公开(公告)号：US20230140290A1

公开(公告)日：2023-05-04

申请号：US17795223

申请日：2021-01-26

申请人： THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SY ,  UNIVERSITY OF SEVILLE ,  SERVICIO ANDALUZ DE SALUD

发明人： Jia ZHOU ,  Jimin XU ,  Javier SANCHEZ-CESPEDES ,  Judith BERASTEGUI-CABRERA ,  Maria Eugenia PACHON-IBANEZ ,  Jeronimo PACHON-DIAZ

IPC分类号： C07F9/6561 ,  C07F9/6512 ,  C07C233/81 ,  C07D307/85 ,  C07C233/76 ,  C07C225/22

摘要： Certain embodiments describe antiviral compounds and related methods of using such compounds.

公开(公告)号：US20230129481A1

公开(公告)日：2023-04-27

申请号：US17959857

申请日：2022-10-04

申请人： Sony Corporation

发明人： Tracy Matray ,  Sharat Singh

IPC分类号： G01N33/58 ,  C09B69/10 ,  G01N33/52 ,  C07F9/09 ,  C07F9/6558 ,  C07F9/6561 ,  G01N33/533 ,  C07F9/572 ,  C09B3/14 ,  C09B11/26

摘要： Compounds useful as fluorescent or colored dyes are disclosed. The compounds have the following structure (I): or a stereoisomer, tautomer or salt thereof, wherein R1, R2, R3, R4, R5, L1, L2, L3, L4, M, m and n are as defined herein. Methods associated with preparation and use of such compounds are also provided.

公开(公告)号：US20230125751A1

公开(公告)日：2023-04-27

申请号：US17854818

申请日：2022-06-30

申请人： Gilead Sciences, Inc.

发明人： Richard L. Mackman ,  Jay P. Parrish ,  Adrian S. Ray ,  Dorothy Agnes Theodore

IPC分类号： C07D487/04 ,  C07H19/04 ,  A61K9/00 ,  A61K31/706 ,  A61K45/06 ,  C07H7/06 ,  C07F9/6561

摘要： Provided are methods for treating Paramyxoviridae virus infections by administering ribosides, riboside phosphates and prodrugs thereof, of Formula I: wherein the 1′ position of the nucleoside sugar is substituted. The compounds, compositions, and methods provided are particularly useful for the treatment of Human parainfluenza and Human respiratory syncytial virus infections.

公开(公告)号：US20230120381A1

公开(公告)日：2023-04-20

申请号：US18045390

申请日：2022-10-10

申请人： Kymera Therapeutics, Inc

发明人： Nello MAINOLFI ,  Nan JI ,  Bin YANG ,  Yi ZHANG

IPC分类号： C07F9/6561 ,  C07F9/6506

摘要： The present invention provides compounds, compositions thereof, and methods of using the same.

公开(公告)号：US11585819B2

公开(公告)日：2023-02-21

申请号：US17070112

申请日：2020-10-14

申请人： THE UNIVERSITY OF HONG KONG

发明人： Dan Yang ,  Nai-Kei Wong ,  Jun Hu

IPC分类号： G01N33/84 ,  C07F9/6561 ,  C07D311/82 ,  C07D491/20 ,  C07D493/10 ,  C07F7/08 ,  G01N33/58

摘要： The invention provides fluorogenic compounds and probes that can be used as reagents for measuring, detecting and/or screening superoxide. The fluorogenic compounds of the invention can produce fluorescence colors, such as green, yellow, red, or far-red. The invention further provides fluorogenic compounds for selectively staining superoxide in the mitochondria of living cells. The invention also provides methods that can be used to measure, directly or indirectly, the presence and/or amount of superoxide in chemical samples and biological samples such as cells and tissues in living organisms, and a high-throughput screening methods for detecting or screening superoxide or compounds that can increase or decease the level of superoxide in chemical and biological samples.

公开(公告)号：US20230040736A1

公开(公告)日：2023-02-09

申请号：US17867216

申请日：2022-07-18

申请人： COMMISSARIAT A L'ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES ,  University of Iceland

发明人： Gaël De Paepe ,  Frédéric Mentink-Vigier ,  Snorri Sigurdsson ,  Anil Jagtap

IPC分类号： C07D401/12 ,  C07F9/6561 ,  G01R33/56

摘要： The present invention relates to novel organic dinitroxide biradical compounds and their use as polarizing agents, in particular, in the techniques of Nuclear Magnetic Resonance (NMR) of solids or liquid samples and medical imaging.

公开(公告)号：US20220372048A1

公开(公告)日：2022-11-24

申请号：US17100687

申请日：2020-11-20

申请人： Intellikine LLC

发明人： Pingda Ren ,  Yi Liu ,  Troy Edward Wilson ,  Katrina Chan ,  Christian Rommel ,  Liansheng Li

IPC分类号： C07D519/00 ,  C07D473/34 ,  C07D487/04 ,  C07D471/04 ,  C07D495/04 ,  C07D513/04 ,  A61K31/519 ,  A61K31/52 ,  A61K31/5377 ,  A61K31/675 ,  A61K45/06 ,  C07F9/6561

摘要： Chemical entities that modulate PI3 kinase activity, and chemical entities, pharmaceutical compositions, and methods of treatments of diseases and conditions associated with P13 kinase activity are described herein.

公开(公告)号：US11472790B2

公开(公告)日：2022-10-18

申请号：US16628207

申请日：2018-07-03

申请人： COMMISSARIAT A L'ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES ,  UNIVERSITY OF ICELAND

发明人： Gaël De Paepe ,  Frédéric Mentink-Vigier ,  Snorri Sigurdsson ,  Anil Jagtap

IPC分类号： C07D401/12 ,  C07F9/6561 ,  G01R33/56 ,  G01R33/46

摘要： The present invention relates to novel organic dinitroxide biradical compounds and their use as polarizing agents, in particular, in the techniques of Nuclear Magnetic Resonance (NMR) of solids or liquid samples and medical imaging.

公开(公告)号：US11466029B2

公开(公告)日：2022-10-11

申请号：US17569367

申请日：2022-01-05

申请人： Nanjing Zhengxiang Pharmaceuticals Co., Ltd.

发明人： Xiaolin Hao ,  Jinfu Yang

IPC分类号： C07D498/14 ,  A61P31/16 ,  C07F9/6561

摘要： The invention provides compounds that may inhibit influenza virus replication, and are accordingly useful for treatment of viral infections caused by influenza virus. The invention further provides pharmaceutical compositions containing these compounds and methods of using these compounds to treat or prevent viral infections caused by influenza virus.

公开(公告)号：US20220315615A1

公开(公告)日：2022-10-06

申请号：US17626790

申请日：2019-10-28

申请人： JILIN ASYMCHEM PHARMACEUTICALS CO., LTD.

发明人： Hao HONG ,  Gage JAMES ,  Chaoyong CHEN ,  Jiangping LU ,  Yong JIANG ,  Jian TAO ,  Yong LUO

IPC分类号： C07F9/6561 ,  B01J31/22 ,  B01J8/02

摘要： The present disclosure discloses a continuous preparation method for a penem intermediate MAP. The continuous preparation method includes the following steps: step S1, in a column-type continuous reactor, using a rhodium-loaded catalyst to catalyze 4-nitrobenzyl(R)-2-diazo-4-((2R,3S)-3-((R)-1-hydroxyethyl)-4-oxoazetidin-2-yl)-3-oxopentanoate to generate a cyclization reaction so as to form a first intermediate, herein the rhodium-loaded catalyst is loaded in the column-type continuous reactor, and the rhodium-loaded catalyst has the following structural formula: step S2, performing an esterification reaction on the first intermediate, a diphenyl chlorophosphate and a diisopropylethylamine in a second continuous reactor, to obtain a product system containing the penem intermediate MAP; and step S3, performing crystallization treatment on the product system, to obtain the penem intermediate MAP.