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公开(公告)号：US12071489B2
公开(公告)日：2024-08-27
申请号：US17318845
申请日：2021-05-12
申请人： CORNELL UNIVERSITY
CPC分类号： C08B37/0003 , B01D11/0288 , C08B37/003 , C08J3/09 , C08J2367/04
摘要： Crosslinked nucleotide polymers. A crosslinked nucleotide polymer may be formed by reaction of a biomass comprising DNA and/or RNA with one or more crosslinker(s). A crosslinked nucleotide polymers may be formed by a crosslinking reaction including an aza-Michael addition reaction. Crosslinked nucleotide polymers may be present in various forms and compositions and form various articles of manufacture. Crosslinked nucleotide polymers may be used in therapeutic methods, coating methods, and cell-free protein production methods.
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公开(公告)号：US20240199822A1
公开(公告)日：2024-06-20
申请号：US18590007
申请日：2024-02-28
申请人： Galderma Holding SA
发明人： Johan OLSSON , Craig Steven HARRIS
IPC分类号： C08J3/075 , A61K8/04 , A61K8/73 , A61K9/00 , A61Q19/00 , C07C209/62 , C07C213/00 , C07C269/06 , C07F7/08 , C08B37/00 , C08B37/08 , C08J3/24 , C08J7/14 , C08K5/09 , C08L5/00 , C08L5/08
CPC分类号： C08J3/075 , A61K8/042 , A61K8/73 , A61K8/735 , A61K9/0019 , A61Q19/00 , C07C209/62 , C07C213/00 , C07C269/06 , C07F7/083 , C08B37/0063 , C08B37/0069 , C08B37/0072 , C08J3/24 , C08J7/14 , C08K5/09 , C08L5/00 , C08L5/08 , C07C2603/18 , C08J2305/00 , C08J2305/08
摘要： A method of preparing a hydrogel product including crosslinked glycosaminoglycan molecules, said method including: i) providing a glycosaminoglycan crosslinked by amide bonds, wherein the crosslinked glycosaminoglycans include residual amine groups; and ii) acylating residual amine groups of the crosslinked glycosaminoglycans provided in i) to form acylated crosslinked glycosaminoglycans.
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公开(公告)号：US20240182651A1
公开(公告)日：2024-06-06
申请号：US18168938
申请日：2023-02-14
申请人： Win Coat Corporation
发明人： Ta-Jo LIU , Hsiu-Feng YEH , Shin-Yi YIN , Yi-Jyun LIAO , Ying-Hua HSU
CPC分类号： C08J3/075 , C08B37/0072 , C08J3/28 , C08J2305/08 , C08J2367/07
摘要： Provided is a hydrogel composition, which comprises a modified HA, PEGDA and water; wherein, based on a total weight of the hydrogel composition, a content of the modified HA is 1 wt % to 7 wt % and a content of PEGDA is 43 wt % to 49 wt %; the modified HA is obtained by modifying HA with methacrylic anhydride; an average molecular weight of PEGDA is 1 kDa to 10 kDa. The hydrogel composition of the present invention has good compatibility of raw materials, which does not cause HA precipitation, and a hydrogel material produced therefrom simultaneously has good mechanical properties, good swell capability and good biocompatibility, such that the hydrogel material can be applied in many fields.
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4.发明公开公开(公告)号：US20240132630A1
公开(公告)日：2024-04-25
申请号：US18480242
申请日：2023-10-03
IPC分类号： C08B37/02 , A61K31/717 , A61K31/721 , A61K31/722 , A61K31/728 , C08B37/00 , C08B37/08
CPC分类号： C08B37/0021 , A61K31/717 , A61K31/721 , A61K31/722 , A61K31/728 , C08B37/003 , C08B37/0072 , C08B37/0087
摘要： Provided are methods of attaching a mannose-binding C-type lectin receptor targeting moiety to a polymeric carbohydrate backbone using an amide linkage. The amide linkage may be found between a leash, such as an amine terminated leash, and the mannose-binding C-type lectin receptor targeting moieties. The compounds and compositions disclosed utilizing the amide linkage provide for highly stable compounds with a significant reduction in loss of mannose-binding C-type lectin receptor targeting moieties from the polymeric carbohydrate backbone.
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公开(公告)号：US20240124656A1
公开(公告)日：2024-04-18
申请号：US18474363
申请日：2023-09-26
发明人： Hyung Joon Cha , Jae Yun Lee , Jin Young Yun , Hyun Tack Woo
IPC分类号： C08H1/00 , C07K14/435 , C08B37/08
CPC分类号： C08H1/00 , C07K14/43504 , C08B37/0072
摘要： The present disclosure relates to a conductive hydrogel including a mussel adhesive protein, a liquid metal, and hyaluronic acid and a preparation method thereof.
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公开(公告)号：US20240101720A1
公开(公告)日：2024-03-28
申请号：US18372969
申请日：2023-09-26
发明人： Meltem Urgun Demirtas , Chaoyi Ba
CPC分类号： C08B37/003 , B29C39/003 , C08J5/18 , B29K2005/00 , C08J2305/08
摘要： A method of forming a plastic component can includes treating a polysaccharide source with an acid solution under conditions sufficient to extract the starch from the polysaccharide source, wherein the polysaccharide precipitates in the acid solution; separating the precipitate from the acid solution; drying the separated precipitate; admixing the dried precipitate with water to form a slurry; and casting or molding the slurry to form the plastic component.
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公开(公告)号：US11939433B2
公开(公告)日：2024-03-26
申请号：US18208527
申请日：2023-06-12
申请人： Galderma Holding SA
发明人： Johan Olsson , Craig Steven Harris
IPC分类号： C08J3/075 , A61K8/04 , A61K8/73 , A61K9/00 , A61Q19/00 , C07C209/62 , C07C213/00 , C07C269/06 , C07F7/08 , C08B37/00 , C08B37/08 , C08J3/24 , C08J7/14 , C08K5/09 , C08L5/00 , C08L5/08
CPC分类号： C08J3/075 , A61K8/042 , A61K8/73 , A61K8/735 , A61K9/0019 , A61Q19/00 , C07C209/62 , C07C213/00 , C07C269/06 , C07F7/083 , C08B37/0063 , C08B37/0069 , C08B37/0072 , C08J3/24 , C08J7/14 , C08K5/09 , C08L5/00 , C08L5/08 , C07C2603/18 , C08J2305/00 , C08J2305/08
摘要： A method of preparing a hydrogel product including crosslinked glycosaminoglycan molecules, said method including: i) providing a glycosaminoglycan crosslinked by amide bonds, wherein the crosslinked glycosaminoglycans include residual amine groups; and ii) acylating residual amine groups of the crosslinked glycosaminoglycans provided in i) to form acylated crosslinked glycosaminoglycans.
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公开(公告)号：US11939409B2
公开(公告)日：2024-03-26
申请号：US17256182
申请日：2019-06-11
申请人： HALLURA LTD.
IPC分类号： C08B37/08 , A61L27/20 , A61L27/52 , C07D237/26 , C07D257/08
CPC分类号： C08B37/0072 , A61L27/20 , A61L27/52 , C07D237/26 , C07D257/08 , A61L2300/402 , A61L2300/428 , A61L2400/06
摘要： The present invention is directed to a polymer comprising a first hyaluronic acid (HA) chain and a second HA chain crosslinked via a linker comprising an unsaturated moiety or a derivative thereof coupled to a tetrazine moiety or a derivative thereof. In some embodiments, the polymer of the invention is characterized by having a crosslinking degree of 0.2 to 4%.
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公开(公告)号：US11920026B2
公开(公告)日：2024-03-05
申请号：US16845636
申请日：2020-04-10
申请人： i-CoreBio Inc.
发明人： Jae Ho Shin , Ki Hak Gwon
IPC分类号： C08L5/08 , A61L31/04 , A61L31/14 , A61L31/16 , D01D1/02 , D01D5/00 , D01D5/38 , B82Y30/00 , C08B37/08
CPC分类号： C08L5/08 , A61L31/042 , A61L31/148 , A61L31/16 , D01D1/02 , D01D5/0015 , D01D5/38 , A61L2300/114 , A61L2400/12 , B82Y30/00 , C08B37/0072 , C08L2201/06 , C08L2203/12
摘要： Disclosed herein is a novel polymer having a structure based on a biodegradable polymer. In the novel polymer, the biodegradable polymer has at least one kind of functional groups from among a hydroxyl group and a carboxyl group, wherein the biodegradable polymer bears a functional group conjugated with a nitric oxide-releasing compound and a different functional group substituted with a photopolymerizable functional group, the nitric oxide-releasing compound comprising a NO donor. Also provided is a nanofiber fabricated from the modified biodegradable polymer. The nanofiber can be fabricated by electrospinning the novel polymer.
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公开(公告)号：US11919975B2
公开(公告)日：2024-03-05
申请号：US14894465
申请日：2014-05-29
发明人： Craig Hardy , Andrew Hoggarth , June Gladman
CPC分类号： C08B37/0003 , A61K31/722 , A61L15/28 , A61L15/40 , A61L26/0023 , A61L26/0061 , C08B37/003 , A61L2300/232 , A61L2300/418 , A61L2400/04 , A61L26/0023 , C08L5/08 , A61L15/28 , C08L5/08
摘要： The present invention relates to a process for producing a low endotoxin alkali chitosan, chitin, chitosan derivative or chitin derivative, and also to a process for producing low endotoxin neutral chitosan, chitosan salt and chitosan derivatives, and to the products of such processes. The process comprises contacting chitosan, chitin, chitosan derivative or chitin derivative with an alkali solution to form a mixture; leaving the mixture for a period of less than 1 hour and optionally drying the mixture. The low endotoxin alkali chitosan may be used in the manufacture of other useful chitosan based products.
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