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公开(公告)号：US20230087259A1
公开(公告)日：2023-03-23
申请号：US17903120
申请日：2022-09-06
发明人： Michael CHEN , Jiahao HUANG , Radu LAZAR , Gordon MCINROY
摘要： The invention relates to methods of synthesizing polymers, biopolymers, and nucleic acids, to immobilised dNTP/NTPs and kits comprising said immobilised dNTP/NTPs for use in said methods of nucleic acid synthesis.
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公开(公告)号：US20220243360A1
公开(公告)日：2022-08-04
申请号：US17622479
申请日：2020-06-26
发明人： Lauren GOODRICH , Victor LYAMICHEV , Jigar PATEL , Richard PINAPATI , Eric SULLIVAN , Todd RICHMOND
摘要： The present technology provides an approach to designing libraries of peptide sequences for discovery and testing of significantly more motifs than would be otherwise available in a given fixed library format. The technology includes a plurality of x-mers embedded in N-mer peptides sequences, where N and x are integers and where N is greater than x. This approach provides for the representation of multiple unique x-mer peptides in a single N-mer peptide feature.
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公开(公告)号：US20220017471A1
公开(公告)日：2022-01-20
申请号：US17260992
申请日：2019-07-17
发明人： Guang Yang , Richard A. Lerner , Biao Jiang , Peixiang Ma , Hongtao Xu
IPC分类号： C07D229/02 , C40B80/00 , C40B70/00 , C40B30/04
摘要： Disclosed herein are methods of labeling organic compounds without depending on any functional group of the compound. In some embodiments, provided are bifunctional linkers useful in the methods.
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公开(公告)号：US20210062185A1
公开(公告)日：2021-03-04
申请号：US17019448
申请日：2020-09-14
申请人： Gen9, Inc.
发明人： Andrew V. Oleinikov
摘要： There is disclosed a process for in vitro synthesis and assembly of long, gene-length polynucleotides based upon assembly of multiple shorter oligonucleotides synthesized in situ on a microarray platform. Specifically, there is disclosed a process for in situ synthesis of oligonucleotide fragments on a solid phase microarray platform and subsequent, “on device” assembly of larger polynucleotides composed of a plurality of shorter oligonucleotide fragments.
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5.发明申请公开(公告)号：US20200010875A1
公开(公告)日：2020-01-09
申请号：US16443674
申请日：2019-06-17
发明人： Janine Mok , Ulrich Schlecht , Austin So
IPC分类号： C12Q1/6811 , C12Q1/6806 , C12Q1/686 , C12Q1/6876 , C12Q1/6855 , C40B40/06 , C40B80/00 , C40B50/08
摘要： The invention comprises a novel method and compositions for sequencing library preparation, which increases the throughput of single-molecule sequencing (SMS) platforms by generating long concatenated templates from pools of short DNA molecules.
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6.发明申请公开(公告)号：US20190338331A1
公开(公告)日：2019-11-07
申请号：US16480128
申请日：2018-01-26
发明人： Michael Chen , Jiahao Huang , Radu Lazar , Gordon McInroy
摘要： The invention relates to methods of synthesizing polymers, biopolymers, and nucleic acids, to immobilised dNTP/NTPs and kits comprising said immobilised dNTP/NTPs for use in said methods of nucleic acid synthesis.
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公开(公告)号：US08932879B2
公开(公告)日：2015-01-13
申请号：US12290447
申请日：2008-10-30
申请人： Mark J. Lim , Kenneth J. Rothschild
发明人： Mark J. Lim , Kenneth J. Rothschild
IPC分类号： G01N33/543 , C40B50/00 , C40B50/14 , C40B50/18 , C12P21/02 , C12N15/10 , C40B40/08 , C40B50/06 , C40B80/00
CPC分类号： C12P21/02 , B01J2219/00459 , B01J2219/005 , B01J2219/00576 , B01J2219/00596 , B01J2219/00648 , B01J2219/00722 , B01J2219/00725 , C12N15/1075 , C40B40/08 , C40B50/06 , C40B80/00
摘要： Methods are described for phototransferring a compound from a first surface to a second surface. Compounds are described with photocleavable linkers. Compounds attached to a first surface through a photocleavable linker are put in proximity (or contact) with a second surface, and then phototransferred to the second surface upon exposure to electromagnetic radiation. Illuminating the compound with radiation photocleaves the compound from the first surface and transfers the compound to the second surface.
摘要翻译： 描述了将化合物从第一表面转移到第二表面的方法。 用可光洁化的接头描述化合物。 通过光可透洗接头连接到第一表面的化合物与第二表面接近（或接触），然后在暴露于电磁辐射时转移到第二表面。 用辐射照射化合物使化合物从第一表面光刻，并将化合物转移到第二表面。
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公开(公告)号：US07976824B2
公开(公告)日：2011-07-12
申请号：US10560553
申请日：2004-07-29
摘要： The invention relates to a compound of formula (I): wherein P1, P2, P3, and P4 are each independently hydrogen or a protecting group; and n is an integer of from 2 to 20 and to the use of such compounds for the synthesis of 18F-FDG.
摘要翻译： 本发明涉及式（I）化合物：其中P1，P2，P3和P4各自独立地为氢或保护基; 并且n是2至20的整数，以及这些化合物用于合成18F-FDG的用途。
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9.发明申请公开(公告)号：US20210363570A1
公开(公告)日：2021-11-25
申请号：US17244321
申请日：2021-04-29
发明人： Janine Mok , Ulrich Schlecht , Austin So
IPC分类号： C12Q1/6811 , C12Q1/6806 , C12Q1/6855 , C12Q1/686 , C12Q1/6876 , C40B40/06 , C40B50/08 , C40B80/00
摘要： The invention comprises a method and compositions for sequencing library preparation, which increases the throughput of single-molecule sequencing (SMS) platforms by generating long concatenated templates from pools of short DNA molecules.
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公开(公告)号：US20210332349A1
公开(公告)日：2021-10-28
申请号：US17305230
申请日：2021-07-01
申请人： Illumina, Inc.
发明人： Steven Norberg , Dmitry Pokholok , Ramesh Ramji , Frank Steemers , Fan Zhang
摘要： Systems, methods, and compositions provided herein relate to preparation of beads encapsulating biomolecules for performing sequential reactions on the biomolecules. Some embodiments include preparation of nucleic acid reactions within the bead, wherein the bead includes pores that allow diffusion of molecules into or out of the beads while retaining other molecules of interest.
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