公开(公告)号：US20240360484A1

公开(公告)日：2024-10-31

申请号：US18443045

申请日：2024-02-15

申请人： Lallemand Hungary Liquidity Management LLC

发明人： Aaron Argyros ,  Trisha Barrett

IPC分类号： C12P7/06 ,  C12N9/00 ,  C12N9/02 ,  C12N9/04 ,  C12N9/06 ,  C12N9/10 ,  C12N9/34 ,  C12N9/50 ,  C12N9/60 ,  C12N15/52 ,  C12P7/10

CPC分类号： C12P7/06 ,  C12N9/0004 ,  C12N9/0006 ,  C12N9/0008 ,  C12N9/0016 ,  C12N9/1029 ,  C12N9/2428 ,  C12N9/50 ,  C12N9/60 ,  C12N9/93 ,  C12N15/52 ,  C12Y104/01002 ,  C12Y104/01004 ,  C12Y104/01014 ,  C12Y603/01002 ,  C12Y603/04006 ,  C12P7/10 ,  C12Y101/01001 ,  C12Y101/01002 ,  C12Y102/0101 ,  C12Y197/01004 ,  C12Y203/01054 ,  C12Y302/01003 ,  C12Y304/23041 ,  Y02E50/10

摘要： The present invention provides for a mechanism to reduce glycerol production and increase nitrogen utilization and ethanol production of recombinant microorganisms. One aspect of this invention relates to strains of S. cerevisiae with reduced glycerol productivity that get a kinetic benefit from higher nitrogen concentration without sacrificing ethanol yield. A second aspect of the invention relates to—metabolic modifications resulting in altered transport and/or intracellular metabolism of nitrogen sources present in corn mash.

公开(公告)号：US20240352493A1

公开(公告)日：2024-10-24

申请号：US18685498

申请日：2022-03-30

申请人： CJ CHEILJEDANG CORPORATION

发明人： Haena OH ,  Seon Hye KIM ,  Heeseok LEE ,  Hyojin YUN ,  Byoung Hoon YOON ,  Ju-yeon KIM ,  Sun Hyoung CHOI ,  Jihyun SHIM

IPC分类号： C12P13/08 ,  C12N9/10

CPC分类号： C12P13/08 ,  C12N9/1022 ,  C12Y202/01006

摘要： The present application relates to: a novel acetohydroxy acid synthase subunit (ilvN) variant; a polynucleotide encoding the variant; an expression vector comprising the polynucleotide; microorganisms producing L-valine including the acetohydroxy acid synthase subunit (ilvN) variant; and a method for producing L-valine using the microorganisms.

公开(公告)号：US12123042B2

公开(公告)日：2024-10-22

申请号：US17899069

申请日：2022-08-30

申请人： EVOLVA SA

发明人： Helene Lunde Robertsen ,  Iben Nordmark Andersen ,  Adam Matthew Takos ,  Swee Chuang Lim Hallwyl ,  Francesca Ambri ,  Manuel Quiros Asensio ,  Michael Dalgaard Mikkelsen ,  Jens Houghton-Larsen ,  Veronique Douchin ,  Jane Dannow Dyekjaer ,  Simon Carlsen ,  Nina Nicoline Rasmussen ,  Esben Halkjaer Hansen

IPC分类号： C12P19/56 ,  A23L27/30 ,  C07H15/256 ,  C12N9/02 ,  C12N9/10 ,  C12N9/88 ,  C12N9/90 ,  C12N15/52

CPC分类号： C12P19/56 ,  A23L27/36 ,  C07H15/256 ,  C12N9/0042 ,  C12N9/0073 ,  C12N9/1085 ,  C12N9/88 ,  C12N9/90 ,  C12N15/52 ,  C12Y106/02004 ,  C12Y114/13078 ,  C12Y114/13079 ,  C12Y205/01029 ,  C12Y402/03019 ,  C12Y505/01013 ,  A23V2002/00 ,  C07K2319/00

摘要： The invention relates to recombinant microorganisms and methods for producing steviol glycosides and steviol glycoside precursors.

公开(公告)号：US12123041B2

公开(公告)日：2024-10-22

申请号：US17276793

申请日：2019-09-20

申请人： Universiteit Gent

发明人： Jo Maertens ,  David Bauwens ,  Wouter Van Bellegem ,  Pieter Coussement ,  Dries Duchi ,  Marjan De Mey

IPC分类号： C12P19/28 ,  C12N9/10 ,  C12P19/26 ,  C12P19/30 ,  C12P19/32 ,  C12P19/44

CPC分类号： C12P19/44 ,  C12P19/26 ,  C12Y205/01007

摘要： A method or producing amino sugar (containing) products using metabolically engineered microorganisms is disclosed, wherein the conversion of UDP-N-acetylglucosamine to cell envelope precursors and molecules is reduced by altering the activity of enzymes involved in the synthesis of cell envelope precursors and molecules.

公开(公告)号：US12123004B2

公开(公告)日：2024-10-22

申请号：US17260984

申请日：2019-07-18

申请人： Modular Genetics, Inc.

发明人： Kevin A. Jarrell ,  Michelle Pynn

IPC分类号： C12N15/52 ,  C12N1/20 ,  C12N9/02 ,  C12N9/10 ,  C12N9/90 ,  C12P13/14 ,  C12R1/125

CPC分类号： C12N15/52 ,  C12N1/20 ,  C12N9/0071 ,  C12N9/1007 ,  C12N9/90 ,  C12P13/14 ,  C12R2001/125 ,  C12Y502/01004

摘要： Engineered polypeptides or engineered microbial cells useful in synthesizing acyl amino acids are provided. In some embodiments, engineered polypeptides or engineered microbial cells are useful in synthesizing acyl amino acids with one or more hydroxyl and/or methyl groups at one or more positions of the fatty acid portion of the acyl amino acid (e.g., at ω-1, ω-2, and/or ω-3 positions of the fatty acid portion of the acyl amino acid). Also provided are methods of making acyl amino acids using engineered polypeptides and/or engineered microbial cells.

公开(公告)号：US20240344040A1

公开(公告)日：2024-10-17

申请号：US18613852

申请日：2024-03-22

申请人： William Marsh Rice University

发明人： Han XIAO ,  Yuda CHEN

IPC分类号： C12N9/10 ,  A61K38/00 ,  C07K14/81 ,  C12N9/00

CPC分类号： C12N9/13 ,  C07K14/811 ,  C12N9/93 ,  C12Y208/02001 ,  C12Y601/01001 ,  A61K38/00 ,  C12N2510/02

摘要： The present disclosure provides an engineered cell comprising a sulfotransferase. In some embodiments, the sulfotransferase is NnSULT1C1 sulfotransferase. The present disclosure also provides methods for the biosynthesis of a peptide containing at least one sulfotyrosine residue, as well as compositions comprising a peptide containing at least one sulfotyrosine residue. In some embodiments, the compositions and methods of the present disclosure provide therapeutic peptides for use in treating and/or preventing a disease or disorder, such as an HIV-1 infection.

公开(公告)号：US20240341256A1

公开(公告)日：2024-10-17

申请号：US18614056

申请日：2024-03-22

申请人： Advanta Holdings BV

发明人： Vicente Trucillo Uriarte ,  Andrés Daniel Zambelli ,  Marcos Kaspar ,  Pedro Alejandro Pardo

IPC分类号： A01H6/46 ,  A01H5/10 ,  C12N9/10 ,  C12N9/88 ,  C12N15/82 ,  C12Q1/6895

CPC分类号： A01H6/4666 ,  A01H5/10 ,  C12N9/1022 ,  C12N9/88 ,  C12N15/8274 ,  C12N15/8278 ,  C12Q1/6895 ,  C12Y202/01006 ,  C12Q2600/156

摘要： A sorghum seed comprising in its genome at least one polynucleotide encoding a polypeptide having an alanine to tyrosine substitution at position 93 of the sorghum AHAS protein large subunit. The plant has increased resistance to one or more herbicides, for example from the imidazolinone group, as compared to wild-type sorghum plants. The sorghum plant may comprise in its genome, one, two, three or more copies of a polynucleotide encoding a mutated large subunit of sorghum AHAS or a sorghum AHAS polypeptide of the invention. In this context, the sorghum plant may be tolerant to any herbicide capable of inhibiting AHAS enzyme activity. For example, the sorghum plant may be tolerant to herbicides of the imidazolinones type, such as imazethapyr, imazapir, and imazapic or to herbicides of the sulfonylurea group.

公开(公告)号：US20240337664A1

公开(公告)日：2024-10-10

申请号：US18617922

申请日：2024-03-27

申请人： Regeneron Pharmaceuticals, Inc.

发明人： Haibo Qiu ,  Sunnie Kim ,  Xiang Zheng ,  Yimeng Zhao

IPC分类号： G01N33/68 ,  C12N9/10 ,  C12N9/48 ,  C12N9/76 ,  G01N30/02 ,  G01N30/72

CPC分类号： G01N33/6857 ,  C12N9/1044 ,  C12N9/485 ,  C12N9/6427 ,  G01N30/7233 ,  G01N33/6842 ,  G01N33/6848 ,  C12Y304/17002 ,  G01N2030/027

摘要： The present invention generally pertains to methods of characterizing crosslinking sites of a protein of interest. In particular, the present invention pertains to the use of size exclusion chromatography, peptide mapping and subunit analysis to identify and quantify crosslinking sites of a protein of interest and determine a contribution of crosslinking to the formation of high molecular weight species.

公开(公告)号：US20240336900A1

公开(公告)日：2024-10-10

申请号：US18436635

申请日：2024-02-08

申请人： BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM

发明人： Andrew Ellington ,  Simon d’Oelsnitz ,  Daniel Diaz

IPC分类号： C12N9/10 ,  C12P17/18 ,  G16B15/00 ,  G16B40/20

CPC分类号： C12N9/1007 ,  C12P17/18 ,  G16B15/00 ,  G16B40/20

摘要： This invention relates to non-naturally occurring methyltransferase, wherein said methyltransferase can methylate norbelladine to form 4-O'Methylnorbelladine. The invention is also drawn to a biosensor for detecting 4-O'Methylnorbelladine, wherein the biosensor comprises an engineered substrate-promiscuous regulator, wherein said substrate-promiscuous regulator has been engineered to interact more efficiently with 4-O'Methylnorbelladine than does a naturally occurring substrate promiscuous regulator; and further wherein the biosensor is engineered to provide an output signal, wherein said output signal is generated when the biosensor interacts with 4-O'Methylnorbelladine.

公开(公告)号：US12110347B2

公开(公告)日：2024-10-08

申请号：US17680581

申请日：2022-02-25

申请人： NUTRITION & BIOSCIENCES USA 4, INC.

发明人： Qiong Cheng ,  Robert DiCosimo ,  Arthur Ouwehand ,  Zheng You ,  Mark S. Payne ,  Jian Ping Lai ,  Kristin Ruebling-Jass ,  Steven Cary Rothman

IPC分类号： C08B37/00 ,  A21D13/45 ,  A21D13/80 ,  A23C9/13 ,  A23G3/36 ,  A23G9/32 ,  A23L2/52 ,  A23L7/126 ,  A23L7/135 ,  A23L21/10 ,  A23L29/30 ,  A23L33/21 ,  A61K31/716 ,  C08L5/00 ,  C12N9/10 ,  C12N9/44 ,  C12P19/04 ,  C12P19/08 ,  C12P19/18

CPC分类号： C08B37/0009 ,  A21D13/45 ,  A21D13/80 ,  A23C9/13 ,  A23G3/36 ,  A23G9/32 ,  A23L2/52 ,  A23L7/126 ,  A23L7/135 ,  A23L21/10 ,  A23L29/37 ,  A23L33/21 ,  A61K31/716 ,  C08L5/00 ,  C12N9/1051 ,  C12N9/246 ,  C12P19/04 ,  C12P19/08 ,  C12P19/18 ,  C12Y204/00 ,  C12Y204/01002 ,  C12Y204/01005 ,  C12Y302/01 ,  C12Y302/01068 ,  A23V2002/00 ,  C08L2203/02 ,  C08L2203/12 ,  C08L2205/16 ,  A61K31/716 ,  A61K2300/00

摘要： An enzymatically produced soluble α-glucan fiber composition is provided suitable for use as a digestion resistant fiber in food and feed applications. The soluble α-glucan fiber composition can be blended with one or more additional food ingredients to produce fiber-containing compositions. Methods for the production and use of compositions comprising the soluble α-glucan fiber are also provided.