公开(公告)号：US11603528B2

公开(公告)日：2023-03-14

申请号：US16718736

申请日：2019-12-18

申请人： President and Fellows of Harvard College

发明人： George M. Church ,  Srivatsan Raman ,  Noah D. Taylor ,  Jameson K. Rogers

IPC分类号： C12P19/02 ,  C12N15/10 ,  C12P1/04 ,  C12P7/02 ,  C12P17/18 ,  C12P17/06 ,  C12P29/00 ,  C12P5/02 ,  C12P7/40 ,  C12P7/42 ,  C12P19/42 ,  C12P13/22 ,  C12P19/12 ,  C12P17/08 ,  C12P7/46 ,  C12N1/38 ,  C12P7/44 ,  C12P19/44 ,  C12N15/52 ,  C12P13/04 ,  C12P7/58 ,  C12P13/14 ,  C12P33/00

摘要： The present invention relates to genetically modified bacteria and methods of optimizing genetically modified bacteria for the production of a metabolite.

公开(公告)号：US11597906B2

公开(公告)日：2023-03-07

申请号：US16416133

申请日：2019-05-17

申请人： Jupeng Bio, Inc.

发明人： Ryan Senaratne ,  McKinzie Fruchtl ,  Abel Price

IPC分类号： C12M1/00 ,  A23L33/195 ,  C12M1/12 ,  A23K10/10 ,  C07K1/36 ,  C07K2/00 ,  C12N1/06 ,  C12N1/20 ,  C12P1/04 ,  C12P21/00 ,  A23L33/135 ,  C12P7/06

摘要： Protein-rich nutrient supplements and animal feed supplements derived from an anaerobic bacterial process are generated through a myriad of cell rupturing and protein fractionation/purification processes. Bacterial fermentation systems and methods of obtaining one or more protein-containing portions from a fermentation process using carbon monoxide-containing gaseous substrates are provided. The invention further provides compositions of protein-rich nutrient supplements with useful applications for intake by a variety of different animals and humans.

公开(公告)号：US20230059296A1

公开(公告)日：2023-02-23

申请号：US17934828

申请日：2022-09-23

申请人： LanzaTech NZ, Inc.

发明人： Sean Dennis Simpson ,  Christophe Collet ,  Michael Cockrem ,  Simon David Oakley ,  Michael Koepke

IPC分类号： C12P7/28 ,  C12M1/00 ,  C12M1/34 ,  C12P1/04 ,  C12P7/08 ,  C12P7/62 ,  C01B3/38 ,  C12P7/54 ,  C12N1/20 ,  C12P3/00 ,  C12P7/00 ,  C12P7/06

摘要： What is described is an integrated steel mill and a bioreactor configured to produce useful products from the waste stream of the steel mill. A waste gas stack which is connected to the steel mill is connected to a heat exchanger to cool the waste gas from the steel mill. The cooled gas is pressurized using a pressurization apparatus connected to the heat exchanger. The pressurized gas is sent to an oxygen removal apparatus connected to the pressurization apparatus. An oxygen depleted waste stream from the oxygen removal apparatus is passed to a bioreactor (connected to the oxygen removal apparatus) where microorganisms ferment the waste stream to products. Optional apparatus such as scrubbers, valves, buffers, are also disclosed. The products of the fermentation in the bioreactor can be ethanol and or acetate.

公开(公告)号：US20220348971A1

公开(公告)日：2022-11-03

申请号：US17744300

申请日：2022-05-13

申请人： DANMARKS TEKNISKE UNIVERSITET

发明人： Peter RUGBJERG ,  Kira SARUP-LYTZEN ,  Morten SOMMER

IPC分类号： C12P7/42 ,  C12P1/04 ,  C12N15/10 ,  C12N15/67 ,  C12P7/40 ,  C12P5/02 ,  C12P1/02 ,  C12P7/64 ,  C12P21/02 ,  C12N9/16 ,  C12N15/72

摘要： The invention provides a genetically modified micro-organism for intracellular biosynthesis of a cellular metabolite, comprising a synthetic error correction system having a penalty gene, whose expression leads to arrested growth or cell death (e.g. a toxin gene) in combination with a survival gene, whose expression provides an antidote that restores cell viability and normal growth (e.g. a cognate antitoxin gene). Alternatively, the system has a survival gene, alone, whose expression is essential for growth (i.e. essential gene). The synthetic error correction system further comprises a biosensor, whose function is to induce expression of the survival gene which leads to cell growth, only, when the cell produces a pre-defined level of a given metabolite. The invention further encompasses: a method for producing the genetically modified micro-organism; a method for producing a cellular metabolite with the genetically modified micro-organism; and use of the genetically modified micro-organism for producing a cellular metabolite.

公开(公告)号：US20220325230A1

公开(公告)日：2022-10-13

申请号：US17844829

申请日：2022-06-21

申请人： JUPENG BIO (HK) LIMITED

发明人： McKinzie Fruchtl ,  Ryan Senaratne

IPC分类号： C12M1/00 ,  A23L33/195 ,  C12M1/12 ,  A23K10/10 ,  C07K1/36 ,  C07K2/00 ,  C12N1/06 ,  C12N1/20 ,  C12P1/04 ,  C12P21/00 ,  A23L33/135 ,  C12P7/06

摘要： Protein-rich nutrient supplements and animal feed supplements derived from an anaerobic bacterial process are generated through a myriad of cell rupturing and protein fractionation/purification processes. Bacterial fermentation systems and methods of obtaining one or more protein-containing portions from a fermentation process using carbon monoxide-containing gaseous substrates increasing protein product yield from bacterial cells are provided. The invention further provides compositions of protein-rich nutrient supplements with useful applications for intake by a variety of different animals and humans.

公开(公告)号：US11419884B2

公开(公告)日：2022-08-23

申请号：US16312506

申请日：2017-06-23

申请人： GLYCOM A/S

发明人： Nikolay Khanzhin ,  Markus Jondelius Hederos ,  Louise Kristine Vigsnæs ,  Bruce McConnell

IPC分类号： A61K31/702 ,  C12P1/04 ,  A61P31/04 ,  A61K31/7016 ,  C07H1/00 ,  C12P19/04 ,  C12N9/10 ,  A61K31/716 ,  A61K31/7032

摘要： The present disclosure relates to synthetic mixtures of certain human milk oligosaccharides and uses thereof. Particular mixtures provided herein include: lacto-N-triose II, lacto-N-neotetraose, para-lacto-N-neohexaose, and, optionally, lactose; and lacto-N-triose II, lacto-N-tetraose, para-lacto-N-hexaose II, and, optionally, lactose. These mixtures are useful in the prevention and treatment of viral and bacterial infections.

公开(公告)号：US20220226534A1

公开(公告)日：2022-07-21

申请号：US17160181

申请日：2021-01-27

申请人： NINGBO RHYSUAIR BIOTECHNOLOGY CO.,LTD.

发明人： Jian ZHOU

IPC分类号： A61L11/00 ,  C12P1/04

摘要： The manufacturing method of high-efficiency plant composite type bacteriostatic deodorant based on HQ22 bean extract includes pretreating the leaves of certain beans and certain plants in the early stage, which are then respectively processed into powder by a pulverizer; uniformly mixing the two powders according to a certain mass ratio, which are then treated with inoculation process with a certain inoculation amount of Bacillus natto seed solution; carrying out fermentation treatment on that mixture to obtain dark brown fermentation liquor; separating and purifying the fermentation liquor to obtain active components of the high-efficiency bacteriostatic deodorant; mixing the active ingredient with a certain proportion of surfactant, buffer, solvent and flavoring agent; and then obtaining high-efficiency plant composite type bacteriostatic deodorant based on HQ22 bean extract was prepared. The method has the advantage of high-efficiency of deodorization and bacteriostasis.

公开(公告)号：US11352650B2

公开(公告)日：2022-06-07

申请号：US15763257

申请日：2016-09-23

申请人： DANMARKS TEKNISKE UNIVERSITET

发明人： Peter Rugbjerg ,  Kira Sarup-Lytzen ,  Morten Sommer

IPC分类号： C12P7/42 ,  C12P1/04 ,  C12N15/10 ,  C12N15/67 ,  C12P7/40 ,  C12P5/02 ,  C12P1/02 ,  C12P7/64 ,  C12P21/02 ,  C12N9/16 ,  C12N15/72 ,  C12N1/21

摘要： The invention provides a genetically modified micro-organism for intracellular biosynthesis of a cellular metabolite, comprising a synthetic error correction system having a penalty gene, whose expression leads to arrested growth or cell death (e.g. a toxin gene) in combination with a survival gene, whose expression provides an antidote that restores cell viability and normal growth (e.g. a cognate antitoxin gene). Alternatively, the system has a survival gene, alone, whose expression is essential for growth (i.e. essential gene). The synthetic error correction system further comprises a biosensor, whose function is to induce expression of the survival gene which leads to cell growth, only, when the cell produces a pre-defined level of a given metabolite. The invention further encompasses: a method for producing the genetically modified micro-organism; a method for producing a cellular metabolite with the genetically modified micro-organism; and use of the genetically modified micro-organism for producing a cellular metabolite.

公开(公告)号：US20220169974A1

公开(公告)日：2022-06-02

申请号：US17437255

申请日：2020-03-13

申请人： DUPONT NUTRITION BIOSCIENCES APS

发明人： Anais JEDRZEJOWSKI ,  Christophe FREMAUX ,  Sabine VAN DILLEN ,  Thomas DESFOUGERES ,  Max Charles JODEAU ,  Damien LUGAND

IPC分类号： C12N1/20 ,  A23C9/123 ,  C12P1/04 ,  G01N33/50 ,  C12N15/74

摘要： The invention relates to a polynucleotide comprising a lacZ gene (lacZFS) encoding a β-galactosidase characterized by a particular profile regarding its efficiency of hydrolysis of lactose. The invention is also directed to a Streptococcus thermophilus strain comprising a lacZFS allele and bacterial composition thereof, and their use to obtain fermented milk not undergoing post-acidification.

公开(公告)号：US20220154225A1

公开(公告)日：2022-05-19

申请号：US16951331

申请日：2020-11-18

申请人： Imam Abdulrahman Bin Faisal University

发明人： Mahmoud Mohamed BEREKAA

IPC分类号： C12P1/04 ,  A01N63/22

摘要： A method for the preparation of bioactive compound by culturing a Bacillus species containing 16S rRNA having nucleotide sequence that is at least 80% identical to the nucleic acid sequence of the 16S rRNA of B. endophyticus DS43 of SEQ ID NO: 1. Tryptone soya broth (TSB) is an effective growth medium for the production of the bioactive compound. A growth medium used in the method contains date syrup and/or molasses. The isolated fluorescent bioactive compound has biocidal activity against bacteria including Serratia marcescens, Staphylococcus aureus, and Escherichia coli.