公开(公告)号：US20240360514A1

公开(公告)日：2024-10-31

申请号：US18685744

申请日：2022-08-30

申请人： University of Maryland, Baltimore

发明人： Valeria R. Mas ,  Daniel G. MALUF

IPC分类号： C12Q1/6883 ,  C12Q1/6806 ,  C12Q1/6851

CPC分类号： C12Q1/6883 ,  C12Q1/6851 ,  C12Q1/6806 ,  C12Q2600/118 ,  C12Q2600/158

摘要： The first genome-wide, large-cohort study to demonstrate donor kidney transcriptomes can capture intrinsic organ quality and carry significant predictive weight for 24-month transplant function is disclosed. These findings shift the paradigm of understanding longer-term kidney transplant outcomes away from recipient factors/post-transplant events and towards intrinsic donor organ quality, which can be captured by molecular techniques. The combined predictive equation provided herein, using both clinical and biological data, can more accurately predict 24-month outcomes as compared to the current established scoring system (KDPI) in an external patient cohort.

公开(公告)号：US12116620B2

公开(公告)日：2024-10-15

申请号：US17072890

申请日：2020-10-16

申请人： Gen-Probe Incorporated

发明人： Mehrdad Majlessi ,  Pamela Douglass ,  Daniel Kolk

IPC分类号： C12Q1/68 ,  C12Q1/6811 ,  C12Q1/6816 ,  C12Q1/6851 ,  C12Q1/6853 ,  C12Q1/686 ,  C12Q1/6876 ,  C12Q1/6888 ,  C12Q1/70

CPC分类号： C12Q1/6811 ,  C12Q1/6816 ,  C12Q1/6851 ,  C12Q1/6853 ,  C12Q1/686 ,  C12Q1/6876 ,  C12Q1/6888 ,  C12Q1/701 ,  C12Q2600/118 ,  C12Q2600/166

摘要： Compositions, methods, kits, and uses are provided for detecting or quantifying an Human Parainfluenza virus 1 (HPIV-1), HPIV-2, HPIV-3, and/or HPIV-4 nucleic acid, e.g., using nucleic acid amplification and hybridization assays. In some embodiments, the compositions, methods, kits, and uses target the HN gene of HPIV-1, HPIV-2, and/or HPIV-3 and/or the NP gene of HPIV-4.

公开(公告)号：US20240327919A1

公开(公告)日：2024-10-03

申请号：US18747138

申请日：2024-06-18

申请人： Natera, Inc.

发明人： MATTHEW RABINOWITZ ,  Matthew Micah HILL ,  Bernhard ZIMMERMANN ,  Johan BANER ,  George GEMELOS ,  Milena Eser BANJEVIC ,  Allison RYAN ,  Styrmir SIGURJONSSON ,  Zachary DEMKO

IPC分类号： C12Q1/6883 ,  C12Q1/6809 ,  C12Q1/6811 ,  C12Q1/6844 ,  C12Q1/6848 ,  C12Q1/6851 ,  C12Q1/6855 ,  C12Q1/6869 ,  C12Q1/6874

CPC分类号： C12Q1/6883 ,  C12Q1/6809 ,  C12Q1/6811 ,  C12Q1/6844 ,  C12Q1/6848 ,  C12Q1/6851 ,  C12Q1/6855 ,  C12Q1/6869 ,  C12Q1/6874 ,  C12Q2600/156

摘要： The invention provides methods for simultaneously amplifying multiple nucleic acid regions of interest in one reaction volume as well as methods for selecting a library of primers for use in such amplification methods. The invention also provides library of primers with desirable characteristics, such as minimal formation of amplified primer dimers or other non-target amplicons.

公开(公告)号：US20240327807A1

公开(公告)日：2024-10-03

申请号：US18742500

申请日：2024-06-13

申请人： New England Biolabs, Inc.

发明人： Guoping Ren ,  Yan Xu ,  Dong Ma ,  Nicole Nichols

IPC分类号： C12N9/12 ,  C12Q1/48 ,  C12Q1/6806 ,  C12Q1/6816 ,  C12Q1/6844 ,  C12Q1/6851 ,  C12Q1/686

CPC分类号： C12N9/1276 ,  C12Q1/48 ,  C12Q1/6806 ,  C12Q1/6816 ,  C12Q1/6846 ,  C12Q1/6851 ,  C12Q1/686 ,  C12Q2521/107 ,  C12Q2521/119 ,  C12Q2527/125 ,  C12Q2527/137 ,  C12Y207/07049

摘要： Provided herein is a reverse transcriptase mixture comprising a reverse transcriptase and a colored dye at a concentration in the range of 0.003%-1% (v/w). The colored dye may be visually observed during transfer of the mix from one vessel to another and addition of the mix to another mix can be confirmed by eye by observing the colored dye.

公开(公告)号：US20240319192A1

公开(公告)日：2024-09-26

申请号：US18261638

申请日：2022-01-13

申请人： Decipher Biosciences, Inc. ,  Northwestern University

发明人： Elai Davicioni ,  Yang Liu ,  Edward Matthew Schaeffer ,  Adam Benjamin Weiner

IPC分类号： G01N33/574 ,  C12Q1/6851 ,  C12Q1/6886 ,  G01N33/569

CPC分类号： G01N33/57434 ,  C12Q1/6851 ,  C12Q1/6886 ,  G01N33/56966 ,  C12Q2600/106 ,  C12Q2600/154 ,  C12Q2600/158

摘要： The present disclosure pertains to the field of personalized medicine and methods for treating prostate cancer. In particular, the disclosure relates to the use of immune content scores to identify individuals in need of treatment for prostate cancer who are likely to be responsive to immunotherapy. The disclosure further relates to methods and immune content scores that identify tumors with enhanced immune activity and are prognostic for metastasis-free and disease-free survival for cancer patients.

公开(公告)号：US20240318252A1

公开(公告)日：2024-09-26

申请号：US18733659

申请日：2024-06-04

申请人： Natera, Inc.

发明人： Matthew RABINOWITZ ,  Matthew Micah HILL ,  Bernhard A. ZIMMERMANN ,  Johan BANER ,  George GEMELOS ,  Milena BANJEVIC ,  Allison RYAN ,  Styrmir SIGURJONSSON ,  Zachary DEMKO

IPC分类号： C12Q1/6883 ,  C12Q1/6809 ,  C12Q1/6811 ,  C12Q1/6844 ,  C12Q1/6848 ,  C12Q1/6851 ,  C12Q1/6855 ,  C12Q1/6869 ,  C12Q1/6874

CPC分类号： C12Q1/6883 ,  C12Q1/6809 ,  C12Q1/6811 ,  C12Q1/6844 ,  C12Q1/6848 ,  C12Q1/6851 ,  C12Q1/6855 ,  C12Q1/6869 ,  C12Q1/6874 ,  C12Q2600/156

摘要： The invention provides methods for simultaneously amplifying multiple nucleic acid regions of interest in one reaction volume as well as methods for selecting a library of primers for use in such amplification methods. The invention also provides library of primers with desirable characteristics, such as minimal formation of amplified primer dimers or other non-target amplicons.

公开(公告)号：US20240315991A1

公开(公告)日：2024-09-26

申请号：US18415255

申请日：2024-01-17

申请人： Sanford Burnham Prebys Medical Discovery Institute

发明人： Fred LEVINE

IPC分类号： A61K31/165 ,  A61P1/16 ,  A61P3/04 ,  C12Q1/48 ,  C12Q1/6851

CPC分类号： A61K31/165 ,  A61P1/16 ,  A61P3/04 ,  C12Q1/48 ,  C12Q1/6851

摘要： Provided herein are methods for using HNF4α agonists and pharmaceutical compositions thereof for reducing body weight, maintaining body weight, reducing diet induced weight gain, reducing mitochondrial stress, treating diseases or disorders such as inflammation, diabetes, nonalcoholic fatty liver disease (NAFLD) or nonalcoholic steatohepatitis (NASH) in a subject.

公开(公告)号：US20240309472A1

公开(公告)日：2024-09-19

申请号：US18282390

申请日：2022-03-16

申请人： Natera, Inc.

发明人： Phil GAUTHIER ,  Hossein TABRIZIANI ,  Paul VAN HUMMELEN ,  Jessica TANG

IPC分类号： C12Q1/70 ,  C12Q1/6851 ,  C12Q1/6883

CPC分类号： C12Q1/701 ,  C12Q1/6851 ,  C12Q1/6883 ,  C12Q2600/118 ,  C12Q2600/156

摘要： The present disclosure provides methods for preparation and analysis of biological samples of transplant recipients for determination of transplant rejection, comprising: (a) measuring the amount of Torque teno virus (TTV) in a blood, plasma, serum, or urine sample of a transplant recipient; (b) measuring the amount of donor-derived cell-free DNA in a blood, plasma, serum, or urine sample of the transplant recipient; and (c) determining whether the amount of donor-derived cell-free DNA or a function thereof exceeds a cutoff threshold indicating transplant rejection and whether the transplant recipient has an increased or decreased amount of TTV indicating decreased or increased immune response, respectively.

公开(公告)号：US20240309467A1

公开(公告)日：2024-09-19

申请号：US18576440

申请日：2022-06-13

申请人： EVONIK OPERATIONS GMBH

发明人： Emeka Ignatius IGWE ,  Marc HUFNAGL ,  Florian BÖHL ,  Andreas KAPPEL ,  Michaela WEISSMANN ,  Michelle DARGATZ ,  Janet SMITH

IPC分类号： C12Q1/689 ,  C12Q1/6851

CPC分类号： C12Q1/689 ,  C12Q1/6851

摘要： The invention pertains to a method for controlling a process of broiler production, the method comprising monitoring the level of the cpa gone in pooled fecal sample material deriving from the broiler flock to be tested at consecutive points in time, wherein a reduction of the cpa level in the pooled fecal sample material over time is an indication of optimal broiler development within the production process with regard to their gut microbiome status.

公开(公告)号：US20240309439A1

公开(公告)日：2024-09-19

申请号：US18677551

申请日：2024-05-29

申请人： Denso Corporation

发明人： Mai NIIMOTO ,  Akira Nukazuka ,  Mana Asano ,  Kazuhisa Nakagawa ,  Kei Hayakawa

IPC分类号： C12Q1/6851 ,  C12Q1/6806 ,  C12Q1/6876

CPC分类号： C12Q1/6851 ,  C12Q1/6876 ,  C12Q1/6806

摘要： An analysis method detects a target substance using a binding substance. The binding substance includes: a single-stranded nucleic acid preparation having activity to bind to the target substance; and a complementary nucleic acid that forms a base pair with a 3′ terminal region of the single-stranded nucleic acid preparation when the single-stranded nucleic acid preparation is not bound to the target substance, and that dissociates from the 3′ terminal region when the single-stranded nucleic acid preparation is bound to the target substance.