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1.发明公开公开(公告)号：US20240327444A1
公开(公告)日：2024-10-03
申请号：US18576587
申请日：2022-07-05
申请人： Japan Science and Technology Agency , National University Corporatjion Tokai National Higher Education and Research System
发明人： Hiroshi Abe , Naoko Abe , Masahito Inagaki , Yasuaki Kimura , Fumitaka Hashiya , Zhenmin Li , Yuko Nakashima
IPC分类号： C07H1/06 , A61K31/7105 , C07F9/24 , C07H17/02 , C07H21/00
CPC分类号： C07H1/06 , A61K31/7105 , C07F9/2458 , C07H17/02 , C07H21/00
摘要： A method for purifying a nucleotide-based substance; including a protecting group introduction step of introducing a hydrophobic protecting group represented by the following formula (P1) or (P2) into a nucleotide-based substance to produce a hydrophobic nucleotide-based substance; an isolation and purification step of isolating and purifying the hydrophobic nucleotide-based substance under a hydrophobic environment; and a deprotection step of deprotecting the hydrophobic protecting group from the hydrophobic nucleotide-based substance to produce the nucleotide-based substance,
wherein R1 represents a linear or branched alkyl group having 1 to 30 carbon atoms, R4 represents hydrogen or a linear or branched alkyl group having 1 to 10 carbon atoms, R2, R3, R5 and R6 represent hydrogen, a linear or branched alkyl group having 1 to 10 carbon atoms, or the like, and may be the same or different; and * means a bond with a nucleotide-based substance.-
公开(公告)号：US20240254159A1
公开(公告)日：2024-08-01
申请号：US18504925
申请日：2023-11-08
CPC分类号： C07H21/04 , A61K47/549 , C07H21/00 , C07K14/003 , Y10S977/932
摘要： Conjugated molecules are prepared that comprise a predetermined number of oligo conjugation components. The conjugated molecules also may comprise one or more detectable labels. Preparation of these molecules can be implemented according to an asymmetric or a symmetric conjugation strategy.
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公开(公告)号：US20240254158A1
公开(公告)日：2024-08-01
申请号：US18288057
申请日：2022-04-27
发明人： Koki KATO , Masaki NOGATA , Shunsuke TODA
IPC分类号： C07H21/00
CPC分类号： C07H21/00
摘要： The present invention relates to a method for producing an oligonucleic acid compound, the method being characterized by (1) treating a compound represented by formula [A-1] and a compound represented by formula [B-1] with a condensation agent in the presence of a base and then (2) treating the compounds with an oxidizing agent and an organic amine to produce a compound represented by formula [C-1] (in the formulae, each symbol is as defined in the description).
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公开(公告)号：US20240245784A1
公开(公告)日：2024-07-25
申请号：US18409330
申请日：2024-01-10
发明人： James HEYES , Richard J. HOLLAND , Alan D. MARTIN , Mark WOOD
IPC分类号： A61K47/54 , A61K31/713 , A61K47/59 , A61K47/60 , C07C235/10 , C07C237/08 , C07H15/08 , C07H15/18 , C07H15/26 , C07H21/00 , C07J51/00 , C07J63/00 , C12N15/113 , C07D207/08 , C07D207/12 , C07D211/42 , C12N15/11 , C12N15/87
CPC分类号： A61K47/549 , A61K31/713 , A61K47/554 , A61K47/59 , A61K47/60 , C07C235/10 , C07C237/08 , C07H15/08 , C07H15/18 , C07H15/26 , C07H21/00 , C07J51/00 , C07J63/008 , C12N15/113 , C07D207/08 , C07D207/12 , C07D211/42 , C12N15/111 , C12N15/87 , C12N2310/14 , C12N2310/315 , C12N2310/321 , C12N2310/346 , C12N2310/351 , C12N2320/32
摘要： The invention provides conjugates that comprise a targeting moiety, a nucleic acid, and optional linking groups as well as synthetic intermediates and synthetic methods useful for preparing the conjugates. The conjugates are useful to target therapeutic nucleic acids to the liver and to treat liver diseases including hepatitis (e.g. hepatitis B and hepatitis D).
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公开(公告)号：US11993626B2
公开(公告)日：2024-05-28
申请号：US18065503
申请日：2022-12-13
发明人： Wing C. Poon , Xiaoyang Guan , David Yu , Ruiming Zou , Xiaojun Li , Michael Su , Gang Zhao , Gengyu Du , Yun-Chiao Yao , Aldrich N. K. Lau
摘要： Embodiments of the present application relate to functionalized N-acetylgalactosamine-analogs, methods of making, and uses of the same. In particular, mono or trivalent N-acetylgalactosamine analogs may be prepared by utilizing a wide variety of linkers containing functional groups. These functionalized N-acetylgalactosamine-analogs may be used in the preparation of targeted delivery of oligonucleotide-based therapeutics.
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公开(公告)号：US11987599B2
公开(公告)日：2024-05-21
申请号：US18003404
申请日：2021-06-28
申请人： United States of America, as represented by the Secretary, Department of Health and Human Services
IPC分类号： C07H21/04 , C07F9/09 , C07F9/655 , C07H21/00 , C07H21/02 , C12N15/10 , C12N15/113 , C40B50/18
CPC分类号： C07H21/04 , C07F9/093 , C07F9/098 , C07F9/65515 , C07H21/00 , C07H21/02 , C12N15/1068 , C12N15/113 , C40B50/18
摘要： Disclosed herein are embodiments of a solid support suitable for synthesizing nucleic acid sequences. The solid support may have a structure according to Formula I, where CPG is controlled pore glass, and m, n, x, y, R1 and R2 are as defined herein.
Also disclosed are methods for making and using the solid support, kits including solid support, and a universal linker phosphoramidite suitable for use in the solid support.-
7.发明公开公开(公告)号：US20240158432A1
公开(公告)日：2024-05-16
申请号：US18514386
申请日：2023-11-20
发明人： Hu CHENG , Chenchen HU , Jiaxin SONG , Yang LIU , Tingting QIAN , Xianzhe WANG , Jimin YANG
IPC分类号： C07H21/00
CPC分类号： C07H21/00
摘要： A composition comprising dichloroacetic acid and glyoxylic acid, wherein, the content of glyoxylic acid is below 1000 pm, and the preparation method and application of the composition. A process for preparing the composition, comprising: mixing a dichloroacetic acid material having greater than 1000 ppm glyoxylic acid with a glyoxylic acid capture reagent, and a process for preparing oligonucleotides, comprising using the composition. It is found that glyoxylic acid is an impurity in commercially available DCA products, which may cause the oligonucleotides synthesis failure. Ion chromatography can be used to detect glyoxylic acid in dichloroacetic acid and accurately determine its concentration.
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公开(公告)号：US20240140981A1
公开(公告)日：2024-05-02
申请号：US18269743
申请日：2021-12-28
申请人： Curative Inc.
摘要： The present disclosure, in some aspects, is directed to nucleic acid purification methods using a water-immiscible solvent wash. In other aspects, the present disclosure is directed to kits, components, and compositions (such as consumables) useful for the nucleic acid purification methods described herein.
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公开(公告)号：US20240117447A1
公开(公告)日：2024-04-11
申请号：US18296978
申请日：2023-04-06
发明人： Andrea DEDENT , Shuyuan MA , Hedia MAAMAR
IPC分类号： C12Q1/689 , C07H21/00 , C07H21/04 , C12Q1/6883
CPC分类号： C12Q1/689 , C07H21/00 , C07H21/04 , C12Q1/6883 , C12Q2600/118 , C12Q2600/16
摘要： Disclosed herein are primers and probes related to the detection of Neisseria gonorrhoeae via nucleic acid amplification testing (NAAT), for example to amplify and determine the presence of N. gonorrhoeae nucleic acids present in test samples. Specifically the present disclosure describes primers and probes that bind to the small subunit rRNA (cytosine (967)-C(5))-methyltransferase or rsmB gene of N. gonorrhoeae for detection via loop mediated isothermal amplification (LAMP) and molecular beacon hybridization.
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公开(公告)号：US20240116977A1
公开(公告)日：2024-04-11
申请号：US17767825
申请日：2020-08-25
发明人： Takuya MIYAGAWA , Hideki OKUMURA
IPC分类号： C07H21/00
CPC分类号： C07H21/00
摘要： The present invention provides an efficient process for preparing a nucleic acid oligomer, in particular, a process for deprotecting efficiently a protecting group of hydroxy group of a ribose in a nucleic acid oligomer. Specifically, the present invention also provides a process for preparing a nucleic acid oligomer represented by formula (4), which comprises contacting a nucleic acid oligomer represented by formula (3) with a fluoride ion under an atmosphere of an inert gas or inert gases containing 15% or less of oxygen concentration (wherein the definitions of each groups described in formula (3) and formula (4) are the same as defined in the Description).
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