公开(公告)号：US11965863B2

公开(公告)日：2024-04-23

申请号：US18070859

申请日：2022-11-29

申请人： Waters Technologies Corporation

发明人： Sylvain Gilles Cormier ,  Joseph D. Antocci ,  Francis Patrick Tracey ,  Charles H. Phoebe, Jr.

IPC分类号： G01N30/24 ,  G01N30/20 ,  G01N30/38 ,  G01N30/02

CPC分类号： G01N30/20 ,  G01N30/24 ,  G01N30/38 ,  G01N2030/027 ,  G01N2030/207

摘要： A liquid chromatography system includes a solvent delivery system, a sample manager including a sample delivery system in fluidic communication with the solvent delivery system, the sample delivery system configured to inject a sample from a sample-vial into a chromatographic flow stream, a liquid chromatography column located downstream from the sample delivery system, and a detector located downstream from the liquid chromatography column. The sample delivery system further includes a first needle drive including a first sample needle configured to extract the sample from the sample-vial and deliver the sample to the liquid chromatography column, and a first syringe in communication with the first sample needle configured to meter extraction of the sample from the sample-vial. The sample manager further includes a sample automation system that includes a second needle drive including a second sample needle configured to add a volume of reagent to the sample-vial.

公开(公告)号：US11874205B2

公开(公告)日：2024-01-16

申请号：US17137967

申请日：2020-12-30

申请人： SHIMADZU CORPORATION

发明人： Ayaka Kisaka ,  Yasuhiro Kimoto ,  Yu Nagao

IPC分类号： G01N30/38 ,  G01N30/02

CPC分类号： G01N30/38 ,  G01N2030/025 ,  G01N2030/382

摘要： A gas chromatograph comprises a sample gas generation unit, separation column, and detector. Multiple gas sources serve as carrier gases to transport sample gas to the separation column. A switching component connects the gas sources to the sample gas generation unit based on user-input information. This information is stored in a gas type memory, which aids a gas type identification component in determining the carrier gas type by monitoring the switching component's status and referring to the stored data.

公开(公告)号：US11835497B2

公开(公告)日：2023-12-05

申请号：US17869244

申请日：2022-07-20

申请人： Activated Research Company, LLC

发明人： Andrew Jones ,  Tommy Saunders ,  Mike Hofflander

IPC分类号： G01N30/64 ,  G01N30/38 ,  G01N30/34 ,  G01N30/02 ,  G01N30/84

CPC分类号： G01N30/64 ,  G01N30/38 ,  G01N2030/027 ,  G01N2030/347 ,  G01N2030/8417 ,  G01N2030/8447 ,  G01N2030/8494

摘要： In the present system and method, a conduit from a LC device continuously transports solvent, buffers, and analytes to the inlet of a solvent removal and analyte conversion device which evaporates the solvents, leaving non-volatile analytes for detection. The device comprises a rotating disk. The liquid chromatograph device can be any device using liquid chromatography to separate molecules. The solvents in the LC effluent can include, but are not limited to, water, methanol, acetonitrile, tetrahydrofuran, and acetone. After removal of the volatile components, the non-volatile analytes are converted with a concentrated energy source so that they may be detectable.

公开(公告)号：US11796521B2

公开(公告)日：2023-10-24

申请号：US17495160

申请日：2021-10-06

申请人： SHIMADZU CORPORATION

发明人： Shigeaki Shibamoto

IPC分类号： G01N33/00 ,  G01N30/38 ,  G01N30/02

CPC分类号： G01N33/0006 ,  G01N33/007 ,  G01N33/0073 ,  G01N2030/025 ,  G01N2030/385

摘要： A gas analyzer includes: a column that separates a component in a sample gas; a valve that switches, between a test sample gas and a standard sample gas, the sample gas to be supplied to the column; a valve that adjusts an introduction amount of the sample gas to be supplied to the column; a detector that detects, by gas chromatography, the component in the sample gas separated by the column; and a control device. The control device controls the valve to allow the introduction amount to be a predetermined amount, calculates a peak area value of a chromatogram obtained by the detector when the introduction amount is the predetermined amount, and calculates a correspondence between the introduction amount and the peak area value.

公开(公告)号：US20230266286A1

公开(公告)日：2023-08-24

申请号：US18104669

申请日：2023-02-01

申请人： Regeneron Pharmaceuticals, Inc.

发明人： Shunhai Wang ,  Yuetian Yan

IPC分类号： G01N30/72 ,  G01N30/38

CPC分类号： G01N30/7266 ,  G01N30/38 ,  G01N30/7273 ,  G01N2030/027

摘要： Disclosed are native liquid chromatography-mass spectrometry systems and methods of use. A native liquid chromatography-mass spectrometry system can include a liquid chromatography system capable of separating a sample; and an electrospray ionization mass spectrometry (ESI-MS) system in fluid communication with the liquid chromatography system, wherein the ESI-MS system comprises a multi-nozzle electrospray ionization emitter and a system for modifying a desolvation gas and a mass spectrometer, wherein the mass spectrometer is configured to receive ions and characterize mass to charge ratio of ions.

公开(公告)号：US11630090B2

公开(公告)日：2023-04-18

申请号：US16943868

申请日：2020-07-30

申请人： Agilent Technologies, Inc.

发明人： Thomas Ortmann ,  Thomas Glauner

IPC分类号： G01N30/20 ,  G01N30/38

摘要： A sample dispatcher for a fluid separation apparatus includes a sampling path including a sampling volume, a sampling unit, and a retaining unit. The sampling unit receives a fluidic sample, and the sampling volume temporarily stores an amount of the received sample. The retaining unit receives and retains from the sampling volume at least a portion of the stored sample, and has different retention characteristics for different components of the sample. A switching unit is coupled to the sampling path, a sampling fluid drive, a mobile phase drive, and a separating device. In a feed injection configuration of the switching unit, the mobile phase drive, the separating device, and the sampling path are coupled together in a coupling point for combining a flow from the sampling fluid drive containing the fluidic sample retained by the retaining unit with a flow of the mobile phase from the mobile phase drive.

公开(公告)号：US20230071525A1

公开(公告)日：2023-03-09

申请号：US17469579

申请日：2021-09-08

申请人： DIONEX CORPORATION

发明人： Kannan SRINIVASAN

IPC分类号： G01N30/86 ,  G01N30/38

摘要： A chromatography system includes an electrolytic eluent generator; a first valve configured to switch between an operating position which directs an output of the electrolytic eluent generator to a continuously generated trap column and a waste position which directs the output of the electrolytic eluent generator to waste; the continuously regenerated trap column; a degasser; a sample injector including a sample injector valve assembly, the sample injector valve assembly configured to switch between an operation mode which directs an output of the degasser to a separation column, a load mode which loads a sample onto the separation column, and a regenerant mode which directs the output of the degasser to a regenerant line; the separation column; a suppressor; and a detector.

公开(公告)号：US11567042B2

公开(公告)日：2023-01-31

申请号：US16921425

申请日：2020-07-06

申请人： DIONEX SOFTRON GMBH

发明人： Martin Rendl

IPC分类号： G01N30/32 ,  G01N30/38 ,  G01M3/26 ,  G01N30/86 ,  G01N30/62 ,  G01N30/02

摘要： A method for determining a state of a fluidic system can include measuring back pressures in the fluidic system at different times and determining a state of the fluidic system. The determination is based on at least the measured back pressures and on additional status information indicative of at least one status of the fluidic system at at least one of the different times.

公开(公告)号：US20220326197A1

公开(公告)日：2022-10-13

申请号：US17764613

申请日：2020-09-10

申请人： HITACHI HIGH-TECH CORPORATION

发明人： Ayano OTSUBO ,  Nobuhiro TSUKADA ,  Hisao INAMI ,  Shoji TOMIDA ,  Mitsuhiko UEDA ,  Daisuke AKIEDA ,  Kenichiro NISHIKI

IPC分类号： G01N30/38 ,  F16K11/074

摘要： A flowpath switch valve is configured for extended service life by spreading the region, of the sliding surfaces of a stator and a rotor, that is subject to wear over the entirety of the sliding surfaces. The stator has fixed stator flowpaths, and the rotor has rotor flowpaths. A flowpath switch valve, depending on the rotor rotation state, realizes connection patterns that include: a first connection pattern wherein a rotor flowpath 241 connects a fixed stator flowpath 31 and a fixed stator flowpath 32; a second connection pattern wherein the rotor flowpath 241 connects the fixed stator flowpath 31 and a fixed stator flowpath 36; a third connection pattern wherein a rotor flowpath 242 connects the fixed stator flowpath 31 and the fixed stator flowpath 32; and a fourth connection pattern wherein the rotor flowpath 242 connects the fixed stator flowpath 31 and the fixed stator flowpath 36.

公开(公告)号：US11378486B2

公开(公告)日：2022-07-05

申请号：US16842789

申请日：2020-04-08

申请人： CHANGSHA UNIVERSITY OF SCIENCE & TECHNOLOGY

发明人： Yan Han ,  Lian Shen ,  Chunsheng Cai ,  Baoxi Xiao ,  Chunguang Li ,  Peng Hu ,  Kuo Wang

IPC分类号： G01M9/04 ,  G01M9/06 ,  G01N33/00 ,  G01N30/38 ,  G01N15/06 ,  G01N15/00

摘要： The present invention discloses a pollutant generation system. The pollutant generation system includes a pollution source and a pollutant emitter. The pollutant emitter is connected to the pollution source. The pollution source is composed of two gases including air and methane. The flows of the gases are strictly controlled. Then, the gases enter a magnetic bead glass bottle. Due to the disturbance of magnetic beads to the flowing of the gases, the gases are sufficiently disordered, and the two gases are sufficiently mixed by using a spiral tube to generate a uniform and stable pollution source.