MICROSCOPY SAMPLE PREPARATION METHODS AND ASSOCIATED SYSTEMS

    公开(公告)号:US20250060289A1

    公开(公告)日:2025-02-20

    申请号:US18451759

    申请日:2023-08-17

    Applicant: FEI Company

    Abstract: In an example, a method includes producing a set of projected sample characterization values associated with each of a plurality of processing axes and identifying a preferred processing axis based on the projected sample characterization values. In another representative example, a method includes extracting a sample specimen, producing a sample image of the sample specimen, identifying a preferred sample tilt angle, and rotating the sample specimen to an orientation corresponding to a preferred sample tilt angle. The method further includes processing the sample specimen to produce a lamella. In another representative example, a system includes a focused ion beam (FIB) system, a sample holder, a stage, and a controller operable to cause the stage to rotate the sample specimen relative to the ion beam axis such that the ion beam approaches the sample specimen along a preferred processing axis.

    SAMPLE PREPARATION SYSTEM, SAMPLE PREPARATION METHOD, AND SAMPLE ANALYSIS SYSTEM

    公开(公告)号:US20250027852A1

    公开(公告)日:2025-01-23

    申请号:US18713940

    申请日:2022-11-25

    Applicant: RIKEN

    Abstract: A sample preparation system (100) includes a position identification section (34) that associates a plurality of cells constituting a cell group with the respective plurality of cells constituting the cell group in which at least a part of junctions between adjacent ones of the plurality of cells is disconnected, in a dispersion process of (i) disconnecting at least the part of the junctions between the adjacent ones of the plurality of cells in the cell group in which the plurality of cells are joined to each other and (ii) dispersing the cell group. This allows the realization of a technique of collecting a cell and specifying the position of the collected cell in an original cell group.

    GASSING DEVICE
    4.
    发明申请

    公开(公告)号:US20250027851A1

    公开(公告)日:2025-01-23

    申请号:US18713000

    申请日:2022-11-23

    Abstract: The disclosure relates to a gassing device having a fluid discharge unit, a flow control unit, a filter unit, and an exposition head unit, wherein the units are in fluid communication without any hose connections.

    Fast whole slide tissue tiling method

    公开(公告)号:US12198336B2

    公开(公告)日:2025-01-14

    申请号:US17636969

    申请日:2020-08-24

    Abstract: The present application relates generally to image tiling, including but not limited to systems and methods of fast whole slide tissue tiling. A computing system may identify a first image of a first dimension from which to select one or more tiles. The computing system may perform a reduction operation on the first image to generate a second image of a second dimension. The computing system may apply a thresholding operation on the second image to identify a first set of pixels corresponding to the presence of the feature and a second set of pixels corresponding to the absence of the feature based on an intensity of each pixel in the second image. The computing system may select, from a plurality of tiles corresponding to the first image, a subset of tiles corresponding to the first set of pixels identified from the second image.

    Method and apparatus for faster pathology

    公开(公告)号:US12196647B2

    公开(公告)日:2025-01-14

    申请号:US17805751

    申请日:2022-06-07

    Abstract: An apparatus and method for faster pathology are provided that removes the need for time consuming preparation of a hardened tissue block. Such hardening is necessary to enable cutting of the thin tissue sections required for pathology evaluation. Rather the tissue specimen is hardened by freezing only at the surface from which tissue is to be sectioned by contact with a cold surface or slide thereby lessening the time required for hardening. Sectioning is performed by passing a cutting member such as a blade, cutting wire or laser along a plane parallel to the cold surface and using the cold surface as a guide.

    IMAGE CALIBRATION SLIDE
    8.
    发明申请

    公开(公告)号:US20250012680A1

    公开(公告)日:2025-01-09

    申请号:US18762817

    申请日:2024-07-03

    Inventor: Byeongyeon KIM

    Abstract: Proposed is an image calibration slide including: a substrate; and an image calibration pattern formed on a surface of the substrate, in which the image calibration pattern is formed by immobilizing and staining a DNA strand.

    METHOD FOR THE QUANTITATIVE MEASUREMENT OF AN ELEMENT IN A PIECE

    公开(公告)号:US20250003944A1

    公开(公告)日:2025-01-02

    申请号:US18700575

    申请日:2022-10-10

    Abstract: A method for the quantitative measurement of an element in a metal test specimen which has received a thermochemical surface treatment, the method including—a—making a cut in the test specimen;—b—taking a photograph, using an optical microscope, of the cut on a surface S with magnification;—c—calculating the ratio of the surfaces s occupied by the element with respect to the surface S in the photograph by an image-processing tool; and—d—obtaining the content of the element in the surface S of the test specimen. A profile of the content of undesirable elements can thus be obtained without the subjective aspect of human checking, which profile is representative of a content obtained by acquiring diffraction of X-rays produced using a synchrotron.

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