公开(公告)号：US20250009742A1

公开(公告)日：2025-01-09

申请号：US18699156

申请日：2022-10-12

Applicant: AM SCIENCES INC ,  KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY

Inventor： Nakcheol JEONG ,  Misun LEE ,  Heewoo SIM ,  Myungjin KIM ,  Jung-Hee KIM ,  Soo Bong HAN ,  Young Sik JUNG ,  Hye jin KIM ,  Chang Soo YUN ,  Heeyeong CHO ,  Mee Hyein KIM ,  Joo Youn LEE

IPC: A61K31/501 ,  A61K31/4155 ,  A61K31/4162 ,  A61K31/422 ,  A61K31/437 ,  A61K31/4439 ,  A61K31/506 ,  A61P31/20 ,  C07D231/12 ,  C07D231/16 ,  C07D231/56 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D403/14 ,  C07D405/14 ,  C07D471/04 ,  C07D491/052 ,  C07D491/056 ,  C07D495/04

Abstract: The present invention relates to a series of novel pyrazolylmethylurea derivatives, and the use thereof for the inhibition of capsid assembly and the prevention or treatment of viral diseases through the inhibition.

公开(公告)号：US20240400552A1

公开(公告)日：2024-12-05

申请号：US18535291

申请日：2023-12-11

Applicant: Sagimet Biosciences Inc.

Inventor： Douglas I. Buckley ,  Gregory Duke ,  Allan S. Wagman ,  Marc Evanchik ,  Robert S. McDowell

IPC: C07D471/04 ,  A61P1/16 ,  A61P31/14 ,  A61P35/00 ,  C07D211/38 ,  C07D401/10 ,  C07D401/12 ,  C07D401/14 ,  C07D405/12 ,  C07D405/14 ,  C07D413/14 ,  C07D487/04 ,  C07D487/10 ,  C07D491/052 ,  C07D491/107 ,  C07D513/04

Abstract: Compounds that are fatty acid synthesis modulators are provided. The compounds may be used to treat disorders characterized by dysregulation of the fatty acid synthase function by modulating the function and/or the fatty acid synthase pathway. Methods are provided for treating such disorders including viral infections, such as hepatitis C infection, cancer and metabolic disorders, such as non-alcoholic steatohepatitis (NASH).

公开(公告)号：US20240391928A1

公开(公告)日：2024-11-28

申请号：US18694167

申请日：2022-02-17

Applicant: Duke University

Inventor： Dan Jansen ,  Juan Jose Marugan ,  Krisztian Toth ,  Lawrence Barak ,  Marc G. Caron ,  Joshua Gross ,  David Kim ,  Tae Gyun Yang

IPC: C07D491/052 ,  A61K31/352 ,  A61K31/357 ,  A61K31/407 ,  A61K31/4178 ,  A61K31/4439 ,  A61K31/501 ,  A61K31/506 ,  A61K31/5377 ,  A61P25/14 ,  C07D311/24 ,  C07D405/12 ,  C07D407/06

Abstract: Embodiments of the instant disclosure relate to novel compounds, compositions, and methods for treating health conditions. In certain embodiments, methods of treating health conditions can include administering an effective amount of at least one of the compounds or compositions disclosed herein to a subject having or suspected of having an imbalance in brain dopamine homeostasis.

公开(公告)号：US20240360085A1

公开(公告)日：2024-10-31

申请号：US18672406

申请日：2024-05-23

Applicant: Kadmon Corporation, LLC

Inventor： Kevin G. Liu ,  Kellen Olszewski ,  Ji-In Kim ,  Masha V. Poyurovsky ,  Koi Morris ,  Xuemei Yu ,  Christophe Lamarque

IPC: C07D239/42 ,  C07D239/94 ,  C07D401/12 ,  C07D401/14 ,  C07D403/04 ,  C07D403/12 ,  C07D405/12 ,  C07D405/14 ,  C07D409/12 ,  C07D413/12 ,  C07D413/14 ,  C07D417/12 ,  C07D471/04 ,  C07D473/34 ,  C07D491/048 ,  C07D491/052 ,  C07D495/04 ,  C07D519/00

CPC classification number: C07D239/42 ,  C07D239/94 ,  C07D401/12 ,  C07D401/14 ,  C07D403/04 ,  C07D403/12 ,  C07D405/12 ,  C07D405/14 ,  C07D409/12 ,  C07D413/12 ,  C07D413/14 ,  C07D417/12 ,  C07D471/04 ,  C07D473/34 ,  C07D491/048 ,  C07D491/052 ,  C07D495/04 ,  C07D519/00

Abstract: This invention provides compounds that modulate glucose uptake activity and cellular transport/uptake of glucose, and particularly GLUT3, but also including but not limited to GLUT1-14 (SLC2A1-SLC2A14). Compounds of the invention are useful for treating diseases, including cancer, autoimmune diseases and inflammation, infectious diseases, and metabolic diseases.

公开(公告)号：US12122785B2

公开(公告)日：2024-10-22

申请号：US18160479

申请日：2023-01-27

Applicant: Sudo Biosciences Limited

Inventor： Anjali Pandey ,  Gregory Dietsch ,  Bhaskar Chaudhuri ,  Seetharaman Manojveer ,  Mahesh Thakkar ,  Athisayamani Jeyaraj Duraiswamy ,  Sukesh Kalva

IPC: A61K31/4162 ,  C07D231/54 ,  C07D471/04 ,  C07D471/14 ,  C07D487/04 ,  C07D491/052

CPC classification number: C07D491/052 ,  C07D471/04 ,  C07D471/14 ,  C07D487/04

Abstract: Described herein are compounds of Formula (I) that are TYK2 inhibitors, methods of making such compounds, pharmaceutical compositions and medicaments comprising such compounds, and methods of using such compounds in the treatment of conditions, diseases, or disorders that would benefit from modulation of TYK2 activity.

公开(公告)号：US12122780B2

公开(公告)日：2024-10-22

申请号：US17427185

申请日：2020-01-22

Applicant: JIANGSU AOSAIKANG PHARMACEUTICAL CO., LTD.

Inventor： Xile Liu ,  Charles Z. Ding ,  Shuhui Chen ,  Lihong Hu ,  Haiwen Wan

IPC: C07D487/04 ,  A61P35/00 ,  C07D401/14 ,  C07D471/14 ,  C07D491/048 ,  C07D491/052 ,  C07D495/04

CPC classification number: C07D487/04 ,  A61P35/00 ,  C07D401/14 ,  C07D471/14 ,  C07D491/048 ,  C07D491/052 ,  C07D495/04

Abstract: Disclosed are a pyrimidinyl group-containing tricyclic compound and applications thereof in preparing a cancer-treating medicament. Specifically disclosed are a compound as represented by formula (I), a pharmaceutically acceptable salt of same, or an isomer thereof.

公开(公告)号：US20240294487A1

公开(公告)日：2024-09-05

申请号：US18402910

申请日：2024-01-03

Applicant: H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC.

Inventor： Juan R. Del Valle ,  Chih-Chi Andrew Hu

IPC: C07D311/16 ,  A01K67/0276 ,  A61K31/37 ,  A61K31/395 ,  A61K31/436 ,  A61K31/519 ,  A61K31/52 ,  A61K31/55 ,  A61K33/243 ,  A61K45/06 ,  C07D311/18 ,  C07D491/052

CPC classification number: C07D311/16 ,  A01K67/0276 ,  A61K31/37 ,  A61K31/395 ,  A61K31/436 ,  A61K31/519 ,  A61K31/52 ,  A61K31/55 ,  A61K33/243 ,  A61K45/06 ,  C07D311/18 ,  C07D491/052 ,  A01K2217/075 ,  A01K2217/077 ,  A01K2227/105 ,  A01K2267/0331

Abstract: Disclosed are XBP-1/IRE-1 inhibitors having formula disclosed herein. Methods of making and using these inhibitors for the treatment of cancer, in particular B cell cancers, are also disclosed. Also disclosed is a genetic XBP-1-knockout cancer mouse model.

公开(公告)号：US20240262840A1

公开(公告)日：2024-08-08

申请号：US18629562

申请日：2024-04-08

Applicant: EMORY UNIVERSITY

Inventor： Keqiang Ye

IPC: C07D491/052 ,  A61K9/00 ,  A61K31/4184 ,  A61P25/24 ,  A61P25/28

CPC classification number: C07D491/052 ,  A61K9/0053 ,  A61K31/4184 ,  A61P25/24 ,  A61P25/28

Abstract: In certain embodiments, the disclosure relates to heterocyclic flavone derivatives, such as those described by formula provided herein, pharmaceutical compositions, and methods related thereto. In certain embodiments, the disclosure relates to methods of treating or preventing diseases or conditions related to BDNF and TrkB activity, such as depression, stroke, Rett syndrome, Parkinson's disease, and Alzheimer's disease by administering effective amounts of pharmaceutical compositions comprising compounds disclosed herein to a subject in need thereof.

公开(公告)号：US20240262822A1

公开(公告)日：2024-08-08

申请号：US18559184

申请日：2022-05-06

Applicant: Vanderbilt University

Inventor： Taekyu Lee ,  Kevin B. Teuscher ,  Somenath Chowdhury ,  Jianhua Tian ,  Kenneth M. Meyers ,  Stephen W. Fesik

IPC: C07D471/04 ,  A61K31/4725 ,  A61K31/496 ,  A61K31/502 ,  A61K31/517 ,  A61K31/5377 ,  C07D401/14 ,  C07D405/14 ,  C07D491/052

CPC classification number: C07D471/04 ,  A61K31/4725 ,  A61K31/496 ,  A61K31/502 ,  A61K31/517 ,  A61K31/5377 ,  C07D401/14 ,  C07D405/14 ,  C07D491/052

Abstract: Isoquinolinone compounds and derivatives inhibit WDR5 and associated protein-protein interactions, and the compounds and their pharmaceutical compositions are useful for treating disorders and conditions in a subject, such as cancer cell proliferation.

公开(公告)号：US20240254133A1

公开(公告)日：2024-08-01

申请号：US18622428

申请日：2024-03-29

Applicant: BOEHRINGER INGELHEIM VETMEDICA GMBH

Inventor： Hannes Fiepko KOOLMAN ,  Bart HERLÉ

IPC: C07D487/04 ,  C07D491/052 ,  C07D513/04

CPC classification number: C07D487/04 ,  C07D491/052 ,  C07D513/04

Abstract: This invention provides for compounds of the formula:






wherein the variables are defined herein, or salt thereof, compositions comprising these compounds, and methods for the treatment, control and/or prevention of a parasitic infestation and/or infection in an animal in need thereof by administering an effective amount of these compounds to said animal.