Y10S514/893 , Y10S514/894 , A61K2300/00
摘要： The present invention relates to opioid and opioid-like compounds, and pharmaceutical formulations thereof, and use thereof for prevention and treatment of disorders such as septic shock and organ damage.
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公开(公告)号：US09694069B2
公开(公告)日：2017-07-04
申请号：US14775644
申请日：2014-03-14
发明人： Mariusz Banaszczyk , Normand Hébert , Neil Stowe
IPC分类号： A61K39/385 , C07D489/02 , C07D489/00 , C07D489/04 , C07F9/6561 , A61K39/00 , A61K39/39 , C07K16/06 , C07K16/44 , C08L25/06 , G01N33/94
CPC分类号： A61K39/385 , A61K39/0013 , A61K39/39 , A61K2039/6081 , A61K2039/627 , C07D489/00 , C07D489/02 , C07D489/04 , C07F9/6561 , C07K16/06 , C07K16/44 , C07K2317/33 , C08L25/06 , G01N33/9486
摘要： The present invention relates to novel 6-acetylmorphine analogs, and methods for their synthesis and use. Such analogs are designed to provide a convenient linkage chemistry for coupling under mild conditions to a suitable group on a target protein, polypeptide, solid phase or detectable label.
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