公开(公告)号：US20240360488A1

公开(公告)日：2024-10-31

申请号：US18429780

申请日：2024-02-01

申请人： 4BASEBIO, S.L.U. ,  4BASEBIO UK LTD

发明人： Heikki Lanckriet ,  Amy Walker ,  Ángel Picher

IPC分类号： C12P19/34 ,  C12N9/22 ,  C12N15/10

CPC分类号： C12P19/34 ,  C12N9/22 ,  C12N15/10 ,  C12N2310/122 ,  C12N2310/315 ,  C12Y207/07 ,  C12Y301/11001 ,  C12Y301/11002

摘要： Methods for producing a linear deoxyribonucleic acid (DNA) product with enhanced resistance to nuclease digestion are provided. The methods comprise, (a) digesting a double-stranded DNA molecule with an endonuclease that cleaves an endonuclease target sequence to generate a digested double-stranded DNA molecule, wherein the digested double-stranded DNA molecule comprises a linear double-stranded region, and a truncated protelomerase sequence at a first end, wherein the truncated protelomerase target sequence is non-functional; (b) appending a first adaptor molecule to the first end of the digested double-stranded DNA molecule and appending a second adaptor molecule to the second end of the digested double-stranded DNA molecule to generate a precursor double-stranded DNA molecule, wherein the first adaptor molecule comprises a truncated protelomerase target sequence that forms a first functional protelomerase target sequence with the truncated protelomerase sequence at the first end of the digested double-stranded DNA molecule; and (c) incubating the precursor double-stranded DNA molecule with a protelomerase to generate the linear DNA product, wherein the protelomerase closes the first end of the precursor double-stranded DNA molecule at the first functional protelomerase target sequence.

公开(公告)号：US20240360427A1

公开(公告)日：2024-10-31

申请号：US18473042

申请日：2023-09-22

申请人： SPECIFIC BIOLOGICS INC.

发明人： Brent E. STEAD

IPC分类号： C12N9/22 ,  A61K48/00 ,  A61P35/00 ,  C12N15/10 ,  C12N15/11

CPC分类号： C12N9/22 ,  A61K48/0066 ,  A61P35/00 ,  C12N15/102 ,  C12N15/111 ,  C12N2310/20

摘要： Provided herein are compositions and methods of using chimeric nucleases comprising an I-TevI nuclease domain and a Cas domain for the targeting of oncogenes.

公开(公告)号：US20240360405A1

公开(公告)日：2024-10-31

申请号：US18696177

申请日：2022-09-30

申请人： LG CHEM, LTD.

发明人： Jungyeon LEE ,  Min Kyung SUNG ,  Jae Hyung KIM

IPC分类号： C12N1/20 ,  C12N9/02 ,  C12N9/10 ,  C12N9/22 ,  C12N9/88 ,  C12P7/52 ,  C12R1/19

CPC分类号： C12N1/205 ,  C12N9/0008 ,  C12N9/1085 ,  C12N9/22 ,  C12N9/88 ,  C12P7/52 ,  C12N2310/20 ,  C12R2001/19 ,  C12Y102/01003 ,  C12Y205/01006 ,  C12Y402/0103

摘要： The present specification pertains to a microorganism and/or Escherichia coli and a use thereof, wherein the microorganism and/or Escherichia coli has 3-hydroxypropionic acid or 3-hydroxypropionate (3-HP) production ability, with a foreign 3-HP production gene inserted into the genomic DNA thereof, and has a use of measuring the production ability of the inserted 3-HP production gene.

公开(公告)号：US20240358721A1

公开(公告)日：2024-10-31

申请号：US18688496

申请日：2022-09-01

申请人： UNIVERSITY OF PITTSBURGH-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION

发明人： Prithu SUNDD

IPC分类号： A61K31/635 ,  A61K31/145 ,  A61K31/553 ,  A61K31/713 ,  A61K39/00 ,  A61P9/12 ,  C07K16/28 ,  C12N9/22 ,  C12N15/11

CPC分类号： A61K31/635 ,  A61K31/145 ,  A61K31/553 ,  A61K31/713 ,  A61P9/12 ,  C07K16/2854 ,  C12N9/22 ,  C12N15/111 ,  A61K2039/505 ,  C12N2310/122 ,  C12N2310/14 ,  C12N2310/20

摘要： The present disclosure relates to methods for treating pulmonary vaso-occlusion in a subject comprising administering to the subject a gasdermin-D inhibitor. In some examples. the disclosed methods are effective at treating subjects resistant to P-selectin-based therapy.

公开(公告)号：US12129497B2

公开(公告)日：2024-10-29

申请号：US18053614

申请日：2022-11-08

申请人： Novozymes A/S

发明人： Morten Gjermansen ,  Klaus Gori ,  Henrik Marcus Geertz-Hansen ,  Jesper Salomon ,  Thomas Holberg Blicher ,  Nikolaj Spodsberg

IPC分类号： C12N9/22 ,  C11D3/20 ,  C11D3/22 ,  C11D3/37 ,  C11D3/386 ,  C12N15/75

CPC分类号： C12N9/22 ,  C11D3/2065 ,  C11D3/22 ,  C11D3/3707 ,  C11D3/38627 ,  C11D3/38636 ,  C11D3/38681 ,  C12Y301/21 ,  C12Y301/21001 ,  C11D2111/12

摘要： The present invention relates to polypeptides, nucleotides encoding the polypeptide, as well as methods of producing the polypeptides. The present invention also relates to detergent compositions comprising polypeptides, a laundering method and the use of polypeptides.

公开(公告)号：US20240352473A1

公开(公告)日：2024-10-24

申请号：US18685643

申请日：2022-08-23

申请人： Futuragene Israel Ltd.

发明人： Dror Avisar ,  Shelly Azulay

IPC分类号： C12N15/82 ,  C12N9/22 ,  C12N15/11

CPC分类号： C12N15/8216 ,  C12N9/22 ,  C12N15/11 ,  C12N15/8203 ,  C12N2310/20 ,  C12N2710/00043

摘要： The present disclosure is directed to a novel sequence constructed from viral elements for use as a transgenic promoter; for example, in transgenic plants. More specifically, the present disclosure is directed to a chimeric transgenic promoter sequence comprising a portion derived from the Figwort Mosaic Vims (FMV/FiMV) genome and a portion derived from the Cassava Vein Mosaic Virus (CsVMV) genome. The present disclosure provides methods and compositions for the making and using such a transgenic promoter.

公开(公告)号：US20240352453A1

公开(公告)日：2024-10-24

申请号：US18584538

申请日：2024-02-22

申请人： Prime Medicine, Inc.

发明人： Wei Hsi YEH ,  Dewi HARJANTO

IPC分类号： C12N15/11 ,  C12N9/12 ,  C12N9/22

CPC分类号： C12N15/111 ,  C12N9/1276 ,  C12N9/22 ,  C12N2310/20

摘要： Provided herein are compositions and methods of using prime editing systems comprising prime editors and prime editing guide RNAs for treatment of genetic disorders.

公开(公告)号：US20240352436A1

公开(公告)日：2024-10-24

申请号：US18685710

申请日：2022-08-22

申请人： GRA&GREEN INC.

发明人： Takehito KOBAYASHI

IPC分类号： C12N9/22 ,  C12N15/10

CPC分类号： C12N9/22 ,  C12N15/102 ,  C07K2319/09 ,  C12N2310/20

摘要： Provided is a genome editing technique that achieves higher genome editing efficiency. Any of Proteins 1 to 3 of the present invention.

公开(公告)号：US20240350666A1

公开(公告)日：2024-10-24

申请号：US18685599

申请日：2022-08-23

申请人： Children`s Medical Center Corporation

发明人： William Pu ,  Nathan VanDusen ,  Suya Wang ,  Mason Eric Sweat

IPC分类号： A61K48/00 ,  A61P9/00 ,  A61P21/00 ,  C12N9/22 ,  C12N15/11 ,  C12N15/86

CPC分类号： A61K48/005 ,  A61P9/00 ,  A61P21/00 ,  C12N9/22 ,  C12N15/111 ,  C12N15/86 ,  C12N2310/20 ,  C12N2740/15043 ,  C12N2750/14143

摘要： Provided herein are compositions and methods for high efficiency genome editing by targeting novel genetic loci.

公开(公告)号：US12121524B2

公开(公告)日：2024-10-22

申请号：US16962441

申请日：2019-01-16

申请人： VERTEX PHARMACEUTICALS INCORPORATED

发明人： Marc Saul Weinberg ,  Diego Sebastian D'Astolfo ,  Sudipta Mahajan

IPC分类号： A61K31/5377 ,  A61K9/00 ,  A61K31/498 ,  A61K31/501 ,  A61K31/506 ,  A61K31/5375 ,  A61K31/7088 ,  A61K38/46 ,  A61P43/00 ,  C07D413/12 ,  C12N9/22 ,  C12N15/11

CPC分类号： A61K31/5377 ,  A61K9/0019 ,  A61K9/0053 ,  A61K31/498 ,  A61K31/501 ,  A61K31/506 ,  A61K31/5375 ,  A61K31/7088 ,  A61K38/465 ,  A61P43/00 ,  C07D413/12 ,  C12N9/22 ,  C12N15/11 ,  C12N2310/20 ,  C12N2320/31 ,  C12N2320/32 ,  C12N2320/35 ,  C12N2800/80

摘要： The present invention relates to compounds useful as inhibitors of DNA-PK. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various diseases, conditions, or disorders.