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公开(公告)号:US12121879B2
公开(公告)日:2024-10-22
申请号:US17298968
申请日:2019-12-02
发明人: Tamaz Guliashvili , Maryann Gruda , Thomas Golobish , David James , Karl-Gustav Ruggeberg , Pamela O'Sullivan , Sarah Patterson
CPC分类号: B01J20/3274 , B01D15/3809 , B01J20/28019 , B01J20/28078 , B01J20/3212 , C07K1/22 , C07K16/065
摘要: The invention concerns polymeric media based on modified natural polysaccharides for removing one or both of Anti-A Antibodies and Anti-B Antibodies from human blood or plasma, the media comprising one or both of (i) a polymeric solid support with a blood group A Antigen ligand attached to the solid support at a ligand loading between 1-5 mg/mL of solid support, and wherein the media is stable under physiological pH conditions, and (ii) a polymeric solid support with a blood group B Antigen ligand attached to the solid support at a ligand loading between 1-5 mg/mL of solid support, and wherein the media is stable under physiological pH conditions.
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公开(公告)号:US12098211B2
公开(公告)日:2024-09-24
申请号:US18194471
申请日:2023-03-31
申请人: Genentech, Inc.
IPC分类号: C07K16/28 , A61K39/395 , A61P5/00 , A61P37/02 , C07K1/14 , C07K1/22 , C07K14/00 , C07K16/32 , C12N1/38 , C12N5/00
CPC分类号: C07K16/2887 , A61K39/39591 , C07K1/14 , C07K2317/24
摘要: The invention concerns methods and means for preventing the reduction of disulfide bonds during the recombinant production of disulfide-containing polypeptides. In particular, the invention concerns the prevention of disulfide bond reduction during harvesting of disulfide-containing polypeptides, including antibodies, from recombinant host cell cultures.
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公开(公告)号:US20240309064A1
公开(公告)日:2024-09-19
申请号:US18637124
申请日:2024-04-16
发明人: Shunhai Wang , Ning Li , Hunter Chen , Amardeep Singh Bhupender Bhalla , Shawn M. Lawrence , Amy S. Johnson , Meghan Casey , Jaimie Grapel
IPC分类号: C07K14/71 , A61K38/18 , C07K1/113 , C07K1/16 , C07K1/18 , C07K1/22 , C07K1/36 , C07K16/22 , C07K16/28 , C12N5/00 , C12N15/66 , C12P21/02 , C12P21/06 , G01N30/02 , G01N30/80
CPC分类号: C07K14/71 , A61K38/1866 , C07K1/113 , C07K1/16 , C07K1/18 , C07K1/22 , C07K1/36 , C07K16/22 , C07K16/283 , C12N5/0018 , C12N5/0031 , C12N15/66 , C12P21/02 , C12P21/06 , G01N30/80 , C07K2317/622 , C07K2319/30 , C07K2319/33 , C12N2800/10 , G01N2030/027
摘要: The present disclosure pertains to compositions comprising anti-VEGF proteins and methods for producing such compositions.
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公开(公告)号:US20240294606A1
公开(公告)日:2024-09-05
申请号:US18638362
申请日:2024-04-17
发明人: Shunhai Wang , Ning Li , Hunter Chen , Amardeep Singh Bhupender Bhalla , Shawn M. Lawrence , Amy Johnson , Meghan Casey , Jaimie Grapel
IPC分类号: C07K14/71 , A61K38/18 , C07K1/113 , C07K1/16 , C07K1/18 , C07K1/22 , C07K1/36 , C07K16/22 , C07K16/28 , C12N5/00 , C12N15/66 , C12P21/02 , C12P21/06 , G01N30/02 , G01N30/80
CPC分类号: C07K14/71 , A61K38/1866 , C07K1/113 , C07K1/16 , C07K1/18 , C07K1/22 , C07K1/36 , C07K16/22 , C07K16/283 , C12N5/0018 , C12N5/0031 , C12N15/66 , C12P21/02 , C12P21/06 , G01N30/80 , C07K2317/622 , C07K2319/30 , C07K2319/33 , C12N2800/10 , G01N2030/027
摘要: The present disclosure pertains to compositions comprising anti-VEGF proteins and methods for producing such compositions.
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5.
公开(公告)号:US20240293335A1
公开(公告)日:2024-09-05
申请号:US18279038
申请日:2022-02-11
申请人: BioApplications Inc.
发明人: Youngmin PARK , Sooji SONG , Kyungmin MIN
CPC分类号: A61K9/5184 , A61K39/12 , C07K1/22 , C07K14/005 , C12N7/00 , C12N15/8205 , C12N15/8257 , A61K2039/5258 , C12N2770/00034 , C12N2770/14022 , C12N2770/14023 , C12N2770/14051
摘要: The present invention relates to a technology for constructing and producing, in the form of virus-like particles (VLPs), alfalfa mosaic virus (AMV) isolated from a plant transformed using a recombinant vector for plant expression that is targeted to the chloroplast, and provides a recombinant vector comprising a polynucleotide encoding a recombinant protein in which a chloroplast-targeting protein and an AMV capsid protein are fused. The present invention also provides a transgenic plant transformed by the recombinant vector, a method for isolating and purifying a target protein from the transgenic plant, a method for producing virus-like particles using same, and the like.
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公开(公告)号:US12077584B2
公开(公告)日:2024-09-03
申请号:US17670398
申请日:2022-02-11
发明人: Natalie Bezman , Alan J. Korman , Shrikant Deshpande , Amy D. Jhatakia , Richard Y. Huang , Guodong Chen , Ginger C. Rakestraw , Karla Ann Henning , Vangipuram S. Rangan , Christine Bee , Xiang Shao
IPC分类号: C07K16/28 , A61K39/00 , A61K39/395 , A61K47/68 , A61P35/00 , C07K1/22 , C12N5/071 , C12N15/85 , C12P21/00 , G01N33/68
CPC分类号: C07K16/2803 , A61K39/3955 , A61K47/6849 , A61P35/00 , C07K1/22 , C12N5/0682 , C12N15/85 , C12P21/005 , G01N33/68 , A61K2039/505 , A61K2039/507 , C07K2317/21 , C07K2317/24 , C07K2317/31 , C07K2317/33 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2317/77 , C07K2317/92 , C07K2317/94 , C12N2510/02 , C12N2800/107
摘要: The present disclosure provides isolated monoclonal antibodies (e.g., humanized and human monoclonal antibodies), or antigen-binding fragments thereof, that specifically bind to human natural killer cell inhibitory receptor group 2A (NKG2A) protein with high affinity and exhibit therapeutically desirable functional properties, such as for the treatment of, for example, cancer. Immunoconjugates, bispecific molecules, and pharmaceutical compositions comprising the anti-NKG2A antibodies of the invention are also provided. Nucleic acid molecules encoding the antibodies, expression vectors, host cells, and methods of treatment of, for example, cancer using the antibodies are further provided. Combination therapy, in which an anti-NKG2A antibody in the present disclosure is co-administered with at least one additional agent such as another antibody (e.g., anti-PD-1, anti-PD-L1, and/or anti-CTLA-4 antibodies), is also provided.
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公开(公告)号:US12070735B2
公开(公告)日:2024-08-27
申请号:US17078435
申请日:2020-10-23
申请人: Puridify Ltd.
IPC分类号: B01D39/14 , B01D15/32 , B01D15/36 , B01D15/38 , B01D39/16 , B01J20/24 , B01J20/26 , B01J20/28 , B01J20/285 , B01J20/287 , B01J20/288 , B01J20/30 , B01J39/05 , B01J39/19 , B01J39/26 , B01J41/07 , B01J41/13 , B01J41/20 , B29C65/00 , B29C65/02 , B32B5/02 , B32B27/08 , B32B27/12 , B32B27/32 , B32B37/06 , B32B37/10 , B32B37/18 , C07K1/16 , C07K1/18 , C07K1/20 , C07K1/22 , B29K601/00 , B29K627/18 , B29L9/00 , C12M1/12
CPC分类号: B01J20/265 , B01D15/327 , B01D15/361 , B01D15/362 , B01D15/363 , B01D15/38 , B01D15/3804 , B01D15/3809 , B01D15/3819 , B01D39/14 , B01D39/16 , B01D39/1623 , B01J20/24 , B01J20/28007 , B01J20/28033 , B01J20/28038 , B01J20/28083 , B01J20/28085 , B01J20/285 , B01J20/287 , B01J20/288 , B01J20/3007 , B01J20/3085 , B01J39/05 , B01J39/19 , B01J39/26 , B01J41/07 , B01J41/13 , B01J41/20 , B29C65/02 , B29C66/45 , B29C66/712 , B29C66/7294 , B32B5/022 , B32B27/08 , B32B27/12 , B32B27/322 , B32B37/06 , B32B37/10 , B32B37/182 , C07K1/165 , C07K1/18 , C07K1/20 , C07K1/22 , B01J2220/54 , B29K2601/12 , B29K2627/18 , B29K2713/00 , B29L2009/00 , B32B2262/04 , B32B2317/18 , B32B2327/18 , C07K1/16 , C12M25/14
摘要: The present invention provides a process for preparing a functionalised polymeric chromatography medium, which process comprises (I) providing two or more non-woven sheets stacked one on top of the other, each said sheet comprising one or more polymer nanofibres, (II) simultaneously heating and pressing the stack of sheets to fuse points of contact between the nanofibres of adjacent sheets, and (III) contacting the pressed and heated product with a reagent which functionalises the product of step (II) as a chromatography medium.
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8.
公开(公告)号:US20240272117A1
公开(公告)日:2024-08-15
申请号:US18569454
申请日:2022-06-16
申请人: PANNON EGYETEM
IPC分类号: G01N27/447 , C07K1/22 , C12Q1/40 , G01N33/58 , G01N33/68
CPC分类号: G01N27/447 , C07K1/22 , C12Q1/40 , G01N33/582 , G01N33/6893 , G01N2333/4728 , G01N2400/10
摘要: In the present invention a method is provided for capillary electrophoresis-based (CE-based) comprehensive N-glycan analysis of urinary PSA. The method is useful for analysis of PSA glycans from urine and for diagnosis of PSA-related conditions.
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公开(公告)号:US20240262925A1
公开(公告)日:2024-08-08
申请号:US18607753
申请日:2024-03-18
申请人: HaemaLogiX Ltd
发明人: Rosanne Dunn , Arunakumari Alahari
CPC分类号: C07K16/2878 , C07K1/22 , C07K2317/565
摘要: The present disclosure relates to a method of purifying a binding protein from undesirable components. Such binding proteins may be useful for treating a disorder such as cancer.
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公开(公告)号:US12054533B2
公开(公告)日:2024-08-06
申请号:US17858629
申请日:2022-07-06
发明人: Andrew Tustian , Ankit Vartak , Thomas Daly , Erica Pyles , Nisha Palackal , Shunhai Wang , Ning Li
IPC分类号: C07K1/36 , A61K38/18 , C07K1/113 , C07K1/16 , C07K1/18 , C07K1/22 , C07K14/71 , C07K16/22 , C07K16/28 , C12N5/00 , C12N15/66 , C12P21/02 , C12P21/06 , G01N30/80 , G01N30/02
CPC分类号: C07K14/71 , A61K38/1866 , C07K1/113 , C07K1/16 , C07K1/18 , C07K1/22 , C07K1/36 , C07K16/22 , C07K16/283 , C12N5/0018 , C12N5/0031 , C12N15/66 , C12P21/02 , C12P21/06 , G01N30/80 , C07K2317/622 , C07K2319/30 , C07K2319/33 , C12N2800/10 , G01N2030/027
摘要: The present disclosure pertains to methods for producing aflibercept from a host cell cultured in a chemically defined medium (CDM) including purification of aflibercept, wherein aflibercept following purification includes aflibercept variants that have at least one oxidized amino acid residue selected from the group consisting of tryptophan, histidine and a combination thereof.
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