公开(公告)号：US20230175970A1

公开(公告)日：2023-06-08

申请号：US17765442

申请日：2021-08-30

申请人： Indian Institute of Technology Madras (IIT Madras)

发明人： Raghavendra Sai ,  V V Lakshmana Swamy

IPC分类号： G01N21/77 ,  G01N21/43

CPC分类号： G01N21/7703 ,  G01N21/431 ,  G01N2021/1789

摘要： The disclosure proposes a portable fiber optic measurement device (100) for physical, chemical, and biological sensing applications that facilitates real-time monitoring. The device (100) includes a fiber optic probe cartridge (120) that is removably attached to a measuring device (110). The device (110) includes a light source, a detector, and the associated electronic measurement and control unit along with a display. The device (100) is configured to measure the real-time changes in the light intensity on the fiber probe cartridge side (130). With a U-bent fiber optic probe cartridge (138) as an example, the device (100) is configured to measure the bulk solution refractive index changes, effective refractive index change, or characteristic optical property of analytes including ions, chemical and bio molecules, polymers, compounds, microorganisms present on the fiber core surface (138). The key facets of this device include high sensitivity, real-time and rapid analysis, handheld, and portable instrumentation at meager operational cost.

公开(公告)号：US11099189B2

公开(公告)日：2021-08-24

申请号：US16162261

申请日：2018-10-16

申请人： BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM

发明人： Jing Yong Ye ,  Jonathan D. Scudder

IPC分类号： G01N33/579 ,  G01N21/31 ,  G01N21/77 ,  G01N21/43

摘要： A pyrogenicity test assay and method of pyrogen testing that allows for rapid and ultrahigh sensitivity testing of parenteral pharmaceuticals or medical devices that contact blood or cerebrospinal fluid by employing a Limulus Amoebocyte Lysate (LAL) assay utilizing a photonic-crystal biosensor. The photonic-crystal biosensor is capable of determining the presence of endotoxins in a test sample by monitoring shifts in the resonant wavelength of an open microcavity affected by the changes in the refractive index of the analyte solutions used.

公开(公告)号：US11079280B2

公开(公告)日：2021-08-03

申请号：US15971455

申请日：2018-05-04

申请人： CORNING INCORPORATED

发明人： Rostislav Vatchev Roussev ,  Vitor Marino Schneider

IPC分类号： G01J4/02 ,  G02B5/04 ,  G02B5/06 ,  G01N21/23 ,  G02B6/34 ,  G01J4/00 ,  G01N21/43 ,  G01N21/41

摘要： Apparatus and methods for measuring mode spectra for ion-exchanged glass substrates having a steep index region are disclosed. An interfacing fluid is provided between the coupling prism and the glass substrate. The interfacing fluid thickness is selected so that the variation in modal birefringence with fluid thickness is reduced to an acceptable level. The coupling prism can include a prism coating on the coupling surface so that the substrate-prism interface includes the prism coating. The coupling prism can also include stand-off members that serve to define the thickness of the interfacing fluid.

公开(公告)号：US20210048388A1

公开(公告)日：2021-02-18

申请号：US16978926

申请日：2019-03-10

申请人： VALIBER LTD.

发明人： Mark SHECHTERMAN

IPC分类号： G01N21/43 ,  G02B5/04 ,  G02B3/00 ,  G01K13/00 ,  G01N33/14

摘要： Disclosed herein, according to an aspect of some embodiments, is a dipping refractometer. The dipping refractometer includes a prism and a casing, housing a light source and a light sensor. The prism is mounted in/on the casing such as to allow dipping the prism in a fluid such that two surfaces of the prism and the fluid forming two respective direct prism-fluid interfaces. The prism, the light source, and the light sensor are configured such that for a continuous range of values of fluid refractive indices, most of the light incident on the light sensor, originating from the light source, undergoes total internal reflection off of each of the two direct prism-fluid interfaces.

公开(公告)号：US10732059B2

公开(公告)日：2020-08-04

申请号：US16371517

申请日：2019-04-01

申请人： CORNING INCORPORATED

发明人： Ryan Claude Andrews ,  Chai Hsin Kuang ,  Rostislav Vatchev Roussev

IPC分类号： G01N21/55 ,  G01L1/24 ,  G01J3/447 ,  G01N33/38 ,  G01N21/23 ,  G01N21/43

摘要： The prism-coupling systems and methods include using a prism-coupling system to collect initial TM and TE mode spectra of a chemically strengthened article having a refractive index profile with a near-surface spike region and a deep region. The initial TM and TE mode spectra are examined to see if they fall within a preferred measurement window that can produce an accurate estimate of the knee stress to within a select tolerance. If not, then measurement configuration of the prism-coupling system is changed and new TM and TE mode spectra are collected. This process is repeated until the new TM and TE mode spectra fall within the preferred measurement window. The new TM and TE mode spectra are then used to determine the knee stress. Changing the measurement configuration can include changing at least one of the measurement wavelength, interfacing fluid thickness and interfacing fluid refractive index.

公开(公告)号：US10585038B2

公开(公告)日：2020-03-10

申请号：US16447136

申请日：2019-06-20

申请人： VAISALA OYJ

发明人： Juha Jääskeläinen

IPC分类号： G01N21/41 ,  F21V8/00 ,  G02B6/04 ,  G01N21/43

摘要： The present disclosure relates to light arrangement for an optical device for measurement of an index of refraction, having a light source, a fiber bundle arrangement for transmitting light from the light source, a diffusing member, and imaging optics for transmitting the light to a measuring window. In order to provide for an arrangement which is durable and accurate even when used for measuring hot specimens where the light source is positioned far from the measuring window, the fiber bundle arrangement includes a novel combination of a first fiber bundle and a second fiber bundle.

公开(公告)号：US20190391074A1

公开(公告)日：2019-12-26

申请号：US16447136

申请日：2019-06-20

申请人： JANESKO OY

发明人： Juha Jääskeläinen

IPC分类号： G01N21/41 ,  G01N21/552 ,  G01N21/43 ,  F21V8/00 ,  G02B6/04

摘要： The present disclosure relates to light arrangement for an optical device for measurement of an index of refraction, having a light source, a fiber bundle arrangement for transmitting light from the light source, a diffusing member, and imaging optics for transmitting the light to a measuring window. In order to provide for an arrangement which is durable and accurate even when used for measuring hot specimens where the light source is positioned far from the measuring window, the fiber bundle arrangement includes a novel combination of a first fiber bundle and a second fiber bundle.

公开(公告)号：US20190360932A1

公开(公告)日：2019-11-28

申请号：US16423733

申请日：2019-05-28

申请人： Biosensing Instrument Inc.

发明人： Nguyen Ly ,  Tianwei Jing

IPC分类号： G01N21/552 ,  G01N21/43 ,  G01N21/59

摘要： A system in an embodiment can comprise an optical assembly, an SPR light source, and an SPR camera. The optical assembly in this embodiment can comprise a hemispherical prism comprising a planar top surface configured to support a surface-plasmon-resonance (SPR) sensor; a high numerical aperture (NA) lens; and a housing configured to mount the hemispherical prism and the high NA lens the such that the high NA lens is located distal from the planar top surface of the hemispherical prism. The SPR light source in this embodiment can be configured to emit a low-coherent monochromatic light beam for SPR imaging toward the high NA lens. The SPR camera in this embodiment can be configured to capture an SPR image formed after the low-coherent monochromatic light beam is incident upon and reflected by a metal-coated sample contacting surface of the SPR sensor. Additionally, the high NA lens in this embodiment can be configured to refract the low-coherent monochromatic light beam from the SPR light source toward the hemispherical prism; and the hemispherical prism can be configured to collimate the low-coherent monochromatic light beam, as refracted by the high NA lens, toward the SPR sensor. Other embodiments are disclosed.

公开(公告)号：US10471404B2

公开(公告)日：2019-11-12

申请号：US15805237

申请日：2017-11-07

申请人： DOLPHIN FLUIDICS S.R.L.

发明人： Diego Andreis ,  Francesco Butera

IPC分类号： B01F15/00 ,  B01F15/04 ,  B01F3/08 ,  B01F5/00 ,  B01F15/02 ,  B67D1/00 ,  F16K11/00 ,  F16K31/02 ,  F16K37/00 ,  G05D11/13 ,  G01N21/43

摘要： A valve for dosing and mixing two fluids includes two respective inlet ducts, a double chamber for controlling the flows, at least one actuator configured to regulate the flow rates of the two fluids to be mixed, an electronic control unit and a Brix degrees optical sensor, arranged on the mixing duct of the mixture of the two fluids and operatively connected to the electronic control unit. The optical sensor is configured to send a measurement and control signal to the electronic control unit to drive the actuator so as to proportionally control the flow rates of the two fluids and, therefore, regulate the mixing ratio of the two fluids.

公开(公告)号：US10408752B2

公开(公告)日：2019-09-10

申请号：US15716518

申请日：2017-09-27

申请人： National Taiwan University

发明人： Cheng Wang ,  Li-Wei Nien ,  Chun-Hway Hsueh ,  Hsin-Chia Ho ,  Yi-Chen Lai

IPC分类号： G01N21/43 ,  G01N21/25 ,  G01N21/552 ,  G01N21/65

摘要： A plasmonic sensor includes at least a substrate and a thin film metallic glass formed on the substrate. The dielectric constant (εr) of the thin film metallic glass is negative. Since the thin film metallic glass with negative εr is used in the plasmonic sensor, the material cost can be significantly reduced, the mechanical property can be improved, and the optoelectronic property can be increased. Since the thin film metallic glass is a kind of supercooled alloy with amorphous structure, it can be applied for imprinting deformation and amorphous without grain boundary scattering.