公开(公告)号：US20250059228A1

公开(公告)日：2025-02-20

申请号：US18723010

申请日：2022-12-22

Applicant: Wisconsin Alumni Research Foundation

Inventor： Michael Sussman ,  Benjamin Minkoff ,  Jamison Wolfer ,  Heather Burch

IPC: C07K1/107 ,  B01J23/72 ,  C07H1/00 ,  C07K1/13 ,  C07K14/765

Abstract: A method of attaching an azide moiety to a biomolecule. The method entails contacting a biomolecule in a solution with an azide and an oxidizing agent, for a time and at a temperature wherein at least one azide moiety is covalently bonded to the biomolecule to yield an azidylated biomolecule. The method can be used to identify hydrophobic microenvironments in soluble proteins. Also, a method of attaching a reagent comprising an alkyne to a biomolecule. The method comprises reacting a biomolecule in a solution with an azide and a reagent comprising an alkyne, for a time and at a temperature wherein at least one reagent comprising an alkyne is covalently bonded to the biomolecule via triazole linkage.

公开(公告)号：US20250041428A1

公开(公告)日：2025-02-06

申请号：US18926901

申请日：2024-10-25

Applicant: Merck Sharp & Dohme LLC

Inventor： Patrick McHugh ,  Janelle Konietzko

IPC: A61K47/54 ,  A61K47/62 ,  C07H1/00

Abstract: The present invention provides a number of process improvements related to the conjugation of capsular polysaccharides from Streptococcus pneumoniae to a carrier protein. These processes are serotype specific and include acid hydrolysis, addition of sodium chloride to the reductive amination reaction, and addition of sucrose to dissolve polysaccharides. Polysaccharide-protein conjugates prepared using the processes of the invention can be included in multivalent pneumococcal conjugate vaccines.

公开(公告)号：US20250034192A1

公开(公告)日：2025-01-30

申请号：US18902678

申请日：2024-09-30

Applicant: Hongene Biotech Corporation

Inventor： Gaomai Yang ,  Jingshe Song ,  Shengdong Wang ,  Yun-Chiao Yao ,  Hongrong Yang ,  David Yu ,  Aldrich N.K. Lau

IPC: C07H1/00 ,  C08F120/68 ,  C08F220/28 ,  C08F220/56 ,  C08F265/10

Abstract: Embodiments of the present application relate to polymers used as polymeric polyvalent hubs for liquid phase oligonucleotide synthesis. Methods for making an oligonucleotide by liquid phase oligonucleotide synthesis using the polymers are also provided.

公开(公告)号：US12195496B2

公开(公告)日：2025-01-14

申请号：US18309435

申请日：2023-04-28

Applicant: Otsuka Pharmaceutical Co., Ltd.

Inventor： Gemma Zuend ,  Ian Scott ,  Nipun Davar ,  Kimiyoshi Annaka ,  Masahiro Miyake ,  Motoshi Matsui

IPC: C07H19/06 ,  C07H1/00

Abstract: The invention relates to methods of synthesizing 2′-deoxy-2′,2′-difluorotetrahydrouridine with increased purity and uniform particle size distribution. In particular, methods of the invention include crystallization and isolation procedures rendering synthetic reaction intermediates. The invention further includes compositions comprising the final compound in highly pure form, including lower number of impurities and lower levels of individual and total impurities.

公开(公告)号：US12180140B2

公开(公告)日：2024-12-31

申请号：US18390545

申请日：2023-12-20

Applicant: Hongene Biotech Corporation

Inventor： Gaomai Yang ,  Min Xie ,  Hongrong Yang ,  Shengdong Wang ,  Aldrich N. K. Lau ,  Ruiming Zou ,  David Yu

IPC: C07C237/22 ,  C07C231/00 ,  C07C233/59 ,  C07H1/00 ,  C07H21/00

Abstract: The present disclosure relates to methods and compounds for liquid phase oligonucleotide synthesis employing the use of small molecules with lipophilic groups. Methods for making an oligonucleotide by liquid phase oligonucleotide synthesis using the compounds described herein are also provided.

公开(公告)号：US20240425543A1

公开(公告)日：2024-12-26

申请号：US18677461

申请日：2024-05-29

Applicant: The Regents of the University of Colorado, a body corporate

Inventor： Ayman Alawneh ,  Marvin Caruthers

IPC: C07H21/04 ,  C07H1/00 ,  C07H19/073

Abstract: Oligonucleotides comprising phosphoramidimidate internucleotide linkages, and methods of efficiently synthesizing these oligonucleotides with high yield are provided. These oligonucleotides form duplexes with complementary DNA or RNA that are more stable than natural DNA or DNA/RNA complexes, are active with RNAse H1, and may be transfected into cells using standard lipid reagents. These analogues are therefore useful for numerous therapeutic antisense applications.

公开(公告)号：US20240417418A1

公开(公告)日：2024-12-19

申请号：US18702855

申请日：2022-10-21

Applicant: BioNTech SE ,  Consejo Superior de Investigaciones Científicas

Inventor： Jorge Moreno Herrero ,  Heinrich Haas ,  Stephanie Erbar ,  José Manuel García Fernández ,  Juan Manuel Benito Hernández ,  Jose Lopez Fernandez ,  Práxedes Sánchez Mellado

IPC: C07H15/04 ,  A61K9/00 ,  A61K31/7105 ,  A61K47/54 ,  C07H1/00

Abstract: The present disclosure provides compounds, compositions, and complexes useful for delivery of certain agents, including, for example, nucleic acids.

公开(公告)号：US20240400601A1

公开(公告)日：2024-12-05

申请号：US18700569

申请日：2022-10-12

Applicant: SOCIÉTÉ D'EXPLOITATION DE PRODUITS POUR LES INDUSTRIES CHIMIQUES SEPPIC

Inventor： Estelle ILLOUS ,  Stéphane DESSILLA

IPC: C07H15/04 ,  C07H1/00

Abstract: Disclosed is a process for preparing alkyl polyglycosides having a color of less than or equal to 1.5 VCS, the process successively involving: a) a glycosylation step a) consisting in a reaction between at least one alcohol of formula (I) and at least one reducing sugar of formula (III): H—O-(G)-H (III), in the presence of at least one acid catalyst (CA) at a minimum temperature of 100° C. and a maximum temperature of 120° C., b) a step b) of neutralizing the reaction medium from step a) with an aqueous solution comprising a basic agent (Ab), c) a step c) of removing the sugar of formula (III), which has not reacted in step a), from the neutralized reaction medium, and d) a step d) of recovering at least one composition (C) having a color of less than or equal to 1.5 VCS.

公开(公告)号：US12110309B2

公开(公告)日：2024-10-08

申请号：US16590676

申请日：2019-10-02

Applicant: SHIMADZU CORPORATION

Inventor： Takashi Nishikaze

IPC: C07H1/00 ,  G01N33/68

CPC classification number: C07H1/00 ,  G01N33/6848 ,  G01N2400/00 ,  G01N2440/38 ,  G01N2560/00

Abstract: A method for preparing an analytical sample for analysis of a glycan contained in a sample includes: performing an amidation reaction that amidates a lactone structure included in the glycan through contacting the sample with a reaction solution that is basic; adding an acidic solution to the reaction solution after the reaction solution is subjected to the amidation reaction; and purifying the sample contained in the reaction solution after the acidic solution is added to the reaction solution by using a carrier for hydrophilic interaction chromatography.

公开(公告)号：US20240327388A1

公开(公告)日：2024-10-03

申请号：US18564512

申请日：2022-05-27

Applicant: JIANGSU HENGRUI PHARMACEUTICALS CO., LTD. ,  SHANGHAI HENGRUI PHARMACEUTICAL CO., LTD.

Inventor： Fanglong YANG ,  Minqiang JIA ,  Huanyu TANG ,  Yonglei QUE ,  Feng HE ,  Weikang TAO

IPC: C07D405/12 ,  A61K31/4709 ,  A61K31/473 ,  A61K31/706 ,  A61P37/06 ,  C07D215/38 ,  C07D401/12 ,  C07D405/14 ,  C07D413/12 ,  C07D491/056 ,  C07H1/00 ,  C07H17/04

CPC classification number: C07D405/12 ,  A61K31/4709 ,  A61K31/473 ,  A61K31/706 ,  A61P37/06 ,  C07D215/38 ,  C07D401/12 ,  C07D405/14 ,  C07D413/12 ,  C07D491/056 ,  C07H1/00 ,  C07H17/04

Abstract: The present invention relates to a quinolinamine compound, a preparation method therefor and an application thereof in pharmaceuticals. Specifically, the present invention relates to a quinolinamine compound as represented by general formula (I), a preparation method therefor, a pharmaceutical composition containing the compound, and use thereof as a therapeutic agent, especially use thereof as a miRNA regulator and use thereof in preparation of a drug for treating diseases or conditions that can be improved by regulating miRNA levels.