公开(公告)号：US11634728B2

公开(公告)日：2023-04-25

申请号：US16956926

申请日：2018-12-28

申请人： HELIXMITH CO., LTD

发明人： Seung Shin Yu ,  Jae Gyun Jeong ,  Jung Hun Lee ,  Su Bin Kim

IPC分类号： C12N15/86 ,  A61K48/00 ,  C07K14/475

摘要： The present invention relates to an AAV vector carrying a predetermined hybrid HGF gene sequence. Use of the AAV vector of the present invention allows a hybrid HGF gene to be delivered to a subject at a high delivery yield.

公开(公告)号：US11604194B2

公开(公告)日：2023-03-14

申请号：US16080577

申请日：2017-02-23

申请人： PUBLIC UNIVERSITY CORPORATION YOKOHAMA CITY UNIVERSITY ,  TOSOH CORPORATION

发明人： Noriaki Arakawa ,  Hisashi Hirano ,  Hiroji Uemura ,  Yusuke Ito ,  Shohei Myoba ,  Norihisa Ohtake

IPC分类号： G01N33/574 ,  G01N33/68 ,  C07K14/475 ,  C07K14/525 ,  C07K16/22

摘要： The present invention aims to provide a method for simply and highly accurately detecting castration-resistant prostate cancer (CRPC), and a reagent that can be used for this method. By measuring the level of GDF15 propeptide present in a sample as a novel detection marker for CRPC, acquisition of castration resistance in a prostate cancer patient during or after endocrine therapy is detected. An antibody that specifically recognizes GDF15 propeptide is included in the CRPC detection reagent.

公开(公告)号：US20230053119A1

公开(公告)日：2023-02-16

申请号：US17605798

申请日：2020-04-22

申请人： LG CHEM, LTD.

发明人： Yeonchul KIM ,  Kyeongsik MIN ,  Young Dok SON ,  Kyubong NA ,  Ji Ho HONG ,  Saem JUNG ,  Myung Won JIN ,  Ji A PARK ,  Soomin NOH

IPC分类号： C07K14/475 ,  C12N15/63 ,  A61P3/04

摘要： Provided is a fusion polypeptide comprising GDF15 (Growth/differentiation factor 15) and an Fc region of immunoglobulin, a pharmaceutical composition comprising the fusion polypeptide, and a method of increasing in vivo duration of GDF15 comprising fusing with an Fc region of immunoglobulin.

公开(公告)号：US20230032478A1

公开(公告)日：2023-02-02

申请号：US17597511

申请日：2020-07-08

申请人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA ,  CONSEJO NACIONAL DE INVESTIGACIONES CIENTÍFICAS Y TÉCNICAS

发明人： JORGE DUBCOVSKY ,  JUAN MANUEL DEBERNARDI ,  DAVID TRICOLI ,  JAVIER PALATNIK

IPC分类号： C12N15/82 ,  C07K14/475

摘要： Disclosed are methods of producing plants with an improved regeneration efficiency using Growth-Regulating Factor (GRF), GRF-Interacting Factor (GIF), or chimeric GRF-GIF genes and proteins. The disclosure also provides plants with an improved regeneration efficiency that are produced by the disclosed methods, methods of reducing the use of exogenous cytokinins in the regeneration of plants, and methods of improving the regeneration efficiency of plants.

公开(公告)号：US11564998B2

公开(公告)日：2023-01-31

申请号：US16577734

申请日：2019-09-20

申请人： ModernaTX, Inc.

发明人： Antonin De Fougerolles ,  Justin Guild

IPC分类号： A61K48/00 ,  C12N15/85 ,  C07K14/47 ,  C12N9/64 ,  C07K14/62 ,  A61K31/7115 ,  C12N9/88 ,  A61K9/127 ,  C12N15/11 ,  C07K14/705 ,  C07K14/505 ,  C07K14/535 ,  C12N9/10 ,  C12N9/00 ,  C12N9/42 ,  C12N15/87 ,  C12P13/04 ,  A61K38/45 ,  C07K14/005 ,  C12N9/16 ,  C12N9/24 ,  C12N15/52 ,  A61K38/17 ,  C07K14/435 ,  C12P21/00 ,  C07K14/485 ,  C07H21/02 ,  C07K14/475 ,  C07K14/495 ,  C07K14/525 ,  C07K14/54 ,  C07K14/56 ,  C07K14/61 ,  C07K14/745 ,  C07K16/28 ,  C07K16/40 ,  C12N9/02 ,  C12N9/12 ,  C12N9/68 ,  A61K47/54 ,  A61K9/14 ,  A61K9/51 ,  A61K38/18 ,  A61K38/19 ,  A61K38/21 ,  A61K38/48 ,  C07K14/515 ,  C07K16/00 ,  A61K38/00

摘要： The invention relates to compositions including polynucleotides encoding polypeptides which have been chemically modified by replacing the uridines with 1-methyl-pseudouridine to improve one or more of the stability and/or clearance in tissues, receptor uptake and/or kinetics, cellular access by the compositions, engagement with translational machinery, mRNA half-life, translation efficiency, immune evasion, protein production capacity, secretion efficiency, accessibility to circulation, protein half-life and/or modulation of a cell's status, function, and/or activity.

公开(公告)号：US20230002460A1

公开(公告)日：2023-01-05

申请号：US17779932

申请日：2020-11-25

申请人： YUHAN CORPORATION

发明人： Seyoung LIM ,  Young Bong PARK ,  Sukyung KIM ,  Bo Ra SIM ,  Wonee CHONG ,  Hyun Ho CHOI ,  Ji Eun YANG ,  Mi Kyeong JU ,  Won Tae KIM ,  Youn Woo LEE ,  Junhwan KIM

IPC分类号： C07K14/475 ,  C12N15/63

摘要： A fusion protein including a GDF15 variant having increased physiological activity and in vivo stability, and a pharmaceutical composition containing the same are disclosed. The GDF15 variant or long-acting GDF15 fusion protein is superior to conventional GDF15 variants in terms of in vitro efficacy, binding affinity for GDF15 receptors, and body weight loss effect. Therefore, a pharmaceutical composition containing, as an active ingredient, the GDF15 variant, the long-acting GDF15 fusion protein, or a dimer of the fusion protein, causes appetite suppression, and thus can be effectively used as a therapeutic agent for metabolic diseases or obesity. Furthermore, the pharmaceutical composition can be used in combination therapy or the like with chemical drugs and other therapeutic agents for metabolic diseases, and can be effectively used in combination therapy with conventional therapeutic agents for metabolic diseases or obesity.

公开(公告)号：US11542308B2

公开(公告)日：2023-01-03

申请号：US17664589

申请日：2022-05-23

申请人： Genentech, Inc.

发明人： Yichin Liu ,  Christine Carine Moussion ,  Travis William Bainbridge ,  Iraj Hosseini ,  Gregory Alan Lazar ,  Sivan Cohen ,  Christopher Charles Kemball ,  Jill M. Schartner

IPC分类号： C07K14/475 ,  A61K38/18 ,  A61K31/713 ,  A61K39/395 ,  C07K16/28 ,  A61K39/00

摘要： The invention provides an effectorless immunoglobulin Fc protein, fusions of the effectorless Fc protein to a Flt3 ligand, and methods of using the same.

公开(公告)号：US20220411795A1

公开(公告)日：2022-12-29

申请号：US17773572

申请日：2020-10-30

申请人： William Marsh Rice University

发明人： Omid VEISEH ,  Isaac HILTON ,  Jing LI ,  Maria Isabel JARVIS RUOCCO ,  Christian Cody SCHREIB

IPC分类号： C12N15/113 ,  C07K14/475 ,  C07K14/54 ,  C07K14/755 ,  C07K14/805 ,  C12N9/22 ,  C12N9/64

摘要： The present disclosure provides expression constructs designed to provide for stable and/or inducible, tightly controlled production of genetically encoded payloads from engineered cells. These cassettes allow cells to be engineered to express genetically encoded payloads despite epigenetic silencing. As such, provided herein are expression systems for use in methods to engineer cells using CRISPR dCas9-activator systems such that expression of genetically encoded payloads (e.g., therapeutic proteins) can be optimized to overcome epigenetic silencing. In addition, provided herein are engineered cells comprising the expression systems.

公开(公告)号：US20220404376A1

公开(公告)日：2022-12-22

申请号：US17866900

申请日：2022-07-18

申请人： Institut National de la Santé et de la Recherche Médicale ,  CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE - CNRS

发明人： Thierry Leveillard ,  Jose-Alain Sahel ,  Celine Jaillard ,  Olivier Poch

IPC分类号： G01N33/68 ,  C07K14/00 ,  C07K14/435 ,  A61K48/00 ,  A61P25/00 ,  A61P25/28 ,  C07K14/47 ,  C07K14/475 ,  A61K38/17

摘要： The present invention concerns a pharmaceutical composition comprising a pharmaceutically acceptable carrier and a compound selected in the group comprising (i) a polypeptide comprising an amino acid sequence selected in the group comprising the amino acid sequence of the long isoform in Homo sapiens of the RdCVF2 gene (SEQ ID NO: 10), orthologs, derivatives and fragments thereof, (ii) a polynucleotide coding for said polypeptide, (iii) a vector comprising said polynucleotide, and (iv) a host cell genetically engineered expressing said polypeptide; the use of such a composition for the manufacture of a medicament for treating and/or preventing a neurodegenerative disorder in a subject; and a method of testing a subject thought to have or be predisposed to having a neurodegenerative disorder.

公开(公告)号：US11518791B2

公开(公告)日：2022-12-06

申请号：US16303406

申请日：2017-05-22

申请人： Luxembourg Institute of Health (LIH) ,  Université de Reims Champagne Ardenne URCA

发明人： Xavier Dervillez ,  Carole Devaux ,  Jacques H. M. Cohen

IPC分类号： C07K14/47 ,  C07K16/30 ,  C12N15/62 ,  C07K14/475 ,  C07K14/52 ,  C07K14/705 ,  C07K16/18 ,  C07K19/00 ,  C07K14/745

摘要： The present invention is situated in the field of multimers used for targeted therapies. More particularly, the invention relates to methods for preparing multifunctional heteromultimeric protein complexes with a defined ratio of functional components and to multifunctional heteromultimeric protein complexes for directing complement-dependent cytolysis, optionally comprising a scaffold, which display three or more different functional components present in a defined relative ratio, of which one is a tracking component.