公开(公告)号：US11787946B2

公开(公告)日：2023-10-17

申请号：US17300459

申请日：2021-07-06

申请人： HOWARD HUGHES MEDICAL INSTITUTE

发明人： Luke Lavis ,  Jonathan B. Grimm

IPC分类号： C09B11/24 ,  C07B59/00 ,  C09B47/04 ,  C09B6/00 ,  C09B3/14 ,  C09B57/00 ,  C09B1/00

CPC分类号： C09B11/24 ,  C07B59/002 ,  C09B1/00 ,  C09B3/14 ,  C09B6/00 ,  C09B47/04 ,  C09B57/001

摘要： The present invention is generally directed to the synthesis and use of fluorophores. It is more specifically directed to the synthesis and use of deuterated fluorophores. In one case, the present invention provides a compound of the structure shown in FIG. 44.

公开(公告)号：US20230272221A1

公开(公告)日：2023-08-31

申请号：US18111220

申请日：2023-02-17

申请人： Ultima Genomics, Inc.

发明人： Linda G. LEE ,  Steven MENCHEN

IPC分类号： C09B49/04 ,  C09B11/24 ,  C07H19/20

CPC分类号： C09B49/04 ,  C09B11/24 ,  C07H19/20

摘要： The present disclosure provides labeling reagents for labeling substrates such as nucleotides, proteins, antibodies, lipids, and cells. The labeling reagents provided herein may comprise fluorescent labels and semi-rigid linkers. Methods for nucleic acid sequencing using materials comprising such labeling reagents are also provided herein. Also provided are labeling reagents for labeling multiple substrates simultaneously using energy transfer.

公开(公告)号：US20230235218A1

公开(公告)日：2023-07-27

申请号：US18193299

申请日：2023-03-30

申请人： Saudi Arabian Oil Company

发明人： Wei Wang

IPC分类号： C09K11/06 ,  C09K8/035 ,  C09B67/00 ,  E21B47/11 ,  C09B11/22 ,  C09B11/24 ,  C09K8/62

CPC分类号： C09K11/06 ,  C09K8/035 ,  C09B68/4253 ,  E21B47/11 ,  C09B11/22 ,  C09B68/4235 ,  C09B68/463 ,  C09B11/24 ,  C09K8/62 ,  C09K2211/1007 ,  C09K2211/1018 ,  C09K2211/1014

摘要： A composition includes a functionalized fluorescent dye. The functionalized fluorescent dye includes an isothiocyanate-containing dye that is functionalized with a functional group. The functional group includes a primary amine. The functionalized fluorescent dye can be mixed with a fluid to form a tracer fluid for tracing fluid flow in a subterranean formation.

公开(公告)号：US20230167303A1

公开(公告)日：2023-06-01

申请号：US17942127

申请日：2022-09-10

申请人： INDIANA UNIVERSITY RESEARCH AND TECHNOLOGY CORPORATION ,  UNIVERSITY OF COPENHAGEN

发明人： Amar H. Flood ,  Bo Wegge Laursen

IPC分类号： C09B11/24 ,  C09B23/01 ,  C09B57/00 ,  C09B19/00 ,  C09K11/06 ,  C09K11/02 ,  G01N1/30

CPC分类号： C09B11/24 ,  C09B23/0091 ,  C09B57/00 ,  C09B19/00 ,  C09B23/0075 ,  C09K11/06 ,  C09K11/02 ,  G01N1/30 ,  C09K2211/1018 ,  C09K2211/1007 ,  G01N2001/302

摘要： The present disclosure concerns the design, formulations, preparations and optical properties of compounds of Formulas (I) and (VI):


(charged dyem+)x·(counterionn−)y·(counterion receptor)z  (I) and



(charged dyem−)x·(counterionn+)y·(counterion receptor)z  (VI).

The charged dyem+ is a cationic dye, counterionn− is an anion, and counterion receptor is a binding ligand for the counterionn−, wherein m, n, x and y are integers greater than or equal to 1, and products of x·n and m·y are identical for formula (I).
The charged dyem− is a anionic dye, counterionn+ is a cation, and counterion receptor is a binding ligand for the counterionn+, wherein m, n, x and y are integers greater than or equal to 1, and products of x·n and m·y are identical for formula (VI).

公开(公告)号：US11572485B2

公开(公告)日：2023-02-07

申请号：US16776717

申请日：2020-01-30

申请人： Seiko Epson Corporation

发明人： Shintaro Hama ,  Tomohiro Aruga ,  Kiyomi Kumamoto ,  Yusuke Mizutaki

IPC分类号： C09D11/037 ,  C09D11/36 ,  C09D11/40 ,  C09D11/322 ,  C09D11/328 ,  C09B11/24 ,  C09B29/46 ,  C09B35/03 ,  C09B35/025 ,  C09B47/24 ,  C09D11/033

摘要： An ink set includes a pigment ink, containing a pigment, and a dye ink containing the compound represented by formula (y-1) below or a salt thereof.

公开(公告)号：US11548909B2

公开(公告)日：2023-01-10

申请号：US15928562

申请日：2018-03-22

申请人： IsoPlexis Corporation

发明人： Mong Sano Marma ,  Jerzy Olejnik ,  Ilia Korboukh

IPC分类号： C12P19/34 ,  C07H19/10 ,  C07F7/18 ,  C07C323/12 ,  C09B11/24 ,  C09B23/08 ,  C07H19/14 ,  C09B1/00 ,  C09B5/24 ,  C09B23/16 ,  C12Q1/6869 ,  C12Q1/6876 ,  C07C323/60 ,  C07D207/46 ,  C12Q1/6811

摘要： The present invention provides methods, compositions, mixtures and kits utilizing deoxynucleoside triphosphates comprising a 3′-O position capped by a group comprising methylenedisulfide as a cleavable protecting group and a detectable label reversibly connected to the nucleobase of said deoxynucleoside. Such compounds provide new possibilities for future sequencing technologies, including but not limited to Sequencing by Synthesis.

公开(公告)号：US20220380845A1

公开(公告)日：2022-12-01

申请号：US17299671

申请日：2019-12-20

申请人： Life Technologies Corporation

发明人： Brian EVANS ,  Scott BENSON

IPC分类号： C12Q1/6876 ,  C09B11/24 ,  C07H21/00

摘要： The present disclosure relates to N-protected NH-rhodamine dyes and their use in nucleic acid detection. In particular, the disclosure relates to methods of making N-protected NH-rhodamine dyes, and methods of use of N-protected NH-rhodamine dyes (e.g., human identification). Certain dyes provided herein have unique spectral properties that complement those in existing dye sets and can be used to expand the number of reporter dyes that can be included for HID applications and other biological assays. Those fluorescent compounds are useful to label synthetic oligonucleotides. Formula (I).

公开(公告)号：US20220372297A1

公开(公告)日：2022-11-24

申请号：US17869366

申请日：2022-07-20

申请人： Sony Corporation

发明人： Tracy Matray ,  Hesham Sherif ,  C. Frederick Battrell

IPC分类号： C09B3/14 ,  C09B5/62 ,  C09B11/24 ,  C09B57/00 ,  C09B57/08 ,  C09B69/10 ,  C07F9/09 ,  C07F9/576 ,  C07F9/655 ,  C07H21/04 ,  C09B1/00 ,  G01N33/58

摘要： Compounds useful as fluorescent or colored dyes are disclosed. The compounds have the following structure (I): including stereoisomers, salts and tautomers thereof, wherein R1, R2, R3, L1, L2, L3, L4, L5, L6, M1, M2, A, q, w and n are as defined herein. Methods associated with preparation and use of such compounds are also provided.

公开(公告)号：US11434374B2

公开(公告)日：2022-09-06

申请号：US17190199

申请日：2021-03-02

申请人： Sony Corporation

发明人： Tracy Matray ,  Hesham Sherif ,  C. Frederick Battrell

IPC分类号： C09B3/14 ,  C09B5/62 ,  C09B11/24 ,  C09B57/08 ,  C07H21/04 ,  C09B1/00 ,  C09B57/00 ,  C09B69/10 ,  C07F9/09 ,  C07F9/576 ,  C07F9/655 ,  G01N33/58

摘要： Compounds useful as fluorescent or colored dyes are disclosed. The compounds have the following structure (I): including stereoisomers, salts and tautomers thereof, R1, R2, R3, L1, L2, L3, L4, L5, L6, M1, M2, A, q, w and n are as defined herein. Methods associated with preparation and use of such compounds are also provided.

公开(公告)号：US20220162251A1

公开(公告)日：2022-05-26

申请号：US17360427

申请日：2021-06-28

申请人： IsoPlexis Corporation

发明人： Mong Sano MARMA ,  Jerzy Olejnik ,  Ilia Korboukh

IPC分类号： C07H19/10 ,  C07F7/18 ,  C07C323/12 ,  C09B11/24 ,  C09B23/08 ,  C07H19/14 ,  C09B1/00 ,  C09B5/24 ,  C09B23/16 ,  C12Q1/6869 ,  C12Q1/6876 ,  C07C323/60 ,  C07D207/46 ,  C12Q1/6811

摘要： The present invention provides methods, compositions, mixtures and kits utilizing deoxynucleoside triphosphates comprising a 3′-O position capped by a group comprising methylenedisulfide as a cleavable protecting group and a detectable label reversibly connected to the nucleobase of said deoxynucleoside. Such compounds provide new possibilities for future sequencing technologies, including but not limited to Sequencing by Synthesis.