公开(公告)号：US20240360492A1

公开(公告)日：2024-10-31

申请号：US18657130

申请日：2024-05-07

申请人： Massachusetts Institute of Technology ,  University of Colorado

发明人： Michael B. Yaffe ,  Chris Barrett ,  Ernest Moore ,  Hunter Moore

IPC分类号： C12Q1/56 ,  G01N33/49 ,  G01N33/86

CPC分类号： C12Q1/56 ,  G01N33/4905 ,  G01N33/86 ,  C12Q2565/629 ,  G01N2333/8121 ,  G01N2333/968

摘要： Coagulation and fibrinolysis assays and related compositions, systems, methods, and kits are provided. In some embodiments, a coagulation and fibrinolysis assay may utilize one or more biological molecules. For instance, the assay may comprise combining a blood or blood-derived patient sample with the biological molecule(s) and measuring one or more properties of the sample associated with coagulation and/or fibrinolysis. The biological molecules may serve to shorten the assay duration and/or enhance the sensitivity of the assay relative to certain conventional assays. In certain embodiments, the biological molecules may allow pathological coagulation and/or fibrinolysis phenotypes to be elucidated. The coagulation and fibrinolysis assays described herein may be used for a wide variety of clinical and/or laboratory applications, including the diagnosis of certain coagulation and/or fibrinolysis disorders, such as trauma-induced coagulopathy and hyperfibrinolysis.

公开(公告)号：US12130280B2

公开(公告)日：2024-10-29

申请号：US17865253

申请日：2022-07-14

申请人： HEWLETT-PACKARD DEVELOPMENT COMPANY, L.P.

发明人： John Rossi ,  Scott A. Linn ,  James Michael Gardner ,  Erik D. Ness

IPC分类号： B41J2/045 ,  A61K47/18 ,  A61K47/26 ,  G01N27/327 ,  G01N33/49 ,  G01N33/66 ,  G06F3/12 ,  B41J2/175

CPC分类号： G01N33/4925 ,  A61K47/18 ,  A61K47/26 ,  B41J2/04543 ,  G01N27/3274 ,  G01N33/66 ,  G06F3/1206 ,  B41J2/04586 ,  B41J2/175 ,  G01N2496/70

摘要： A fluid ejection controller interface includes input logic to receive control data packets and a first clock signal, each control data packet including a set of primitive data bits and a set of random bits, wherein the input logic identifies the random bits in the received control data packets to facilitate the creation of modified control data packets. The fluid ejection controller interface includes a clock signal generator to generate a second clock signal that is different than the first clock signal, and output logic to receive the modified control data packets, and output the modified control data packets to a fluid ejection controller of a fluid ejection device based on the second clock signal.

公开(公告)号：US20240345011A1

公开(公告)日：2024-10-17

申请号：US18735347

申请日：2024-06-06

申请人： MEDTRONIC MINIMED, INC.

发明人： Keith Nogueira ,  Taly G. Engel ,  Xiaolong Li ,  Bradley C. Liang ,  Rajiv Shah ,  Jaeho Kim ,  Mike C. Liu ,  Andy Y. Tsai ,  Andrea Varsavsky ,  Fei Yu

IPC分类号： G01N27/02 ,  G01N33/487 ,  G01N33/49

CPC分类号： G01N27/026 ,  G01N33/48707 ,  G01N33/49

摘要： A method of optimizing operation of a glucose sensor includes performing an electrochemical impedance spectroscopy (EIS) procedure to obtain imaginary impedance values for an electrode of a glucose sensor, calculating a change value as a difference between a threshold reference for the imaginary impedance values and a most-recent imaginary impedance value, and obtaining measurements of the calibration factor for the glucose sensor. The method also includes comparing the change value to a first threshold and the calibration factor to a second threshold and determining, based on the comparison, whether sensor data from the glucose sensor is valid.

公开(公告)号：US12114973B2

公开(公告)日：2024-10-15

申请号：US17579525

申请日：2022-01-19

申请人： Fresenius Medical Care Holdings, Inc.

发明人： Louis LeeGrande Barrett

IPC分类号： A61B5/1455 ,  G01J1/02 ,  G01J3/02 ,  G01J3/28 ,  G01J3/42 ,  G01N15/06 ,  G01N21/27 ,  G01N21/31 ,  G01N21/3577 ,  G01N33/49 ,  A61B5/00 ,  G01J1/44 ,  G01N15/01 ,  G01N15/075

CPC分类号： A61B5/1455 ,  A61B5/14557 ,  G01J1/0214 ,  G01J3/0205 ,  G01J3/28 ,  G01J3/42 ,  G01N15/06 ,  G01N21/274 ,  G01N21/314 ,  G01N21/3577 ,  G01N33/49 ,  A61B5/0022 ,  A61B2560/0223 ,  G01J2001/444 ,  G01N15/01 ,  G01N15/075 ,  G01N2201/062 ,  G01N2201/0624

摘要： A measurement system for measuring blood characteristics includes a controller, an emitter, a sensor, and a reference sensor. The emitter emits light at a plurality of wavelengths from a first side of a blood flow channel to a second side of the blood flow channel. The sensor is provided on the second side of the blood flow channel. The reference sensor is provided on the first side of the blood flow channel. The controller compensates measurements from the sensor based upon measurements from the reference sensor. The reference sensor may be disposed in a position to increase noise immunity of the measurement system. The measurement system may be connected to or part of a dialysis system.

公开(公告)号：US20240337644A1

公开(公告)日：2024-10-10

申请号：US18748567

申请日：2024-06-20

申请人： Shenzhen Mindray Animal Medical Technology Co., Ltd.

发明人： Xinjun ZHANG ,  Fangang KONG ,  Tao SHI ,  Zhuxiang YANG ,  Shengxi WANG

IPC分类号： G01N33/49

CPC分类号： G01N33/4915

摘要： A sample analyzer and an animal reticulocyte testing method. After collecting a blood sample of an animal, the sample analyzer can determine, according to the animal type of the animal, a reticulocyte incubation time corresponding to the animal, and control an incubation time of the blood sample on the basis of the reticulocyte incubation time to prepare a sample fluid to be tested. The fragmentation of reticulocytes in said sample liquid obtained by using the reticulocyte incubation time is within a preset reasonable range, such that the accuracy of a testing result of the reticulocytes is ensured, and the application range of the animal testing is improved.

公开(公告)号：US20240328995A1

公开(公告)日：2024-10-03

申请号：US18738534

申请日：2024-06-10

申请人： Siemens Healthcare Diagnostics Inc.

发明人： Wei Zhang ,  Kevin Horan

IPC分类号： G01N27/416 ,  G01N27/333 ,  G01N33/49

CPC分类号： G01N27/4163 ,  G01N27/333 ,  G01N33/49 ,  G01N2496/00

摘要： Reagents are disclosed for use with potentiometric magnesium ion selective electrodes, along with kits containing same as well as methods of use thereof.

公开(公告)号：US12099049B2

公开(公告)日：2024-09-24

申请号：US17686250

申请日：2022-03-03

申请人： Shenzhen Mindray Bio-Medical Electronics Co., Ltd.

发明人： Wenbo Zheng ,  Bo Ye ,  Wentao Wei

IPC分类号： G01N33/49 ,  G01N1/40

CPC分类号： G01N33/49 ,  G01N1/4044

摘要： Provided are a method and device for recognizing hook effect in immune turbidimetry, and a computer readable medium. This method generates a reaction curve using light signals measured in a predetermined time period by immune reaction of analyte in a sample, and uses distribution information of the reaction curve in the predetermined time period to determine whether the sample has hook effect. This method only uses measurement information of a small predetermined time period in entire reaction time to determine whether a sample has hook effect, and terminates the test in time, thus accelerating the speed of immune turbidimetry detection of samples with hook effect.

公开(公告)号：US12092631B2

公开(公告)日：2024-09-17

申请号：US16903907

申请日：2020-06-17

申请人： The General Hospital Corporation

发明人： Seemantini K. Nadkarni ,  Zeinab Hajjarian ,  Markandey Tripathi ,  Diane Tshikudi

IPC分类号： G01N33/49 ,  B01L3/00 ,  G01N11/00 ,  G01N15/00 ,  G01N21/27 ,  G01N21/51 ,  G01N21/82 ,  G01N33/86 ,  G01N15/0205 ,  G01N21/47

CPC分类号： G01N33/4905 ,  B01L3/502715 ,  G01N11/00 ,  G01N15/00 ,  G01N21/272 ,  G01N21/51 ,  G01N21/82 ,  G01N33/86 ,  B01L2300/0654 ,  B01L2300/0816 ,  B01L2300/0864 ,  B01L2400/0487 ,  B01L2400/0688 ,  G01N2015/0092 ,  G01N2015/0222 ,  G01N2021/479 ,  G01N2021/825 ,  G01N2201/0221 ,  G01N2203/0094

摘要： Hand-held optical thromboelastographic sensor and method of using the same for simultaneous assessment of multiple parameters of blood coagulation at a point-of-care. The sensor includes an optical system registering laser speckle intensities associated with portions of a blood sample delivered through a fluid switch to analysis chambers of a cartridge of the sensor, and data-processing circuitry programmed to derive the multiple parameters from speckle intensity. The circuitry may be part of a mobile device configured to operate without communication with a central server and/or data storage.

公开(公告)号：US12089588B2

公开(公告)日：2024-09-17

申请号：US17400931

申请日：2021-08-12

申请人： Biomatrica, Inc.

发明人： Joel Desharnais ,  Victoria Arendt ,  Margrith Mattmann

IPC分类号： A01N1/02 ,  G01N15/05 ,  G01N33/49

CPC分类号： A01N1/021 ,  G01N15/05 ,  G01N33/491

摘要： The present invention relates to reduction of erythrocyte sedimentation rate in a blood sample. In particular, formulations, compositions, articles of manufacture, kits and methods for reduced erythrocyte sedimentation rate in a blood sample are provided.

公开(公告)号：US12064765B2

公开(公告)日：2024-08-20

申请号：US17264487

申请日：2019-07-31

申请人： Siemens Healthcare Diagnostics Inc.

发明人： Kalpesh Mehta ,  Mohiudeen Azhar

IPC分类号： B01L3/00 ,  B03C5/00 ,  B03C5/02 ,  G01N21/17 ,  G01N21/31 ,  G01N27/447 ,  G01N33/49

CPC分类号： B01L3/502753 ,  B01L3/502761 ,  B03C5/005 ,  B03C5/024 ,  G01N21/1717 ,  G01N21/31 ,  G01N27/44721 ,  G01N27/44791 ,  G01N33/4925 ,  B01L2300/0645 ,  B01L2300/0822 ,  B01L2400/0424 ,  G01N2021/1721

摘要： A method and system for determining a concentration of one or more analytes in whole blood is provided. In one aspect of the invention, the system includes a channel configured to carry whole blood. The system further includes a light source configured to emit light on the channel. Additionally, the system includes an actuation module associable with the channel, wherein the actuation module is configured to generate a cell-free plasma layer in the channel. Furthermore, the system includes an optical module associable with the channel.