公开(公告)号：US20240352050A1

公开(公告)日：2024-10-24

申请号：US18684217

申请日：2022-11-11

申请人： DOW SILICONES CORPORATION

发明人： Michael Depierro ,  Kitty Liu ,  Xiaoyuan Zhou ,  Reza Panah ,  Aaron Greiner

IPC分类号： C07F7/18 ,  C08K5/5475 ,  C09J183/04

CPC分类号： C07F7/188 ,  C09J183/04 ,  C08K5/5475

摘要： A process for preparing cyanoethyltrimethoxysilane is performed via transesterification of cyanoethyltriethoxysilane with methanol in the presence of a catalyst. The cyanoethyltrimethoxysilane is useful as an adhesion promoter, a coupling agent, or a crosslinker. The cyanoethyltrimethoxysilane may be formulated in a polyorganosiloxane sealant composition.

公开(公告)号：US20240352049A1

公开(公告)日：2024-10-24

申请号：US18632442

申请日：2024-04-11

申请人： Momentive Performance Materials Inc.

发明人： Kenrick Martin Lewis ,  Abellard Mereigh

IPC分类号： C07F7/18 ,  B01J23/72 ,  B01J35/45

CPC分类号： C07F7/1872 ,  B01J23/72 ,  B01J35/45

摘要： An improved catalyzed reaction of silicon metal with alcohol is provided for the formation of alkoxysilanes, particularly trialkoxysilanes. The Direct Synthesis reaction of silicon metal and alcohol employs a catalytically effective amount of a copper-aluminum alloy as a catalyst precursor and further benefits from an effective catalyst-promoting amount of a catalyst promoter.

公开(公告)号：US12122730B2

公开(公告)日：2024-10-22

申请号：US17433518

申请日：2020-02-24

申请人： The Regents of the University of California

发明人： Ohyun Kwon ,  Andrew Smaligo

IPC分类号： C07B37/00 ,  C07B33/00 ,  C07B63/04 ,  C07C29/00 ,  C07C37/00 ,  C07C41/03 ,  C07C45/28 ,  C07C45/40 ,  C07C45/64 ,  C07C45/67 ,  C07C67/00 ,  C07C67/333 ,  C07C67/39 ,  C07C315/02 ,  C07C319/14 ,  C07F7/18 ,  C07F9/53

CPC分类号： C07B37/00 ,  C07B33/00 ,  C07B63/04 ,  C07C29/00 ,  C07C41/03 ,  C07C45/28 ,  C07C45/40 ,  C07C45/64 ,  C07C45/673 ,  C07C67/00 ,  C07C67/333 ,  C07C67/39 ,  C07C315/02 ,  C07C319/14 ,  C07F7/1892 ,  C07F9/5325 ,  C07B2200/07 ,  C07C2601/02 ,  C07C2601/04 ,  C07C2601/10 ,  C07C2601/14 ,  C07C2602/08 ,  C07C2602/26 ,  C07C2602/28 ,  C07C2602/46 ,  C07C2603/74 ,  C07C29/00 ,  C07C31/276 ,  C07C29/00 ,  C07C31/137 ,  C07C29/00 ,  C07C31/1355 ,  C07C45/673 ,  C07C49/497 ,  C07C45/64 ,  C07C49/517 ,  C07C67/333 ,  C07C69/757 ,  C07C67/00 ,  C07C69/16 ,  C07C41/03 ,  C07C43/196 ,  C07C67/39 ,  C07C69/24 ,  C07C67/39 ,  C07C69/74 ,  C07C67/39 ,  C07C69/753 ,  C07C45/28 ,  C07C49/517 ,  C07C45/40 ,  C07C49/517 ,  C07C45/28 ,  C07C49/497 ,  C07C45/28 ,  C07C49/637 ,  C07C45/28 ,  C07C49/713 ,  C07C67/39 ,  C07C69/738 ,  C07C45/673 ,  C07C49/513 ,  C07C45/673 ,  C07C49/637 ,  C07C67/39 ,  C07C69/757 ,  C07C29/00 ,  C07C35/14 ,  C07C29/00 ,  C07C35/32 ,  C07C319/14 ,  C07C323/22 ,  C07C319/14 ,  C07C323/18 ,  C07C319/14 ,  C07C323/63 ,  C07C315/02 ,  C07C317/22 ,  C07C315/02 ,  C07C317/24 ,  C07C319/14 ,  C07C321/28

摘要： The present disclosure relates to methods of carbon-carbon bond fragmentation.

公开(公告)号：US20240336638A1

公开(公告)日：2024-10-10

申请号：US18571763

申请日：2022-06-28

申请人： Guoqin ZHUGE ,  Xiaoqin LI

发明人： Xiaoqin LI ,  Jianfang CHEN

IPC分类号： C07F7/18 ,  A61K31/216 ,  A61K31/4178 ,  A61K31/4439 ,  A61K31/501 ,  A61K31/506 ,  A61K31/695 ,  A61P7/02 ,  A61P9/10 ,  C07C69/757 ,  C07D213/16 ,  C07D233/58 ,  C07D233/68 ,  C07D401/06 ,  C07D401/14 ,  C07D403/06 ,  C07D403/10

CPC分类号： C07F7/1804 ,  A61K31/216 ,  A61K31/4178 ,  A61K31/4439 ,  A61K31/501 ,  A61K31/506 ,  A61K31/695 ,  A61P7/02 ,  A61P9/10 ,  C07C69/757 ,  C07D213/16 ,  C07D233/58 ,  C07D233/68 ,  C07D401/06 ,  C07D401/14 ,  C07D403/06 ,  C07D403/10

摘要： An imidazole compound as shown in formula I or a pharmaceutically acceptable salt and an intermediate thereof. The imidazole compound as shown in formula I can significantly inhibit AA-induced platelet aggregation, improves MCAO/R-induced rat cerebral ischemia injury, has excellent metabolic stability, and can improve the distribution of a drug within the brain tissue, such that the pharmacodynamic activity of the imidazole compound in treatment of dyskinesia associated with acute thrombotic cerebral infarction and cerebral infarction is improved.

公开(公告)号：US20240327655A1

公开(公告)日：2024-10-03

申请号：US18551558

申请日：2022-03-25

申请人： DEBOGY MOLECULAR, INC.

发明人： Othman BOULOUSSA ,  Maha ALQURAFI

IPC分类号： C09D5/22 ,  A01N33/12 ,  A01N43/40 ,  A01P1/00 ,  A01P3/00 ,  C07D311/18 ,  C07F7/18 ,  C08F8/18 ,  C08F8/30 ,  C08G73/02 ,  C09B69/10 ,  C09D5/14 ,  C09D7/41 ,  C09D125/18 ,  C09D139/08 ,  C09D179/02 ,  C09K11/06

CPC分类号： C09D5/22 ,  A01N33/12 ,  A01N43/40 ,  A01P1/00 ,  A01P3/00 ,  C07D311/18 ,  C07F7/1804 ,  C08F8/18 ,  C08F8/30 ,  C08G73/0206 ,  C09B69/109 ,  C09D5/14 ,  C09D7/41 ,  C09D125/18 ,  C09D139/08 ,  C09D179/02 ,  C09K11/06 ,  C09K2211/1433 ,  C09K2211/145 ,  C09K2211/1466

摘要： Biocidal polymers and compounds comprising detectable moieties, coatings including same, and methods of making and using the same for controlling the growth of at least one bacteria, fungi, protozoa, or virus are disclosed.

公开(公告)号：US20240317988A1

公开(公告)日：2024-09-26

申请号：US18422186

申请日：2024-01-25

申请人： Bausch + Lomb Ireland Limited

发明人： James Anthony DiBella, Jr. ,  Wendy G. Ahearn ,  Alok Kumar Awasthi

IPC分类号： C08L43/04 ,  C07F7/18 ,  C08F226/08 ,  C08F230/08

CPC分类号： C08L43/04 ,  C07F7/18 ,  C08F226/08 ,  C08F230/08 ,  C08L2203/02

摘要： A monofunctional silicone monomer is represented by a structure of Formula I:




wherein R1, R2, R3, R4, R5, R6, R7, x and y are as defined herein. An ophthalmic device having optical clarity is a polymerization product of a monomeric mixture includes (a) one or more of the monofunctional silicone monomers represented by a structure of Formula I, and (b) one or more ophthalmic device-forming hydrophilic comonomers.

公开(公告)号：US20240293799A1

公开(公告)日：2024-09-05

申请号：US18644518

申请日：2024-04-24

申请人： Waters Technologies Corporation

发明人： Kevin D. Wyndham ,  Michael F. Morris ,  Darryl W. Brousmiche ,  Jason F. Hill ,  Jacob N. Fairchild

IPC分类号： B01J20/283 ,  B01D15/26 ,  B01D15/30 ,  B01D15/32 ,  B01D15/40 ,  B01D53/02 ,  B01J20/22 ,  B01J20/28 ,  B01J20/282 ,  B01J20/284 ,  B01J20/285 ,  B01J20/288 ,  B01J20/289 ,  B01J20/30 ,  B01J20/32 ,  C07F7/18

CPC分类号： B01J20/283 ,  B01D15/26 ,  B01D15/30 ,  B01D15/305 ,  B01D15/322 ,  B01D15/40 ,  B01D53/025 ,  B01J20/22 ,  B01J20/28004 ,  B01J20/28016 ,  B01J20/28042 ,  B01J20/28057 ,  B01J20/28059 ,  B01J20/28061 ,  B01J20/28064 ,  B01J20/28066 ,  B01J20/28069 ,  B01J20/28071 ,  B01J20/28073 ,  B01J20/28076 ,  B01J20/28078 ,  B01J20/28083 ,  B01J20/28085 ,  B01J20/288 ,  B01J20/289 ,  B01J20/3085 ,  B01J20/3204 ,  B01J20/3206 ,  B01J20/3208 ,  B01J20/3246 ,  B01J20/3285 ,  B01J20/3293 ,  C07F7/1804 ,  B01J20/282 ,  B01J20/284 ,  B01J20/285 ,  B01J20/32 ,  B01J20/3234 ,  B01J2220/54 ,  B01J2220/80

摘要： In one aspect, the present invention provides a chromatographic stationary phase material for various different modes of chromatography represented by Formula 1: [X](W)a(Q)b(T)c (Formula 1). X can be a high purity chromatographic core composition having a surface comprising a silica core material, metal oxide core material, an inorganic-organic hybrid material or a group of block copolymers thereof. W can be absent and/or can include hydrogen and/or can include a hydroxyl on the surface of X. Q can be a functional group that minimizes retention variation over time (drift) under chromatographic conditions utilizing low water concentrations. T can include one or more hydrophilic, polar, ionizable, and/or charged functional groups that chromatographically interact with the analyte. Additionally, b and c can be positive numbers, with the ratio 0.05≤(b/c)≤100, and a≥0.

公开(公告)号：US20240217993A1

公开(公告)日：2024-07-04

申请号：US18555306

申请日：2022-03-22

申请人： TOKYO OHKA KOGYO CO., LTD.

发明人： YuehChun LIAO ,  Michihito TAKAHASHI

IPC分类号： C07F7/18 ,  C01G23/053

CPC分类号： C07F7/188 ,  C01G23/053

摘要： Provided are: a compound used as a capping agent which imparts particles having excellent dispersibility and refractive index; particles coated with the compound; a method for producing the same; and a dispersion composition containing said particles. A compound according to the present invention has a structure represented by formula (1). In the formula, R1 represents an organic group having 1-30 carbon atoms, R2 represents a group represented by OR3 or a group represented by formula (2), R3 represents an organic group having 1-30 carbon atoms, n1 and n2 each represent an integer of at least 0, n1+2×n2 represents a valence determined by the type of L, L represents aluminum, gallium, yttrium, titanium, zirconium, hafnium, bismuth, tin, vanadium, or tantalum, * represents a bond, R4 and R5 each represent an organic group having 1-30 carbon atoms which may have an oxygen atom. Particles according to the present invention have a structure represented by formula (1) on a surface thereof.

公开(公告)号：US20240197924A1

公开(公告)日：2024-06-20

申请号：US18428591

申请日：2024-01-31

申请人： RAMOT AT TEL-AVIV UNIVERSITY LTD.

发明人： Doron Shabat ,  Ronit Satchi-Fainaro ,  Nir Hananya ,  Ori Green ,  Tal Eilon

IPC分类号： A61K49/00 ,  C07D321/00 ,  C07F5/02 ,  C07F5/04 ,  C07F7/18 ,  C07F9/12 ,  C07F9/655 ,  C07H15/203 ,  C07H15/26 ,  C09B11/24 ,  C09B23/01 ,  C09B23/04 ,  C09B23/08 ,  C09K11/06

CPC分类号： A61K49/0052 ,  C07D321/00 ,  C07F5/025 ,  C07F5/04 ,  C07F7/1804 ,  C07F9/12 ,  C07F9/65512 ,  C07H15/203 ,  C07H15/26 ,  C09B11/24 ,  C09B23/0066 ,  C09B23/04 ,  C09B23/083 ,  C09K11/06 ,  C09K2211/1018

摘要： The present invention provides dioxctane-based chemiluminescence probes, more specifically fluorophore-tethered dioxctane-based chemiluminescence probes and compositions thereof. The chemiluminescence probes disclosed are useful for both diagnostics and in vivo imaging.

公开(公告)号：US20240182476A1

公开(公告)日：2024-06-06

申请号：US18450646

申请日：2023-08-16

申请人： GILEAD SCIENCES, INC. ,  CARNA BIOSCIENCES, INC.

发明人： Masaaki Sawa ,  Mai Arai ,  Ryoko Nakai ,  Hirokazu Matsumoto ,  Catherine Pugh ,  Eric Hu ,  Juan Guerrero ,  Jesse Jacobsen ,  Jonathan William Medley ,  Jie Xu ,  Latesh Lad ,  Leena Patel ,  Michael Graupe ,  Qingming Zhu ,  Stephen Holmbo ,  Tetsuya Kobayashi ,  Will Watkins ,  Yasamin Moazami ,  Suet C. Yeung ,  Julian A. Codelli ,  Heath A. Weaver

IPC分类号： C07D487/04 ,  A61K31/395 ,  A61K31/519 ,  A61K31/5377 ,  A61K31/538 ,  A61K31/55 ,  A61K31/553 ,  A61K31/695 ,  A61K31/704 ,  A61K31/7068 ,  A61K35/15 ,  A61K35/17 ,  A61K39/395 ,  A61K45/06 ,  C07D519/00 ,  C07F7/18

CPC分类号： C07D487/04 ,  A61K31/519 ,  A61K31/5377 ,  A61K31/538 ,  A61K31/55 ,  A61K31/553 ,  A61K31/5545 ,  A61K31/695 ,  A61K31/704 ,  A61K31/7068 ,  A61K35/15 ,  A61K35/17 ,  A61K39/3955 ,  A61K45/06 ,  C07D519/00 ,  C07F7/1804

摘要： The present disclosure provides diacylglycerol kinase modulating compounds, and pharmaceutical compositions thereof, for treating cancer, including solid tumors, and viral infections, such as HIV or hepatitis B virus infection. The compounds can be used alone or in combination with other agents.