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1.发明公开公开(公告)号：US20240066109A1
公开(公告)日：2024-02-29
申请号：US18270043
申请日：2021-12-29
Applicant: VaxNewMo LLC
Inventor： Christian Michael Harding , Cory James Knoot
IPC: A61K39/108 , A61K47/64 , A61P31/04 , C07K14/26
CPC classification number: A61K39/0266 , A61K47/646 , A61P31/04 , C07K14/26 , A61K2039/6037
Abstract: Provided herein is a bioconjugate comprising a K. pneumoniae O-antigen covalently linked to a fusion protein comprising a ComP protein or a glycosylation tag fragment. The K. pneumoniae O-antigen bioconjugate of this disclosure can be used as a conjugate vaccine including multivalent conjugate vaccines comprising multiple K. pneumoniae O-antigens.
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公开(公告)号：US11857606B2
公开(公告)日：2024-01-02
申请号：US16954120
申请日：2018-12-13
Applicant: Bactoclear Holdings Pte. Ltd.
Inventor： Anisha Ambady , Chemira Biddappa Appaiah , Deepak Balasubramanian , Vivek Daniel Paul , R. Sanjeev Saravanan , Umender Kumar Sharma
Abstract: The present invention provides methods and compositions to reduce growth of microbial colonies, including infections, and includes therapeutic compositions, methods for treatment of infections, and methods for identifying additional such compositions.
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公开(公告)号：US11542511B2
公开(公告)日：2023-01-03
申请号：US16768786
申请日：2018-11-30
Applicant: GS CALTEX CORPORATION
Inventor： Jong-Myoung Park , Chelladurai Rathnasingh , Hyo-Hak Song
Abstract: The present invention relates to a recombinant microorganism which is capable of simultaneously fermenting at least two sugars in a lignocellulosic saccharified liquid, and also capable of generating diol.
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公开(公告)号：US10662432B2
公开(公告)日：2020-05-26
申请号：US15706353
申请日：2017-09-15
Applicant: The Regents of the University of California
Inventor： Ethan Mirsky , Karsten Temme , Christopher A. Voigt , Dehua Zhao
IPC: C12N15/63 , C12N15/00 , C12N1/20 , G16B25/00 , G16B30/00 , C07K14/255 , C07K14/26 , C12N15/52 , C12N15/67 , C12N15/74 , C12N9/02
Abstract: Methods for making synthetic gene clusters are described.
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公开(公告)号：US10570185B2
公开(公告)日：2020-02-25
申请号：US15152093
申请日：2016-05-11
Applicant: Northwestern University
Inventor： Jing Jin , Xunrong Luo , Grazia Aleppo
Abstract: Provided herein are epitopes and mimotopes thereof useful in the diagnosis and treatment of type 1 diabetes (T1D), as well as antibodies recognizing such epitopes, and diagnostics, therapeutics, kits, and methods of use thereof.
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公开(公告)号：US10034919B2
公开(公告)日：2018-07-31
申请号：US15717205
申请日：2017-09-27
Applicant: VIB VZW , Universiteit Gent , Centre National de la Recherche Scientifique , Universite Montpellier 2 , Centre Hospitalier Regional Universitaire de Montpellier , Universitat Osnabruck
Inventor： Jan Tavernier , Gilles Uzé , Guillaume Cartron , Franciane Paul , Jacob Piehler
CPC classification number: A61K38/212 , A61K47/6813 , C07K14/56 , C07K16/2827 , C07K16/2863 , C07K16/2869 , C07K16/2878 , C07K16/32 , C07K2317/22 , C07K2317/569 , C07K2317/622 , C07K2319/31 , C07K2319/74
Abstract: This disclosure relates to a modified α-helical bundle cytokine, with reduced activity via an α-helical bundle cytokine receptor, wherein the α-helical bundle cytokine is specifically delivered to target cells. Preferably, the α-helical bundle cytokine is a mutant, more preferably it is a mutant interferon, with low affinity to the interferon receptor, wherein the mutant interferon is specifically delivered to target cells. The targeting is realized by fusion of the modified α-helical bundle cytokine to a targeting moiety, preferably an antibody. This disclosure relates further to the use of such targeted modified α-helical bundle cytokine to treat diseases. A preferred embodiment is the use of a targeted mutant interferon, to treat diseases, preferably viral diseases and tumors.
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公开(公告)号：US09957509B2
公开(公告)日：2018-05-01
申请号：US15288916
申请日：2016-10-07
Applicant: The Regents of the University of California
Inventor： Ethan Mirsky , Karsten Temme , Christopher A. Voigt , Dehua Zhao
CPC classification number: C12N15/635 , C07K14/255 , C07K14/26 , C12N9/0095 , C12N15/52 , C12N15/63 , C12N15/67 , C12N15/74 , C12Y118/06001 , G06F19/20 , G06F19/22
Abstract: Methods for making synthetic gene clusters are described.
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8.发明申请Apoptogenic-bacteriocins combining broad spectrum antibiotic and selective anti-tumoral activities, and compositions and uses thereof 审中-公开结合广谱抗生素和选择性抗肿瘤活性的凋亡细菌素及其组合物和用途
公开(公告)号：US20050159349A1
公开(公告)日：2005-07-21
申请号：US10506857
申请日：2003-03-05
Applicant: Claudio Soto , Rosalba Lagos
Inventor： Claudio Soto , Rosalba Lagos
IPC: A61K38/00 , C07K14/26 , C12N15/31 , A61K38/16 , C07K14/195
Abstract: The present invention relates generally to bacterial proteins, particularly to apoptogenic-bacteriocins, which are capable of killing other bacteria and of also inducing apoptosis in certain eukaryotic cells. The apoptogenic-bacteriocin of the present invention produces apoptosis in tumor-derived cells or cancer cells, while being not cytotoxic to normal cells and not inducing any evident toxicityin vivo in normal animals. Uses of the apoptogenic-bacteriocin and methods of treating cancer, tumors and other diseases of the aberrant cell growth are provided.
Abstract translation: 本发明一般涉及能够杀死其他细菌并且在某些真核细胞中诱导细胞凋亡的细菌蛋白质，特别是细胞凋亡细菌素。 本发明的细胞凋亡细胞因子在肿瘤衍生的细胞或癌细胞中产生细胞凋亡，而对正常细胞不具有细胞毒性，并且在正常动物体内不诱导任何明显的毒性。 提供了凋亡细菌素的用途和治疗癌症，肿瘤等异常细胞生长的疾病的方法。
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公开(公告)号：US4412946A
公开(公告)日：1983-11-01
申请号：US300910
申请日：1981-09-10
Applicant: Rene Zalisz , Marie-France Salles
Inventor： Rene Zalisz , Marie-France Salles
IPC: C07K14/195 , A61K35/74 , A61K38/00 , A61K39/108 , A61P37/04 , C07K14/00 , C07K14/26 , C07K14/41 , C12P21/00 , C12R1/22 , A61K37/02 , A61K39/40 , C07G7/00
CPC classification number: C07K14/26 , A61K38/00 , Y10S435/852 , Y10S530/806 , Y10S530/825
Abstract: Novel water-soluble, immunostimulating glycoproteins extracted from Klebsiella pneumoniae containing 30 to 45% by weight of proteins, 30 to 40% by weight of neutral saccharides, up to 4% by weight of glucuronic acid, 2 to 5% by weight of osamines and having a molecular weight of about 350,000 daltons.
Abstract translation: 从肺炎克雷伯杆菌提取的新型水溶性免疫刺激性糖蛋白，其含有30至45重量％的蛋白质，30至40重量％的中性糖，至多4重量％的葡萄糖醛酸，2至5重量％的osamine， 分子量约为350,000道尔顿。
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公开(公告)号：US12226469B2
公开(公告)日：2025-02-18
申请号：US17088683
申请日：2020-11-04
Applicant: Evaxion Biotech ApS
Inventor： Niels Iversen Møller , Andreas Holm Mattsson
IPC: A61K39/108 , A61K38/03 , A61K38/16 , C07K14/26 , C07K16/12 , C12N15/70 , C12N15/75 , C12N15/79 , G01N33/569
Abstract: The present invention relates to proteins and nucleic acids derived from Klebsiella pneumoniae as well as therapeutic and diagnostic uses of the proteins and nucleic acids.
