公开(公告)号：US12215317B2

公开(公告)日：2025-02-04

申请号：US18143533

申请日：2023-05-04

Applicant: Helix Nanotechnologies Inc.

Inventor： Nikhil Dhar ,  Kyle Backman ,  Dario de Jesus Davila Pasillas ,  Justin Sean Huang ,  Nikolai Eroshenko

IPC: C12N15/11 ,  C07H13/04 ,  C07H19/10 ,  C07H19/16 ,  C07H19/20

Abstract: Disclosed herein is a modified ribonucleotide comprising a nucleoside comprising 2′-O-acetylated ribose, and polyribonucleotides comprising the same. Also provided herein are compositions comprising a polyribonucleotide of the present disclosure and methods of making and using the same.

公开(公告)号：US12195493B2

公开(公告)日：2025-01-14

申请号：US17208831

申请日：2021-03-22

Applicant: MGI Tech Co., Ltd. ,  BGI Shenzhen

Inventor： Handong Li ,  Snezana Drmanac ,  Radoje Drmanac ,  Xun Xu ,  Lingling Peng ,  Scott Gablenz

IPC: C07H15/04 ,  C07H19/10 ,  C07H19/20 ,  C07H21/04 ,  C12Q1/6869

Abstract: Reversibly blocked nucleoside analogues and methods of using such nucleoside analogues for sequencing of nucleic acids are provided.

公开(公告)号：US20250002524A1

公开(公告)日：2025-01-02

申请号：US18293593

申请日：2022-07-29

Applicant: CureVac SE

Inventor： Rainer Joachim SCHWARZ

IPC: C07H21/02 ,  A61K31/7088 ,  C07H19/20

Abstract: The present invention is inter alia concerned with (A) a compound of formula (I) as defined herein or a salt, stereoisomer, tautomer or deuterated version thereof, (B) a cap analog comprising a 5′ terminal acyclonucleoside, wherein the acyclonucleoside comprises a linear unbranched structure or a linear single-branched structure instead of a ribose, wherein the 5′ terminal acyclonucleoside is optionally deuterated (C) an RNA molecule comprising at least three nucleotides and comprising a 5′ end of formula (III) as defined herein, wherein the 5′ end is optionally deuterated (D) an RNA molecule comprising at least three nucleotides and comprising a 5′ terminal acyclonucleoside, wherein the acyclonucleoside comprises a linear unbranched structure or a linear single-branched structure instead of a ribose, wherein the 5′ terminal acyclonucleoside is optionally deuterated (E) an in vitro method for synthesizing an RNA molecule, (F) the RNA molecule obtained thereby, (G) compositions comprising the RNA molecule, (H) kits comprising the compound of formula (I) or the cap analog, (I) uses as well as (J) methods as outlined herein.

公开(公告)号：US20240400604A1

公开(公告)日：2024-12-05

申请号：US18732149

申请日：2024-06-03

Applicant: SHANDONG UNIVERSITY

Inventor： Rong CAI ,  Can GAO ,  Mengxuan LI ,  Zhiming WANG ,  Jing TAN ,  Wenwen LI ,  Jing XU

IPC: C07H19/20 ,  C12Q1/48 ,  G01N30/02 ,  G01N30/72 ,  G01N30/88 ,  G01N33/58

Abstract: A nucleoside triphosphate photoaffinity probe, method for preparing same, and applications thereof. The nucleoside triphosphate photoaffinity probe is a novel small molecule activity probe for detecting nucleoside triphosphate-binding proteins and is based on the structure of nucleoside triphosphates (GTP and ATP) connected to a smaller photoaffinity side chain modification. This probe can effectively label nucleoside triphosphate-binding proteins in cell lysates for high-throughput proteomics analysis, identify and analyze the binding sites of the probe, and can also be used to analyze the action sites of nucleoside triphosphate competitive inhibitors, thus having significant practical application value.

公开(公告)号：US12129501B2

公开(公告)日：2024-10-29

申请号：US17903120

申请日：2022-09-06

Applicant: Nuclera Ltd.

Inventor： Michael Chen ,  Jiahao Huang ,  Radu Lazar ,  Gordon McInroy

IPC: C12P19/34 ,  C07H1/02 ,  C07H19/10 ,  C07H19/20 ,  C40B50/04 ,  C40B50/18 ,  C40B80/00

CPC classification number: C12P19/34 ,  C07H1/02 ,  C07H19/10 ,  C07H19/20 ,  C40B50/04 ,  C40B50/18 ,  C40B80/00

Abstract: The invention relates to methods of synthesizing polymers, biopolymers, and nucleic acids, to immobilised dNTP/NTPs and kits comprising said immobilised dNTP/NTPs for use in said methods of nucleic acid synthesis.

公开(公告)号：US20240352057A1

公开(公告)日：2024-10-24

申请号：US18516459

申请日：2023-11-21

Applicant: Arcus Biosciences, Inc.

Inventor： Laurent Pierre Paul DEBIEN ,  Juan Carlos Jaen ,  Jaroslaw Kalisiak ,  Kenneth V. Lawson ,  Manmohan Reddy Leleti ,  Erick Allen Lindsey ,  Dillon Harding Miles ,  Eric Newcomb ,  Jay Patrick Powers ,  Brandon Reid Rosen ,  Ehesan Ui Sharif

IPC: C07H19/23 ,  A61K31/70 ,  A61K31/7052 ,  A61K31/706 ,  A61K31/7064 ,  A61K31/7076 ,  A61K45/06 ,  C07F9/6561 ,  C07H19/04 ,  C07H19/14 ,  C07H19/16 ,  C07H19/20 ,  C07H19/207

CPC classification number: C07H19/23 ,  A61K31/70 ,  A61K31/7052 ,  A61K31/706 ,  A61K31/7064 ,  A61K31/7076 ,  A61K45/06 ,  C07F9/6561 ,  C07F9/65616 ,  C07H19/04 ,  C07H19/14 ,  C07H19/16 ,  C07H19/20 ,  C07H19/207

Abstract: Compounds that modulate the conversion of AMP to adenosine by 5′-nucleotidase, ecto, and compositions containing the compounds and methods for synthesizing the compounds, are described herein. The use of such compounds and compositions for the treatment and/or prevention of a diverse array of diseases, disorders and conditions, including cancer- and immune-related disorders, that are mediated by 5′-nucleotidase, ecto is also provided.

公开(公告)号：US12054510B2

公开(公告)日：2024-08-06

申请号：US17833780

申请日：2022-06-06

Applicant: Nucana plc

Inventor： Hugh Griffith ,  Christopher McGuigan ,  Valentina Ferrari ,  Michaela Serpi ,  Carmen Jimenez Antunez

IPC: C07H19/20 ,  C07H19/173

CPC classification number: C07H19/20 ,  C07H19/173

Abstract: The present invention relates to chemical compounds, the compounds for use in a method of treatment, particularly in a method of prophylaxis or treatment for cancer, a process for preparation of the compounds and pharmaceutical compositions comprising the compounds. The compounds may, in particular, be useful in the treatment of leukaemia, lymphoma and/or solid tumours in Homo sapiens. The compounds are derivatives of cordycepin (3′-deoxyadenosine).

公开(公告)号：US20240165146A1

公开(公告)日：2024-05-23

申请号：US18340192

申请日：2023-06-23

Applicant: Ionis Pharmaceuticals, Inc.

Inventor： Nicholas J. Viney ,  Richard S. Geary ,  Yanfeng Wang ,  Zhengrong Yu ,  Rudy Gunawan

IPC: A61K31/712 ,  A61K9/00 ,  A61K48/00 ,  A61P3/06 ,  C07H19/20 ,  C07H21/00 ,  C07H21/02 ,  C07H21/04 ,  C12N15/113

CPC classification number: A61K31/712 ,  A61K9/0019 ,  A61K48/0016 ,  A61K48/005 ,  A61K48/0083 ,  A61P3/06 ,  C07H19/20 ,  C07H21/00 ,  C07H21/02 ,  C07H21/04 ,  C12N15/113 ,  C12N2310/341 ,  C12N2310/3515

Abstract: Provided herein are methods of administering gapmer oligomeric compounds with GalNAc conjugate groups to a human.

公开(公告)号：US11975016B2

公开(公告)日：2024-05-07

申请号：US17482224

申请日：2021-09-22

Applicant: Atea Pharmaceuticals, Inc.

Inventor： Jean-Pierre Sommadossi ,  Adel Moussa

IPC: A61K31/7076 ,  A61K31/675 ,  A61P1/00 ,  A61P31/14 ,  C07H19/16 ,  C07H19/20

CPC classification number: A61K31/7076 ,  A61K31/675 ,  A61P1/00 ,  A61P31/14 ,  C07H19/16 ,  C07H19/20

Abstract: The use of described compounds or pharmaceutically acceptable salts or compositions thereof for the treatment of a host infected with an RNA virus other than HCV, or other disorder more fully described herein.

公开(公告)号：US20240140977A1

公开(公告)日：2024-05-02

申请号：US18547207

申请日：2022-02-25

Applicant: Ansa Biotechnologies, Inc.

Inventor： Daniel Arlow ,  Sebastian Palluk ,  Weidong Wu

IPC: C07H19/10 ,  C07H19/14 ,  C07H19/20 ,  C12Q1/6869

CPC classification number: C07H19/10 ,  C07H19/14 ,  C07H19/20 ,  C12Q1/6869

Abstract: The present application is directed to, in part, nucleotide analogs with a novel design of a 3′-OH reversible terminator that comprises an enzyme-cleavable linkage.