公开(公告)号：US20250000913A1

公开(公告)日：2025-01-02

申请号：US18690594

申请日：2022-09-09

Applicant: Regents of the University of Minnesota

Inventor： Daniel Alan Saltzman ,  Janet Louise Schottel ,  Lance Bischoff Augustin

IPC: A61K35/74 ,  A61K38/20 ,  A61P35/00 ,  C12N1/36 ,  C12N15/74

Abstract: Provided herein is the ability for intravenous delivery of bacteria without the septic side-effects and for delivery of immune modulating proteins that are systemically toxic to be delivered directly to the tumor micro-environment without any systemic toxicity.

公开(公告)号：US12180462B2

公开(公告)日：2024-12-31

申请号：US18320834

申请日：2023-05-19

Applicant: Wisconsin Alumni Research Foundation

Inventor： Adel M. Talaat

IPC: C12N1/20 ,  A61K39/00 ,  A61K39/04 ,  C07K14/195 ,  C07K14/35 ,  C12N1/36 ,  C12N15/10 ,  C12N15/113 ,  C12Q1/689 ,  C12R1/32 ,  G01N33/569

Abstract: Described herein is a mycobacterium mutant, comprising at least one mutation in at least one gene sequence encoding global gene regulators (GGRs) selected from the group consisting of sigH, sigL, sigE, ECF-1, and mixtures thereof, wherein the GGR gene is at least partially inactivated. Described herein also is a vaccine based on the mutant and a method of differentiating between subjects that have been infected with mycobacterium and subjects that have not been infected with mycobacterium or have been vaccinated with a mycobacterium vaccine.

公开(公告)号：US20240374656A1

公开(公告)日：2024-11-14

申请号：US18610886

申请日：2024-03-20

Applicant: Indaptus Therapeutics, Inc.

Inventor： Michael J. Newman

IPC: A61K35/74 ,  A61K31/664 ,  A61K39/00 ,  A61K39/108 ,  A61K39/112 ,  A61K39/395 ,  A61K45/06 ,  C12N1/20 ,  C12N1/36

Abstract: Provided herein are compositions comprising substantially non-viable Gram-negative bacterial organisms that have a substantial reduction in endotoxin activity and/or pyrogenicity and methods for treating a cancer using the same. Also provided are methods for treating cancer provided herein, comprising administering to a mammal diagnosed with cancer, substantially non-viable Gram-negative bacteria having a substantial reduction in endotoxin activity and/or pyrogenicity, in an amount sufficient to inhibit growth or metastasis of the cancer. An additional method is provided comprising administering viable or non-viable Gram-negative bacterial organisms that have a genetic defect that results in a substantial loss of lipopolysaccharide within the outer membrane of the bacteria. Further provided are methods for reducing endotoxin activity and/or pyrogenicity in Gram-negative bacteria comprising treatment with polymyxin and glutaraldehyde.

公开(公告)号：US12138952B2

公开(公告)日：2024-11-12

申请号：US18146158

申请日：2022-12-23

Applicant: Brown University

Inventor： Thomas J. Webster

IPC: B44C1/22 ,  A61M16/04 ,  C12N1/36 ,  C12N11/00 ,  C23F1/14

Abstract: The present invention is directed to methods for inhibiting growth of bacteria and to nanometer scale surfaces having antibacterial properties.

公开(公告)号：US20240115671A1

公开(公告)日：2024-04-11

申请号：US18276628

申请日：2022-02-09

Applicant: University of Massachusetts ,  Ernest Pharmaceuticals, Inc.

Inventor： Neil S. Forbes ,  Vishnu Raman ,  Nele Van Dessel ,  Jeanne A. Hardy

IPC: A61K38/48 ,  A61K35/74 ,  A61K38/46 ,  C12N1/20 ,  C12N1/36 ,  C12N9/16 ,  C12N9/64 ,  C12N15/74

CPC classification number: A61K38/4873 ,  A61K35/74 ,  A61K38/465 ,  C12N1/20 ,  C12N1/36 ,  C12N9/16 ,  C12N9/6472 ,  C12N15/74 ,  C12Y301/04 ,  C12Y304/22056 ,  C12N2800/101 ,  C12N2830/002

Abstract: Provided herein is a bacterial delivery platform that harnesses mechanisms unique to Salmonella to intracellularly deliver protein-based drugs.

公开(公告)号：US11904008B2

公开(公告)日：2024-02-20

申请号：US16985458

申请日：2020-08-05

Applicant: Elanco Tiergesundheit AG

Inventor： Klaus Linde ,  Anke Grosse-Herrenthey

IPC: A61K39/02 ,  A61K39/112 ,  A61K39/106 ,  A61K39/00 ,  C12N1/36

CPC classification number: A61K39/105 ,  A61K39/0275 ,  C12N1/36 ,  A61K2039/106 ,  A61K2039/522 ,  A61K2039/542 ,  A61K2039/55 ,  A61K2039/552 ,  Y02A50/30

Abstract: Described is a method for the generation of a live vaccine containing stable bacteria carrying at least three attenuating mutations and a vaccine containing bacteria obtained by said method.

公开(公告)号：US20230390373A1

公开(公告)日：2023-12-07

申请号：US17927139

申请日：2021-05-21

Applicant: Versitech Limited

Inventor： Jiandong HUANG ,  Kwok Yung YUEN ,  Baozhong ZHANG ,  Jian DENG ,  Hin CHU

IPC: A61K39/085 ,  C12N1/36 ,  C12N1/20

CPC classification number: A61K39/085 ,  C12Y205/01063 ,  C12N1/36 ,  C12N1/205 ,  C12R2001/445

Abstract: The invention relates to the field of biomedicine. In particular, the invention relates to a live strain of Staphylococcus aureus and uses thereof. More particularly, the invention relates to a live strain of Staphylococcus aureus which lacks adenosine synthase A (AdsA) activity, to a vaccine against Staphylococcus aureus infection comprising said live strain, and a method for preventing and/or treating Staphylococcus aureus infection in a subject by administering said live strain.

公开(公告)号：US11779639B2

公开(公告)日：2023-10-10

申请号：US17054872

申请日：2019-05-10

Applicant: THE WALTER AND ELIZA HALL INSTITUTE OF MEDICAL RESEARCH ,  THE UNIVERSITY OF MELBOURNE

Inventor： Chris Tonkin ,  Alessandro Uboldi ,  Malcolm McConville ,  Martin Blume

IPC: A61K39/002 ,  A61P33/02 ,  C12N1/10 ,  C12N1/36 ,  C12N9/10 ,  C12N9/12 ,  C12N9/16 ,  A61K39/00

CPC classification number: A61K39/002 ,  A61P33/02 ,  C12N1/10 ,  C12N1/36 ,  C12N9/1051 ,  C12N9/1205 ,  C12N9/16 ,  C12Y204/01015 ,  C12Y207/01001 ,  C12Y301/03012 ,  A61K2039/522 ,  A61K2039/523 ,  A61K2039/552

Abstract: The present disclosure provides mutant parasites, in particular protozoan parasites comprising a mutation of the trehalose-6-phosphate synthase/6-phosphate phosphatase (TPS/TPP)-like gene of Toxoplasma gondii (herein referred to as ‘Toxoplasma’) or a homologue thereof as well as vaccines comprising same.

公开(公告)号：US11773367B2

公开(公告)日：2023-10-03

申请号：US17475182

申请日：2021-09-14

Applicant: Tongji University ,  Jiangnan University

Inventor： Yinguang Chen ,  Xiong Zheng ,  Xuemeng Zhang ,  Jing Zhou ,  Meirou Wu ,  Chen Wang ,  Wenquan Ruan ,  Hengfeng Miao ,  Mingxing Zhao

IPC: C12N1/36 ,  C12P7/52 ,  C12P7/54

CPC classification number: C12N1/36 ,  C12P7/52 ,  C12P7/54

Abstract: The present invention provides a method of enhancing continuous directional high-value biological conversion of an urban wet garbage open system. The method includes wet garbage crushing, low-energy consumption hydrolysis, continuous conversion of organic components of wet garbage into short-chain fatty acid, continuous directional conversion of other components of short-chain fatty acid into acetic acid, separation and microbial reflux of acetic acid, and the like. In this method, by crushing wet garbage, performing low-energy consumption hydrolysis, and seeding acclimatized activated sludge, two stages of anaerobic fermentations are carried out to firstly convert organic components of the wet garbage continuously into short-chain fatty acid, and then continuously and directionally convert other components of short-chain fatty acid into acetic acid, so as to realize continuous directional high-value biological conversion of the urban wet garbage in an open system without adding pure microbes and a large amount of chemicals.

公开(公告)号：US11766475B2

公开(公告)日：2023-09-26

申请号：US17207948

申请日：2021-03-22

Applicant: UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INCORPORATED

Inventor： Roy Curtiss, III ,  Soo-Young Wanda

IPC: A61K39/02 ,  A61K39/112 ,  A61K39/205 ,  C07K14/205 ,  C12N1/36 ,  C12N15/74 ,  A61K39/00

CPC classification number: A61K39/0275 ,  A61K39/105 ,  A61K39/205 ,  C07K14/205 ,  C12N1/36 ,  C12N15/74 ,  A61K2039/522 ,  A61K2039/523 ,  A61K2039/58 ,  A61K2039/70

Abstract: Described herein are compositions and methods for making and using recombinant bacteria that are capable of regulated attenuation, regulated expression of one or more antigens of interest, and/or N-glycan modification of secreted/surface antigens.