公开(公告)号：US20250051493A1

公开(公告)日：2025-02-13

申请号：US18925611

申请日：2024-10-24

Applicant: AGC Inc. ,  NATIONAL INSTITUTE OF ADVANCED INDUSTRIAL SCIENCE AND TECHNOLOGY

Inventor： Samuel Ying Fu HO ,  Kosuke YAMASAKI ,  Yoshitaka SUNAYAMA ,  Yumiko NAKAJIMA ,  Yuki NAGANAWA ,  Yoshihiro SHIMOYAMA ,  Haiqing GUO

IPC: C08F8/42 ,  C08G65/332 ,  C08K5/09

Abstract: The present invention relates to a method for producing a reactive silicon group-containing organic polymer having a reactive silicon group represented by the following Formula (1), the method including reacting an unsaturated group-containing organic polymer with a silylating agent in the presence of a group 8 metal catalyst and a co-catalyst containing a carboxylic acid compound having a carbon-carbon triple bond, —SiRaX3-a   Formula (1) [In the Formula (1), R is a monovalent organic group having 1 to 20 carbon atoms and represents an organic group other than a hydrolyzable group, and X represents a hydroxyl group, a halogen atom, or a hydrolyzable group; a is an integer from 0 to 2; when a is 2, R groups may be the same as or different from each other, and when a is 0 or 1, X groups may be the same as or different from each other.]

公开(公告)号：US20250043145A1

公开(公告)日：2025-02-06

申请号：US18790743

申请日：2024-07-31

Applicant: ChampionX LLC

Inventor： Jing Wu ,  Shelley Zhou ,  Jeremy Moloney

IPC: C09D171/02 ,  C08G65/332 ,  C09D5/08 ,  C09D7/20 ,  C23F11/173

Abstract: Compositions for corrosion inhibitions, methods of making a chemically modified, maleated unsaturated fatty acids and salts thereof corrosion inhibitor, and methods of using the same are disclosed to provide alternatives for corrosion inhibition under harsh conditions with improved performance.

公开(公告)号：US12202939B2

公开(公告)日：2025-01-21

申请号：US17485611

申请日：2021-09-27

Applicant: DAIKIN INDUSTRIES, LTD.

Inventor： Tsuneo Yamashita ,  Hisashi Mitsuhashi ,  Takeshi Maehira ,  Yoshimi Motonari

IPC: C08G65/336 ,  C08G65/332 ,  C08G65/333 ,  C09D171/00

Abstract: A fluoropolyether group-containing compound of formula (1) or (2): wherein RF1, RX1, RX2 and RSi are as defined herein.

公开(公告)号：US11879097B2

公开(公告)日：2024-01-23

申请号：US17047659

申请日：2019-04-15

Applicant: TOKUYAMA CORPORATION

Inventor： Masayuki Miyazaki ,  Junji Takenaka

IPC: C09K9/02 ,  C08G18/72 ,  C08L83/06 ,  C08G65/332 ,  C08G77/14 ,  C08K5/1545

CPC classification number: C09K9/02 ,  C08G18/722 ,  C08G65/332 ,  C08G77/14 ,  C08K5/1545 ,  C08L83/06 ,  C09K2211/1088

Abstract: The invention is a photochromic compound having an indenonaphthopyran skeleton, and the indenonaphthopyran skeleton has an alkenyl group having 10 to 30 carbon atoms, and an oligomer chain group A having 3 or more recurring units selected from a polyalkylene oxide oligomer chain group, a polyester oligomer chain group, a polysiloxane chain group and a polyester polyether oligomer chain group. The invention can provide a photochromic compound capable of expressing excellent photochromic characteristics in various cured products and capable of preventing cured products from becoming cloudy.

公开(公告)号：US11845812B2

公开(公告)日：2023-12-19

申请号：US17174720

申请日：2021-02-12

Applicant: Trustees of Dartmouth College

Inventor： Chenfeng Ke ,  Qianming Lin

IPC: C08B37/16 ,  C08G83/00 ,  C08L71/02 ,  A61L27/26 ,  A61L15/60 ,  A61L15/22 ,  A61K47/69 ,  B33Y70/00 ,  A61L27/52 ,  A61L26/00 ,  C08J3/075 ,  C08G65/332 ,  C08J3/24 ,  B33Y80/00 ,  A61L27/18 ,  B33Y10/00 ,  A61L27/20 ,  A61L15/26 ,  A61L15/28 ,  A61K9/00 ,  A61K9/06

CPC classification number: C08B37/0015 ,  A61K47/6951 ,  A61L15/225 ,  A61L15/26 ,  A61L15/28 ,  A61L15/60 ,  A61L26/008 ,  A61L26/0019 ,  A61L26/0023 ,  A61L27/18 ,  A61L27/20 ,  A61L27/26 ,  A61L27/52 ,  B33Y10/00 ,  B33Y70/00 ,  B33Y80/00 ,  C08G65/332 ,  C08G83/007 ,  C08G83/008 ,  C08J3/075 ,  C08J3/246 ,  C08L71/02 ,  A61K9/0024 ,  A61K9/06 ,  C08G2650/58 ,  C08J2300/21 ,  C08J2371/02 ,  C08L2203/02 ,  A61L27/20 ,  C08L5/16 ,  A61L15/28 ,  C08L5/16 ,  A61L26/0023 ,  C08L5/16 ,  A61L27/18 ,  C08L71/02 ,  A61L15/26 ,  C08L71/02 ,  A61L26/0019 ,  C08L71/02

Abstract: Provided are supramolecular polypseudorotaxane hydrogel compositions and 3-D structures capable of reversible 3-D structural deformation which include (a) a solvent; (b) an at least partially linear polymer, where the polymer further comprises groups capable of covalent crosslinking between the polymers; (ii) at least one first macrocyclic ring which forms a pseudorotaxane with a polymer in the polymer network; and (iii) at least one second macrocyclic ring that does not form the pseudorotaxane. The hydrogel composition has a viscosity which allows for 3-D printing of the hydrogel to form a 3-D structure, and a storage (elastic) modulus after crosslinking that allows for the 3-D structure to undergo reversible 3-D structural deformation upon change of solvent conditions. Also provided are methods of manufacturing the compositions and 3-D structures.

公开(公告)号：US11672776B2

公开(公告)日：2023-06-13

申请号：US16026979

申请日：2018-07-03

Applicant: Nektar Therapeutics

Inventor： Antoni Kozlowski ,  Samuel P. McManus ,  Jennifer Riggs-Sauthier ,  Xiaoming Shen ,  Wen Zhang

IPC: A61K31/337 ,  A61K38/00 ,  A61K31/785 ,  C08G79/08 ,  A61K47/60 ,  A61K31/4745 ,  C08G65/332 ,  C08G65/333

CPC classification number: A61K31/337 ,  A61K31/4745 ,  A61K31/785 ,  A61K38/00 ,  A61K47/60 ,  C08G65/3328 ,  C08G65/33344 ,  C08G79/08

Abstract: Among other aspects, provided herein are multi-armed polymer conjugates comprising an alkanoate-linker, compositions comprising such conjugates, and related methods of making and administering the same. Methods of treatment employing such conjugates and related uses are also provided. The conjugates are prepared with high drug loading efficiencies.

公开(公告)号：US11639415B2

公开(公告)日：2023-05-02

申请号：US16867994

申请日：2020-05-06

Applicant: BATTELLE MEMORIAL INSTITUTE

Inventor： Ramanathan S. Lalgudi ,  Robert J. Cain

IPC: C08G12/00 ,  C08G2/00 ,  C08G61/04 ,  C08G59/16 ,  C08G59/32 ,  C08G65/332 ,  B65D23/02 ,  B65D25/14 ,  C09D177/00 ,  C09D179/02 ,  B05D7/14 ,  B05D7/22

Abstract: Provided are poly(AAG)-compositions, and corresponding coatings, foams, and coated articles. Also provided are methods for preparing the poly(AAG)-compositions and corresponding reagents including, e.g., polyol-AAG compositions. Coatings using the poly(AAG)-compositions may be useful for, e.g., replacing bisphenol-A cross-linked coatings used in food and beverage containers, coating metal articles, and the like.

公开(公告)号：US20220153683A1

公开(公告)日：2022-05-19

申请号：US17599172

申请日：2020-03-25

Applicant: NOF CORPORATION

Inventor： Akihide ONOZAWA ,  Takashi ICHIKAWA

IPC: C07C213/06 ,  C07C213/10 ,  C08G65/08 ,  C08G65/333 ,  C08G65/332 ,  C08G65/30

Abstract: The present invention provides a method for producing a hetero-type monodisperse polyethylene glycol, which includes a step (A) of carrying out a nucleophilic substitution reaction between a compound of the formula (2) and a compound of the formula (3) so as to satisfy the requirement of the expression (F1) to obtain a compound of the formula (4), a step (B) of carrying out the Michaels addition reaction of a compound of the formula (5) to the compound of the formula (4) at a temperature condition of 10° C. or lower to obtain a compound of the formula (6), a step (C) of detritylating or debenzylating the compound of the formula (6) to obtain a reaction product containing a compound of the formula (7), a step (D) of purifying the compound of formula (7) from the reaction product, a step (E) of reacting the compound of the formula (7) with phthalimide and performing dephthalimidation to obtain a compound of the formula (8), and a step (F) of subjecting the compound of formula (8) to an acid hydrolysis treatment to obtain a compound represented by the formula (1).

公开(公告)号：US11305018B2

公开(公告)日：2022-04-19

申请号：US16801014

申请日：2020-02-25

Applicant: Vanderbilt University

Inventor： Eva M. Harth ,  Dain B. Beezer ,  GuangZhao Li ,  Benjamin R. Spears ,  David M. Stevens

IPC: A61K47/32 ,  A61K47/34 ,  C08G65/22 ,  A61K9/00 ,  A61K9/50 ,  C08G64/42 ,  C08G65/00 ,  C08G65/26 ,  C08G65/332 ,  C08G65/334 ,  C08G65/34

Abstract: Disclosed herein are glycidol-based polymers, nanoparticles, and methods related thereto useful for drug delivery. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

公开(公告)号：US20220079936A1

公开(公告)日：2022-03-17

申请号：US17535385

申请日：2021-11-24

Applicant: Nektar Therapeutics

Inventor： Xuan Zhao ,  Michael D. Bentley ,  Zhongxu Ren ,  Tacey X. Viegas

IPC: A61K31/4745 ,  C08G65/331 ,  C08G65/332 ,  C08G65/333 ,  C08G65/334 ,  A61K47/59 ,  A61K47/61 ,  A61K47/64 ,  A61K31/4709 ,  A61K47/60

Abstract: Provided herein are water-soluble prodrugs, compositions comprising such prodrugs, and related methods of making and administering the same. The prodrugs of the invention comprise a water-soluble polymer having three or more arms, at least three of which are typically covalently attached to an active agent, e.g., a small molecule. The conjugates of the invention provide an optimal balance of polymer size and structure for achieving improved drug loading, since the conjugates of the invention possess three or more active agents releasably attached to a multi-armed water-soluble polymer. The prodrugs of the invention are therapeutically effective, and exhibit improved properties in-vivo when compared to unmodified parent drug.