公开(公告)号：US12227666B2

公开(公告)日：2025-02-18

申请号：US17623504

申请日：2020-06-22

Applicant: BASF Coatings GmbH

Inventor： Yang Zhang ,  Ji Ming Wang ,  Lei He ,  Christian Gerhard Schaefer ,  Wen Mei Liu ,  Ranjit Salvi ,  Stefan Hirsemann

IPC: C09D5/00 ,  B05D1/36 ,  B05D1/38 ,  B32B27/30 ,  B32B27/36 ,  C07F7/08 ,  C07F7/18 ,  C09D7/20 ,  C09D7/63 ,  C09D7/65 ,  C09D133/06 ,  C09D133/08 ,  C09D133/10 ,  C09D133/12 ,  C09D133/14 ,  C09D167/00 ,  B32B15/082 ,  B32B15/09

Abstract: Described herein is a 2K clearcoat composition including, Component I including a). at least one resin having carboxylic acid groups with acid value of 50 to 400 mg KOH/g; b). at least one resin having hydroxyl functional groups with a hydroxyl value of 10 to 800 mg KOH/g; c). at least one catalyst; and d). at least one solvent, and Component II including e). at least one epoxy-functional alkoxysilane and/or its oligomer and/or its polymer; and f). at least one crosslinker reactive to hydroxyl groups. Also described herein are a substrate coated with the dried and cured 2K clearcoat composition and an automotive including the substrate.

公开(公告)号：US20250051488A1

公开(公告)日：2025-02-13

申请号：US18708471

申请日：2022-11-09

Applicant: ENEOS Materials Corporation

Inventor： Naoki OHTA ,  Ken-ichi ITOU ,  Hiroyuki MORITA ,  Makoto HARAGUCHI

IPC: C08C19/25 ,  C07F7/10 ,  C07F7/18

Abstract: A modified conjugated diene-based polymer is produced by a method which includes a step of polymerizing a monomer containing a conjugated diene compound in the presence of a polymerization initiator which contains a silicon-containing initiator having a group F2 and an alkali metal element or an alkaline earth metal element. F2: a group “*1—Si(R1)n(Y1)3-n” (wherein R1 represents a C1 to C20 hydrocarbyl group; Y1 represents group “—OR2” or group “—NR3R4”; each of R2, R3, and R4 independently represents a C1 to C20 hydrocarbyl group; n is an integer of 0 to 2).

公开(公告)号：US20250042854A1

公开(公告)日：2025-02-06

申请号：US18710330

申请日：2022-11-15

Applicant: Ecole Nationale Supérieure de Chimie de Rennes ,  Institut National des Sciences Appliquées ,  Universite de Rennes ,  University of California, San Diego ,  Centre National de la Recherche Scientifique

Inventor： Marc MAUDUIT ,  Jennifer MORVAN ,  Jakub TALCIK ,  Rodolphe JAZZAR ,  Guy BERTRAND ,  Mohand-Ameziane MELAIMI ,  Melinda Rachel SERRATO

IPC: C07D209/56 ,  B01J31/22 ,  C07D209/96 ,  C07F7/08 ,  C07F7/18 ,  C07F15/00

Abstract: The present invention relates to an iminium salt having the following formula (I) and also to a ruthenium complex having the following formula (II): as well as the use of said ruthenium complex as catalyst, in particular in olefin metathesis.

公开(公告)号：US20250034111A1

公开(公告)日：2025-01-30

申请号：US18651572

申请日：2024-04-30

Applicant: Bayer Pharma Akitengesellschaft

Inventor： Ulrich BOTHE ,  Holger SIEBENEICHER ,  Nicole SCHMIDT ,  Reinhard NUBBEMEYER ,  Ulf BÖMER ,  Judith GÜNTHER ,  Holger STEUBER ,  Martin LANGE ,  Christian STEGMANN ,  Andreas SUTTER ,  Alexandra RAUSCH ,  Christian FRIEDRICH ,  Peter HAUFF

IPC: C07D401/12 ,  A61K31/4439 ,  A61P19/02 ,  C07D405/14 ,  C07F7/18

Abstract: The present application relates to novel substituted indazoles, to processes for preparation thereof, to the use thereof alone or in combinations for treatment and/or prophylaxis of diseases, and to the use thereof for production of medicaments for treatment and/or prophylaxis of diseases, especially for treatment and/or prophylaxis of endometriosis and endometriosis-associated pain and other endometriosis-associated symptoms such as dysmenorrhoea, dyspareunia, dysuria and dyschezia, of lymphoma, rheumatoid arthritis, spondyloarthritis (especially psoriatic spondyloarthritis and Bekhterev's disease), lupus erythematosus, multiple sclerosis, macular degeneration, COPD, gout, fatty liver disorders, insulin resistance, neoplastic disorders and psoriasis.

公开(公告)号：US20250010331A1

公开(公告)日：2025-01-09

申请号：US18701169

申请日：2022-10-11

Applicant: VERSUM MATERIALS US, LLC

Inventor： MATTHEW R. MACDONALD ,  XINJIAN LEI ,  MICHAEL JAMES FOODY

IPC: B05D1/00 ,  C07F7/18 ,  C23C16/505 ,  C23C16/52

Abstract: A method for making a dense organosilicon film with improved mechanical properties includes the steps of: providing a substrate within a reaction chamber; introducing into the reaction chamber a gaseous composition comprising alkoxy silane; and applying energy to the gaseous composition comprising alkoxysilane in the reaction chamber to induce reaction of the gaseous composition comprising alkoxysilane to deposit an organosilicon film on the substrate, wherein the organosilicon film has a dielectric constant of from ˜2.40 to ˜3.20, an elastic modulus of from ˜6 to ˜30 GPa, and an at. % carbon of from ˜10 to ˜45 as measured by XPS.

公开(公告)号：US20240383901A1

公开(公告)日：2024-11-21

申请号：US18569790

申请日：2022-06-14

Applicant: SANOFI

Inventor： Patrick Bernardelli ,  Stéphanie Deprets ,  Laurent Dubois ,  John Macor ,  Frédéric Petit ,  Corinne Terrier ,  Marc Bianciotto

IPC: C07D487/04 ,  A61K31/519 ,  C07F7/18

Abstract: Disclosed are compounds of formula (I), or a pharmaceutically acceptable salt thereof, wherein R1 and R2 are defined herein. Also disclosed are methods of using such compounds as inhibitors of LRRK2, and pharmaceutical compositions comprising such compounds. These compounds are useful in treating neurodegenerative diseases such as Parkinson's disease.

公开(公告)号：US20240352050A1

公开(公告)日：2024-10-24

申请号：US18684217

申请日：2022-11-11

Applicant: DOW SILICONES CORPORATION

Inventor： Michael Depierro ,  Kitty Liu ,  Xiaoyuan Zhou ,  Reza Panah ,  Aaron Greiner

IPC: C07F7/18 ,  C08K5/5475 ,  C09J183/04

CPC classification number: C07F7/188 ,  C09J183/04 ,  C08K5/5475

Abstract: A process for preparing cyanoethyltrimethoxysilane is performed via transesterification of cyanoethyltriethoxysilane with methanol in the presence of a catalyst. The cyanoethyltrimethoxysilane is useful as an adhesion promoter, a coupling agent, or a crosslinker. The cyanoethyltrimethoxysilane may be formulated in a polyorganosiloxane sealant composition.

公开(公告)号：US20240352049A1

公开(公告)日：2024-10-24

申请号：US18632442

申请日：2024-04-11

Applicant: Momentive Performance Materials Inc.

Inventor： Kenrick Martin Lewis ,  Abellard Mereigh

IPC: C07F7/18 ,  B01J23/72 ,  B01J35/45

CPC classification number: C07F7/1872 ,  B01J23/72 ,  B01J35/45

Abstract: An improved catalyzed reaction of silicon metal with alcohol is provided for the formation of alkoxysilanes, particularly trialkoxysilanes. The Direct Synthesis reaction of silicon metal and alcohol employs a catalytically effective amount of a copper-aluminum alloy as a catalyst precursor and further benefits from an effective catalyst-promoting amount of a catalyst promoter.

公开(公告)号：US12122730B2

公开(公告)日：2024-10-22

申请号：US17433518

申请日：2020-02-24

Applicant: The Regents of the University of California

Inventor： Ohyun Kwon ,  Andrew Smaligo

IPC: C07B37/00 ,  C07B33/00 ,  C07B63/04 ,  C07C29/00 ,  C07C37/00 ,  C07C41/03 ,  C07C45/28 ,  C07C45/40 ,  C07C45/64 ,  C07C45/67 ,  C07C67/00 ,  C07C67/333 ,  C07C67/39 ,  C07C315/02 ,  C07C319/14 ,  C07F7/18 ,  C07F9/53

CPC classification number: C07B37/00 ,  C07B33/00 ,  C07B63/04 ,  C07C29/00 ,  C07C41/03 ,  C07C45/28 ,  C07C45/40 ,  C07C45/64 ,  C07C45/673 ,  C07C67/00 ,  C07C67/333 ,  C07C67/39 ,  C07C315/02 ,  C07C319/14 ,  C07F7/1892 ,  C07F9/5325 ,  C07B2200/07 ,  C07C2601/02 ,  C07C2601/04 ,  C07C2601/10 ,  C07C2601/14 ,  C07C2602/08 ,  C07C2602/26 ,  C07C2602/28 ,  C07C2602/46 ,  C07C2603/74 ,  C07C29/00 ,  C07C31/276 ,  C07C29/00 ,  C07C31/137 ,  C07C29/00 ,  C07C31/1355 ,  C07C45/673 ,  C07C49/497 ,  C07C45/64 ,  C07C49/517 ,  C07C67/333 ,  C07C69/757 ,  C07C67/00 ,  C07C69/16 ,  C07C41/03 ,  C07C43/196 ,  C07C67/39 ,  C07C69/24 ,  C07C67/39 ,  C07C69/74 ,  C07C67/39 ,  C07C69/753 ,  C07C45/28 ,  C07C49/517 ,  C07C45/40 ,  C07C49/517 ,  C07C45/28 ,  C07C49/497 ,  C07C45/28 ,  C07C49/637 ,  C07C45/28 ,  C07C49/713 ,  C07C67/39 ,  C07C69/738 ,  C07C45/673 ,  C07C49/513 ,  C07C45/673 ,  C07C49/637 ,  C07C67/39 ,  C07C69/757 ,  C07C29/00 ,  C07C35/14 ,  C07C29/00 ,  C07C35/32 ,  C07C319/14 ,  C07C323/22 ,  C07C319/14 ,  C07C323/18 ,  C07C319/14 ,  C07C323/63 ,  C07C315/02 ,  C07C317/22 ,  C07C315/02 ,  C07C317/24 ,  C07C319/14 ,  C07C321/28

Abstract: The present disclosure relates to methods of carbon-carbon bond fragmentation.

公开(公告)号：US20240336638A1

公开(公告)日：2024-10-10

申请号：US18571763

申请日：2022-06-28

Applicant: Guoqin ZHUGE ,  Xiaoqin LI

Inventor： Xiaoqin LI ,  Jianfang CHEN

IPC: C07F7/18 ,  A61K31/216 ,  A61K31/4178 ,  A61K31/4439 ,  A61K31/501 ,  A61K31/506 ,  A61K31/695 ,  A61P7/02 ,  A61P9/10 ,  C07C69/757 ,  C07D213/16 ,  C07D233/58 ,  C07D233/68 ,  C07D401/06 ,  C07D401/14 ,  C07D403/06 ,  C07D403/10

CPC classification number: C07F7/1804 ,  A61K31/216 ,  A61K31/4178 ,  A61K31/4439 ,  A61K31/501 ,  A61K31/506 ,  A61K31/695 ,  A61P7/02 ,  A61P9/10 ,  C07C69/757 ,  C07D213/16 ,  C07D233/58 ,  C07D233/68 ,  C07D401/06 ,  C07D401/14 ,  C07D403/06 ,  C07D403/10

Abstract: An imidazole compound as shown in formula I or a pharmaceutically acceptable salt and an intermediate thereof. The imidazole compound as shown in formula I can significantly inhibit AA-induced platelet aggregation, improves MCAO/R-induced rat cerebral ischemia injury, has excellent metabolic stability, and can improve the distribution of a drug within the brain tissue, such that the pharmacodynamic activity of the imidazole compound in treatment of dyskinesia associated with acute thrombotic cerebral infarction and cerebral infarction is improved.