公开(公告)号：US20210299154A1

公开(公告)日：2021-09-30

申请号：US17307047

申请日：2021-05-04

申请人： Rubedo Life Sciences, Inc.

发明人： Mark A. Gallop ,  Julian Klein ,  Marco Quarta

IPC分类号： A61K31/7072 ,  A61P35/04 ,  C07H5/04

摘要： Provided herein are senolytic agents for selectively killing senescent cells that are associated with numerous pathologies and diseases, including age-related pathologies and diseases. As disclosed herein, senescent cell-associated diseases and disorders may be treated or prevented by administering at least one senolytic agent or pharmaceutical compositions thereof. The senescent cell-associated diseases or disorders treated or prevented by the methods described herein include, but are not limited to, cardiovascular diseases or disorders, cardiovascular diseases and disorders associated with arteriosclerosis, such as atherosclerosis, idiopathic pulmonary fibrosis (IPF), chronic obstructive pulmonary disease (COPD), osteoarthritis, inflammatory diseases or disorders, autoimmune diseases or disorders, pulmonary diseases or disorders, neurological diseases or disorders, dermatological diseases or disorders, chemotherapeutic side effects, radiotherapy side effects, metastasis and metabolic diseases.

公开(公告)号：US11117996B2

公开(公告)日：2021-09-14

申请号：US16303285

申请日：2017-02-27

申请人： Oji Holdings Corporation

发明人： Kazuyo Morita ,  Kimiko Hattori

IPC分类号： C08F293/00 ,  H01L21/027 ,  C07H5/04 ,  H01L21/311

摘要： It is an object of the present invention to provide a self-assembly composition for pattern formation having a wide range of applicable pattern size and being capable of forming a favorable phase-separated structure. The present invention relates to a self-assembly composition for pattern formation, which comprises a block copolymer comprising a polymerization unit (a) having at least one selected from a structure represented by the following formula (103) and a structure represented by the following formula (104), and a polymerization unit (b) having a structure represented by the following formula (105), wherein the content rate of a sugar moiety in the block copolymer is 3% by mass or more and 80% by mass or less based on the total mass of the block copolymer:

公开(公告)号：US20210147603A1

公开(公告)日：2021-05-20

申请号：US17164278

申请日：2021-02-01

申请人： Oji Holdings Corporation

发明人： Kazuyo MORITA ,  Kimiko HATTORI

IPC分类号： C08F293/00 ,  H01L21/027 ,  C07H5/04 ,  H01L21/311

摘要： It is an object of the present invention to provide a self-assembly composition for pattern formation having a wide range of applicable pattern size and being capable of forming a favorable phase-separated structure. The present invention relates to a self-assembly composition for pattern formation, which comprises a block copolymer comprising a polymerization unit (a) having at least one selected from a structure represented by the following formula (103) and a structure represented by the following formula (104), and a polymerization unit (b) having a structure represented by the following formula (105), wherein the content rate of a sugar moiety in the block copolymer is 3% by mass or more and 80% by mass or less based on the total mass of the block copolymer:

公开(公告)号：US20190330492A1

公开(公告)日：2019-10-31

申请号：US16504310

申请日：2019-07-07

申请人： KNAUF INSULATION, INC. ,  KNAUF INSULATION SPRL

发明人： Brian Lee SWIFT ,  Ronald E. KISSELL

IPC分类号： C09D167/04 ,  F16L59/14 ,  F16L59/02 ,  C09D105/00 ,  C09D5/08 ,  C03C17/28 ,  E04B1/84 ,  E04B1/78 ,  B29C70/68 ,  C08L51/02 ,  C08F251/02 ,  C07H5/04 ,  E04B1/88 ,  C03C25/14

摘要： A curable aqueous composition is disclosed comprising a carbohydrate, a crosslinking agent, and an amine base, wherein the curable aqueous composition has a pH adjusted by the amine base. Further disclosed is a method of forming a curable aqueous solution.

公开(公告)号：US10435523B2

公开(公告)日：2019-10-08

申请号：US15388355

申请日：2016-12-22

申请人： COLORADO STATE UNIVERSITY RESEARCH FOUNDATION

发明人： Susan P. James ,  Min Zhang ,  Guy Beauregard ,  Rachael Kurkowski Oldinski

IPC分类号： C07H5/04 ,  C07H1/00 ,  C08B37/08 ,  C08J3/24 ,  C08B37/00 ,  C08L5/08 ,  A61L31/04 ,  C08J9/42

摘要： The present disclosure provides, inter alia, a method of producing an outer layer material for forming into a structure and that comprises an entanglement having a hydrophobic polymer host and a hydrophilic guest, including in one embodiment the steps of: intermingling cloaked hydrophilic guest complexes with the hydrophobic host; crosslinking molecules of the guest with the guest; and performing a hydrolysis reaction.

公开(公告)号：US10087242B2

公开(公告)日：2018-10-02

申请号：US14310667

申请日：2014-06-20

申请人： INSTITUT PASTEUR ,  Centre National De La Recherche Scientifique ,  Universite Paris Descartes

发明人： Laurence Mulard ,  Julien Boutet ,  Catherine Guerreiro ,  Farida Nato ,  Philippe Sansonetti ,  Armelle Phalipon

IPC分类号： C07H5/04 ,  C07H1/00 ,  C07K16/12 ,  C07H3/06 ,  C07H3/04 ,  A61K47/64

摘要： The present invention relates to compounds derived from sugars which reproduce the epitopes of Shigella flexneri serotypes 3a and X and to the use thereof for the preparation of vaccine compositions. More specifically, the subject matter of the present invention relates to novel glycoconjugated compounds comprising oligosaccharides or polysaccharides described hereinafter, to the method for synthesizing these oligosaccharides or polysaccharides and glycoconjugates, to derivatives of these oligosaccharides or polysaccharides, to compositions containing same, and also to the use of the glycoconjugates for vaccination purposes. Finally, the present invention relates to methods for diagnosing a Shigella flexneri infection using one or more oligosaccharides or polysaccharides or conjugates thereof.

公开(公告)号：US20180164320A1

公开(公告)日：2018-06-14

申请号：US15580662

申请日：2015-12-16

申请人： KOREA ADVANCED INSTITUTE OF SCIENCE AND TECHNOLOGY

发明人： Jung Hoe Kim ,  Sung Hyeon Lee ,  Seung Yeol Park ,  Hyun Joo An ,  Jae-Han Kim ,  Myung Jin Oh ,  Jin Man Kim ,  Ju A Lee

IPC分类号： G01N33/574 ,  G01N30/86 ,  G01N30/72 ,  C07H5/04

CPC分类号： G01N33/57419 ,  C07H5/04 ,  G01N30/7233 ,  G01N30/8631 ,  G01N2030/027 ,  G01N2560/00

摘要： The present invention relates to a method of diagnosing colorectal cancer by detection of glycan changes, and more particularly to a method of diagnosing colorectal cancer using mass spectrometry, in which, when specific glycan structures increase, decrease or significantly change due to a change in N-linked glycosylation of a colorectal cancer patient-derived glycoprotein, as detected by mass spectrometry, the glycan structures are selected as diagnostic markers.

公开(公告)号：US20180002577A1

公开(公告)日：2018-01-04

申请号：US15702087

申请日：2017-09-12

申请人： KNAUF INSULATION SPRL ,  KNAUF INSULATION, INC.

发明人： Carl HAMPSON ,  Benedicte PACOREL ,  Roger JACKSON

IPC分类号： C09J105/00 ,  F16L59/02 ,  B29C71/00 ,  C07H5/04 ,  B27N3/00 ,  B29K79/00

CPC分类号： C09J105/00 ,  B27N3/002 ,  B29C71/00 ,  B29K2079/00 ,  B29K2405/00 ,  C07H5/04 ,  C09J161/20 ,  C09J161/22 ,  F16L59/028

摘要： The present invention relates to a water-soluble pre-reacted binder composition, a method of its manufacture, a use of said pre-reacted binder composition, a method of manufacturing a collection of matter bound by a polymeric binder, a binder solution or dispersion comprising said pre-reacted binder composition, as well as products comprising the pre-reacted binder composition in a cured state.

公开(公告)号：US09856283B2

公开(公告)日：2018-01-02

申请号：US14847439

申请日：2015-09-08

申请人： The Regents of The University of California ,  University College Dublin

发明人： Stefan Oscarson ,  John Vincent Fahy ,  Shaopeng Yuan ,  Stephen Carrington

IPC分类号： C07H15/04 ,  C07H5/04 ,  A61K31/7028 ,  A61K31/70 ,  A61K31/7016 ,  A61K31/702 ,  C07D309/10 ,  C07H13/04

CPC分类号： C07H15/04 ,  A61K31/70 ,  A61K31/7016 ,  A61K31/702 ,  A61K31/7028 ,  C07D309/10 ,  C07H5/04 ,  C07H13/04

摘要： There are provided, inter alia, methods for decreasing mucus elasticity or decreasing mucus viscosity in a subject in need thereof, the methods including administering to the subject an effective amount of a thiosaccharide mucolytic agent, and compounds and pharmaceutical compositions useful for the methods.

公开(公告)号：US20170335135A1

公开(公告)日：2017-11-23

申请号：US15665867

申请日：2017-08-01

申请人： KNAUF INSULATION INC. ,  KNAUF INSULATION SPRL

发明人： Brian Lee SWIFT ,  Ronald E. KISSELL

IPC分类号： C09D167/04 ,  F16L59/02 ,  B29C70/68 ,  C03C17/28 ,  E04B1/88 ,  C03C25/14 ,  E04B1/78 ,  C09D105/00 ,  C08L51/02 ,  C08F251/02 ,  C07H5/04 ,  F16L59/14 ,  E04B1/84

摘要： A curable aqueous composition is disclosed comprising a carbohydrate, a crosslinking agent, and an amine base, wherein the curable aqueous composition has a pH adjusted by the amine base. Further disclosed is a method of forming a curable aqueous solution.