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    Nanopore technologies
    4.
    发明授权
    Nanopore technologies 有权

    公开(公告)号：US11454624B2

    公开(公告)日：2022-09-27

    申请号：US16584205

    申请日：2019-09-26

    申请人： SENSONANO LTD.

    发明人： Ofer Israel Wilner ,  Ori Kaplan

    IPC分类号： G01N33/487 ,  G01N27/26 ,  B82Y5/00

    摘要： A test cartridge includes a membrane separating an internal space of the cartridge into a sample chamber and a second chamber. A first electrode is disposed within the sample chamber, and a second electrode is disposed within the second chamber. A device includes a dock and circuitry. The dock includes a first dock-terminal and a second dock-terminal, and is configured to receive the cartridge such that the circuitry is electrically connected to the electrodes via contact between terminals of the dock and terminals of the cartridge. The circuitry performs, while the cartridge remains docked with the dock: (a) a verification step that verifies an absence of nanopores in the membrane, (b) subsequently, a nanoporation subroutine, and (c) subsequently, an assay subroutine. The circuitry enables the nanoporation subroutine only if the verification step successfully verifies the absence of nanopores. Other embodiments are also described.

    ANTIGEN MEASURING METHOD AND MEASURING APPARATUS
    6.
    发明申请
    ANTIGEN MEASURING METHOD AND MEASURING APPARATUS 有权

    公开(公告)号：US20220260558A1

    公开(公告)日：2022-08-18

    申请号：US17425150

    申请日：2020-01-23

    申请人： PROVIGATE INC.

    发明人： Yuuya MIYAZAWA

    IPC分类号： G01N33/543 ,  G01N27/26 ,  G01N33/68 ,  G01N21/78

    摘要： There is provided a method for measuring an antigen, comprising: providing a solution containing an antigen; providing a first antibody that specifically recognizes the antigen and is bound to a magnetic carrier; providing a second antibody that specifically recognizes the antigen and is modified with an oxidase; providing (a substrate liquid including) a substrate which reacts with the oxidase; allowing the first antibody to recognize the antigen; allowing the second antibody to recognize the antigen; using a magnetic field to capture an antigen-antibody complex of the antigen recognized by the first antibody and the second antibody in the magnetic field; washing the antigen-antibody complex while it is captured in the magnetic field; reacting the substrate with the antigen-antibody complex to produce hydrogen peroxide; and measuring the hydrogen peroxide.

    APPARATUSES AND METHODS INVOLVING PROTEIN EXPLORATION THROUGH PROTEOLYSIS AND NANOPORE TRANSLOCATION
    8.
    发明申请
    APPARATUSES AND METHODS INVOLVING PROTEIN EXPLORATION THROUGH PROTEOLYSIS AND NANOPORE TRANSLOCATION 有权

    公开(公告)号：US20220074920A1

    公开(公告)日：2022-03-10

    申请号：US17416243

    申请日：2018-12-21

    申请人： SRI International

    发明人： Kathryn G. Todd ,  Matthew D. Puster ,  Keith Laderoute ,  Kevin Luebke ,  David Huber ,  Maneesh Yadav

    IPC分类号： G01N33/487 ,  G01N27/26

    摘要： Embodiments in accordance with the present disclosure are directed to methods and apparatuses used for evaluating a protein in a sample using proteolysis and translocation. An example method includes isolating a single protein from a sample in a chamber having at least a first well and a second well separated from the first well by a membrane with a nanopore, the nanopore providing fluidic communication between the first and second wells. The single protein is cleaved into a plurality of peptide fragments via exposure to a protease in the first well, and translocated through the nanopore by applying an electric potential to the nanopore in the chamber after cleavage of the single protein by the protease. The method further includes detecting events indicative of the translocations of the plurality of peptide fragments through the nanopore and to the second well.