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公开(公告)号:US07160677B1
公开(公告)日:2007-01-09
申请号:US09645572
申请日:2000-08-25
IPC分类号: C16Q1/70
CPC分类号: C12Q1/6897 , C07K14/4705
摘要: The invention provides a polynucleotide in substantially isolated form which includes a contiguous sequence of nucleotides which is capable of selectively hybridizing to SEQ ID NO: 1 or the complement of SEQ ID NO: 1, and a polypeptide in substantially isolated form which includes: (a) the protein in SEQ ID NO: 2; or (b) an allelic variant or species homologue thereof; or (c) a protein at least 70% homologous to (a); or (d) a fragment of any one of (a) to (c) capable of forming a complex with the E2 F-1 protein or related family member; or (e) a fragment of any one of (a) to (c) of at least 15 amino acids.
摘要翻译: 本发明提供了基本上分离形式的多核苷酸,其包括能够与SEQ ID NO:1或SEQ ID NO:1的互补序列选择性杂交的连续核苷酸序列和基本上分离形式的多肽,其包括:(a )SEQ ID NO:2中的蛋白质; 或(b)等位基因变体或其物种同系物; 或(c)与(a)至少70%同源的蛋白质; 或(d)能够与E2F-1蛋白质或相关家族成员形成复合物的(a)至(c)中任一项的片段; 或(e)至少15个氨基酸的(a)至(c)中任一项的片段。