公开(公告)号：US12188937B2

公开(公告)日：2025-01-07

申请号：US16977270

申请日：2019-11-29

Applicant: BEIJING BOE TECHNOLOGY DEVELOPMENT CO., LTD. ,  BOE TECHNOLOGY GROUP CO., LTD.

Inventor： Zijian Zhao ,  Siyi Yin

IPC: G01N33/574 ,  C07C233/36 ,  C07K7/04 ,  C40B40/10 ,  G01N33/68

Abstract: Embodiments disclosed herein provide a peptoid compound comprising a structure shown in Formula I and a detection chip having the peptoid compound coupled onto its surface. The peptoid compound has a strong binding ability with EpCAM protein on the surface of circulating tumor cells. The diagnostic technology of colorectal adenocarcinoma, gastric adenocarcinoma, breast cancer, ovarian cancer, lung adenocarcinoma, prostate cancer, pancreatic cancer, stem cell cancer, retinoblastoma, or primary esophageal squamous cell carcinoma based on the peptoid compound can realize rapid detection or diagnosis. In addition, the peptoid compound can be made by a simple synthesis method with high preparation efficiency and low production cost.

公开(公告)号：US20230399374A1

公开(公告)日：2023-12-14

申请号：US18033665

申请日：2021-08-26

Applicant: PURDUE RESEARCH FOUNDATION

Inventor： Philip Stewart LOW ,  Stewart A. LOW ,  Jeffrey Jay Howard NIELSEN

IPC: C07K14/635 ,  A61K38/28 ,  C07K7/04 ,  A61P19/10

CPC classification number: C07K14/635 ,  A61K38/28 ,  C07K7/04 ,  A61P19/10

Abstract: Osteotropic ligand-bone anabolic agent compounds and related compositions and methods of use to treat bone fractures.

公开(公告)号：US20230313126A1

公开(公告)日：2023-10-05

申请号：US18163607

申请日：2023-02-02

Applicant: University of Pittsburgh - Of the Commonwealth System of Higher Education

Inventor： Ipsita Banerjee ,  Prashant Kumta ,  Thomas Richardson

IPC: C12N5/00 ,  C07K14/00 ,  C07K7/04 ,  C07K14/705 ,  C12N5/0735 ,  C07K17/10

CPC classification number: C12N5/0068 ,  C12N5/0018 ,  C07K14/00 ,  C07K7/04 ,  C07K14/705 ,  C12N5/0606 ,  C12N5/0012 ,  C07K17/10 ,  C12N2513/00 ,  C12N2533/74 ,  C12N2537/10

Abstract: Compositions useful for propagation of pluripotent stem cells are provided. The compositions comprise a polysaccharide hydrogel linked to a peptide fragment of the extracellular domain of epithelial cadherin. Methods of making the composition, and culturing pluripotent stem cells also are provided.

公开(公告)号：US11591365B2

公开(公告)日：2023-02-28

申请号：US16758888

申请日：2018-11-09

Applicant: WntRx Pharmaceuticals Inc.

Inventor： David Zhu ,  Robert Perni ,  Yvonne Angell

IPC: C07K7/04 ,  A61P35/00 ,  A61K38/00

Abstract: Disclosed here are polypeptides derived from the HD2 domain of human B-cell CLL/lymphoma 9 (BCL9) protein and variants thereof, as well as their use in the diagnosis, prevention, and/or treatment of a disease or disorder. Also disclosed are methods of generating such polypeptides and variants thereof.

公开(公告)号：US20220315909A1

公开(公告)日：2022-10-06

申请号：US17615633

申请日：2020-06-05

Applicant: Chugai Seiyaku Kabushiki Kaisha

Inventor： Mika SAKURAI ,  Tatsuya KAWA ,  Hitoshi KATADA ,  Naoka HIRONIWA

IPC: C12N9/72 ,  C07K16/28 ,  C07K7/04 ,  C12N15/79

Abstract: The present application relates to protease substrates, peptide sequences cleavable by a protease, polypeptides comprising a protease cleavage sequence and methods for production thereof, pharmaceutical compositions comprising a polypeptide comprising a protease cleavage sequence, and methods for releasing an antigen-binding domain or a ligand by the cleavage of a protease cleavage sequence included in a polypeptide.

公开(公告)号：US11186613B2

公开(公告)日：2021-11-30

申请号：US16461871

申请日：2017-11-17

Applicant: Kagoshima University ,  Daicel Corporation

Inventor： Yuji Ito ,  Seiichi Uchimura

IPC: C07K7/04 ,  C07K17/00 ,  C07K1/22 ,  C07K16/00 ,  G01N30/88 ,  C12N15/09 ,  C07K7/08 ,  C07K1/16 ,  C07K17/08 ,  C07K17/10

Abstract: The present invention provides an IgG-binding peptide which can be used for the purification of IgG and has excellent stability, e.g., alkali stability. The present invention also provides a method for purifying IgG using the IgG-binding peptide. Specifically, the present invention relates to a solid-phase support including an IgG-binding peptide, an IgG separation column including the solid-phase support, a kit including the solid-phase support or the column, and a method for purifying IgG using the solid-phase support or the column.

公开(公告)号：US11117941B2

公开(公告)日：2021-09-14

申请号：US17229610

申请日：2021-04-13

Applicant: Immatics Biotechnologies GmbH

Inventor： Colette Song ,  Heiko Schuster ,  Daniel Johannes Kowalewski ,  Oliver Schoor ,  Jens Fritsche ,  Toni Weinschenk ,  Harpreet Singh

IPC: A61K35/17 ,  A61K38/08 ,  C07K7/04 ,  C12N5/0783 ,  C07K14/47 ,  G16B25/10 ,  A61K39/00 ,  C07K14/725 ,  C07K14/74 ,  C07K16/18 ,  C12Q1/6886 ,  C07K7/06

Abstract: The present invention relates to peptides, proteins, nucleic acids and cells for use in immunotherapeutic methods. In particular, the present invention relates to the immunotherapy of cancer. The present invention furthermore relates to tumor-associated T-cell peptide epitopes, alone or in combination with other tumor-associated peptides that can for example serve as active pharmaceutical ingredients of vaccine compositions that stimulate anti-tumor immune responses, or to stimulate T cells ex vivo and transfer into patients. Peptides bound to molecules of the major histocompatibility complex (MHC), or peptides as such, can also be targets of antibodies, soluble T-cell receptors, and other binding molecules.

公开(公告)号：US11085056B2

公开(公告)日：2021-08-10

申请号：US15756006

申请日：2016-08-26

Applicant: MOLECULAR TRANSFER, INC.

Inventor： Gulilat Gebeyehu ,  Joel Jessee

IPC: A61K38/00 ,  C12N15/87 ,  C07K7/06 ,  C07K7/08 ,  C07K14/00 ,  C07K5/097 ,  C07K5/00 ,  C07K5/072 ,  C07K5/09 ,  C07K7/04 ,  C07K5/083 ,  C07K5/068 ,  C07K5/087 ,  C07K5/11

Abstract: Disclosed herein are transfection complexes comprising at least one cell surface ligand; at least one helper lipid component; and a transfection enhancer. Also disclosed are pharmaceutical compositions comprising the disclosed transfection complexes, and a pharmaceutically acceptable carrier. Further, disclosed are methods of transfecting a cell, the method comprising the steps of: obtaining a transfection complex as disclosed; and contacting a cell with the transfection complex.

公开(公告)号：US10077293B2

公开(公告)日：2018-09-18

申请号：US15364398

申请日：2016-11-30

Applicant: INDUSTRY-ACADEMIC COOPERATION FOUNDATION, KUNSAN NATIONAL UNIVERSITY

Inventor： Jung-Kil Seo ,  Ki-Young Lee ,  Sang-man Cho ,  In-Ah Lee

IPC: C07K7/04 ,  A61K38/04 ,  A61Q17/00 ,  A61Q19/00 ,  A61Q19/10 ,  C07K14/435 ,  A61K8/64 ,  A61K8/04 ,  A23K20/147 ,  A23L33/18 ,  A61K38/00

CPC classification number: C07K14/43504 ,  A23K20/147 ,  A23L3/3526 ,  A23L33/18 ,  A23V2002/00 ,  A61K8/046 ,  A61K8/64 ,  A61K38/00 ,  A61Q17/005 ,  A61Q19/00 ,  A61Q19/007 ,  A61Q19/10 ,  Y02A50/473 ,  Y02A50/475

Abstract: The present disclosure relates to an antimicrobial peptide analog derived from abalone and an antimicrobial pharmaceutical composition containing the same. The antimicrobial peptide analog according to the present disclosure is designed based on hdMolluscidin which is a peptide derived from the gill of abalone and has been designed to be commercially viable by reducing the number of amino acids. Despite the reduced number of amino acids, the designed peptide analog exhibits very superior antimicrobial activity as well as high membrane permeability and low hemolytic activity.

公开(公告)号：US10035122B2

公开(公告)日：2018-07-31

申请号：US15506361

申请日：2015-08-28

Applicant: UNIVERSITE DE LORRAINE ,  CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE

Inventor： Brigitte Jamart ,  Alain Degiovanni ,  Sébastien Son ,  Yves Jannot ,  Guillaume Pickaert

IPC: B01J13/00 ,  C07K7/02 ,  C08G69/00 ,  B27K3/15 ,  B27K3/02 ,  E04B1/74 ,  C08L97/02 ,  C07K7/04 ,  D06M13/342 ,  D06M13/422 ,  D06M13/35 ,  B27K3/34

CPC classification number: B01J13/0091 ,  B27K3/0278 ,  B27K3/153 ,  B27K3/343 ,  B27K2200/10 ,  B27K2240/70 ,  C07K7/02 ,  C07K7/04 ,  C08G69/00 ,  C08L97/02 ,  D06M13/342 ,  D06M13/35 ,  D06M13/422 ,  E04B1/74 ,  E04B2001/742 ,  F26B21/14

Abstract: A heat insulation material is provided that is produced by drying a fibrous matrix impregnated with a solution of pseudo-peptides of formula (I), wherein: R is a side-chain of a natural or synthetic amino acid, R1 is either a linear or branched (C1-C3)alkyl group, or a linear or branched (C1-C3)alcoxy group, or an aryl group, or an aryl(C1-C3)alkyl group, or an aryloxy group, or a saturated or unsaturated heterocycle, n=1 or 2, and A is an aromatic or heteroaromatic group with at least one cycle.