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公开(公告)号:US20230139442A1
公开(公告)日:2023-05-04
申请号:US18067709
申请日:2022-12-17
申请人: SUTRO BIOPHARMA, INC
IPC分类号: C07D213/55 , C07K14/00 , C07K16/00 , C07C271/20 , C07C275/14 , C07C247/04
摘要: Provided herein are modified amino acids comprising an azido group, polypeptides, antibodies and conjugates comprising the modified amino acids, and methods of producing the polypeptides, antibodies and conjugates comprising the modified amino acids. The polypeptides, antibodies and conjugates are useful in methods of treatment and prevention, methods of detection and methods of diagnosis.
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公开(公告)号:US20230134536A1
公开(公告)日:2023-05-04
申请号:US17518221
申请日:2021-11-03
发明人: Pierce Ogden , Gleb Kuznetsov , Shane Lofgren , Kathleen Nudel , Hoong Chuin Lim , Karen Duffy , Jeffrey Chang
摘要: Methods and systems for quantification of an abundance of one or more payloads (e.g. proteins) in a mixture (e.g. a complex mixture (e.g. in vivo)) using barcodes (e.g. peptide barcodes), binders (e.g. polypeptide binders), and binding agents (e.g. phage) are provided herein.
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公开(公告)号:US11639367B2
公开(公告)日:2023-05-02
申请号:US17947932
申请日:2022-09-19
IPC分类号: C07K1/22 , C07K1/26 , B01D69/10 , B01D15/38 , B01D57/02 , B01D15/20 , B01D15/18 , B01D63/10 , B01D69/02 , B01D69/14 , C07K16/00 , C07K1/36 , C07K1/34 , B01D71/68 , B01D59/10
摘要: Provided herein are, inter alia, biological manufacturing and downstream purification processes.
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公开(公告)号:US20230130874A1
公开(公告)日:2023-04-27
申请号:US17743727
申请日:2022-05-13
申请人: Genentech, Inc.
发明人: Sunil Bhakta , Hans Erickson , Jagath R. Junutula , Katherine Kozak , Rachana Ohri , Thomas Harden Pillow
IPC分类号: C07K16/32 , A61K47/68 , C07K16/18 , C07K16/28 , C07K16/30 , A61K51/10 , C07K16/00 , C07K16/40 , G01N33/58
摘要: Cysteine engineered antibodies comprising a free cysteine amino acid in the heavy chain or light chain are prepared by mutagenizing a nucleic acid sequence of a parent antibody and replacing one or more amino acid residues by cysteine to encode the cysteine engineered antibody; expressing the cysteine engineered antibody; and isolating the cysteine engineered antibody.
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公开(公告)号:US20230129523A1
公开(公告)日:2023-04-27
申请号:US18068922
申请日:2022-12-20
申请人: AMGEN INC.
摘要: The invention provides a method for culturing mammalian cells. The method provides greater control over cell o growth to achieve high product titer cell cultures.
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公开(公告)号:US20230129340A1
公开(公告)日:2023-04-27
申请号:US17804072
申请日:2022-05-25
摘要: Herein are provided a method for producing a multispecific antibody comprising the steps of providing a mammalian cell expressing the antibody, transfecting said mammalian cell with an expression vector comprising an expression cassette encoding a polypeptide of the antibody that has a domain crossover, cultivating the transfected cell and recovering the antibody from the cell or the cultivation medium and thereby producing the multispecific antibody.
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公开(公告)号:US20230124998A1
公开(公告)日:2023-04-20
申请号:US17872042
申请日:2022-07-25
申请人: GigaGen, Inc.
IPC分类号: C40B40/08 , C12N15/10 , C12Q1/6888 , C07K16/00 , C07K14/725 , C07K14/74 , C12Q1/6869 , C40B50/06 , C12Q1/6806
摘要: Provided herein are methods that enable parallel evaluation of multiple functional nucleic acids in individual cells or subpopulations of cells, in the context of incubation with other types of single cells. The key insight is concurrent measurement of polynucleic acids derived from small populations of at least two different cell types, such that function in one cell type is linked to the clonal identity of another cell. These methods simultaneously process thousands, millions, or more single cells or small populations of cells. The method integrates molecular, algorithmic, and engineering approaches. This invention has broad and useful application in a number of biological and medical fields, including immunology and drug discovery.
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公开(公告)号:US20230121427A1
公开(公告)日:2023-04-20
申请号:US18085190
申请日:2022-12-20
摘要: The invention provides a polypeptide containing at least one IgG Fc region region, said polypeptide having a higher anti-inflammatory activity and a lower cytotoxic activity as compared to an unpurified antibody and methods of production of such polypeptide.
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公开(公告)号:US11629434B2
公开(公告)日:2023-04-18
申请号:US16862851
申请日:2020-04-30
申请人: X-Body, Inc.
发明人: Yan Chen , Tod M. Woolf , Richard W. Wagner
摘要: Provided are methods and compositions for the production of novel antibodies that bind specifically to a target antigen. These methods and compositions are particularly useful for producing antibodies having the antigen binding specificity of a reference antibody but with improved properties (e.g., binding affinity, immunogenicity, and thermodynamic stability) relative to the reference antibody.
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公开(公告)号:US11623964B2
公开(公告)日:2023-04-11
申请号:US16303831
申请日:2017-05-23
IPC分类号: C07K16/46 , A61P37/06 , C07K16/00 , A61K39/395
摘要: The present disclosure relates to compositions and methods of engineered IgG Fc constructs, wherein the Fc constructs include one or more Fc domains.
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