公开(公告)号：US20040251426A1

公开(公告)日：2004-12-16

申请号：US10833768

申请日：2004-04-28

申请人： Leica Microsystems Heidelberg GmbH

发明人： Holger Birk ,  Rafael Storz

IPC分类号： G01N021/64

CPC分类号： G01N21/6458 ,  G01N21/6428

摘要： A method for classifying a plurality of object image regions of an object to be detected using a scanning microscope includes labeling each of the image areas of the object with a different marker so that light of a respective characteristic emanates from each marker. The intensity of the light from each marker is detected using at least two channels so as to generate detection signals, each detection signal being a function of the intensity of the detected light. The object regions are classified using ratios of the detection signals.

摘要翻译： 使用扫描显微镜对待检测对象的多个对象图像区域进行分类的方法包括使用不同的标记来标记对象的每个图像区域，使得各个特征的光从每个标记发出。 使用至少两个通道来检测来自每个标记的光的强度，以产生检测信号，每个检测信号是检测到的光的强度的函数。 使用检测信号的比例对对象区域进行分类。

公开(公告)号：US20040241047A1

公开(公告)日：2004-12-02

申请号：US10841274

申请日：2004-05-07

申请人： Biosite, Inc.

发明人： Kenneth F. Buechler ,  Joseph M. Anderberg ,  Paul H. McPherson

IPC分类号： G01N021/64

CPC分类号： G01N21/645 ,  Y10T436/112499 ,  Y10T436/115831

摘要： A fluorometer for sensing the fluorescence of a sample utilizes an optical energy source for exciting a sample to be tested and an optical energy detector for detecting the emitted energy from the excited sample. Drive electronics are used for positioning the sample with respect to the optical components allowing a plurality of sample regions to be tested. A processor is utilized to control the operation of the test in accordance with test instructions and for processing the emitted energy detected from the sample to determine test results. A ROM chip socket accepts a plurality of ROM chips, wherein each ROM chip stores test data sets for one or more test types to be performed. ROM chips can be swapped to allow the fluorometer to be configured and reconfigured to perform a plurality of different tests. A communications interface facilitates the sharing of test information between the fluorometer and external entities.

公开(公告)号：US20040235185A1

公开(公告)日：2004-11-25

申请号：US10771872

申请日：2004-02-04

发明人： Carina Horn ,  Joachim Hoenes ,  Jurgen Spinke

IPC分类号： G01N021/64

CPC分类号： G01N21/6428 ,  G01N2021/7786 ,  Y10T436/104998 ,  Y10T436/106664 ,  Y10T436/144444

摘要： The invention concerns methods and reagent kits for the fluorimetric determination of analytes.

摘要翻译： 本发明涉及用于荧光测定分析物的方法和试剂盒。

公开(公告)号：US20040232351A1

公开(公告)日：2004-11-25

申请号：US10791713

申请日：2004-03-04

申请人： NAGOYA UNIVERSITY

发明人： Masahiro Ishiura ,  Kazuhisa Okamoto

IPC分类号： G01N021/64

CPC分类号： G01N21/763

摘要： A method for measuring and analyzing bioluminescence, including the steps of receiving in real-time a luminescence measurement result group from a creature sample group, displaying and maintaining in real-time the luminescence measurement result group, receiving in real-time another luminescence measurement result group from the creature sample group, and displaying and maintaining in real-time the another luminescence measurement result group, instead of the luminescence measurement result group.

摘要翻译： 一种用于测量和分析生物发光的方法，包括以下步骤：实时接收来自生物样品组的发光测量结果组，实时显示和维持发光测量结果组，实时接收另一发光测量结果 组，并且实时显示和维持另一发光测量结果组，而不是发光测量结果组。

公开(公告)号：US20040227101A1

公开(公告)日：2004-11-18

申请号：US10771729

申请日：2004-02-04

申请人： Japan Science and Technology Agency ,  OLYMPUS CORPORATION ,  HAMAMATSU PHOTONICS K.K. ,  Nippon Roper KK

发明人： Yoshinori Iketaki ,  Takeshi Watanabe ,  Masaaki Fujii ,  Yasunori Igasaki ,  Toshio Suzuki

IPC分类号： G01N021/64

CPC分类号： G02B26/08

摘要： A microscope capable of being shaped into a beam with complete hollow shape by removing the disorder of the wavefront to the erase light, particularly, and capable of improving the spatial resolution by inducing a super-resolution near the limit, is provided. In the microscope, wherein a first light to excite a molecule from a ground-state to first electron excited state or a second light to excite the molecule from the first electron excited state to the second electron excited state with higher energy level, for a sample 56 including the molecule with three electronic states including at least a ground-state, are spatial phase-modulated into the prescribed beam shape, and parts of these first light and the second light are overlapped and focused to detect luminescence from the sample 56, a wavefront compensation means 61 is provided in the optical path of the first light and/or in the optical path of the second light, and the wavefront aberration caused in the first light and/or in the second light, is removed by the wavefront compensation means 61.

摘要翻译： 提供了能够通过将擦除光的波阵面除去特别是并且能够通过在接近极限附近引起超分辨率来改善空间分辨率而将具有完全中空形状的光束成形为的显微镜。 在显微镜中，其中将分子从基态激发到第一电子激发态的第一光或第二光以将分子从第一电子激发态激发至具有较高能级的第二电子激发态，对于样品 包括具有至少包括基态的三种电子状态的分子被空间相位调制成规定的波束形状，并且这些第一光和第二光的一部分被重叠和聚焦以检测来自样品56的发光， 波前补偿装置61设置在第一光的光路和/或第二光的光路中，并且在第一光和/或第二光中引起的波前像差被波前补偿装置除去 61。

公开(公告)号：US20040206916A1

公开(公告)日：2004-10-21

申请号：US10824587

申请日：2004-04-15

申请人： Sensors for Medicine and Science, Inc.

发明人： Arthur E. Colvin JR. ,  John S. Gerig ,  Paul Samel Zerwekh ,  Jeffery C. Lesho ,  Benjamin N. McLeod

IPC分类号： G01N021/64

CPC分类号： A61B5/14556 ,  A61B5/0031 ,  A61B5/14532 ,  A61B5/1459 ,  A61B5/681 ,  G01N21/6428 ,  G01N21/645 ,  G01N2201/1244 ,  H05K1/0306 ,  H05K1/165 ,  H05K3/403 ,  H05K2201/086 ,  H05K2201/09972 ,  H05K2201/10106

摘要： A printed circuit device used in conjunction with inductive power and data transmission applications is formed substantially of ferrite material, with an inductive coil conductor formed around the substrate to increase the electromagnetic properties of the coil for both power and data transmission functions, thereby eliminating the need for a discrete ferrite core wire-wound coil to be connected to the circuit device.

摘要翻译： 与感应电力和数据传输应用结合使用的印刷电路器件基本上由铁氧体材料形成，在基板周围形成感应线圈导体，以增加用于功率和数据传输功能的线圈的电磁特性，从而消除了需要 用于连接到电路装置的分立的铁氧体磁芯绕线线圈。

公开(公告)号：US20040206915A1

公开(公告)日：2004-10-21

申请号：US10486585

申请日：2004-02-11

发明人： Yoshihiko Matsumura ,  Shinji Fujimura

IPC分类号： G01N021/64

CPC分类号： G01N21/6452 ,  G01N21/253 ,  G01N21/6458 ,  G01N2021/6417 ,  G01N2201/04 ,  G01N2201/0415

摘要： A fluorescence measuring apparatus is arranged to measure, substantially at the same time, a plurality of samples in a sample chamber or a plurality of points of the same sample, with the use of an excitation light source. The fluorescence measuring apparatus has a rotary sample stand (2) at the excitation light irradiation position, a plurality of through-holes (2a) are formed in the circumference of the rotary sample stand (2), and a sample placing unit (3) is insertable in each of the through-holes (2a). By moving the sample stand (2) relatively to the excitation light irradiation position, fluorescence measurement can be made on a plurality of samples without sample replacement required in a sample chamber (1).

摘要翻译： 荧光测量装置被布置成基本上同时使用激发光源来测量样品室中的多个样品或相同样品的多个点。 荧光测定装置在激发光照射位置具有旋转样品台（2），在旋转样品台（2）的周围形成有多个通孔（2a），样品放置单元（3） 可插入每个通孔（2a）中。 通过相对于激发光照射位置移动样品台（2），可以在多个样品上进行荧光测量，而不需要在样品室（1）中进行样品更换。

公开(公告)号：US20040200978A1

公开(公告)日：2004-10-14

申请号：US10787216

申请日：2004-02-27

申请人： NIDEC COPAL Corporation

发明人： Hideaki Kamijo

IPC分类号： G01N021/64

CPC分类号： G01N21/643 ,  G01N21/89 ,  G07D7/1205

摘要： A banknote inspection apparatus has a conveyance path, and midway of this conveyance path there are conveyance rollers for conveying a banknote, and a fluorescence sensor for detecting a fluorescent component included in the banknote. The fluorescence sensor has a housing and in this housing there are a light-emitting device for emitting light toward a banknote, and a light-detecting device for detecting fluorescence emitted from the surface of the banknote irradiated with ultraviolet light. A fluorescent member that generates fluorescence in response to the light emitted from the light-emitting device is placed in an inspection area of the conveyance path. In inspection of the banknote, the quantity of fluorescence from the fluorescent member is first detected, and the quantity of the light emitted from the light-emitting device is corrected based on the quantity of the fluorescence detected. Then the content of the fluorescent component in the banknote is detected in that state.

摘要翻译： 纸币检查装置具有输送路径，并且在该输送路径的中途具有用于输送纸币的输送辊和用于检测纸币中包含的荧光成分的荧光传感器。 荧光传感器具有壳体，并且在该壳体中具有向纸币发射光的发光装置，以及用于检测从紫外线照射的纸币的表面发出的荧光的光检测装置。 响应于从发光装置发出的光产生荧光的荧光部件被放置在输送路径的检查区域中。 在检查纸币时，首先检测来自荧光部件的荧光量，并且基于所检测的荧光量来校正从发光装置发射的光量。 然后在该状态下检测纸币中的荧光成分的含量。

公开(公告)号：US20040190813A1

公开(公告)日：2004-09-30

申请号：US10630928

申请日：2003-07-30

申请人： The Regents of the University of Michigan

发明人： Raoul Kopelman ,  Heather Clark ,  Susan Barker

IPC分类号： G02B006/00 ,  G01N021/64

CPC分类号： B82Y30/00 ,  B82Y15/00 ,  G01N21/6408 ,  G01N21/6428 ,  G01N21/7703 ,  G01N2021/6439 ,  G01N2021/6482 ,  G01N2021/6484 ,  G01N2021/772 ,  G01N2021/7786

摘要： Optical fiber sensors and fiberless optical sensors for measuring analytes, and in particular nitric oxide, are described utilizing metals, and more particularly, metal colloids. Proteins (or fragments thereof) with selective binding are immobilized on metal particles. The proteins may be dye-labeled for increased sensitivity.

摘要翻译： 使用金属，更具体地，金属胶体描述用于测量分析物，特别是一氧化氮的光纤传感器和无纤维光学传感器。 具有选择性结合的蛋白质（或其片段）固定在金属颗粒上。 蛋白质可能被染色标记以提高灵敏度。

公开(公告)号：US20040184961A1

公开(公告)日：2004-09-23

申请号：US10769220

申请日：2004-01-30

发明人： Ilya Feygin

IPC分类号： G01N021/64

CPC分类号： G01N21/35 ,  G01N21/3563

摘要： An apparatus and method for monitoring a large number of binding interactions and obtaining data related to the interactions. In accordance with the illustrative embodiment, the apparatus includes an IR sensor, a sliding separator, and IR-transmitting fibers that are optically coupled, at a first end thereof, to the sensor. The sliding separator adjusts the spacing between fibers as is required for interfacing the second end of the fibers with any of a variety of sample carriers. The second end of the fibers capture chemical entities form the sample carriers. The chemical entities at the end of the fibers are then contacted with a binding compound. If binding activity occurs, a thermal signal indicative thereof will be transmitted through the fiber to the sensor.

摘要翻译： 用于监测大量结合相互作用并获得与相互作用相关的数据的装置和方法。 根据说明性实施例，该装置包括IR传感器，滑动分离器和IR传输光纤，其在其第一端光耦合到传感器。 滑动分离器调节纤维之间的间距，如将纤维的第二端与各种样品载体中的任何一个接合所需要的。 纤维的第二端捕获化学实体形成样品载体。 然后将纤维末端的化学实体与结合化合物接触。 如果发生结合活动，则表示其的热信号将通过光纤传输到传感器。