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公开(公告)号：US12097304B2
公开(公告)日：2024-09-24
申请号：US15591728
申请日：2017-05-10
Inventor： Karrer M. Alghazali , Zeid A. Nima , Alexandru S. Biris
IPC: A61L27/36 , A61L27/12 , A61L27/14 , A61L27/18 , A61L27/20 , A61L27/38 , A61L27/54 , A61L27/56 , A61L27/58 , A61K9/14 , A61K31/4453 , A61K31/704 , C07C211/38 , C07C229/36 , C07D209/14 , C07D209/24 , C07D211/22 , C07D215/22 , C07D265/18 , C07D277/56 , C07D405/12 , C07D473/18 , C07D473/30 , C07D491/22 , C07D501/22 , C07H15/252 , C07H17/08
CPC classification number: A61L27/3695 , A61L27/12 , A61L27/14 , A61L27/18 , A61L27/20 , A61L27/3608 , A61L27/38 , A61L27/54 , A61L27/56 , A61L27/58 , A61L2300/256 , A61L2300/258 , A61L2300/414 , A61L2400/08 , A61L2400/12 , A61L2430/02 , A61L27/18 , C08L67/04
Abstract: A method for forming a biocompatible structure includes the steps of forming a layered structure having alternatively disposed first layers and second layers, where the first layers includes at least one polymer and first particles, and the second layers includes second particles; and treating the layered structure with a washing solvent to form the biocompatible structure, where the first particles are solvable in the washing solvent.
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公开(公告)号：US20240262856A1
公开(公告)日：2024-08-08
申请号：US18563056
申请日：2022-06-08
Applicant: Acies Bio d.o.o.
Inventor： Nika Lendero Krajnc , Gregor Kosec , Petra Kralj , Stefan Fujs , Mirjan Svagelj , Nicholas Camp
Abstract: The present invention generally relates to the field of pesticides. More specifically, the present invention relates to novel spinosyn compounds having advantageous properties, processes for their preparation, and their use as pesticides.
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公开(公告)号：US20230250124A1
公开(公告)日：2023-08-10
申请号：US17773279
申请日：2020-10-27
Applicant: HIKAL LIMITED , GALAPAGOS
Inventor： Sudhir NAMBIAR , Rakesh Ramesh GANORKAR , Kiran CHAUDHARI , Anil GOHAR , Deeksha SINGH , Patrick CLAERHOUT STIJN POL
Abstract: The present invention relates to substantially pure Clarithromycin 9-oxime more particularly Clarithromycin 9(E)-oxime having purity more than 98% and corresponding (Z)-isomer not more than 1%. The present invention further relates to a process for preparation of Clarithromycin 9(E)-oxime of formula (I), its pharmaceutically acceptable salts and purification.
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公开(公告)号：US11673910B2
公开(公告)日：2023-06-13
申请号：US16609120
申请日：2018-04-27
Inventor： Andrew G. Myers , Ziyang Zhang , Takehiro Fukuzaki , Udara Anulal Premachandra Ilandari Dewage , Senkara Rao Allu , Roger B. Clark , Jonathan F. Lawrence , Wesley Francis Austin , Xiben Li , Wenying Wang , Sushmita D. Lahiri , Yoshitaka Ichikawa
Abstract: Provided are macrolide compounds for the treatment of infectious diseases. The macrolides disclosed herein include 14-membered ketolides and 14-15-membered azaketolides, and may comprise modified sugars which are desosamine analogues. The disclosed macrolides may have a bicyclic structure. Also provided are pharmaceutical compositions and methods of treating infectious diseases, and in particular, disease which results from Gram negative bacteria using the disclosed macrolides. This disclosure additionally provides methods of preparing the macrolides by a strategy that enables late-stage modification of the 6′-position of the sugar moiety, thereby allowing facile access to previously difficult-to-make macrolide compounds.
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公开(公告)号：US20230159581A1
公开(公告)日：2023-05-25
申请号：US17873451
申请日：2022-07-26
Applicant: Michael W. Burnet , Synovo GmbH
Inventor： Nikolas Pietrzik , Michael W. Burnet , Christiane Baeuerlein , Mary Eggers , Jan-Hinrich Guse , Ulrike Hahn , Simon Strass
IPC: C07H17/08 , C07C217/40 , C07D215/42 , C07D401/04
CPC classification number: C07H17/08 , C07C217/40 , C07D215/42 , C07D401/04 , A61K45/06
Abstract: Lysosomally accumulated substances that release a nitroxy group, or a short chain fatty acid or a product of anaerobic metabolism or a thiol or a sulfide often from an ester or similar labile linkage have anti-inflammatory, anti-cancer and anti-bacterial activity. They are useful in treating infectious, inflammatory and malignant disease.
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公开(公告)号：US20230129438A1
公开(公告)日：2023-04-27
申请号：US17801337
申请日：2021-03-11
Applicant: Zoetis Services LLC
Inventor： Christopher A. Zook , Todd M. Maddux , Tomasz Respondek
Abstract: Defined herein are immunomodulating Formula (1) compounds wherein R1, R2, R3, and W are as defined herein, stereoisomers thereof, and pharmaceutically acceptable salts thereof; and compositions comprising said compounds. The invention also includes methods for treating an inflammatory and/or immunological disease or disorder in an animal by administering a therapeutically effective amount of a Formula (1) compound, stereoisomer thereof, and a pharmaceutically acceptable salt thereof; or use of said compound of Formula (1) to prepare a medicament for treating an inflammatory and/or immunological disease or disorder in an animal.
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公开(公告)号：US11591360B2
公开(公告)日：2023-02-28
申请号：US17268252
申请日：2019-08-15
Applicant: DSM IP ASSETS B.V.
Inventor： Alexander Lucia Leonardus Duchateau , Peter Philip Lankhorst , Willebrordus Bernardus Van Scheppingen
IPC: C07H17/08
Abstract: The present invention is directed to a process for purifying natamycin, to an epoxide polyene amphoteric macrolide, to a composition comprising said polyene amphoteric macrolide and to a process for preparing said polyene amphoteric macrolide.
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公开(公告)号：US20220332749A1
公开(公告)日：2022-10-20
申请号：US17841383
申请日：2022-06-15
Applicant: Azura Ophthalmics Ltd.
Inventor： Ian HOLMES , Yair ALSTER , Hila EPSTEIN-BARASH , Charles BOSWORTH , Omer RAFAELI , Robert M. BURK , Marc GLEESON , Mark Richard STEWART , Jonathan DUNN , Alexander James NICHOLLS
Abstract: Described herein are compositions and methods for the treatment or prevention of ocular surface disorders including meibomian gland dysfunction, blepharitis, dry eye disease and other inflammatory and/or infectious diseases of the anterior surface of the eye(s). Said compositions and methods comprise keratolytic conjugates which demonstrate keratolytic activity, and anti-inflammatory or other desirable activities. Topical administration of said compositions to the eyelid margin or surrounding areas provides therapeutic benefit to patients suffering from ocular surface disorders.
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公开(公告)号：US20220332748A1
公开(公告)日：2022-10-20
申请号：US17222802
申请日：2021-04-05
Applicant: Azura Ophthalmics Ltd.
Inventor： Ian HOLMES , Yair ALSTER , Hila BARASH , Charles BOSWORTH , Omer RAFAELI , Robert M. BURK , Marc GLEESON , Mark Richard STEWART , Jonathan DUNN , Alexander James NICHOLLS
Abstract: Described herein are compositions and methods for the treatment or prevention of ocular surface disorders including meibomian gland dysfunction, blepharitis, dry eye disease and other inflammatory and/or infectious diseases of the anterior surface of the eye(s). Said compositions and methods comprise keratolytic conjugates which demonstrate keratolytic activity, and anti-inflammatory or other desirable activities. Topical administration of said compositions to the eyelid margin or surrounding areas provides therapeutic benefit to patients suffering from ocular surface disorders.
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公开(公告)号：US11364189B2
公开(公告)日：2022-06-21
申请号：US16347336
申请日：2017-11-07
Applicant: L'OREAL
Inventor： Marie-céline Frantz
IPC: A61K8/60 , A61Q19/02 , A61Q19/08 , A61Q5/08 , C07H1/00 , C07H3/02 , C07H17/08 , C07D493/04 , C07D405/06 , C07D309/10
Abstract: The present invention relates to a method for the cosmetic treatment of keratin materials, comprising the application of a composition to the keratin materials, such as the skin, said composition comprising a compound (I), wherein R1, R2 and R3 are as defined in the description and S* is a mono or polysaccharide.
