公开(公告)号：US20230097644A1

公开(公告)日：2023-03-30

申请号：US17881605

申请日：2022-08-05

申请人： JIANGSU UNIVERSITY

发明人： Xiaofeng REN ,  Qiufang LIANG ,  Haile MA ,  Yuqing DUAN ,  Ronghai HE ,  Xiaoming YANG ,  Xi ZHANG ,  Ting HOU ,  Xinxiang CHEN

IPC分类号： C07K1/36 ,  A23L33/18 ,  C07K5/103 ,  C07K14/47 ,  C12P21/06

摘要： An ultrasound-assisted simulated digestion method of a milk protein active peptide and an application thereof in health foods, pertaining to the technical field of intensive processing of dairy products and preparation of health foods. The method firstly employs ultrasonic pretreatment of casein and β-lactoglobulin, followed by enzymatic hydrolysis with a protease to prepare casein and β-lactoglobulin polypeptide, and traces the activity of the polypeptide by simulating gastrointestinal digestion, and then simulates absorption by intestinal epithelial cells with Caco-2 cells, to characterize a highly active milk protein polypeptide digested by the gastrointestinal tract and absorbed by the Caco-2 cells simulating absorption by the inner wall of the small intestine. The method has identified five such highly active milk protein polypeptides.

公开(公告)号：US11555054B2

公开(公告)日：2023-01-17

申请号：US17003940

申请日：2020-08-26

申请人： The Johns Hopkins University

发明人： Jun Liu ,  Jingxin Wang ,  Zhaoli Sun ,  Sam Hong

IPC分类号： C07K5/103 ,  C07D498/18 ,  C07D519/00 ,  A61K47/54 ,  A61K38/07

摘要： A compound of Formula I, and its analogs are provided. Compositions that include Formula I can be used to inhibit human equilibrative nucleoside transporter 1, increase adenosine signaling and produce effects that include increasing antiviral activity, increasing antiparasitic activity, increasing alcohol tolerance, decreasing pain protecting from ischemia as well as many other conditions.

公开(公告)号：US11548927B2

公开(公告)日：2023-01-10

申请号：US15773273

申请日：2016-11-02

申请人： GENEXINE, INC.

发明人： Donghoon Choi ,  Changyong Eun ,  Seong Hoon Jeong ,  Jun Yeul Lim

IPC分类号： C07K14/54 ,  C07K7/06 ,  C07K5/083 ,  C07K5/103 ,  C07K5/062 ,  A61K47/26 ,  A61K9/08 ,  A61K47/12 ,  A61K47/10 ,  A61K47/18 ,  A61K38/20

摘要： Provided is a pharmaceutical formulation comprising a modified IL-7 protein. More particularly, it comprises (a) a modified IL-7 fusion protein; (b) a basal buffer with a concentration of 10 to 50 mM; (c) a sugar with a concentration of 2.5 to 5 w/v %; and (d) a surfactant with a concentration of 0.05 to 6 w/v %. Such pharmaceutical formulation of a modified IL-7 fusion protein does not show aggregates formation, but shows protective effects on proteins under stress conditions such as oxidation or agitation, and thus can effectively be used for the treatment of a patient.

公开(公告)号：US20220411436A1

公开(公告)日：2022-12-29

申请号：US17761417

申请日：2020-09-17

申请人： SICHUAN BAILI PHARMACEUTICAL CO., LTD

发明人： Yi ZHU ,  Weili WAN ,  Shi ZHUO ,  Wei ZHANG ,  Yiying ZHANG ,  Tao K. XU

IPC分类号： C07D491/22 ,  A61P35/00 ,  C07K5/103 ,  A61K47/68

摘要： An antitumor pharmaceutical camptothecin derivative and an antibody-drug conjugate thereof. By means of a series of molecular structure modifications, an optimal camptothecin antitumor drug is obtained, so as to be more suitable as a drug for antibody conjugation.

公开(公告)号：US11492374B2

公开(公告)日：2022-11-08

申请号：US16911701

申请日：2020-06-25

申请人： Humanwell Pharmaceutical US

发明人： Subo Liao ,  Jun Yang ,  Jinliang Lv ,  Zongquan Liao ,  Hao Zhou ,  Jueyuan Gao ,  Tianpeng Xie ,  Quanli Yang

IPC分类号： C07K1/10 ,  C07K5/103 ,  C07K1/06 ,  A61K38/00

摘要： The present invention provides compounds which are selective kappa-opioid receptor agonist, method of preparation of these compounds, compositions that comprise these compounds, and methods for treating kappa-opiod receptor agonist related medical disorders.

公开(公告)号：US20220226486A1

公开(公告)日：2022-07-21

申请号：US17702348

申请日：2022-03-23

申请人： Syntab Therapeutics GmbH

发明人： Christian BECKER ,  Manuel BREHS ,  Karine THEWES ,  Ute STEINBUSCH ,  Andre JG PÖTGENS ,  Janett SCHWARZ

IPC分类号： A61K47/64 ,  C07K16/28 ,  C07K14/705 ,  A61K39/39 ,  C07K7/06 ,  C07K5/103 ,  A61K47/68 ,  A61K47/60 ,  A61K38/08

摘要： The present invention relates to a synthetic compound comprising at least one effector moiety and at least one binder moiety, wherein the effector moiety is associated to the binder moiety, and wherein further the effector moiety comprises a N-formyl methionine peptide which comprises an isoleucine residue.

公开(公告)号：US11365215B2

公开(公告)日：2022-06-21

申请号：US15921596

申请日：2018-03-14

申请人： Research & Business Foundation Sungkyunkwan University ,  Korea Research Institute of Chemical Technology

发明人： Kwangho Lee ,  Sang Dal Rhee ,  Gildon Choi ,  Imran Ali ,  Chong Hak Chae ,  Moon Kook Jeon ,  Seok Hee Park ,  Youn Sook Lee

IPC分类号： A61K47/54 ,  C07K5/117 ,  C07K5/103 ,  C07K5/107 ,  C07K5/097 ,  C07D207/04 ,  A61P1/00 ,  C07D403/06 ,  A61K38/00

摘要： Pyrrolidine carboxamido derivatives, optical isomers thereof, and salts thereof that are able to prevent, improve, and/or treat inflammatory conditions, including inflammatory bowel disease, and methods for preparing and using the same are provided.

公开(公告)号：US11324687B2

公开(公告)日：2022-05-10

申请号：US16848142

申请日：2020-04-14

申请人： Sederma

发明人： Olivier Peschard ,  Philippe Mondon

IPC分类号： C07K5/103 ,  C07K5/093 ,  C07K5/087 ,  C07K5/097 ,  C07K5/078 ,  C07K5/062 ,  A61K38/00 ,  A61Q19/02 ,  A61K8/64 ,  A61Q5/10 ,  A61Q19/04 ,  A61Q19/08 ,  C07K5/083 ,  A61Q19/00

摘要： Provided is at least one peptide of formula (I) and its use, where formula (I) is as follows: X-(Xaa1)n-Pro*-(Xaa2)m-Y (I). In formula (I), n=0 and m=1. At the N terminal end of the peptide, X is selected from H, —CO—R1 and —SO2—R1. At the C terminal end of the peptide, Y is selected from OH, OR1, NH2, NHR1 or NR1R2, R1 and R2 being independently selected from an alkyle, aryle, aralkyle, alkylaryl, alkoxy and aryloxy group, that can be linear, branched, cyclic, poly-cyclic, non-saturated, hydroxylated, carbonylated, phosphorylated and/or sulphured, with the possibility to have in said group skeleton a O, S and/or N heteroatom. Pro* corresponds to a Proline, an analogue or derivative thereof.

公开(公告)号：US20220112239A1

公开(公告)日：2022-04-14

申请号：US17558190

申请日：2021-12-21

申请人： NAUREX, INC.

发明人： Saibaba RACHA

IPC分类号： C07K5/10 ,  C07K5/103 ,  C07K1/08 ,  C07K5/117 ,  C07K1/12

摘要： Disclosed is a new process and intermediates for preparing dipyrrolidine peptide compounds such as, for example, rapastinel. Advantageously, the process may be industrially scalable and cost-effective and use less toxic reagents and/or solvents. Further, the process may be used to prepare peptide compounds having improved purity.

公开(公告)号：US20220056074A1

公开(公告)日：2022-02-24

申请号：US17401434

申请日：2021-08-13

申请人： KING ABDULLAH UNIVERSITY OF SCIENCE AND TECHNOLOGY

发明人： Charlotte A.E. HAUSER ,  Hepi Hari SUSAPTO

IPC分类号： C07K5/103 ,  A61L26/00 ,  C08J3/075 ,  C08J3/09 ,  A61L27/22 ,  A61L27/52 ,  A61L31/04 ,  A61L31/14 ,  C12N5/00

摘要： The present disclosure relates to ultrashort peptides capable of forming a gel, to a gel comprising a peptide in accordance with the present disclosure, and to a method of preparing such gel. Such gel is a hydrogel or an organogel. The peptides are suitable bioinks for a bioprinter to build 3D structures through 3D printing as well as other applications.