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2.发明授权Random peptides that bind to gastro-intestinal tract (GIT) transport receptors and related methods 失效结合胃肠道（GIT）转运受体的随机肽和相关方法公开(公告)号：US06703362B1
公开(公告)日：2004-03-09
申请号：US09079723
申请日：1998-05-15
申请人： Vernon L. Alvarez , Daniel J. O'Mahony , Imelda J. Lambkin , Catherine A. Patterson , Judith Singleton , Benjamin A. Belinka, Jr. , John M. Carter , Gerard M. Cagney
发明人： Vernon L. Alvarez , Daniel J. O'Mahony , Imelda J. Lambkin , Catherine A. Patterson , Judith Singleton , Benjamin A. Belinka, Jr. , John M. Carter , Gerard M. Cagney
IPC分类号： C12D2106
CPC分类号： C07K7/08 , A61K38/00 , C07K1/047 , C07K5/1013 , C07K5/1016 , C07K14/001
摘要： This invention relates to proteins (e.g., peptides) that are capable of facilitating transport of an active agent through a human or animal gastro-intestinal tissue, and derivatives (e.g., fragments) and analogs thereof, and nucleotide sequences coding for said proteins and derivatives. The proteins of the invention have use in facilitating transport of active agents from the lumenal side of the GIT into the systemic blood system, and/or in targeting active agents to the GIT. Thus, for example, by binding (covalently or noncovalently) a protein of the invention to an orally administered drug, the drug can be targeted to specific receptor sites or transport pathways which are known to operate in the human gastrointestinal tract, thus facilitating its absorption into the systemic system.
摘要翻译： 本发明涉及能够促进活性剂通过人或动物胃肠组织及其衍生物（例如片段）及其类似物以及编码所述蛋白质和衍生物的核苷酸序列的蛋白质（例如肽） 。 本发明的蛋白质用于促进活性剂从GIT的内腔侧输送到全身血液系统中，和/或将活性剂靶向GIT。 因此，例如，通过将本发明的蛋白质（共价或非共价）结合到口服给药的药物，该药物可以靶向已知在人胃肠道中操作的特异性受体位点或转运途径，从而有助于其吸收 进入系统系统。
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公开(公告)号：US06187561B1
公开(公告)日：2001-02-13
申请号：US09210009
申请日：1998-12-11
IPC分类号： C12D2106
摘要： The invention provides hisS polynucleotides which encode hisS polypeptide, polynucleotides related thereto, and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing the hisS polynucleotides and polypeptides to screen for antibacterial compounds and for the detection of pathogens.
摘要翻译： 本发明提供了编码hisS多肽的HisS多核苷酸，与其相关的多核苷酸，以及通过重组技术产生此类多肽的方法。 还提供了利用hisS多核苷酸和多肽筛选抗菌化合物和检测病原体的方法。
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公开(公告)号：US06387656B1
公开(公告)日：2002-05-14
申请号：US09162524
申请日：1998-09-29
IPC分类号： C12D2106
CPC分类号： C07K14/47 , A01K2217/05
摘要： This invention provides an isolated nucleic acid molecule encoding a motor neuron restricted pattern, MNR2, protein. This invention provides an isolated nucleic acid molecule of at least 15 contiguous nucleotides capable of specifically hybridizing with a unique sequence included within the sequence of the nucleic acid molecule encoding a MNR2 protein. This invention provides a purified MNR2 protein, a polyclonal and monoclonal antibody directed to an epitope of an MNR2 protein. This invention provides a method of inducing differentiation somatic motor neurons which comprises expressing MNR2 protein in any neural progenitor cells. This invention provides a transgenic animal which expresses an MNR2 protein. This invention provides a pharmaceutical composition comprising a MNR2 protein and pharmaceutically acceptable carrier. This invention provides methods of treating subjects afflicted with an abnormality associated with a lack of normally functioning motor neurons, neurodegenerative disease, an acute nervous system injury and a neuromuscular disease which comprises contacting the subject with a pharmaceutical composition comprising a MNR2 protein and pharmaceutically acceptable carrier. This invention provides a functionally equivalent analog of MNR2 that induces or prevents MNR2 differentiation of neural progenitor cells.
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公开(公告)号：US06346395B1
公开(公告)日：2002-02-12
申请号：US09239052
申请日：1999-01-27
申请人： Alison Francis Chalker , Christine Debouck , David John Holmes , Karen Anne Ingraham , Deborah Dee Jaworski , Anna Lisa Kosmatka , Damien McDevitt , Jeffrey Mooney , Stewart C Pearson , Chi Yong So , Nicola Gail Wallis , Min Wang , Richard Lloyd Warren , Yi Yi Zhong
发明人： Alison Francis Chalker , Christine Debouck , David John Holmes , Karen Anne Ingraham , Deborah Dee Jaworski , Anna Lisa Kosmatka , Damien McDevitt , Jeffrey Mooney , Stewart C Pearson , Chi Yong So , Nicola Gail Wallis , Min Wang , Richard Lloyd Warren , Yi Yi Zhong
IPC分类号： C12D2106
CPC分类号： C12N9/0006 , A61K38/00 , C12Y101/011
摘要： The invention provides FabG polypeptides and polynucleotides encoding FabG polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing FabG polypeptides to screen for antibacterial compounds.
摘要翻译： 本发明提供了FabG多肽和编码FabG多肽的多核苷酸以及通过重组技术产生此类多肽的方法。 还提供了利用FabG多肽筛选抗菌化合物的方法。
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