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公开(公告)号：US11667874B2
公开(公告)日：2023-06-06
申请号：US16569852
申请日：2019-09-13
Applicant: Corning Incorporated
Inventor： Gregory Roger Martin , Allison Jean Tanner
CPC classification number: C12M23/12 , C12M1/14 , C12M3/04 , C12M23/16 , C12M25/14 , C12M29/10 , C12M1/00 , C12M3/00
Abstract: A cell culture apparatus includes one or more plates having a first major surface and an opposing second major surface. The first major surface comprises a structured surface defining a plurality of wells. Each well has an interior surface defining an upper aperture and a nadir, wherein the upper aperture of each well has a diametric dimension in a range from 100 micrometers to 2000 micrometers. The apparatus also includes a plurality of spacers extending from the first major surface along a length of the bottom surface. A plurality of flow channels are defined between adjacent rails.
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公开(公告)号：US20200148990A1
公开(公告)日：2020-05-14
申请号：US16569852
申请日：2019-09-13
Applicant: Corning Incorporated
Inventor： Gregory Roger Martin , Allison Jean Tanner
Abstract: A cell culture apparatus includes one or more plates having a first major surface and an opposing second major surface. The first major surface comprises a structured surface defining a plurality of wells. Each well has an interior surface defining an upper aperture and a nadir, wherein the upper aperture of each well has a diametric dimension in a range from 100 micrometers to 2000 micrometers. The apparatus also includes a plurality of spacers extending from the first major surface along a length of the bottom surface. A plurality of flow channels are defined between adjacent rails.
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公开(公告)号：US20190309250A1
公开(公告)日：2019-10-10
申请号：US15945000
申请日：2018-04-04
Applicant: Southwest Research Institute
Inventor： Jian LING
IPC: C12M1/12 , C12N5/0783 , C12M1/00 , C07K16/28 , C12M1/14
Abstract: The present invention relates to the application of a three-dimensional (3D) bioreactor for T-cell expansion for immunotherapy.
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公开(公告)号：US10222365B2
公开(公告)日：2019-03-05
申请号：US15959841
申请日：2018-04-23
Applicant: Icahn School of Medicine at Mount Sinai
Inventor： Dac Nguyen , Basil Hanss
IPC: C12M1/14 , G01N33/92 , G01N33/48 , G01N33/483 , G01N33/487 , C12M1/00 , G01N27/453 , C12N15/88 , G01N21/77 , B01L3/00 , G01N33/00 , A61K9/127
Abstract: A method for forming a droplet interface bilayer (DIB) comprises the steps of: (1) providing an assembly that includes a housing contained within an enclosure, wherein the housing includes at least one aperture that comprises a cis portion and a trans portion, at least one cis electrode receptacle and at least one trans electrode receptacle, wherein the cis electrode receptacle is operatively connected to the cis portion, and the trans electrode receptacle is operatively connected to the trans portion; (2) inserting an electrode into each of the cis and trans electrode receptacles; (3) introducing an oil/lipid phase to the enclosure such that the oil/lipid phase flows into the housing through the aperture; (4) delivering at least two aqueous droplets to the oil/lipid phase in such a manner that at least one aqueous droplet is disposed within the cis portion of the aperture and at least one aqueous droplet is disposed within the trans portion of the aperture; and (5) lowering a level of the oil/lipid phase in the cis and trans portions of the aperture to cause the aqueous droplets in the cis and trans portions to expand and move closer to one another until the aqueous droplets contact one another thereby forming the lipid bilayer at the location at which the aqueous droplets contact one another.
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公开(公告)号：US10138455B2
公开(公告)日：2018-11-27
申请号：US15071144
申请日：2016-03-15
Applicant: Billups-Rothenberg, Inc.
Inventor： Barry E. Rothenberg
Abstract: A incubator chamber comprises a base, lid and plurality of trays, each of which are stackable upon one another in an open or closed configuration. A clamp could be provided having an interior cavity sized and dimensioned to simultaneously receive a portion of a perimeter of each of a base and a lid.
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公开(公告)号：US20180100131A1
公开(公告)日：2018-04-12
申请号：US15566427
申请日：2016-04-26
Applicant: 3M INNOVATIVE PROPERTIES COMPANY
Inventor： Evan D. Brutinel , Mary B. Forester , Adam J. Stanenas , Jason W. Bjork
CPC classification number: C12M1/045 , C12M1/005 , C12M1/007 , C12M1/14 , C12M23/14 , C12M23/22 , C12M25/02 , C12M25/06 , C12M41/34 , C12M41/36 , C12N1/20 , C12Q1/04
Abstract: A device for culturing anaerobic microorganisms is provided. The device comprises a body comprising a waterproof base, a waterproof coversheet attached to the base, and a growth compartment disposed between the base and the coversheet. The growth compartment has a perimeter and an opening that provides liquid access to the growth compartment. A portion of the perimeter is defined by a waterproof seal. The portion includes >50% of the perimeter. A dry cold water-soluble gelling agent is adhered to the base in the growth compartment. A dry first oxygen-scavenging reagent is disposed in the growth compartment.
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公开(公告)号：US09932551B2
公开(公告)日：2018-04-03
申请号：US15463448
申请日：2017-03-20
Applicant: CPSI Holdings, LLC
Inventor： John G. Baust , Joshua T. Smith , Kimberly L. Santucci , Kristi K. Snyder , Anthony T. Robilotto , Robert G. Van Buskirk , John M. Baust , William L. Corwin , Jennie F. McKain
CPC classification number: C12M21/08 , C12M25/06 , C12M25/14 , C12M27/00 , C12M29/00 , C12N5/0062 , C12N5/0068 , C12N5/0697 , C12N2537/00 , G01N33/5008 , G01N33/5017
Abstract: A tissue engineered model (TEM) structure, an apparatus and method for making a TEM structure, and methods of using a TEM structure are disclosed. In an embodiment, the TEM structure includes at least one TEM segment. Each TEM segment includes a frame defining a bounded area, the frame having a height, a first edge, and a second edge opposite the first edge, each of the first edge and the second edge defining a perimeter of the bounded area, and the height defining a distance between the first edge and the second edge; a membrane affixed to the first edge about a perimeter of the frame; and a solidified gel and cell matrix disposed within the bounded area within the frame, wherein the solidified gel and cell matrix substantially fills a volume defined by the bounded area and the height of the frame.
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8.发明授权Conditioning chamber for storing samples in a time-controlled manner and method for storing samples in a time-controlled manner 有权用于以时间控制的方式存储样品的调节室和用于以时间控制的方式存储样品的方法
公开(公告)号：US09562214B2
公开(公告)日：2017-02-07
申请号：US13885149
申请日：2011-11-17
Applicant: Klaus-Guenter Eberle , Gavin Clarke
Inventor： Klaus-Guenter Eberle , Gavin Clarke
IPC: C12M1/00 , C12M3/00 , C12M1/14 , C12M3/04 , C12M1/26 , B01L1/02 , G01N35/00 , C12M1/22 , B01L7/00 , G01N35/02 , G01N35/04
CPC classification number: C12M33/00 , B01L1/025 , B01L7/00 , C12M23/10 , C12M23/48 , C12M23/50 , C12M41/14 , C12M45/22 , G01N35/00 , G01N35/0099 , G01N35/025 , G01N2035/00356 , G01N2035/00445 , G01N2035/0093 , G01N2035/0427 , G01N2035/0441 , G01N2035/0455 , G01N2035/0465
Abstract: The invention relates to an air-conditioning space (10) for storing samples in a time-controlled manner, comprising a device (22) for automatically feeding sample containers (18) into a climatically sealed space (12) having at least one wall (43), into which a sample container (18) can be inserted into the climatically sealed space (12) through an opening (40, 42), wherein the feed device (22) has at least one drive and control unit, and an incubator receptacle (30) for receiving the samples (18) is provided inside the climatically sealed space (12). The invention is distinguished by the fact that the feed device has an automatic feed arm (22, 24) which grips a sample container (18) from a receiving position outside the climatically sealed space (12) and deposits the sample container (18) there in a clear deposit position in an incubator receptacle (30).
Abstract translation: 本发明涉及一种用于以时间控制的方式存储样品的空调空间（10），包括用于将样品容器（18）自动供给到具有至少一个壁的气候密封空间（12）中的装置（22） 43），其中样品容器（18）可以通过开口（40,42）插入气候密封空间（12）中，其中进料装置（22）具有至少一个驱动和控制单元，以及培养箱 设置在气候密封空间（12）内的用于接收样品（18）的容器（30）。 本发明的区别在于进料装置具有自动进料臂（22,24），该自动进料臂将样品容器（18）从位于气候密封空间（12）外部的接收位置夹持并将样品容器（18）沉积在那里 在培养箱容器（30）中处于清楚的沉积位置。
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公开(公告)号：US08329457B2
公开(公告)日：2012-12-11
申请号：US12593864
申请日：2008-03-28
Applicant: Jung Keug Park , Sung Koo Kim , Suk Koo Lee , Young-Jin Kim , Doo-Hoon Lee , Ji-Hyun Lee , Hee-Hoon Yoon , Jae-Nam Ryu , Choon-Hyuck Kwon , Jeong-Kwon Noh , Hey-Jung Park
Inventor： Jung Keug Park , Sung Koo Kim , Suk Koo Lee , Young-Jin Kim , Doo-Hoon Lee , Ji-Hyun Lee , Hee-Hoon Yoon , Jae-Nam Ryu , Choon-Hyuck Kwon , Jeong-Kwon Noh , Hey-Jung Park
CPC classification number: A61M1/3472 , A61M1/1698 , A61M1/3489 , C12N5/0671 , C12N2533/74
Abstract: The present invention discloses a bioartificial liver system comprising a fixed-bed bioreactor packed with gel beads containing hepatocytes of an animal, a plasma reservoir, a plasma separator, and an efflux chamber, wherein the plasma reservoir is located at a position higher than the bioreactor, a ventilation filter in contact with atmosphere is provided at the top of the plasma reservoir, and the top of the plasma reservoir is directly connected to the efflux chamber via a connecting line. The inventive system satisfactorily performs the essential liver functions without the problems of gel bead damage or channeling.
Abstract translation: 本发明公开了一种生物人造肝系统，其包括固定床生物反应器，该固定床生物反应器填充有含有动物肝细胞，血浆储存器，血浆分离器和流出室的凝胶珠，其中等离子体储存器位于高于生物反应器 在等离子体容器的顶部设置有与气氛接触的通风过滤器，并且等离子体容器的顶部经由连接线直接连接到流出室。 本发明的系统令人满意地执行必要的肝功能，而没有凝胶珠损伤或引流的问题。
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公开(公告)号：US20120244611A1
公开(公告)日：2012-09-27
申请号：US13082707
申请日：2011-04-08
Applicant: James BRANHAM
Inventor： James BRANHAM
IPC: C12M1/14
CPC classification number: C05F17/0009 , C05F17/0205 , Y02P20/145 , Y02W30/43
Abstract: A vermicomposting device for vermicomposting organic material, comprises a casing including an annular hollow body member defining an internal cavity, a head member mounted to an upper end portion of the body member and a base member removably attached to a lower end portion of the body member, and a plurality of composting trays removably disposed within the internal cavity in a stacked relationship. Each of the composting trays is an open top tray including a circular perforated bottom wall surrounded by an annular side wall upwardly extending from the perforated bottom wall. The base member includes a support portion and a drip bucket disposed under the composting trays to receive and collect any liquid byproduct from the vermicomposting process. The head member is movable relative to the body member so as to provide an access to the internal cavity of the body member.
Abstract translation: 一种用于捣碎有机材料的捣碎装置，包括壳体，其包括限定内腔的环形中空本体构件，安装到主体构件的上端部的头构件和可移除地附接到主体构件的下端部的基座构件 ，以及以堆叠的关系可拆卸地设置在内部空腔内的多个堆肥托盘。 每个堆肥托盘是一个敞开的顶部托盘，其中包括圆形穿孔的底壁，该圆形穿孔的底壁被从穿孔底壁向上延伸的环形侧壁包围。 基部构件包括设置在堆肥托盘下方的支撑部分和滴水桶，用于接收和收集来自蚯蚓生产过程的任何液体副产物。 头部构件相对于本体构件可移动，以便提供对本体构件的内部空腔的通路。
