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公开(公告)号：US20240360397A1
公开(公告)日：2024-10-31
申请号：US18647679
申请日：2024-04-26
申请人： CORNING INCORPORATED
发明人： Ye Fang , Anthony Glenn Frutos , Vasiliy Nikolaevich Goral , Joel Andrew Schultes , Elena Ravilievna Streltsova , Todd Michael Upton , Jennifer Lynn Weber
摘要： A cell culture bioreactor is disclosed that has a cell culture vessel with an interior reservoir to contain a cell substrate, an inlet fluidly connected to the reservoir, and an outlet fluidly connect to the reservoir. The bioreactor also has a sensor system for measuring impedance within the reservoir. The sensor system includes a pair of electrodes that are spaced apart from each other with at least a portion of the cell substrate disposed between the pair of electrodes. Each electrode of the pair of electrodes includes a plurality of pores to allow at least one of cells and culture media to flow through the electrode.
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公开(公告)号：US20240352503A1
公开(公告)日：2024-10-24
申请号：US18685453
申请日：2023-03-30
发明人： Kentaro TSUDA , Hisato TAMIYA
摘要： For providing a method for estimating a microbial growth rate in food that is capable of rapidly and non-destructively evaluating shelf life of food (e.g., best-by date) and the like while reducing cost and labor associated with the evaluation, the present disclosure includes: a step of placing a hydrophilic membrane filter on a surface of a food sample, and inoculating microorganisms on the hydrophilic membrane filter; a step of imaging the microorganisms growing on the hydrophilic membrane filter over time using a microscope; a step of digitizing area of the microorganisms from the image taken over time; and a step of estimating a growth rate of the microorganisms based on the digitized data.
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公开(公告)号：US20240352398A1
公开(公告)日：2024-10-24
申请号：US18642596
申请日：2024-04-22
申请人： Ecovative Design LLC
CPC分类号： C12M41/48 , C12M29/06 , C12M35/02 , C12M41/12 , C12M41/34 , C12M41/40 , C12N1/14 , C12R2001/645
摘要： A method of growing an extra-particle aerial mycelium employs electrostatically charged mist to control mist deposition uniformity in a growth environment, and on a growth matrix (or growing extra-particle aerial mycelium on a growth matrix) comprising nutritive substrate and a fungus in a growth environment with a predetermined environment of humidity, temperature, carbon dioxide, and oxygen. Control of mist deposition by electrostatically charging mist allows for control of the morphology and uniformity of the extra-particle aerial mycelium produced, independent of airflow uniformity, growth environment size, and structural obstacles that may be present within a growth environment. Control of mist deposition by electrostatically charging mist also offers the potential for targeted mist application where it might be needed most for fungal organism growth.
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4.发明公开公开(公告)号：US20240352397A1
公开(公告)日：2024-10-24
申请号：US18763141
申请日：2024-07-03
发明人： Tomoro DAN , Hiroaki KII , Takayuki UOZUMI , Yoshiko SATO , Shinsuke YOSHIDA
摘要： A passage timing calculation device includes a processor and a memory encoded with instructions executed by the processor, wherein the instructions causing the processor to perform operations comprising calculating a time change in an area occupied by an extraction target region that is a region in which a striated pattern appears from a plurality of images of pluripotent stem cells captured at different times, detecting a change point of the time change in an area occupied by the extraction target region, and calculating a passage timing of the pluripotent stem cells on the basis of the change point.
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公开(公告)号：US20240344014A1
公开(公告)日：2024-10-17
申请号：US18635861
申请日：2024-04-15
发明人： Qi HUANG , Lena SMIRNOVA , David H. GRACIAS
摘要： A device for electrically connecting with and holding organoids includes a substrate and a multielectrode array (MEA) attached to said substrate. The MEA includes an electrical bus attached to the substrate, and a plurality of leaflets each having a first end pivotably connected to the electrical bus while remaining portions thereof are free to move relative to the substrate while remaining connected and pivoting at each first end. Each leaflet of the plurality of leaflets includes an electrical wire embedded therein that extends from each respective leaflet into the electrical bus. The MEA has a size that is suitable to electrically connect to and hold an organoid that is between 250 μm to 2 cm while at least one leaflet of the plurality of leaflets is pivoted up away from the substrate so as to securely hold the organoid in place and form a three-dimensional electrical connection with the organoid.
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公开(公告)号：US12117381B2
公开(公告)日：2024-10-15
申请号：US15894570
申请日：2018-02-12
发明人： Daniel Lapen , David Zahniser , Mark Licari , Brian J. McKeen , Eric D. Yeaton , Dennis Poole , Stephen Conroy
CPC分类号： G01N1/312 , G01N35/00029
摘要： The apparatus disclosed herein features a substrate arm and gripper, a platform having a top surface located opposite the substrate when the substrate arm is in a specimen processing position and featuring at least one fluid port located on a surface of the platform facing the substrate and at least one vacuum port located on the surface of the platform facing the substrate, and during operation, the apparatus is configured to (a) dispense a first quantity of fluid from the at least one fluid port to fill a separation between the substrate and the platform, (b) dispense an additional quantity of fluid from the at least one fluid port into the separation to displace a portion of the first quantity of fluid, and (c) remove the portion of the first quantity of fluid from the separation through the at least one vacuum port.
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公开(公告)号：US20240335776A1
公开(公告)日：2024-10-10
申请号：US18748880
申请日：2024-06-20
申请人： Repligen Corporation
发明人： Rudolf Pavlik , Ralf Kuriyel
CPC分类号： B01D35/26 , B01D29/11 , B01D29/66 , B01D29/902 , B01D29/908 , B01D65/02 , B01D69/08 , C12M29/16 , C12M41/44 , B01D2201/165 , B01D2321/04 , B01D2321/12
摘要： A fluid filtration system includes a fluid storage vessel such as a bioreactor, a filter housing including a filter element disposed therein, a pump coupled between the fluid storage vessel and the filter housing, and a flow diverter disposed between the pump and the filter housing. The pump is configured to move fluid from the fluid storage vessel through the filter element, and the flow diverter is configured for selectively directing fluid received from the pump to the first or second end of the filter housing. In a first mode of operation, the flow diverter directs flow through the filter housing in a first direction, while in a second mode of operation, the flow diverter directs flow through the filter housing in a second direction opposite the first direction.
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公开(公告)号：US20240327778A1
公开(公告)日：2024-10-03
申请号：US18739392
申请日：2024-06-11
申请人： PBS BIOTECH, INC.
发明人： Chanyong Brian Lee
CPC分类号： C12M41/48 , C12M23/24 , C12M23/28 , C12M23/34 , C12M27/02 , C12M29/08 , C12M41/26 , C12M41/34
摘要： Systems and methods for treating media in large-scale bioreactors can include a method of using a large-scale bioreactor system. The method can include (a) mixing a mixture of at least cells, and media in a bioreactor, and (b) removing a portion of the media through an output port of the bioreactor. The method can also include (c) retaining the cells within the bioreactor using a screen covering the port. The method can also include (d) receiving a second media, which may in some examples include the portion of the first media removed from the bioreactor, into a media preparation container external to the bioreactor, (e) treating the second media within the media preparation container to produce oxygenated media within a threshold pH range, and (f) introducing the oxygenated media into the bioreactor using a return port of the bioreactor.
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公开(公告)号：US20240327777A1
公开(公告)日：2024-10-03
申请号：US18709000
申请日：2022-11-10
申请人： DSM IP ASSETS B.V.
发明人： Natalia CHRAPKOVA , Peter BECKER , Ted JOHANSON , Mikael JANSEN
摘要： A feed control system and related methods for a heterologous product, such as a human milk oligosaccharide, fermentation system are disclosed. The feed control system comprises a feed controller. The feed controller comprises a processor and an interface. The processor is configured to obtain a biomass content in a fermentation broth. The processor is configured to determine a carbon input parameter based on the biomass content. The processor is configured to control a carbon input to the fermentation broth according to the carbon input parameter.
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公开(公告)号：US20240318109A1
公开(公告)日：2024-09-26
申请号：US18575217
申请日：2022-07-15
发明人： Mark VARLEY , Sean SULLIVAN , Adrian Neil BARGH
摘要： A consumable (1) for a bioreactor system is provided. The consumable comprises a plurality of bioreaction vessels (2), each suitable for holding the contents of a bioreaction. The plurality of bioreaction vessels are provided as a single-piece construction, and each bioreaction vessel includes an agitator (4) configured to agitate the contents of the respective bioreaction vessel. Each agitator has a stirring end which extends into the bioreaction vessel and a drive end.
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