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16 条记录 (耗时 0.009 秒)

    Aryl-substituted-pyrido(2,3-d)pyrimidin-2-ones
    1.
    发明授权
    Aryl-substituted-pyrido(2,3-d)pyrimidin-2-ones 失效
    芳基取代的吡啶（2,3-D）吡啶二酮-2-酮

    公开(公告)号：US3709888A

    公开(公告)日：1973-01-09

    申请号：US3709888D

    申请日：1970-06-01

    申请人： SANDOZ AG

    发明人： HARDTMANN G

    IPC分类号： C07D213/74 ,  C07D213/85 ,  C07D471/04 ,  C07D57/20

    CPC分类号： C07D213/74 ,  C07D213/85 ,  C07D471/04 ,  Y10S514/87

    摘要： COMPOUNDS ARE OF THE CLASS OF ARYL-SUBSTITUTED-1-SUBSTITUTED-4-ARYL-PYRIDO(2,3,-D)PYRIMIDIN-2-ONES, WHICH ARE USEFUL AS ANTI-INFLAMMATORY AGENTS. INTERMEDIATES FOR PREPARATION INCLUDE THE CORRESPONDING 1-UNSUBSTITUTED-4-ARYLPYRIDO(2,3-D)PYRIMIDIN-2-ONES, COMPOUNDS WHICH ARE PYRIDYL-PHENYL KETONE IMINES AND COMPOUNDS WHICH ARE ARYL-SUBSTITUTED-2-AMINO-NICOTINONITRILES OF WHICH THE LATTER ARE ALSO USEFUL AS ANTI-INFLAMMATORY AGENTS.

    2,4-diamino-substituted pyrido(3,2-d)pyrimidines and salts thereof
    5.
    发明授权
    2,4-diamino-substituted pyrido(3,2-d)pyrimidines and salts thereof 失效
    2,4-二氨基取代的吡啶（3,2-D）吡啶并及其盐

    公开(公告)号：US3843638A

    公开(公告)日：1974-10-22

    申请号：US24179172

    申请日：1972-04-06

    申请人： BOEHRINGER SOHN INGELHEIM

    发明人： NICKI J ,  ROCH J ,  MULLER E ,  BARR B

    IPC分类号： C07D401/04 ,  A61K31/495 ,  A61K31/54 ,  C07D471/04 ,  C07D57/20

    CPC分类号： C07D471/04 ,  A61K31/495 ,  A61K31/54

    摘要： Compounds of the formula

    WHEREIN R1 and R2, which may be identical to or different from each other, are each morpholino, thiomorpholino, 1-oxidothiomorpholino, 1,1-dioxido-thiomorpholino or piperidino, where each of these may optionally have a lower alkyl substituent attached thereto; piperazino; N''-acyl-piperazino; N''-carbamoylpiperazino; N''-lower alkyl-piperazino; dialkanol-amino; or alkylenediamino; and R3 is hydrogen or methyl; AND THEIR NON-TOXIC, PHARMACOLOGICALLY ACCEPTABLE ACID ADDITION SALTS; THE COMPOUNDS AS WELL AS THEIR SALTS ARE USEFUL AS INHIBITORS OF THROMBOCYTE AGGREGATION AND ADHESIVENESS.

    2,4,7-TRISUBSTITUTED-{8 PYRIDO 2,3-d{9 PYRIMIDINE-6-CARBOXAMIDES
    8.
    发明授权
    2,4,7-TRISUBSTITUTED-{8 PYRIDO 2,3-d{9 PYRIMIDINE-6-CARBOXAMIDES 失效
    2,4,7-三唑并[9]吡啶2,3-d {9]嘧啶-6-羧酸

    公开(公告)号：US3725405A

    公开(公告)日：1973-04-03

    申请号：US3725405D

    申请日：1970-06-18

    申请人： AMERICAN HOME PROD

    发明人： SANTILLI A ,  KIM D

    IPC分类号： C07D239/48 ,  C07D471/04 ,  C07D57/20

    CPC分类号： C07D471/04 ,  C07D239/48

    摘要： Novel 2,4,7-trisubstituted-pyrido(2,3-d)pyrimidine-6carboxamides have been produced which have central nervous system depressant activity and are useful pharmacological agents in the calming of animals.

    摘要翻译： 已经制备了具有中枢神经系统抑制活性的新型2,4,7-三取代 - 吡啶并[2,3-d]嘧啶-6-甲酰胺，并且在动物平静中是有用的药理学试剂。

    Certain 2-substituted-5,8-dihydro-5-oxopyrido{8 2,3-d{9 pyrimidine-6-carboxylic acid derivatives
    9.
    发明授权
    Certain 2-substituted-5,8-dihydro-5-oxopyrido{8 2,3-d{9 pyrimidine-6-carboxylic acid derivatives 失效
    某些2-取代的5,8-二氢-5-氧代吡啶{8 2,3-D {9'-吡啶-6-羧酸衍生物

    公开(公告)号：US3673184A

    公开(公告)日：1972-06-27

    申请号：US3673184D

    申请日：1970-09-02

    申请人： DAINIPPON PHARMACEUTICAL CO

    发明人： MINAMI SHINSAKU ,  SHONO TOSHIHIRO ,  SHMMIZU MASANAO ,  TAKASE YOSHIYUKI

    IPC分类号： C07D239/42 ,  C07D239/46 ,  C07D239/47 ,  C07D239/48 ,  C07D239/56 ,  C07D471/04 ,  C07D57/20

    CPC分类号： C07D239/42 ,  C07D239/47 ,  C07D239/48 ,  C07D239/56 ,  C07D471/04

    摘要： WHEREIN R1 stands for hydrogen or a lower alkyl radical; R2 stands for hydrogen, a lower alkyl radical, hydroxyl group, a halogen atom, a lower alkoxy radical, an amino radical or a lower alkylthio radical; R3 stands for hydrogen, a lower alkyl radical, hydroxyl group, a lower alkoxy radical, a lower alkylthio radical or a radical represented by the formula (WHEREIN R'' stands for hydrogen, an alkyl radical, a cycloalkyl radical, an amino radical, a hydroxyalkyl group or an alkyl substituted amino alkyl radical, and R'''' stands for hydrogen or an alkyl radical, R'' and R'''' may be the same or a different radical and R'' and R'''' may bond together to form a 5- or 6membered heterocyclic ring containing a nitrogen hetero atom); and R4 stands for hydrogen or an alkyl group. Such derivatives are useful as antibacterial agents.
    A 5,8-dihydro-5-oxopyrido (2,3-d) pyrimidine derivative represented by the following formula

    摘要翻译： 由下式表示的5,8-二氢-5-氧代吡啶并[2,3-d]嘧啶衍生物代表氢或低级烷基; R2代表氢，低级烷基，羟基，卤原子，低级烷氧基，氨基或低级烷硫基; R3代表氢，低级烷基，羟基，低级烷氧基，低级烷硫基或由式（WHEREIN R'代表氢，烷基，环烷基，氨基， 羟基烷基或烷基取代的氨基烷基，R“表示氢或烷基，R'和R”可以相同或不同，R'和R“可以键合在一起形成5 - 或6-元杂环）; R4代表氢或烷基。 这样的衍生物可用作抗菌剂。