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公开(公告)号：US20230117671A1
公开(公告)日：2023-04-20
申请号：US17962965
申请日：2022-10-10
IPC分类号： C12M1/00 , B01D5/00 , C12M1/06 , C12M1/12 , F28F21/06 , B01F23/233 , B01F23/231 , B01F27/88 , B01F27/90 , B01F27/91 , B01F27/2121 , B01F35/51 , B01F35/92 , B01F35/10 , B01F35/513 , B01D47/05 , C12N1/10 , C12N1/12 , C12N1/14 , C12N1/20 , C12N5/00 , C12N5/04 , C12M1/02 , F28B1/02 , F28F3/12
摘要： A bag assembly for use with a heat exchanger includes a flexible bag having of one or more sheets of polymeric material, the bag having a first end that bounds a first compartment and an opposing second end that bounds a second compartment, a support structure being disposed between the first compartment and the second compartment so that the first compartment is separated and isolated from the second compartment. A first inlet port, a first outlet port, and a first drain port are coupled with the flexible bag so as to communicate with the first compartment. A second inlet port, a second outlet port, and a second drain port are coupled with the flexible bag so as to communicate with the second compartment.
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公开(公告)号：US11629327B2
公开(公告)日：2023-04-18
申请号：US16487854
申请日：2018-02-20
发明人： Ohad Bashan , Oded Bashan , Stephen Drummey
IPC分类号： B01F35/22 , C12M1/36 , C12M1/00 , C12M1/06 , C12M1/34 , B01F23/20 , B01F23/231 , B01F35/21 , B01F35/221 , B01F101/44
摘要： An algae cultivation system may include: a plurality of panels within a cultivation container, positioned along a first axis perpendicular to the gravitational force, wherein a cultivation volume is created between each pair of panels, and wherein the cultivation volumes are fluidly coupled so as to allow horizontal flow therebetween along the first axis; at least one first sparger, to distribute a first fluid into the container at a first operating flow rate; at least one second sparger, to distribute a second fluid into the container at a second operating flow rate; and at least one controller, to control the first operating flow rate and the second operating flow rate. The first operating flow rate may be adapted to allow turbulent mixing the algae in the cultivation container, and the second operating flow rate may be adapted to allow assimilation of materials in a liquid in the cultivation container.
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公开(公告)号：US11629322B2
公开(公告)日：2023-04-18
申请号：US16466670
申请日：2017-12-04
IPC分类号： C12M1/06 , B01F23/233 , B01F27/191 , B01F27/053 , B01F27/1111 , B01F27/1125 , B01F33/453 , B01F35/92 , B01F35/513 , B01F35/90 , B01F101/44
摘要： An impeller, for example, a Rushton impeller for a bioreactor system is disclosed. The impeller includes a hub, optionally including a slot, a plurality of blades, and one or more turbulators. The plurality of blades is disposed along a circumferential direction of the hub and spaced apart from each other. Each of the plurality of blades is coupled to at least a portion of a circumference and/or a top surface of the hub. Each blade of the plurality of blades includes a pressure face and a suction face. The one or more turbulators is disposed on at least a portion of the suction face, the pressure face, or both, of a blade of the plurality of blades.
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公开(公告)号：US20230065504A1
公开(公告)日：2023-03-02
申请号：US17930413
申请日：2022-09-07
发明人： Matthias WAGNER , Suvi AIVIO , Mariangela AMENDUNI , Catherine PILSMAKER , Arnaldo PEREIRA , Ananya ZUTSHI , Ozge WHITING , George HARB , Steven NAGLE , Anthia TOURE , Matthew SULLIVAN , Maya BERLIN-UDI , Lukas VASADI , Alexander STANGE , Sangkyun LEE , Stefanie MORGAN , Nick SEAY , Scott LURO
IPC分类号： B01L3/00 , C12M1/00 , C12M3/00 , C12M1/12 , C12M1/06 , C12M1/34 , C12M1/36 , C12N5/00 , G01N15/10 , G06T7/00
摘要： Disclosed herein are platforms, systems, and methods including a cell culture system that includes a cell culture container comprising a cell culture, the cell culture receiving input cells, a cell imaging subsystem configured to acquire images of the cell culture, a computing subsystem configured to perform a cell culture process on the cell culture according to the images acquired by the cell imaging subsystem, and a cell editing subsystem configured to edit the cell culture to produce output cell products according to the cell culture process.
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公开(公告)号：US20230042475A1
公开(公告)日：2023-02-09
申请号：US17968217
申请日：2022-10-18
申请人： STOBBE GMBH
发明人： Per STOBBE
摘要： A Disposable Bioprocess System including a Single-Use-Bioreactor, a Single-Use-Pump and a single-use micro-organism retention filter. Combined most suitable for cultivation of suspended micro-organisms in a liquid media at high micro-organism concentration in a perfusion mode continuous process for expression of biological material. The inlet port of the liquid Single-Use-Pump connects via a valve to the broth reservoir of the Single-Use-Bioreactor through a liquid conveying port. The outlet port of the liquid pumping Single-Use-Pump connects via a valve to a micro-organism retention filter. And a method for operating said sterile Disposable Bioprocess System in perfusion mode for continuously processing.
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公开(公告)号：US11566215B2
公开(公告)日：2023-01-31
申请号：US16863220
申请日：2020-04-30
申请人： 3D Biotek, LLC
发明人： Zongsen Wang , Wing Lau , Faribourz Payvandi , Peng Yue , Azadeh Jadali , Peter Materna
摘要： A bioreactor for culturing of cells is described. Screens suitable as a cell growth scaffold may comprise crossed fibers. Screens may be contained loosely in a screen holder, which in turn may be contained inside a manifold assembly. A lower manifold, screen holder and upper manifold may have identical or similar interior open cross-sections. Flow of liquid medium can occur upwardly through the array of screens, then flowing over a weir in the presence of an air pocket, and into a moat and a pump. The screen holder may have slots whose exterior-facing ligaments are rounded, and may have grooves whose interior-facing edges are rounded. These components may be located inside an incubator suitable to maintain desired environmental conditions and cleanliness.
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公开(公告)号：US20230016345A1
公开(公告)日：2023-01-19
申请号：US17863868
申请日：2022-07-13
申请人： ITility, L.L.C.
发明人： Pete SLOAD , Erik OVERBY , Benjamin FRANK , Kevin LAUER , Eric WALBERG
摘要： There is disclosed a modular anaerobic digestion point-of-waste to renewable energy system. The system is directed to a modular and scalable anaerobic digestion system for point-of-waste use. The System includes a pretreatment process for removing inhibitory nutrients from a feedstock, an in-treatment process for providing clean renewable energy and a post-treatment process for further providing clean renewable energy for subsequent use. The System includes a leaching bed; a liquids tank; a mixing tank; an anaerobic digester reactor; a precipitation tank; a stripping tank; a hydrogen sulfide scrubber; a water remover; a gas bladder; a dewaterer; and a flare system.
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公开(公告)号：US20230002718A1
公开(公告)日：2023-01-05
申请号：US17757211
申请日：2020-12-11
发明人： Luis HAUPT , Julia HUPFELD
摘要： The present invention relates to a method of changing culture medium of a suspension culture, the suspension culture comprising cells suspended in the culture medium, the method comprising: (i) transferring a fraction of the suspension culture into a container, wherein the container comprises at least one opening at the bottom; (ii) allowing the cells comprised in the fraction of the suspension to settle at the at least one opening at the bottom of the container by gravitation, thereby forming a supernatant; (iii) dispensing the cells settled at the bottom of the container (back) into the suspension culture; (iv) discarding the supernatant.
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公开(公告)号：US20230001365A1
公开(公告)日：2023-01-05
申请号：US17781563
申请日：2020-12-02
申请人： Doo-Hyun Kim
发明人： Doo-Hyun Kim
摘要： The present invention relates to a bio-reaction stirrer using a magnetic force. According to an embodiment of the present invention, a driving coupling part is axially formed inside a housing part and a plurality of impellers are provided according to the height direction of the driving coupling part, and the respective impellers can be selectively driven as necessary, thereby efficiently stirring the entire inside of the housing part.
The changes to the abstract are shown below:
The present invention relates to a bio-reaction stirrer using a magnetic force. According to an embodiment of the present invention, a driving coupling part is axially formed inside a housing part and a plurality of impellers are provided according to the height direction of the driving coupling part, and the respective impellers can be selectively driven as necessary, thereby efficiently stirring the entire inside of the housing part.-
公开(公告)号：US20220411742A1
公开(公告)日：2022-12-29
申请号：US17847827
申请日：2022-06-23
摘要： The present disclosure relates to a device for liquid processing in the process of cell culture, comprises: a settling tank which is configured to store a cell culture fluid from a bioreactor; a communicating tube that allows the bioreactor to communicate with the settling tank; a first excretory tube for discharging a cell concentrate, which is connected to the settling tank; a second excretory tube for discharging a supernatant, which is connected to the settling tank; a pump; and a control unit. In such device, after the cell culture fluid is separated into the supernatant and the cell concentrate by the gravitational settling in the settling tank, the control unit is configured to control the pump to (a) return the supernatant to the bioreactor through the communicating tube and harvest the cell concentrate through the first excretory tube and/or (b) harvest the supernatant through the second excretory tube and return the cell concentrate to the bioreactor through the communicating tube.
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