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公开(公告)号：US11633737B2
公开(公告)日：2023-04-25
申请号：US16095107
申请日：2017-04-20
申请人： Cellix Limited
发明人： Dmitry Kashanin , Igor Shvets , Francesco Dicorato
摘要： A microfluidic chip for focussing a stream of particulate containing fluid comprises a sample microfluidic channel configured to receive the stream of particulate containing fluid, a guidance microfluidic channel having a polygonal cross-sectional area and configured to receive a stream of guidance fluid, and a common microfluidic channel having a polygonal cross sectional area formed by the merging of the sample microfluidic channel and the guidance 10 microfluidic channel at an oblique angle along only part of one or more sides of the guidance microfluidic channel, and a detection zone disposed in the common microfluidic channel having one or more sensors. The merging of the sample microfluidic channel and the guidance microfluidic channel is configured to provide a composite fluid stream containing a focussed beam of particulates that is disposed asymmetrically in the common microfluidic channel 15 adjacent a corner or side of the common microfluidic channel and wherein the one or more sensors are configured for sensing a characteristic of the focussed beam of particulates in the common channel.
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公开(公告)号：US20230118941A1
公开(公告)日：2023-04-20
申请号：US17979101
申请日：2022-11-02
申请人： Owl biomedical, Inc.
发明人： Daryl GRUMMITT , John HARLEY , John FOSTER , Mark NAIVAR
摘要： A MEMS-based particle manipulation system which uses a particle manipulation stage and a plurality of laser interrogation regions. The laser interrogation regions may be used to assess the effectiveness or accuracy of the particle manipulation stage. In one exemplary embodiment, the particle manipulation stage is a microfabricated, flap-type fluid valve, which sorts a target particle from non-target particles in a fluid stream. The laser interrogation stages are disposed in the microfabricated fluid channels at the input and output of the flap-type sorting valve. The laser interrogation regions may be used to assess the effectiveness or accuracy of the sorting, and to control or adjust sort parameters during the sorting process. One or more feedback loops may be used to improve the particle manipulation process, based on data acquired during the first interrogation and/or during a downstream confirmation. Artificial intelligence techniques may be used to good effect.
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3.发明授权公开(公告)号：US11630052B2
公开(公告)日：2023-04-18
申请号：US17017966
申请日：2020-09-11
IPC分类号： G01N15/14 , B01L3/00 , G01N21/64 , C12M1/00 , G01N21/00 , G06V10/141 , G06V20/69 , G01N15/10 , G01N15/00 , G01N21/17
摘要： A high-throughput optofluidic device for detecting fluorescent droplets is disclosed. The device uses time-domain encoded optofluidics to detect a high rate of droplets passing through parallel microfluidic channels. A light source modulated with a minimally correlating maximum length sequences is used to illuminate the droplets as they pass through the microfluidic device. By correlating the resulting signal with the expected pattern, each pattern formed by passing droplets can be resolved to identify individual droplets.
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公开(公告)号：US20230113336A1
公开(公告)日：2023-04-13
申请号：US17798369
申请日：2020-06-10
申请人： BGI SHENZHEN
发明人： ZHONGHAI WANG , CHUTIAN XING , JIANJUN JIANG , HEMING JIANG , YONGWEI ZHANG
摘要： A biological sample image collection device (100), comprising support (30) and an optical imaging assembly (50), also comprises: a plurality of movable platforms (40), for placing biological samples (20) wherein the plurality of movable platforms (40) are arranged on the support (30) in an array; the plurality of movable platforms (40) can move relative to the support (30); and forces acting on the support (30) during the movement of the movable platforms can cancel each other out, so as to avoid vibrations affecting the support (30) and the biological samples (20) are canceled. The optical imaging assembly (50) collects images of the biological samples (20) on the movable platforms (40) when the plurality of movable platforms (40) move, relative to the center of the array, in the same direction and at the same speed. Further provided is a gene sequencer including the biological sample image collection device (100).
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公开(公告)号：US20230112565A1
公开(公告)日：2023-04-13
申请号：US17799230
申请日：2021-02-12
发明人： Nongjian TAO , Shaopeng WANG , Pengfei ZHANG
IPC分类号： G01N33/68 , B01L3/00 , G01N33/543 , G01N15/14
摘要： Detecting single molecules includes binding the single molecules to a surface of an optically transparent substrate, irradiating the surface of the substrate with light having an incident angle selected to achieve total reflection of the light, thereby scattering light from the surface and from the single molecules bound to the surface, and collecting light scatted by the surface and by the single molecules bound to the surface to form a series of images. Systems for detecting single molecules include an optically transparent substrate, a means for flowing a sample solution over a surface of the substrate, a light source configured to irradiate the surface, a camera, and a collection optical system configured to collect light scatted by the surface and by the target molecules on the surface to form a series of images on the camera.
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公开(公告)号：US20230093848A1
公开(公告)日：2023-03-30
申请号：US17934473
申请日：2022-09-22
申请人： X Development LLC
摘要： Methods, systems, and apparatus, including computer programs encoded on computer storage media, for processing recycled concrete aggregate (RCA). One of the methods includes obtaining first optical measurements of RCA particles as the RCA particles are conveyed past the first optical sensors; determining, based on the first measurements, an initial characterization of the RCA particles; iteratively performing a carbonation process on the RCA particles, obtaining second optical measurements of the RCA particles, and determining, from the second measurements, a second characterization of the RCA particles, wherein conditions of the carbonation process are initially set based on the initial characterization, and the conditions of the carbonation process are adjusted based on the second characterization; ceasing the iterative performance of the carbonation process in response to the second characterization meeting target carbonation characteristics; iteratively performing a densification process on the RCA particles, obtaining third optical measurements of the RCA particles, and determining, from the third measurements, a third characterization of the RCA particles, wherein conditions of the densification process are initially set based on the initial characterization or the second characterization, and the conditions of the densification process are adjusted based on the third characterization; and ceasing the iterative performance of the densification process in response to the third characterization meeting target densification characteristics.
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公开(公告)号：US20230089109A1
公开(公告)日：2023-03-23
申请号：US18060527
申请日：2022-11-30
申请人： SYSMEX CORPORATION
发明人： Osamu KIKUCHI , Takahito MIHARA , Yuji MASUDA , Atsushi SHIRAKAMI , Takuma WATANABE , Daigo FUKUMA , Masaharu SHIBATA
摘要： A blood analyzer according to one or more embodiments may include: a specimen preparation part that prepares a measurement specimen by mixing a reagent into a blood preparation; a measurement part that measures the measurement specimen; a measurement mode selection unit that receives an input of a type of blood preparation as a measurement target selected from a plurality of types of blood preparations; and a controller. The controller may cause the specimen preparation part to prepare the measurement specimen depending on the selected type of blood preparation.
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公开(公告)号：US20230088338A1
公开(公告)日：2023-03-23
申请号：US17940591
申请日：2022-09-08
申请人： ILLUMINA, INC.
发明人： Thomas Baker , Kevin Early , Siqi Zhang , Rachel Abaskharon , Anmiv Prabhu , Patrick Wen
摘要： Generation and use of a focus quality metric that is intensity independent is described. In one example, the focus quality metric is generated by acquiring an image, such as an image of a patterned surface of a flow cell, and processing all or part (e.g., a sub-region or sub-image) to generate a Fourier transform of the respective image data. By way of example, in one embodiment a discrete Fourier transform may be applied to a sub-region of an image of a patterned flow cell surface. A focus quality metric that is intensity independent may be derived from the Fourier transform of the image data.
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公开(公告)号：US11609177B2
公开(公告)日：2023-03-21
申请号：US15472020
申请日：2017-03-28
发明人： Pierce O. Norton
摘要： Aspects of the present disclosure include a particle sorting module for sorting components of a sample, such as cells in a biological sample. Particle sorting modules according to certain embodiments include an enclosed housing having an aligner for coupling the housing with a particle sorting system, a flow cell nozzle positioned at the proximal end of the housing, a sample interrogation region in fluid communication with the orifice of the flow cell nozzle and a droplet deflector. A particle sorting system and methods for separating components of a sample as well as kits, including one or more particle sorting module, suitable for coupling with a particle sorting system and for practicing the subject methods are also provided.
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公开(公告)号：US20230076689A1
公开(公告)日：2023-03-09
申请号：US17896176
申请日：2022-08-26
申请人： ILLUMINA, INC.
发明人： Mohsen Rezaei , Craig Hetherington , Arvin Emadi , Stanley Hong
IPC分类号： G01N15/14 , G02B5/20 , H01L27/146
摘要： An apparatus includes a flow cell body with an array of reaction sites positioned along a floor of a channel. An optical filter layer is positioned under the floor of the channel and includes at least a portion spanning uninterruptedly along a length corresponding to the length of the array of reaction sites. Imaging regions are positioned under the optical filter layer. Each imaging region is positioned directly under a corresponding reaction site. The optical filter layer is configured to permit one or more selected wavelengths of light to pass from each reaction site to the imaging region forming a sensing pair with the reaction site. The optical filter layer is configured to reduce transmission of excitation light directed toward the reaction sites; and to reduce transmission of light emitted from each reaction site to imaging regions not forming a sensing pair with the reaction site.
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