公开(公告)号：US20250059240A1

公开(公告)日：2025-02-20

申请号：US18775573

申请日：2024-07-17

Applicant: Sanofi

Inventor： Gary J. Nabel ,  Chih-Jen Wei ,  Kurt Swanson ,  Pradeep Dhal ,  Ram Dharanipragada ,  Magnus Besev

IPC: C07K14/195

Abstract: This disclosure relates to antigenic respiratory syncytial virus (RSV) polypeptides for use in eliciting antibodies against RSV. Also disclosed are antigenic polypeptides comprising an RSV polypeptide and a ferritin protein.

公开(公告)号：US12215333B2

公开(公告)日：2025-02-04

申请号：US18466111

申请日：2023-09-13

Applicant: AgBiome, Inc.

Inventor： Jessica Parks ,  Kira Bulazel Roberts ,  Rebecca E. Thayer

IPC: C12N15/82 ,  A01N37/46 ,  A01N63/50 ,  C07K14/195 ,  C07K14/32 ,  C07K14/325

Abstract: Compositions having pesticidal activity and methods for their use are provided. Compositions include isolated and recombinant polypeptides having pesticidal activity, recombinant and synthetic nucleic acid molecules encoding the polypeptides, DNA constructs and vectors comprising the nucleic acid molecules, host cells comprising the vectors, and antibodies to the polypeptides. Polynucleotide sequences encoding the polypeptides can be used in DNA constructs or expression cassettes for transformation and expression in organisms of interest. The compositions and methods provided are useful for producing organisms with enhanced pest resistance or tolerance. Transgenic plants and seeds comprising a nucleotide sequence that encodes a pesticidal protein of the invention are also provided. Such plants are resistant to insects and other pests. Methods are provided for producing the various polypeptides disclosed herein, and for using those polypeptides for controlling or killing a pest. Methods and kits for detecting polypeptides of the invention in a sample are also included.

公开(公告)号：US12207658B2

公开(公告)日：2025-01-28

申请号：US18235247

申请日：2023-08-17

Applicant: Syngenta Participations AG

Inventor： Joseph M Watts

IPC: C12N15/82 ,  A01N37/46 ,  A01N63/10 ,  A01N63/50 ,  C07K14/195 ,  C07K14/32 ,  C07K14/325

Abstract: The present invention is directed to the vegetative insecticidal proteins (Vips) modified to comprise heterologous bacterial carbohydrate binding modules and the methods of use thereof. Expression of modified proteins resulted in variations to activity against lepidopteran pest species of agricultural importance such as Corn earworm and Fall armyworm conveying broad spectrum insect control.

公开(公告)号：US20250025545A1

公开(公告)日：2025-01-23

申请号：US18714854

申请日：2022-12-01

Applicant: Kanagawa Institute of Industrial Science and Technology ,  University of Tsukuba ,  Metagen, Inc.

Inventor： Shinji Fukuda ,  Gaku Nakato ,  Nozomu Obana ,  Risako Furukawa

IPC: A61K39/02 ,  C07K14/195

Abstract: Determination of the mechanism of allergy development in which a bacterium of the family Lachnospiraceae, which is an enteric bacterium, including Ruminococcus gnavus is involved and developing a method for preventing or treating allergies by intervening in the mechanism. Since the Ibp protein from a bacterium of the family Lachnospiraceae is involved in development of allergies, allergic reactions occurring in vivo can be prevented by administration or induction of in vivo production of a substance that binds to the Ibp protein.

公开(公告)号：US20250002897A1

公开(公告)日：2025-01-02

申请号：US18704449

申请日：2022-10-26

Applicant: NANJING GENSCRIPT BIOTECH CO., LTD.

Inventor： Juan CHEN ,  Lumeng YE

IPC: C12N15/10 ,  C07K14/195

Abstract: A method for purifying single-stranded DNA is provided. The method can comprise: mixing a sample containing single-stranded DNA with a single-stranded DNA binding protein, and incubating for a first time period to obtain a first product, the first product containing a conjugate of the single-stranded DNA and the single-stranded DNA binding protein; purifying the first product by using affinity chromatography to obtain a second product; and purifying the second product to at least remove the single-stranded DNA binding protein to obtain a target product containing a purified single-stranded DNA. Also provided are a kit for purifying single-stranded DNA, the kit comprising a single-stranded DNA binding protein and a purification reagent; and a use of a single-stranded DNA binding protein in purifying single-stranded DNA.

公开(公告)号：US12180502B2

公开(公告)日：2024-12-31

申请号：US17829316

申请日：2022-05-31

Applicant: Inscripta, Inc.

Inventor： Andrew Garst ,  Ryan T. Gill ,  Tanya Elizabeth Warnecke Lipscomb

IPC: C12N15/90 ,  C07K14/195 ,  C12N9/22 ,  C12N15/10 ,  C12N15/11 ,  C12N15/113 ,  C12N15/63 ,  C12N15/70 ,  C12N15/81 ,  C12N15/85

Abstract: Disclosed herein are nucleic acid-guided nucleases, guide nucleic acids, and targetable nuclease systems, and methods of use. Disclosed herein are engineered non-naturally occurring nucleic acid-guided nucleases, guide nucleic acids, and targetable nuclease systems, and methods of use. Targetable nuclease systems can be used to edit genetic targets, including recursive genetic engineering and trackable genetic engineering methods.

公开(公告)号：US12180462B2

公开(公告)日：2024-12-31

申请号：US18320834

申请日：2023-05-19

Applicant: Wisconsin Alumni Research Foundation

Inventor： Adel M. Talaat

IPC: C12N1/20 ,  A61K39/00 ,  A61K39/04 ,  C07K14/195 ,  C07K14/35 ,  C12N1/36 ,  C12N15/10 ,  C12N15/113 ,  C12Q1/689 ,  C12R1/32 ,  G01N33/569

Abstract: Described herein is a mycobacterium mutant, comprising at least one mutation in at least one gene sequence encoding global gene regulators (GGRs) selected from the group consisting of sigH, sigL, sigE, ECF-1, and mixtures thereof, wherein the GGR gene is at least partially inactivated. Described herein also is a vaccine based on the mutant and a method of differentiating between subjects that have been infected with mycobacterium and subjects that have not been infected with mycobacterium or have been vaccinated with a mycobacterium vaccine.

公开(公告)号：US12171823B2

公开(公告)日：2024-12-24

申请号：US17888916

申请日：2022-08-16

Applicant: VAXXINOVA US, INC.

Inventor： Charles Nelson Carver, III ,  Daryll A. Emery

IPC: A61K39/02 ,  A61K39/114 ,  A61K39/39 ,  A61P31/04 ,  C07K14/195 ,  G01N33/569

Abstract: The present invention provides isolated polypeptides isolatable from a Fusobacterium spp. Also provided by the present invention are compositions that include one or more of the polypeptides, and methods for making and methods for using the polypeptides.

公开(公告)号：US20240402189A1

公开(公告)日：2024-12-05

申请号：US18744293

申请日：2024-06-14

Applicant: Serimmune Inc.

Inventor： Patrick Sean Daugherty ,  Kathryn Vinaya Louise Kamath ,  Jack Ryan Reifert

IPC: G01N33/68 ,  C07K14/195 ,  C07K14/285 ,  C07K14/315 ,  C07K14/435 ,  C07K14/44 ,  C07K14/45 ,  C12N15/10 ,  C12Q1/689 ,  G01N33/53 ,  G01N33/564 ,  G01N33/569

Abstract: The present invention provides compositions and methods that can be used to determine a peptide signature for an antibody repertoire in a sample comprising multiple antibodies. The method can be used to characterize a phenotype in a sample, such as providing a diagnosis, prognosis or theranosis of a medical condition.

公开(公告)号：US20240401067A1

公开(公告)日：2024-12-05

申请号：US18672924

申请日：2024-05-23

Applicant: Wisconsin Alumni Research Foundation

Inventor： Victor Ujor

IPC: C12N15/78 ,  C07K14/195 ,  C12N9/00 ,  C12N9/02 ,  C12N9/04 ,  C12N9/10 ,  C12N9/88

Abstract: Microbes and methods for selectively detoxifying lignocellulosic biomass, such as microbes and methods for removing furanic and phenolic aldehydes from lignocellulosic hydrolysates.