公开(公告)号：US20250066715A1

公开(公告)日：2025-02-27

申请号：US18927196

申请日：2024-10-25

Applicant: Kiverdi, Inc.

Inventor： Lisa Dyson ,  John Reed ,  Jil Geller ,  Sonali Hande

IPC: C12N1/20 ,  A23J1/00 ,  A23J3/20 ,  C12P1/04 ,  C12P7/64 ,  C12P13/04 ,  C12P21/02

Abstract: Microorganisms and bioprocesses are provided that convert gaseous substrates, such as renewable H2 and waste CO2 producer gas, or syngas into high-protein biomass that may be used directly for human nutrition, or as a nutrient for plants, fungi, or other microorganisms, or as a source of soil carbon, nitrogen, and other mineral nutrients. Renewable H2 used in the processes described herein may be generated by electrolysis using solar or wind power. Producer gas used in the processes described herein may be derived from sources that include gasification of waste feedstock and/or biomass residue, waste gas from industrial processes, or natural gas, biogas, or landfill gas.

公开(公告)号：US20250059498A1

公开(公告)日：2025-02-20

申请号：US18823543

申请日：2024-09-03

Applicant: Kiverdi, Inc.

Inventor： Lisa Dyson ,  John Reed ,  Jil Geller ,  Sonali Hande

IPC: C12N1/20 ,  A23J1/00 ,  A23J3/20 ,  C12P1/04 ,  C12P7/64 ,  C12P13/04 ,  C12P21/02

Abstract: Microorganisms and bioprocesses are provided that convert gaseous substrates, such as renewable H2 and waste CO2 producer gas, or syngas into high-protein biomass that may be used directly for human nutrition, or as a nutrient for plants, fungi, or other microorganisms, or as a source of soil carbon, nitrogen, and other mineral nutrients. Renewable H2 used in the processes described herein may be generated by electrolysis using solar or wind power. Producer gas used in the processes described herein may be derived from sources that include gasification of waste feedstock and/or biomass residue, waste gas from industrial processes, or natural gas, biogas, or landfill gas.

公开(公告)号：US20250051811A1

公开(公告)日：2025-02-13

申请号：US18723271

申请日：2022-12-26

Applicant: CJ CHEILJEDANG CORPORATION

Inventor： Min Kyung KWON ,  Jihyun SHIN ,  Jong Hyun KIM ,  Sang Min PARK ,  Ji-hun KANG ,  Min Sup KIM

IPC: C12P13/04 ,  A23K10/12 ,  A23K20/142 ,  A23K20/24 ,  A23K40/10

Abstract: The present application relates to a method for preparing amino acid granules from a fermentation broth, wherein the prepared amino acid granules contain no cells.

公开(公告)号：US20250051714A1

公开(公告)日：2025-02-13

申请号：US18927305

申请日：2024-10-25

Applicant: Kiverdi, Inc.

Inventor： Lisa Dyson ,  John Reed ,  Jil Geller ,  Sonali Hande

IPC: C12N1/20 ,  A23J1/00 ,  A23J3/20 ,  C12P1/04 ,  C12P7/64 ,  C12P13/04 ,  C12P21/02

Abstract: Microorganisms and bioprocesses are provided that convert gaseous substrates, such as renewable H2 and waste CO2 producer gas, or syngas into high-protein biomass that may be used directly for human nutrition, or as a nutrient for plants, fungi, or other microorganisms, or as a source of soil carbon, nitrogen, and other mineral nutrients. Renewable H2 used in the processes described herein may be generated by electrolysis using solar or wind power. Producer gas used in the processes described herein may be derived from sources that include gasification of waste feedstock and/or biomass residue, waste gas from industrial processes, or natural gas, biogas, or landfill gas.

公开(公告)号：US20250018062A1

公开(公告)日：2025-01-16

申请号：US18760652

申请日：2024-07-01

Applicant: Moderna TX, Inc.

Inventor： Antonin DE FOUGEROLLES ,  Justin GUILD

IPC: A61K48/00 ,  A61K9/127 ,  A61K9/14 ,  A61K9/51 ,  A61K31/7115 ,  A61K38/00 ,  A61K38/17 ,  A61K38/18 ,  A61K38/19 ,  A61K38/21 ,  A61K38/45 ,  A61K38/48 ,  A61K47/54 ,  C07H21/02 ,  C07K14/005 ,  C07K14/435 ,  C07K14/47 ,  C07K14/475 ,  C07K14/485 ,  C07K14/495 ,  C07K14/505 ,  C07K14/515 ,  C07K14/525 ,  C07K14/535 ,  C07K14/54 ,  C07K14/56 ,  C07K14/61 ,  C07K14/62 ,  C07K14/705 ,  C07K14/745 ,  C07K16/00 ,  C07K16/28 ,  C07K16/40 ,  C12N9/00 ,  C12N9/02 ,  C12N9/10 ,  C12N9/12 ,  C12N9/16 ,  C12N9/24 ,  C12N9/42 ,  C12N9/64 ,  C12N9/68 ,  C12N9/88 ,  C12N15/11 ,  C12N15/52 ,  C12N15/85 ,  C12N15/87 ,  C12P13/04 ,  C12P21/00

Abstract: The invention relates to compositions and methods for the preparation, manufacture and therapeutic use of polynucleotides, primary transcripts and mmRNA molecules.

公开(公告)号：US20240425992A1

公开(公告)日：2024-12-26

申请号：US18823526

申请日：2024-09-03

Applicant: Kiverdi, Inc.

Inventor： John S. Reed ,  Jil Geller ,  Sonali Hande

IPC: C25B1/04 ,  C12N1/20 ,  C12P1/04 ,  C12P5/00 ,  C12P7/64 ,  C12P7/6409 ,  C12P13/00 ,  C12P13/04 ,  C12P17/16 ,  C12P21/02 ,  C12P25/00

Abstract: Microorganisms and bioprocesses are provided that convert gaseous Cl containing substrates, such as syngas, producer gas, and renewable H2 combined with CO2, into nutritional and other useful bioproducts.

公开(公告)号：US20240417763A1

公开(公告)日：2024-12-19

申请号：US18712705

申请日：2021-11-29

Applicant: WACKER CHEMIE AG

Inventor： Rupert PFALLER ,  Günter WICH

IPC: C12P13/04 ,  C12N9/88

Abstract: A process for producing taurine. Where the taurine is produced from O-acetyl-L-serine (OAS) using biotransformation. In a first processing step (biotransformation 1), L-cysteic acid is produced from OAS using an enzyme selected from a class of OAS sulfhydrylases (EC 4.2.99.8) in the presence of a salt of sulfurous acid. Where the biotransformation is carried out under active pH control. In a second processing step (biotransformation 2), L-cysteic acid is decarboxylated to taurine. Where the OAS concentration in the batch is at least 10 g/L and the OAS sulfhydrylase is CysM.

公开(公告)号：US12152264B2

公开(公告)日：2024-11-26

申请号：US17604412

申请日：2020-12-26

Applicant: ZHEJIANG UNIVERSITY OF TECHNOLOGY

Inventor： Yaping Xue ,  Feng Cheng ,  Jumou Li ,  Qinghua Li ,  Yuguo Zheng ,  Shuping Zou ,  Jianmiao Xu

IPC: C12P13/04 ,  C12N1/20 ,  C12N15/52 ,  C12N15/70

Abstract: Disclosed are a phosphinothricin dehydrogenase mutant, a recombinant bacterium and a one-pot multi-enzyme synchronous directed evolution method. The phosphinothricin dehydrogenase mutant, with an amino acid sequence as shown in SEQ ID No.1, is obtained by mutating alanine at position 164 to glycine, arginine at position 205 to lysine, and threonine at position 332 to alanine in a phosphinothricin dehydrogenase derived from Pseudomonas fluorescens. The recombinant bacterium is obtained by introducing a gene encoding the phosphinothricin dehydrogenase mutant into a host cell. The host cell can also incorporate a gene encoding a glucose dehydrogenase or a gene encoding a formate dehydrogenase to undergo synchronous directed evolution to achieve double gene overexpression. The one-pot multi-enzyme synchronous directed evolution method of the present invention can screen recombinant bacteria with greatly improved activity. Compared with other catalysis processes such as the transaminase method, the method for preparing L-PPT of the present invention features relatively simple process, high conversion of raw materials of up to 100%, and high stereo selectivity.

公开(公告)号：US12110524B2

公开(公告)日：2024-10-08

申请号：US17750276

申请日：2022-05-20

Applicant: Modular Genetics, Inc.

Inventor： Kevin A. Jarrell

IPC: C12N9/90 ,  C12P7/6418 ,  C12P13/00 ,  C12P13/04

CPC classification number: C12P13/001 ,  C12N9/90 ,  C12P7/6418 ,  C12P13/04 ,  C12Y501/01011

Abstract: Methods, compositions, and cells for generating acyl alcohols. Compositions comprising acyl alcohols. Methods of cleaving acyl amino acids and/or acyl alcohols to generate free fatty acids, free amino acids, and/or free alcohols.

公开(公告)号：US20240287558A1

公开(公告)日：2024-08-29

申请号：US18569989

申请日：2022-05-31

Applicant: Evonik Operations GmbH

Inventor： Ludger Lautenschütz ,  Steffen Oßwald ,  Markus Pötter ,  Jakob Müller

IPC: C12P13/04 ,  C12N9/80 ,  C12N9/90

CPC classification number: C12P13/04 ,  C12N9/80 ,  C12N9/90 ,  C12Y305/01087 ,  C12Y305/02002 ,  C12Y501/99005

Abstract: An enzymatic method for the production of an L-glufosinate P-alkyl ester can be performed. This method is characterized by reacting an L-glufosinate P-alkyl ester carbamoylate to give the corresponding L-glufosinate P-alkyl ester. This is catalyzed by a carbamoylase. The L-glufosinate P-alkyl ester carbamoylate employed may be obtained by a reaction from the corresponding L-glufosinate hydantoin P-alkyl ester. This is catalyzed by a hydantoinase, preferably an L-enantioselective hydantoinase. In a second aspect, an enzymatic method for enantioselective production of an L-glufosinate P-alkyl ester from a mixture MIIIA of L- and D-glufosinate P-alkyl ester hydantoins can be performed. The L-glufosinate P-alkyl ester obtained in the methods according to the first or second aspect of the invention may be saponified to give L-glufosinate.