Amphiphilic block copolymer, preparation method thereof and nanomicelle drug-loading system

    公开(公告)号:US11225551B2

    公开(公告)日:2022-01-18

    申请号:US16969397

    申请日:2019-02-12

    Applicant: Fuyao Zhang

    Abstract: The present invention relates to an amphiphilic block copolymer represented by formula I, a preparation method thereof, and a nanomicelle drug delivery system formed from the copolymer and a poorly soluble drug. The amphiphilic block copolymer includes a hydrophilic chain segment, a hydrophobic chain segment, and a linker for linking the hydrophilic chain segment to the hydrophobic chain segment. The linker contains an unsaturated structure, which can enhance the interaction between the poorly soluble drug and the copolymer to improve the drug loading ability and stability of the nanomicelle. The invention also relates to a nanomicelle drug-loading system, a preparation method thereof, and the use of the nanomicelle drug-loading system for preparing medicines for treating tumors, inflammation, diabetes, central nervous system diseases, cardiovascular diseases, and psychological disorders.

    COMPOSITION
    9.
    发明申请
    COMPOSITION 审中-公开

    公开(公告)号:US20200283568A1

    公开(公告)日:2020-09-10

    申请号:US16765297

    申请日:2018-11-20

    Abstract: Provided herein is a bioresorbable polyester wherein the metal content of the polyester is >0 ppm and 0 ppm comprising the steps of: i) dissolving the polyester in an organic solvent to form a polyester-solvent solution, wherein the organic solvent comprises at least one heteroatom selected from oxygen, nitrogen, sulphur and phosphorus; ii) precipitating the polyester from the polyester-solvent solution by combining the polyester-solvent solution with an organic non-solvent, said non-solvent being an alcohol; and (iii) separating the precipitated polyester from the solvent and non-solvent to obtain a purified polyester.

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