公开(公告)号：US20230333070A1

公开(公告)日：2023-10-19

申请号：US18026659

申请日：2021-09-14

申请人： SEKISUI CHEMICAL CO., LTD. ,  SEKISUI MEDICAL CO., LTD.

发明人： Shoutarou KOBARU ,  Takamasa KOUNO ,  Nobuhiko INUI ,  Kazuhiko IMAMURA ,  Sou YAMAGUCHI ,  Katsura UCHIDA ,  Tatsunori TAKAMATSU

IPC分类号： G01N35/08 ,  G01N30/26

CPC分类号： G01N30/26 ,  G01N35/08

摘要： Provided is an inspection chip with simplified channel switching structure, which is generally complicated. An inspection chip 1 including a chip main body 2 having a specimen introduction channel, an adsorption channel including an adsorption unit, a first waste liquid channel, a recovery liquid introduction channel, and a detection channel including a detection unit; and a rotary valve 3 attached to the chip main body 2 so as to be rotatable about a rotation axis, the rotary valve 3 having a plurality of connection channels, the plurality of connection channels being arranged so that the rotary valve 3 is capable of taking at least a first state and a second state when the rotary valve 3 rotates about the rotation axis, the first state being a state in which the specimen introduction channel, the adsorption channel, and the first waste liquid channel are connected so as to be provided in this order from an upstream side, and the second state being a state in which the recovery liquid introduction channel, the adsorption channel, and the detection channel are connected so as to be provided in this order from the upstream side.

公开(公告)号：US20220326195A1

公开(公告)日：2022-10-13

申请号：US17641679

申请日：2020-11-18

申请人： SHIMADZU CORPORATION

发明人： Akira AONO ,  Shota HATA ,  Naru MARUOKA ,  Hideki SATO

IPC分类号： G01N30/20 ,  G01N30/88 ,  G01N30/26

摘要： A switching mechanism 110 can perform switching to a pressurized state in which gas is supplied from a pipe 203 to an insertion tube 101, or a derivation state in which gas in a head space 23 that is pressurized is derived from the insertion tube 101 to the pipe 207 via a collection unit 104. The switching mechanism 110 includes a discharge valve 103 that puts the insertion tube 101 and the pipe 207 into a non-communication state in the pressurized state and puts the insertion tube 101 and the pipe 207 into a communication state in the derivation state. A resistance pipe 206 supplies gas to a channel between the collection unit 104 and the discharge valve 103 in the derivation state.

公开(公告)号：US11460455B2

公开(公告)日：2022-10-04

申请号：US15525613

申请日：2015-11-11

申请人： Cytiva Sweden AB

发明人： Lena Nyholm ,  Johan Arthursson ,  Eva Olsson ,  Ulrika Ohman

IPC分类号： G01N30/86 ,  G01N30/26 ,  G01N30/50

摘要： Method for determining the influence of least a first and a second experimental parameter on a liquid chromatography protocol for purifying one or more target molecules from a sample, comprising the steps: —performing chromatography purifications of the sample at a plurality of different experimental conditions where at least the first and the second experimental parameter each are varied over a predetermined range, each purification being registered as a chromatogram by monitoring an output parameter indicative of the purification result during the purification; and—displaying in a graphical user interface at least a subset of the registered chromatograms as chromatogram-miniatures in an evaluation diagram wherein the position of each displayed chromatogram-miniature is determined by the experimental parameters for the corresponding purification, thereby allowing a user to visually determine trends and the influence of the experimental parameters on the liquid chromatography protocol.

公开(公告)号：US20200319152A1

公开(公告)日：2020-10-08

申请号：US16768136

申请日：2018-11-29

申请人： UCL BUSINESS LTD

发明人： Stuart Ibsen ,  Alaric Taylor ,  Simon Dawes ,  Luis Antonio Serrano Gonzalez ,  Stefan Guldin

IPC分类号： G01N30/90 ,  G01N30/74 ,  G01N30/14 ,  G01N30/26 ,  G01N1/40 ,  G01N33/94

摘要： The invention relates to cartridges for thin layer chromatography (TLC) which hermetically seal the TLC mobile phase during loading, performance of the TLC process, and analysis of the chromatogram. It further relates to associated methods of use—for example for detecting or quantifying an analyte in a sample. It further relates to processes for assembling the cartridge, to associated equipment adapted for use with them, and kits of parts.

公开(公告)号：US10364900B2

公开(公告)日：2019-07-30

申请号：US15038895

申请日：2015-01-22

申请人： Hitachi High-Technologies Corporation

发明人： Takaaki Hara ,  Hiroshi Moriya ,  Ayano Otsubo ,  Yoshihiro Nagaoka ,  Kiyotoshi Mori ,  Shoji Tomita

IPC分类号： F16K3/06 ,  G01N30/20 ,  F16K11/074 ,  G01N30/26 ,  G01N30/38

摘要： Provided are: a flow path switching valve that reduces the pressure load in a contact surface outer peripheral section of the flow path switching valve and inhibits friction between constituent components; and a liquid chromatographic device using the flow path switching valve. The flow path switching valve is provided with a stator having a plurality of through holes and a seal having conduction grooves for causing the through holes to conduct. The seal has a first portion present vertically beneath a region comprising at least a surface of contact with the stator, and a second portion having lower rigidity than the first portion, on the outside of the first portion. Due to this configuration, it is possible to reduce the pressure load when a flow path of a liquid is switched under high-pressure conditions, and inhibit the phenomenon of friction itself.

公开(公告)号：US20190170683A1

公开(公告)日：2019-06-06

申请号：US16323532

申请日：2017-12-13

申请人： Panasonic Intellecutal Property Management Co., Ltd.

发明人： TOSHIHIRO SAKAMOTO ,  CHIAKI SHIDO

IPC分类号： G01N27/447 ,  G01N30/26 ,  G01N30/88 ,  G01N30/92 ,  G01N30/94 ,  G01N33/543

摘要： Provided is a thin layer chromatography plate that makes it possible to separate a plurality of components from each other more simply and more quickly. Thin layer chromatography plate includes substrate and separation layer that is disposed on substrate for separating multiple components included in a sample from each other. Separation layer has first layer that has a band shape and extends in first development direction and second layer that extends in second development direction orthogonal to first development direction. Second layer is in contact with first layer. First layer includes a hydrophilic porous body. Second layer includes a hydrophobic porous body.

公开(公告)号：US20190145941A1

公开(公告)日：2019-05-16

申请号：US15815039

申请日：2017-11-16

申请人： Shimadzu Corporation

发明人： Shingo MASUDA

IPC分类号： G01N30/26 ,  G05D7/06 ,  G01N30/68

CPC分类号： G01N30/26 ,  G01N30/10 ,  G01N30/32 ,  G01N30/68 ,  G01N2030/025 ,  G01N2030/324 ,  G01N2030/6013 ,  G05D7/06

摘要： When a flow rate of a carrier gas calculated by a column flow rate calculation unit is controlled to be a first flow rate, and when the flow rate of the carrier gas is controlled to be a second flow rate, the flow rates of the carrier gas are detected by a whole flow rate detection unit, and a gas leakage determination unit determines of leakage of the carrier gas on the basis of the rates. Since the flow rate of the carrier gas is changed and the detected value of the whole flow rate detection unit is used at different flow rates, a case can be discriminated where an offset occurs in the detected value of the whole flow rate detection unit and a case where leakage of the carrier gas occurs. Thus, it is satisfactorily determined the presence or absence of the leakage of the carrier gas.

公开(公告)号：US09664655B2

公开(公告)日：2017-05-30

申请号：US14093691

申请日：2013-12-02

申请人： Dionex Corporation

发明人： John M. Riviello

IPC分类号： G01N30/02 ,  G01N30/26 ,  G01N30/96 ,  B01D15/16 ,  B01D15/36

CPC分类号： G01N30/96 ,  B01D15/16 ,  B01D15/36 ,  G01N2030/965

摘要： Electrolytic eluent recycle systems for ion chromatography using a multi-channel electrolytic ion exchange device which integrates suppression, eluent generation, and eluent recycle. The systems recycle the eluent into the analytical system without passing the eluent through the electrode chambers. Also, such systems with a channel for electrolytic removal of ions from the suppression effluent before recycle.

公开(公告)号：US09588100B2

公开(公告)日：2017-03-07

申请号：US14308499

申请日：2014-06-18

申请人： PREMIUM GENETICS (UK) LTD.

发明人： David Appleyard ,  Jeff Betthauser ,  Marjorie Faust ,  John Larsen ,  Guocheng Shao ,  Zheng Xia ,  Yu Zhou

IPC分类号： G01N21/01 ,  G01N30/26 ,  G01N33/48 ,  G01N33/483 ,  G01N1/44 ,  G01N21/64 ,  G01N15/10 ,  G01N15/14

CPC分类号： G01N15/1484 ,  B01L3/502761 ,  B01L2200/0636 ,  B01L2200/0652 ,  B01L2300/0627 ,  C12N13/00 ,  G01N1/44 ,  G01N15/1404 ,  G01N21/01 ,  G01N21/6486 ,  G01N33/4833 ,  G01N2015/1006 ,  G01N2015/1409 ,  G01N2015/1413

摘要： An apparatus and method of identifying objects includes: a microfluidic chip in which are disposed a plurality of channels, the microfluidic chip including: a main fluid channel into which a sample fluid mixture of objects to be identified is introduced; a plurality of sheath fluid channels into which sheath fluids are introduced, the sheath fluids which orient the objects in the main fluid channel in a predetermined direction while still maintaining laminar flow in the main fluid channel; an interrogation apparatus which detects and interrogates the oriented objects in the main fluid channel; and a focused energy apparatus which performs an action on the objects.

摘要翻译： 识别物体的装置和方法包括：微流体芯片，其中布置有多个通道，所述微流体芯片包括：主流体通道，待识别的物体的样品流体混合物被引入到该主流体通道中; 多个护套流体通道，其中引入护套流体;护套流体，其沿着预定方向定向主流体通道中的物体，同时仍保持主流体通道中的层流; 询问装置，其检测并询问主流体通道中的定向物体; 以及对物体执行动作的聚焦能量装置。

公开(公告)号：US20160216239A1

公开(公告)日：2016-07-28

申请号：US14649336

申请日：2013-11-11

申请人： HITACHI HIGH-TECHNOLOGIES CORPORATION

发明人： Toshimichi AOTA ,  Satoshi MITSUYAMA ,  Masahito ITO ,  Chihiro YOSHIOKA ,  Takaaki SUZUKI

IPC分类号： G01N30/26

CPC分类号： G01N30/26 ,  G01N30/16 ,  G01N30/34 ,  G01N30/8651 ,  G01N30/8658

摘要： In the present invention, differences in liquid feed properties between liquid chromatographic devices are determined, a liquid feed time table that takes these differences into account is acquired by way of system changes, and flow control is performed by a pump. Furthermore, the liquid feed time table after the system changes is divided into a plurality of intervals, and instructions are sent to the pump after approximate calculations are performed. Thus, by efficiently performing system change processes, the same measurement results can be obtained in a plurality of different liquid chromatograph devices, regardless of the differences in liquid feed properties.

摘要翻译： 在本发明中，确定了液相色谱装置之间的液体进料性能的差异，考虑到这些差异的液体进料时间表是通过系统改变获得的，并且通过泵进行流量控制。 此外，系统变化后的液体供给时间表被分成多个间隔，并且在执行近似计算之后将指令发送到泵。 因此，通过有效地执行系统变更处理，可以在多种不同的液相色谱装置中获得相同的测量结果，而与液体进料性质的差异无关。