公开(公告)号：US20240361296A1

公开(公告)日：2024-10-31

申请号：US18429862

申请日：2024-02-01

申请人： Northeastern University ,  University of York

发明人： Meni Wanunu ,  Alfred Antson ,  Sandra Greive ,  Benjamin Cressiot

IPC分类号： G01N33/487 ,  B81B1/00 ,  B82Y15/00 ,  C07K14/005 ,  C12Q1/6869

CPC分类号： G01N33/48721 ,  B81B1/002 ,  C07K14/005 ,  C12Q1/6869 ,  B82Y15/00 ,  C12N2795/00022 ,  Y10S930/22

摘要： Hybrid nanopores, comprising a protein pore supported within a solid-state membrane, which combine the robust nature of solid-state membranes with the easily tunable and precise engineering of protein nanopores. In an embodiment, a lipid-free hybrid nanopore comprises a water soluble and stable, modified portal protein of the Thermus thermophilus bacteriophage G20c, electrokinetically inserted into a larger nanopore in a solid-state membrane. The hybrid pore is stable and easy to fabricate, and exhibits low peripheral leakage, allowing sensing and discrimination among different types of biomolecules.

公开(公告)号：US20240358753A1

公开(公告)日：2024-10-31

申请号：US18291142

申请日：2022-07-29

申请人： Tevogen Bio Inc.

发明人： Ryan SAADI

IPC分类号： A61K35/17 ,  A61K39/00 ,  C07K14/005 ,  C12N5/0783

CPC分类号： A61K35/17 ,  A61K39/4611 ,  A61K39/464838 ,  C07K14/005 ,  C12N5/0638 ,  C12N2770/20033

摘要： Disclosed herein are methods of preparing peptide specific cytotoxic T cells (CTLs) against an emerged strain of a virus. The methods include providing an initial peptide composition specific to a prior strain of a virus, against which prior CTLs were sensitized, wherein the prior CTLs have reduced efficacy against an emerged strain of a virus relative to their efficacy against the prior strain of the virus; identifying an immunodominant peptide against a prior strain of a virus in an initial peptide composition; reducing the proportion of an immunodominant peptide in an initial peptide composition to yield an immunodominant-peptide-diluted peptide composition; and sensitizing mononuclear cells with an immunodominant-peptide-diluted peptide composition, thereby producing expansion of the peptide specific CTLs against an emerged strain of a virus. The virus can be SARS-COV2 (COVID-19) and the emerged strain can be Delta or Omicron BA.2.75.

公开(公告)号：US20240350622A1

公开(公告)日：2024-10-24

申请号：US18682740

申请日：2022-08-11

申请人： Macfarlane Burnet Institute for Medical Research and Public Health Limited

发明人： Pantelis Poumbourios ,  Heidi Drummer

IPC分类号： A61K39/215 ,  A61K39/00 ,  A61P31/14 ,  C07K14/005 ,  C12N7/00

CPC分类号： A61K39/215 ,  A61P31/14 ,  C07K14/005 ,  C12N7/00 ,  A61K2039/55505 ,  A61K2039/55555 ,  A61K2039/55566 ,  A61K2039/575 ,  C12N2770/20022 ,  C12N2770/20034 ,  C12N2770/20051

摘要： The field of the specification relates broadly to SARS-CoV-2 vaccine spike protein antigens and methods of using and manufacturing these antigens. The invention also relates to vectors and polynucleotides encoding the SARS-CoV-2 vaccine antigens and vaccines, kits, devices and strips comprising the coronavirus vaccine antigen. The spike protein from SARS-CoV-2 has prolines substituted at positions 986, 987 (2P or S-2P) and additional alanine cavity filling mutations at positions A1016 and A1020.

公开(公告)号：US20240350619A1

公开(公告)日：2024-10-24

申请号：US18027132

申请日：2022-05-10

申请人： GUANGZHOU RIBOBIO CO., LTD. ,  ARGORNA PHARMACEUTICALS CO., LTD.

发明人： Bill Biliang ZHANG ,  Lin MA ,  Jian WEN ,  Hong ZHANG ,  Huiling ZHONG

IPC分类号： A61K39/215 ,  A61K39/00 ,  A61P31/14 ,  C07K14/005 ,  C12N7/00 ,  C12N15/11 ,  C12N15/85

CPC分类号： A61K39/215 ,  A61P31/14 ,  C07K14/005 ,  C12N7/00 ,  C12N15/11 ,  C12N15/85 ,  A61K2039/53 ,  A61K2039/55555 ,  A61K2039/70 ,  C12N2770/20022 ,  C12N2770/20034 ,  C12N2830/50

摘要： This disclosure provides vaccines and compositions based on SARS-COV-2 S protein, and specifically relates to recombinant SARS-COV-2 spike protein (Sprotein) and mRNA and DNA coding thereof. This disclosure also relates to recombinant plasmid comprising DNA sequence encoding recombinant S protein. This disclosure further relates to composition comprising the recombinant S protein and/or mRNA mentioned above, mRNA-carrier particle such as lipid nanoparticle (LNP), and composition such as a vaccine composition.

公开(公告)号：US12117447B2

公开(公告)日：2024-10-15

申请号：US16761473

申请日：2018-11-02

申请人： SONA NANOTECH INC.

发明人： Kulbir Singh ,  Michael Mcalduff ,  D. Gerrard Marangoni

IPC分类号： G01N33/574 ,  A61K9/20 ,  A61K41/00 ,  A61K47/68 ,  A61K49/00 ,  B22F1/054 ,  B22F9/24 ,  C07C211/63 ,  C07K14/005 ,  C07K16/00 ,  C07K17/14 ,  G01N33/543 ,  B82Y5/00 ,  B82Y15/00 ,  B82Y40/00

CPC分类号： G01N33/574 ,  A61K9/2072 ,  A61K41/0052 ,  A61K47/6835 ,  A61K49/0002 ,  B22F1/0547 ,  B22F1/0549 ,  B22F9/24 ,  C07C211/63 ,  C07K14/005 ,  C07K16/00 ,  C07K17/14 ,  G01N33/54346 ,  B22F2301/255 ,  B82Y5/00 ,  B82Y15/00 ,  B82Y40/00 ,  C12N2740/16111

摘要： A method for making metal nanorods comprises combining a source of metal cations with at least one surfactant to form a mixture, wherein the metal cations are reduced and the metal nanorods are produced. Metal nanorods produced by the method and uses thereof. The metal nanorods are useful in devices such as lateral flow devices.

公开(公告)号：US12116384B2

公开(公告)日：2024-10-15

申请号：US17045087

申请日：2019-04-03

申请人： Ginkgo Bioworks, Inc.

发明人： Daniel McCoy ,  Garrett E. Berry

IPC分类号： C07K14/005 ,  C12N9/22 ,  C12N15/11 ,  C12N15/86 ,  A61K48/00

CPC分类号： C07K14/005 ,  C12N9/22 ,  C12N15/11 ,  C12N15/86 ,  A61K48/00 ,  C12N2310/20 ,  C12N2750/14122 ,  C12N2750/14143 ,  C12N2750/14145 ,  C12N2800/80

摘要： The present disclosure provides AAV capsid proteins comprising a modification in the amino acid sequence and virus vectors comprising the modified AAV capsid protein. The disclosure also provides methods of administering the virus vectors and virus capsids of the disclosure to a cell or to a subject in vivo.

公开(公告)号：US20240335525A1

公开(公告)日：2024-10-10

申请号：US18682372

申请日：2022-08-10

申请人： SANOFI PASTEUR INC.

发明人： Mario BARRO ,  Yvonne CHAN ,  Guadalupe CORTES-GARCIA ,  Raul GOMILA ,  Liqun HAN ,  Justin KLEKOTA ,  Fuqin MA ,  Satyajit RAY ,  Svetlana STEGALKINA ,  Tod STRUGNELL ,  Irina USTYUGOVA ,  Thorsten VOGEL ,  Jianxin ZHANG

IPC分类号： A61K39/145 ,  A61K39/00 ,  A61P37/04 ,  C07K14/005 ,  C07K14/705 ,  C12N9/24

CPC分类号： A61K39/145 ,  A61P37/04 ,  C07K14/005 ,  C07K14/70596 ,  C12N9/2402 ,  C12Y302/01018 ,  A61K2039/645 ,  C07K2319/02 ,  C12N2760/16134

摘要： Provided are modified influenza virus subtype 2 neuraminidase molecules lacking all or substantially all of the stalk region that form active, soluble tetrameric neuraminidase when expressed in host cells and vaccine compositions comprising the tetrameric neuraminidase or a nucleic acid encoding the modified monomeric influenza virus subtype 2 neuraminidase molecules that forms tetrameric NA when expressed in a cell. Also provided are methods of using the vaccine compositions to vaccinate or immunize a subject against influenza virus.

公开(公告)号：US20240335523A1

公开(公告)日：2024-10-10

申请号：US18294912

申请日：2022-08-04

申请人： The Regents of the University of California

发明人： Rebecca Dubois ,  John Dzimianski

IPC分类号： A61K39/145 ,  A61K39/12 ,  A61K39/21 ,  A61K39/215 ,  C07K14/005

CPC分类号： A61K39/145 ,  A61K39/12 ,  A61K39/21 ,  A61K39/215 ,  C07K14/005 ,  C07K2319/20 ,  C07K2319/91 ,  C12N2760/16122 ,  C12N2760/16134

摘要： Provided are polypeptides comprising, consisting essentially of, or consisting of a foldon domain comprising an N-linked glycosylation motif. In some embodiments, the foldon domain is fused to a heterologous amino acid sequence, non-limiting examples of which include immunogenic polypeptides. Trimers of three polypeptides of the present disclosure are also provided, as are related immunogenic compositions and methods of inducing an immune response in an individual. Also included are vectors, e.g., cloning and/or expression vectors that include a nucleic acid sequence encoding a foldon as disclosed herein.

公开(公告)号：US20240327867A1

公开(公告)日：2024-10-03

申请号：US18605384

申请日：2024-03-14

申请人： FLAGSHIP PIONEERING INNOVATIONS V, INC.

发明人： Joseph Michael Cabral ,  Cato Hawkins Prince ,  Bryan Alexander McGuffie ,  Hassana Kia Oyibo ,  Simon Delagrave ,  Dhananjay Maniklal Nawandar ,  Kevin James Lebo ,  Cesar Augusto Arze ,  Agamoni Bhattacharyya ,  Nathan Lawrence Yozwiak ,  Roger Joseph Hajjar ,  Geoffrey Parsons

IPC分类号： C12N15/86 ,  A61K47/64 ,  C07K14/005

CPC分类号： C12N15/86 ,  A61K47/64 ,  C07K14/005 ,  C12N2750/00022 ,  C12N2750/00023 ,  C12N2750/00043 ,  C12N2750/00051 ,  C12N2750/00071 ,  C12N2830/008 ,  C12N2840/203

摘要： This invention relates generally to modified anellovirus capsid proteins, anellovectors, anelloVLPs, and compositions and uses thereof.

公开(公告)号：US20240327865A1

公开(公告)日：2024-10-03

申请号：US18577545

申请日：2022-07-08

申请人： REPLICATE BIOSCIENCE, INC.

发明人： Nathaniel Stephen WANG ,  Shigeki Joseph MIYAKE-STONER ,  Parinaz ALIAHMAD

IPC分类号： C12N15/86 ,  A01K67/0275 ,  A61K9/00 ,  A61K9/51 ,  A61K38/00 ,  A61K39/00 ,  A61K48/00 ,  A61P31/00 ,  C07K14/005 ,  C12N7/00 ,  C12N15/88

CPC分类号： C12N15/86 ,  A01K67/0275 ,  A61K9/0019 ,  A61K9/5123 ,  A61K48/0041 ,  A61P31/00 ,  C07K14/005 ,  C12N7/00 ,  C12N15/88 ,  A01K2267/01 ,  A61K38/00 ,  A61K39/00 ,  A61K2039/53 ,  C12N2770/36122 ,  C12N2770/36134 ,  C12N2770/36143

摘要： The present disclosure relates to the field of molecular virology, including nucleic acid molecules comprising modified viral genomes or replicons (e.g., self-replicating RNAs), pharmaceutical compositions containing the same, and the use of such nucleic acid molecules and compositions for production of desired products in cell cultures or in a living body. Also provided are methods for eliciting an immune response in a subject in need thereof, as well as methods for preventing and/or treating various health conditions.