公开(公告)号：US20250066834A1

公开(公告)日：2025-02-27

申请号：US18939049

申请日：2024-11-06

Applicant: AOBIOME LLC

Inventor： David R. Whitlock ,  James Heywood ,  Spiros Jamas ,  Larry Weiss

IPC: C12Q1/04 ,  C12N1/20

Abstract: This disclosure provides, inter alia, systems and methods for testing products for ammonia oxidizing bacteria, quality control, and providing products with ammonia oxidizing bacteria. The systems and methods herein may be used, inter alia, to treat diseases associated with low nitrite levels, skin diseases, and diseases caused by pathogenic bacteria.

公开(公告)号：US12221647B2

公开(公告)日：2025-02-11

申请号：US17526048

申请日：2021-11-15

Applicant: BACTERIA DETECTION LTD

Inventor： Aryeh Gassel ,  Yaron Suissa ,  Raphael Gassel ,  Maoz Tal ,  Iaacov Man ,  Boaz Arieli

IPC: C12Q1/24 ,  C12N1/00 ,  C12Q1/04 ,  C12Q1/6806

Abstract: This disclosure relates to methods for isolating bacterial cells, fungal cells, and single-celled parasites present in a blood sample containing higher eukaryotic cells; particularly wherein the microorganisms are present at a concentration significantly lower than the eukaryotic cells in the sample.

公开(公告)号：US12203123B2

公开(公告)日：2025-01-21

申请号：US17280454

申请日：2019-09-25

Applicant: NORTH CAROLINA STATE UNIVERSITY

Inventor： Rodolphe Barrangou ,  Claudio Hidalgo Cantabrana

IPC: C12Q1/04 ,  C12N9/22 ,  C12N15/11 ,  C12N15/74 ,  C12N15/90

Abstract: This invention relates to recombinant Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR) arrays and recombinant nucleic acid constructs encoding Type I-E CASCADE complexes, plasmids, retroviruses and bacteriophage comprising the same, and methods of use thereof for screening for variant cells of an organism.

公开(公告)号：US12188076B2

公开(公告)日：2025-01-07

申请号：US17968831

申请日：2022-10-19

Applicant: KOOKMIN UNIVERSITY INDUSTRY ACADEMY COOPERATION FOUNDATION

Inventor： Se-Wook Oh ,  Unji Kim ,  Ji Hye Baek ,  So-Young Lee

IPC: C12Q1/04 ,  C12N1/20 ,  C12Q1/10

Abstract: A medium composition for detection of P. carotovorum includes pectin, cellobiose, and inositol as active ingredients. P. carotovorum is highly likely to cause soft rot during cultivation as well as storage and transportation such that continuous monitoring is required. In order to solve the issues, the medium composition ensures remarkably outstanding selectivity for P. carotovorum.

公开(公告)号：US20240417772A1

公开(公告)日：2024-12-19

申请号：US18823249

申请日：2024-09-03

Applicant: IP Specialists Ltd.

Inventor： Dana A. Marshall ,  Theodore S. McMinn ,  Dan Vadim Regelman

IPC: C12Q1/04 ,  B01L3/00 ,  G01N21/47 ,  G01N21/51 ,  G16B50/00 ,  G16B50/30

Abstract: An optical measurement instrument is an integrated instrument that includes an optical cavity with a light source, a sample cuvette, and an optical sensor. The instrument can be used for taking measurements of organism concentration in one or more samples. Preferably, the instrument holds multiple, individually-loaded, independent fluid samples and determines bacteria concentration via a forward-scattering signal. The instrument can incorporate onboard incubation to promote bacterial growth in the samples such that, once a certain bacterial concentration is achieved, the higher concentration sample can be used with a mass spectrometer to identify the type of bacteria. The instrument and mass spectrometer can be a part of a network for medical diagnostic testing data where data is stored in a manner that is inherently untainted by patient identifiable information.

公开(公告)号：US12157909B2

公开(公告)日：2024-12-03

申请号：US17264992

申请日：2019-08-02

Applicant: Poonam Narula

Inventor： Poonam Narula

IPC: C12Q1/04 ,  G01N31/22 ,  G01N33/02

Abstract: A system and method for the real time determination of microbial growth in or on perishable products. The system can predict the extent of microbial growth, e.g., whether food is spoiled, in real time by measuring chemicals released, e.g., CO2, from the perishable product during microbial growth. The output from a sensor can be correlated to the extent of microbial growth, i.e., spoilage, and provide information about the extent of microbial growth to the user, for example, through their smart devices.

公开(公告)号：US12152990B2

公开(公告)日：2024-11-26

申请号：US18080481

申请日：2022-12-13

Applicant: Trustees of Boston University

Inventor： Ji-Xin Cheng ,  Yi Zhang ,  Cheng Zong

IPC: G01N21/64 ,  C12Q1/04 ,  G01N21/65 ,  G01N33/50

Abstract: Microscopic analysis of a sample includes a fluorescent dye disposed within the sample. A mid-IR optical source generates a mid-infrared beam, which is directed onto the sample to induce a temperature change by absorption of the mid-infrared beam. An optical source generates a probe beam directed to impinge on the sample. A detector detects fluorescent emissions from the sample when the probe beam impinges on the sample. A data acquisition and processing system acquires and processes the detected fluorescent emissions from the sample to: (i) generate a signal indicative of infrared absorption by the sample, (ii) generate a signal indicative of temperature in the sample based on the signal indicative of infrared absorption by the sample, (iii) generate an image of the sample using the signal indicative of temperature in the sample.

公开(公告)号：US20240384322A1

公开(公告)日：2024-11-21

申请号：US18564946

申请日：2022-05-18

Applicant: 3M INNOVATIVE PROPERTIES COMPANY

Inventor： G. Marco Bommarito ,  Joshua D. Erickson ,  Feng Zeng

IPC: C12Q1/22 ,  C12M1/12 ,  C12Q1/04 ,  C12Q1/18

Abstract: The disclosed process challenge device is a casing and a self-contained biological indicator operatively connected to the casing. The biological indicator has a housing with an open end and an interior space, a plurality of viable test microorganisms or an active enzyme in the housing, a sterilant pathway extending through the housing to the test microorganisms or the active enzyme, a detection reagent in the interior space, and an aqueous liquid in an openable container. The aqueous liquid is in selective communication with the viable test microorganisms or active enzyme. A first portion of the biological indicator has an open end and is disposed in the casing and a second portion of the self-contained biological indicator is disposed outside the casing. The second portion of the biological indicator comprises a part of the housing through which the aqueous liquid and detection reagent can be observed.

公开(公告)号：US12145156B2

公开(公告)日：2024-11-19

申请号：US17055987

申请日：2019-11-12

Applicant: Sartorius Stedim Biotech GmbH

Inventor： Stefan Weisshaar ,  Mario Deuse ,  Martin Leuthold ,  Thomas Krumbein

IPC: B01L3/00 ,  B01F23/00 ,  B01F23/41 ,  B01F101/23 ,  B01L9/00 ,  B01L9/02 ,  B23Q17/24 ,  C07K14/705 ,  C12M1/00 ,  C12M1/34 ,  C12M3/00 ,  C12Q1/04 ,  C12Q1/18 ,  C12Q1/686 ,  G01N21/3577 ,  G01N21/359 ,  G01N21/39 ,  G01N21/45 ,  G01N21/64 ,  G01N21/77 ,  G01N21/78 ,  G01N27/414 ,  G01N30/12 ,  G01N30/68 ,  G01N30/70 ,  G01N30/72 ,  G01N30/88 ,  G01N33/00 ,  G01N33/18 ,  G01N33/50 ,  G01N33/53 ,  G01N33/543 ,  G01N33/68 ,  G01N33/74 ,  G01N35/00 ,  G01N35/10 ,  G06T7/00 ,  G06T7/90 ,  H10K10/46 ,  H10K85/00 ,  H10K85/20

Abstract: A configurable device arrangement for performing at least one unit operation in a biopharmaceutical process includes a base rack and a plurality of holders for releasable direct or indirect attachment of process components, in particular single-use process components, for the unit operation. The holders are in turn adapted to be releasably attached directly or indirectly to the base rack. The device arrangement further includes a positioning system which defines specific positions for the holders relative to the base rack.

公开(公告)号：US20240376516A1

公开(公告)日：2024-11-14

申请号：US18665203

申请日：2024-05-15

Applicant: TRAC Research, LLC

Inventor： Rella P. Christensen ,  Brad J. Ploeger

IPC: C12Q1/04 ,  A61L2/00 ,  C12Q1/02 ,  G16B35/10 ,  G16B35/20 ,  G16H50/20

Abstract: A system and method for novel processes of isolation, aseptic collection, genus-specie identification and quantification, and mapping of a restricted mixed microbe infection in living tissues in situ showing spatial distribution of the microbes within a sample of the living tissue. A tooth lesion or extraction socket and an endodontic entry excavation adjacent to an implant are examples of lesions resulting from such mixed microbe infections. The process may be incorporated into treatment procedures in a restricted area within hard or soft tissue, diagnostic techniques, minimizing failure of treatment processes, and validation of methods and products claiming antimicrobial or other properties in a treatment or preventive technique.