公开(公告)号：US20250066376A1

公开(公告)日：2025-02-27

申请号：US18893561

申请日：2024-09-23

Applicant: Nirsum Laboratories, Inc.

Inventor： Nikej N. Shah

IPC: C07D489/08 ,  A61K31/485 ,  C07D221/28

Abstract: Provided herein are prodrugs of opioid receptor antagonists such as samidorphan, methocinnamox, and naloxone, pharmaceutical compositions comprising said compounds, and methods for using said compounds for the treatment of diseases and disorders such as a depressive disorder, alcohol dependence and opioid dependence.

公开(公告)号：US12060361B2

公开(公告)日：2024-08-13

申请号：US18330932

申请日：2023-06-07

Applicant: Purdue Pharma L.P. ,  Purdue Pharmaceuticals L.P. ,  Rhodes Technologies

Inventor： Robert Chapman ,  Lonn S. Rider ,  Qi Hong ,  Donald Kyle ,  Robert Kupper

IPC: A61K31/485 ,  A61K9/14 ,  A61K9/20 ,  A61K9/48 ,  C07D489/02 ,  C07D489/04 ,  C07D489/08

CPC classification number: C07D489/08 ,  A61K9/14 ,  A61K9/20 ,  A61K9/2095 ,  A61K9/48 ,  A61K9/4833 ,  A61K31/485 ,  C07D489/02 ,  C07D489/04

Abstract: In certain embodiments the invention is directed to a process for preparing an oxycodone hydrochloride composition having less than 25 ppm of 14-hydroxycodeinone.

公开(公告)号：US20240208984A1

公开(公告)日：2024-06-27

申请号：US18552761

申请日：2022-03-30

Applicant: VIRGINIA COMMONWEALTH UNIVERSITY

Inventor： Yan ZHANG

IPC: C07D489/08 ,  A61K9/19 ,  A61K31/485 ,  A61K47/55 ,  G01N33/68

CPC classification number: C07D489/08 ,  A61K9/19 ,  A61K31/485 ,  A61K47/55 ,  G01N33/6863

Abstract: Bivalent ligands which bind to MOR-CCR5 heterodimers are provided. The bivalent ligands comprise two discrete pharmacophores, naltrexone and maraviroc, linked by a spacer and bind to MOR-CCR5 heterodimers, e.g. at the surface of a cell. The bivalent ligands are useful in assays to detect MOR-CCR5 heterodimers, as therapeutic agents to prevent and/or treat diseases characterized by the presence of MOR-CCR5 heterodimers.

公开(公告)号：US20230159548A1

公开(公告)日：2023-05-25

申请号：US17811736

申请日：2022-07-11

Applicant: Purdue Pharma L.P. ,  Purdue Pharmaceuticals L.P. ,  Rhodes Technologies

Inventor： Robert CHAPMAN ,  Lonn S. RIDER ,  Qi HONG ,  Donald KYLE ,  Robert KUPPER

IPC: C07D489/08 ,  C07D489/02 ,  A61K9/20 ,  A61K9/48 ,  A61K31/485 ,  A61K9/14 ,  C07D489/04

CPC classification number: C07D489/08 ,  C07D489/02 ,  A61K9/20 ,  A61K9/48 ,  A61K31/485 ,  A61K9/14 ,  A61K9/2095 ,  A61K9/4833 ,  C07D489/04

Abstract: In certain embodiments the invention is directed to a process for preparing an oxycodone hydrochloride composition having less than 25 ppm of 14-hydroxycodeinone.

公开(公告)号：US20230130617A1

公开(公告)日：2023-04-27

申请号：US17949681

申请日：2022-09-21

Applicant: RHODES TECHNOLOGIES

Inventor： Stuart James GEBBIE ,  Joshua R. GIGUERE ,  Keith MCCARTHY ,  Lonn S. RIDER

IPC: C07D489/08 ,  A61K31/485

Abstract: Compounds and compositions for use as starting materials or intermediate materials in the preparation of opioids including, e.g., oxymorphone base and/or an oxymorphone salt; processes for preparing these compounds and compositions; uses of these compounds and compositions in the preparation of APIs and pharmaceutical dosage forms; and uses of said APIs and pharma ceutical dosage forms in the treatment of medical conditions.

公开(公告)号：US11020386B2

公开(公告)日：2021-06-01

申请号：US15431624

申请日：2017-02-13

Applicant: Albany Molecular Research, Inc. ,  John K. Thottathil

Inventor： Matthew Surman ,  Kathryn Golden ,  Paolo Pasetto ,  Xiaomin Jin ,  Xiaowu Jiang ,  Fatoumata Camara ,  John K. Thottathil

IPC: A61K31/485 ,  C07D489/08 ,  A61K47/54

Abstract: Abuse-resistant opioid compounds, drug delivery systems, pharmaceutical compositions comprising an opioid covalently bound to a chemical moiety are provided. Methods of delivering an active ingredient to a subject and methods of preventing opioid abuse are also provided.

公开(公告)号：US11014933B2

公开(公告)日：2021-05-25

申请号：US16726420

申请日：2019-12-24

Applicant: Virginia Commonwealth University

Inventor： Yan Zhang

IPC: C07D489/08

Abstract: Non-peptide MOR opioid receptor modulators are provided. The compounds exhibit predominantly central activity and are used to treat e.g. substance use disorders, and pain.

公开(公告)号：US20210094964A1

公开(公告)日：2021-04-01

申请号：US17014134

申请日：2020-09-08

Applicant: RHODES TECHNOLOGIES

Inventor： Stuart James GEBBIE ,  Joshua R. GIGUERE ,  Keith MCCARTHY ,  Lonn S. RIDER

IPC: C07D489/08

Abstract: Compounds and compositions for use as starting materials or intermediate materials in the preparation of opioids including, e.g., oxycodone base and/or an oxycodone salt; processes for preparing these compounds and compositions; uses of these compounds and compositions in the preparation of APIs and pharmaceutical dosage forms; and uses of said APIs and pharmaceutical dosage forms in the treatment of medical conditions.

公开(公告)号：US20210061815A1

公开(公告)日：2021-03-04

申请号：US16971733

申请日：2019-02-22

Applicant: RHODES TECHNOLOGIES

Inventor： Ping CHANG ,  Raymond GLOWAKY ,  Michael David ROGERS

IPC: C07D489/08 ,  A61K9/00 ,  A61P25/36

Abstract: This invention relates to novel opioid derivatives of Formula I: or a pharmaceutically acceptable salt or solvate thereof, wherein R1, R3, R4 and Z are as defined herein in the disclosure. The invention also relates to the use of such compounds for the treatment or prevention of, for example, pain.

公开(公告)号：US20200325146A1

公开(公告)日：2020-10-15

申请号：US16860316

申请日：2020-04-28

Applicant: Rhodes Technologies

Inventor： Robert J. KUPPER ,  Raymond C. GLOWAKY

IPC: C07D489/08 ,  C07D491/20 ,  C07D489/09 ,  A61K9/00 ,  A61K31/485 ,  A61K45/06 ,  C07D489/02

Abstract: This invention relates to opioid ketal compounds of Formula (I), Formula (II), or Formula (III): or a pharmaceutically acceptable salts thereof, wherein R1 is H or CH3, R2 is H or OH, n is 0, 1, 2 or 3, R3 and R4 are independently H or optionally substituted C1-C4 alkyl, or when n is 0, then R3 and R4 and the carbon atoms to which they are attached together form six, or seven membered ring, which is optionally mono or disubstituted by C1-C4 alkyl. The invention also relates to oxycodone ketal compounds of Formula (IV) or (V): or a pharmaceutically acceptable salts thereof. The invention also relates to the use of such compounds for the treatment, prevention, or amelioration of pain.