公开(公告)号：US20240350677A1

公开(公告)日：2024-10-24

申请号：US18596815

申请日：2024-03-06

申请人： On Target Laboratories, Inc.

发明人： Sumith A. Kularatne

IPC分类号： A61K49/00 ,  A61K49/16 ,  C07D209/20 ,  C07K5/062 ,  C07K5/065 ,  C07K5/072 ,  C07K5/078 ,  C07K5/083 ,  C07K5/087 ,  C07K5/09 ,  C07K5/11 ,  C07K7/02 ,  C07K7/06 ,  G01N21/64 ,  G01N33/574 ,  G01N33/58

CPC分类号： A61K49/0052 ,  A61K49/0032 ,  A61K49/0034 ,  A61K49/0056 ,  C07D209/20 ,  C07K5/06026 ,  C07K5/0606 ,  C07K5/06078 ,  C07K5/06095 ,  C07K5/06121 ,  C07K5/06147 ,  C07K5/06156 ,  C07K5/0806 ,  C07K5/0812 ,  C07K5/0817 ,  C07K5/1019 ,  C07K7/02 ,  C07K7/06 ,  G01N21/6428 ,  G01N33/57434 ,  G01N33/57492 ,  G01N33/582 ,  A61K49/0017 ,  A61K49/16 ,  C12Y304/17021 ,  G01N2021/6439 ,  G01N2333/948

摘要： The present disclosure relates to prostate specific membrane antigen (PSMA) targeted compounds conjugated to near-infra red (NIR) dyes and methods for their therapeutic and diagnostic use. More specifically, this disclosure provides compounds and methods for diagnosing and treating diseases associated with cells and/or vasculature expressing prostate specific membrane antigen (PSMA), such as prostate cancer and related diseases. The disclosure further describes methods and compositions for making and using the compounds, methods incorporating the compounds, and kits incorporating the compounds.

公开(公告)号：US12115228B2

公开(公告)日：2024-10-15

申请号：US17189135

申请日：2021-03-01

申请人： Concortis Biosystems, Corp.

发明人： Zhenwei Miao ,  Yufeng Hong ,  Tong Zhu ,  Alexander Wilhelm Chucholowski

IPC分类号： A61K47/68 ,  A61K38/07 ,  C07D207/08 ,  C07D207/09 ,  C07D277/593 ,  C07D401/12 ,  C07D403/12 ,  C07F5/02 ,  C07K5/06 ,  C07K5/062 ,  C07K5/103 ,  C07K7/06

CPC分类号： A61K47/6855 ,  A61K38/07 ,  A61K47/6803 ,  A61K47/6811 ,  A61K47/6849 ,  A61K47/6889 ,  C07D207/08 ,  C07D207/09 ,  C07D277/593 ,  C07D401/12 ,  C07D403/12 ,  C07F5/025 ,  C07K5/06008 ,  C07K5/06034 ,  C07K5/06052 ,  C07K5/1008 ,  C07K7/06

摘要： In one aspect, an active agent-conjugate, methods of preparing the active agent-conjugate, and uses thereof is provided.

公开(公告)号：US20240261363A1

公开(公告)日：2024-08-08

申请号：US18483874

申请日：2023-10-10

申请人： FILAMENT BIOSOLUTIONS INC.

发明人： Thomas P. CIRRITO ,  Kate M. Rochlin

IPC分类号： A61K38/05 ,  A61K9/00 ,  A61K33/30 ,  A61K45/06 ,  A61K47/18 ,  A61P35/00 ,  C07C231/24 ,  C07C237/06 ,  C07K5/00 ,  C07K5/062

CPC分类号： A61K38/05 ,  A61K9/0053 ,  A61K33/30 ,  A61K47/183 ,  A61P35/00 ,  C07C231/24 ,  C07C237/06 ,  C07K5/00 ,  C07K5/06026 ,  A61K45/06

摘要： Provided herein are Alanyl-Glutamine (Ala-Gin) formulations for use in treating and preventing side effects associated with cancer treatment. Also provided herein are methods of using the formulations provided herein to treat or prevent side effects associated with cancer treatment.

公开(公告)号：US20240254162A1

公开(公告)日：2024-08-01

申请号：US18527402

申请日：2023-12-04

申请人： The Second People's Hospital of Shenzhen(Shenzhen Institute of Geriatrics)

发明人： Zhengzhi Wu ,  Bohua Long ,  Liuyang Pu ,  Zhiyue Li ,  Shengquan Hu ,  Limin Li

IPC分类号： C07K5/02 ,  C07C227/20 ,  C07K1/107 ,  C07K5/062

CPC分类号： C07K5/0202 ,  C07C227/20 ,  C07K1/107 ,  C07K5/06026 ,  A61K38/00

摘要： A CyclotheonellazoleA, a synthesis method therefor, and an application method thereof are provided, and a compound with a structure of formula (I) and a pharmaceutically acceptable salt thereof are provided, the structure of formula (I) is as follows:




R1, R2, R3 and R4 are independently selected form the group consisting of a hydrogen group (H), an alkyl group with carbon atoms in a range of 1-6, an alkoxy group with carbon atoms in a range of 1-6, a halogen group, a hydroxyl group, an amino group, a nitro group, a cyano group and a sulfydryl group. A CyclotheonellazoleA natural product is successfully synthesized by a classical retrosynthesis analysis, a stereoscopic structure of the CyclotheonellazoleA natural product is confirmed, extremely excellent protease inhibitory activity of the CyclotheonellazoleA natural product is confirmed by combining a protease inhibition activity experiment, and the CyclotheonellazoleA has a strong application prospect in a pharmaceutical industry.

公开(公告)号：US12037405B2

公开(公告)日：2024-07-16

申请号：US17898384

申请日：2022-08-29

申请人： Ambrx, Inc.

发明人： Richard S Barnett ,  Nickolas Knudsen ,  Ying Sun ,  Sandra Biroc ,  Timothy Buss ,  Tsotne Javahishvili ,  Damien Bresson ,  Shailaja Srinagesh ,  Amha Hewet ,  Jason Pinkstaff

IPC分类号： C07K16/28 ,  A61K47/42 ,  A61K47/68 ,  C07K5/062

CPC分类号： C07K16/2875 ,  A61K47/42 ,  A61K47/6817 ,  A61K47/6845 ,  A61K47/6889 ,  C07K5/06052 ,  C07K2317/76

摘要： This invention relates to anti-CD70 antibodies and antibody drug conjugates comprising at least one non-naturally-encoded amino acid. Disclosed herein are αCD70 antibodies with one or more non-naturally encoded amino acids and further disclosed are antibody drug conjugates wherein the αCD70 antibodies of the invention are conjugated to one or more toxins. Further disclosed are methods for using such non-natural amino acid antibody drug conjugates, including therapeutic, diagnostic, and other biotechnology uses.

公开(公告)号：USRE49816E1

公开(公告)日：2024-01-30

申请号：US16893086

申请日：2020-06-04

申请人： CORNELL UNIVERSITY

发明人： Gang Lin ,  Carl Nathan ,  Aihao Ding ,  Xiaojing Ma

IPC分类号： C07K5/072 ,  C07K5/078 ,  C07K5/062 ,  C07K5/097 ,  C07K5/083 ,  C07K5/06 ,  C07K5/068 ,  A61K38/00

CPC分类号： C07K5/06104 ,  C07K5/0606 ,  C07K5/06026 ,  C07K5/06069 ,  C07K5/06086 ,  C07K5/06113 ,  C07K5/06139 ,  C07K5/06191 ,  C07K5/0806 ,  C07K5/0821 ,  A61K38/00

摘要： The compounds of the present invention are represented by the following compounds having Formula (I) where the substituents R1-R10, X, Y, k, m, n, q, and s are as defined herein. These compounds are used in the treatment of cancer, immunologic disorders, autoimmune disorders, neurodegenerative disorders, or inflammatory disorders or for providing immunosuppression for transplanted organs or tissues.

公开(公告)号：US20230312642A1

公开(公告)日：2023-10-05

申请号：US17883973

申请日：2022-08-09

申请人： CASE WESTERN RESERVE UNIVERSITY

发明人： Zheng-Rong Lu ,  Amita M. Vaidya

IPC分类号： C12N15/11 ,  C07K5/062

CPC分类号： C07K5/0606 ,  C12N15/111 ,  C12N2310/14 ,  C12N2310/3513 ,  C12N2320/32

摘要： A nanosized complex includes siRNA and a compound comprising formula (I):

公开(公告)号：US20230277676A1

公开(公告)日：2023-09-07

申请号：US18087338

申请日：2022-12-22

申请人： R.P. Scherer Technologies, LLC

发明人： Stepan Chuprakov ,  Ayodele O. Ogunkoya ,  Penelope M. Drake

IPC分类号： A61K47/54 ,  A61K47/64 ,  C07D471/14 ,  C07D491/22 ,  C07K5/062

CPC分类号： A61K47/545 ,  A61K47/64 ,  C07D471/14 ,  C07D491/22 ,  C07K5/06026

摘要： The present disclosure provides antibody-drug conjugate (ADC) structures, which include a camptothecine or a camptothecine derivative linked to a polypeptide (e.g., an antibody) through a linker. The disclosure also encompasses compounds and methods for production of such conjugates, as well as methods of using the conjugates.

公开(公告)号：US11738090B2

公开(公告)日：2023-08-29

申请号：US17677147

申请日：2022-02-22

申请人： CASE WESTERN RESERVE UNIVERSITY

发明人： Nicole F. Steinmetz

IPC分类号： A61K47/69 ,  C07K5/062 ,  A61K47/64 ,  A61K47/68 ,  A61K47/65 ,  A61P35/00 ,  A61K31/401 ,  A61K39/12

CPC分类号： A61K47/6901 ,  A61K31/401 ,  A61K39/12 ,  A61K47/646 ,  A61K47/65 ,  A61K47/6811 ,  A61P35/00 ,  C07K5/06052

摘要： Anti-lymphoma plant virus particles are described. The anti-lymphoma plant virus particles include a filamentous or rod-shaped plant virus particle linked to an antimitotic agent. A therapeutically effective amount of an anti-lymphoma plant virus particle can be administered to a subject to provide a method of treating lymphoma.

公开(公告)号：US20230212113A1

公开(公告)日：2023-07-06

申请号：US18175495

申请日：2023-02-27

申请人： AF Chemicals, LLC,

发明人： MICHAEL KELNER

IPC分类号： C07C317/44 ,  C07C225/14 ,  A61K38/06 ,  C07K5/083 ,  A61K31/4015 ,  C07K5/062 ,  A61K31/265 ,  C07D207/444 ,  A61K31/215 ,  A61K31/27 ,  A61K47/54 ,  A61K38/05 ,  C07C271/34 ,  C07C309/72 ,  C07C311/16 ,  A61K31/255 ,  C07C205/42

CPC分类号： C07C317/44 ,  C07C225/14 ,  A61K38/06 ,  C07K5/0806 ,  A61K31/4015 ,  C07K5/06052 ,  A61K31/265 ,  C07K5/06026 ,  C07D207/444 ,  A61K31/215 ,  A61K31/27 ,  A61K47/554 ,  A61K38/05 ,  C07C271/34 ,  C07C309/72 ,  C07C311/16 ,  A61K31/255 ,  C07C205/42 ,  C07C2603/94

摘要： In an embodiment of the invention, a composition for treating a cell population comprises a medicant. The medicant moiety can be an illudofulvene analog. In an embodiment of the invention, a composition for treating a cell population comprises an Affinity Medicant Conjugate (AMC). The affinity moiety can be an antibody, an antibody fragment, a receptor protein, a peptidic growth factor, an anti-angiogenic protein, a specific binding peptide, protease cleavable peptide, a glycopeptide, a peptide, a peptidic toxin, a protein toxin and an oligonucleotide. The affinity moiety can be covalently bound to the medicant via a linker.